pinacidil has been researched along with Hemorrhagic Shock in 2 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the beneficial effect of pinacidil pretreatment on vascular reactivity, calcium sensitivity, and animal survival after hemorrhagic shock, its relationship to protein kinase Cα (PKCα), protein kinase Cε (PKCε), and adenosine." | 3.78 | Pinacidil pretreatment improves vascular reactivity after shock through PKCα and PKCε in rats. ( Li, T; Liu, L; Xu, J; Yang, G, 2012) |
| "A loss of 5%-10% blood for preconditioning could not improve the survival rate of rat after hemorrhagic shock, while pinacidil preconditioning significantly increased the survival rate of rats with hemorrhagic shock lasting for 120 minutes." | 3.74 | [Effects of preconditioning on the responsiveness of superior mesenteric artery after hemorrhagic shock in rats]. ( Liu, LM; Zhou, R, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, J | 1 |
| Li, T | 1 |
| Yang, G | 1 |
| Liu, L | 1 |
| Zhou, R | 1 |
| Liu, LM | 1 |
2 other studies available for pinacidil and Hemorrhagic Shock
| Article | Year |
|---|---|
Pinacidil pretreatment improves vascular reactivity after shock through PKCα and PKCε in rats.
Topics: Adenosine; Animals; Calcium; Disease Models, Animal; Female; Fluid Therapy; Male; Mesenteric Artery, | 2012 |
[Effects of preconditioning on the responsiveness of superior mesenteric artery after hemorrhagic shock in rats].
Topics: Animals; Disease Models, Animal; Female; Ischemic Preconditioning; Male; Mesenteric Artery, Superior | 2007 |