Page last updated: 2024-11-02

pinacidil and Heart Failure

pinacidil has been researched along with Heart Failure in 4 studies

Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)

Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Glibenclamide (10 μM) terminated these arrhythmias and restored APDs to control values."1.37Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. ( Ambrosi, CM; Chang, R; Efimov, IR; Fedorov, VV; Glukhov, AV; Janks, D; Kostecki, G; Moazami, N; Nichols, CG; Schuessler, RB, 2011)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brennan, S1
Jackson, R1
Patel, M1
Sims, MW1
Hudman, D1
Norman, RI1
Lodwick, D1
Rainbow, RD1
Fedorov, VV1
Glukhov, AV1
Ambrosi, CM1
Kostecki, G1
Chang, R1
Janks, D1
Schuessler, RB1
Moazami, N1
Nichols, CG1
Efimov, IR1
Traverse, JH1
Chen, Y1
Hou, M1
Li, Y1
Bache, RJ1
Satoh, K1

Reviews

1 review available for pinacidil and Heart Failure

ArticleYear
[Ca-antagonist, K-channel-opener in the treatment of patients with congestive heart failure].
    Nihon rinsho. Japanese journal of clinical medicine, 1993, Volume: 51, Issue:5

    Topics: Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Guanidines; Heart Failure; Hemodynamics;

1993

Other Studies

3 other studies available for pinacidil and Heart Failure

ArticleYear
Early opening of sarcolemmal ATP-sensitive potassium channels is not a key step in PKC-mediated cardioprotection.
    Journal of molecular and cellular cardiology, 2015, Volume: 79

    Topics: Action Potentials; Adenosine; Animals; Cardiotonic Agents; Cell Separation; Diazoxide; Enzyme Activa

2015
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.
    Journal of molecular and cellular cardiology, 2011, Volume: 51, Issue:2

    Topics: Action Potentials; Adolescent; Adult; Arrhythmias, Cardiac; Coronary Vessels; Diazoxide; Female; Gen

2011
Effect of K+ATP channel and adenosine receptor blockade during rest and exercise in congestive heart failure.
    Circulation research, 2007, Jun-08, Volume: 100, Issue:11

    Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Cardiac Pacing, Artifi

2007