pinacidil has been researched along with Heart Disease, Ischemic in 47 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias." | 7.73 | Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 7.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| "It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias." | 3.73 | Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| "We previously demonstrated that pinacidil does not affect Na(+)(i) accumulation, cellular energy depletion, or acidosis during myocardial ischemia, but dramatically improves the cationic/energetic status during reperfusion." | 3.72 | Early reperfusion levels of Na(+) and Ca(2+) are strongly associated with postischemic functional recovery but are disassociated from K(ATP) channel-induced cardioprotection. ( Digerness, SB; Guo, LL; Pike, MM; Takayama, E, 2004) |
| "Glibenclamide (10 μM) terminated these arrhythmias and restored APDs to control values." | 1.37 | Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. ( Ambrosi, CM; Chang, R; Efimov, IR; Fedorov, VV; Glukhov, AV; Janks, D; Kostecki, G; Moazami, N; Nichols, CG; Schuessler, RB, 2011) |
| "Pinacidil solutions have been shown to have significant cardioprotective effects." | 1.32 | Donor heart preservation with pinacidil: the role of the mitochondrial K ATP channel. ( Damiano, RJ; Diodato, MD; Gaynor, SL; Lawton, JS; Prasad, SM; Shah, NR, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 25 (53.19) | 18.2507 |
| 2000's | 21 (44.68) | 29.6817 |
| 2010's | 1 (2.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fedorov, VV | 1 |
| Glukhov, AV | 1 |
| Ambrosi, CM | 1 |
| Kostecki, G | 1 |
| Chang, R | 1 |
| Janks, D | 1 |
| Schuessler, RB | 1 |
| Moazami, N | 1 |
| Nichols, CG | 1 |
| Efimov, IR | 1 |
| Kupriyanov, VV | 1 |
| Xiang, B | 1 |
| Sun, J | 1 |
| Jilkina, O | 1 |
| Legtenberg, RJ | 2 |
| Rongen, GA | 1 |
| Houston, RJ | 2 |
| Oeseburg, B | 2 |
| Smits, P | 2 |
| Ikizler, M | 1 |
| Dernek, S | 1 |
| Sevin, B | 1 |
| Maxey, TS | 1 |
| Kural, T | 1 |
| Fischbach, PS | 1 |
| Barrett, TD | 1 |
| Reed, NJ | 1 |
| Lucchesi, BR | 3 |
| Das, B | 1 |
| Sarkar, C | 1 |
| Wang, J | 1 |
| Zhou, X | 1 |
| Zhao, Y | 1 |
| Tang, H | 1 |
| Hu, Y | 1 |
| Zhu, HF | 1 |
| Dong, JW | 1 |
| Zhu, WZ | 1 |
| Ding, HL | 1 |
| Zhou, ZN | 1 |
| Lindhardt, TB | 1 |
| Gadsbøll, N | 1 |
| Kelbaek, H | 1 |
| Saunamäki, K | 1 |
| Madsen, JK | 1 |
| Clemmensen, P | 1 |
| Hesse, B | 1 |
| Haunsø, S | 1 |
| Takayama, E | 1 |
| Guo, LL | 2 |
| Digerness, SB | 1 |
| Pike, MM | 2 |
| Diodato, MD | 1 |
| Shah, NR | 1 |
| Prasad, SM | 1 |
| Gaynor, SL | 1 |
| Lawton, JS | 3 |
| Damiano, RJ | 5 |
| Er, F | 1 |
| Michels, G | 1 |
| Gassanov, N | 1 |
| Rivero, F | 1 |
| Hoppe, UC | 1 |
| Ferrier, GR | 1 |
| Howlett, SE | 1 |
| Nishizawa, K | 1 |
| Wolkowicz, PE | 1 |
| Yamagishi, T | 1 |
| Trénor, B | 1 |
| Ferrero, JM | 1 |
| Rodríguez, B | 1 |
| Montilla, F | 1 |
| Wu, S | 1 |
| Hayashi, H | 1 |
| Lin, SF | 1 |
| Chen, PS | 1 |
| Jerome, SN | 1 |
| Akimitsu, T | 1 |
| Gute, DC | 1 |
| Korthuis, RJ | 1 |
| Hoffman, BF | 2 |
| Ren, XL | 2 |
| Grover, GJ | 4 |
| D'Alonzo, AJ | 1 |
| Darbenzio, RB | 1 |
| Hess, TA | 1 |
| Sewter, JC | 1 |
| Sleph, PG | 1 |
| Black, SC | 1 |
| Walsh, RS | 1 |
| Tsuchida, A | 1 |
| Daly, JJ | 1 |
| Thornton, JD | 2 |
| Cohen, MV | 1 |
| Downey, JM | 4 |
| Van Wagoner, DR | 1 |
| Lamorgese, M | 1 |
| Cavero, I | 1 |
| Premmereur, J | 1 |
| McPherson, CD | 1 |
| Pierce, GN | 1 |
| Cole, WC | 1 |
| Nakaya, H | 1 |
| Thornton, CS | 1 |
| Sterling, DL | 1 |
| Kubota, I | 1 |
| Yamaki, M | 1 |
| Shibata, T | 1 |
| Ikeno, E | 1 |
| Hosoya, Y | 1 |
| Tomoike, H | 1 |
| Armstrong, SC | 1 |
| Liu, GS | 2 |
| Ganote, CE | 1 |
| Liu, Y | 1 |
| Gao, WD | 1 |
| O'Rourke, B | 1 |
| Marban, E | 1 |
| Harrington, GC | 1 |
| Allen, CT | 1 |
| Hsia, PW | 2 |
| Sellke, FW | 1 |
| Wang, SY | 1 |
| Stamler, A | 1 |
| Lopez, JJ | 1 |
| Li, J | 2 |
| Simons, M | 1 |
| Kanda, A | 1 |
| Watanabe, I | 1 |
| Williams, ML | 1 |
| Engle, CL | 1 |
| Li, S | 1 |
| Koch, GG | 1 |
| Gettes, LS | 1 |
| Critz, SD | 1 |
| Chujo, M | 1 |
| McClain, LC | 1 |
| Maier, GW | 1 |
| Jayawant, M | 1 |
| Stephenson, ER | 1 |
| Liang, BT | 1 |
| Tanhehco, EJ | 1 |
| Yasojima, K | 1 |
| McGeer, PL | 1 |
| Washington, RA | 1 |
| Kilgore, KS | 1 |
| Homeister, JW | 1 |
| Vanden Hoek, T | 1 |
| Becker, LB | 1 |
| Shao, ZH | 1 |
| Li, CQ | 1 |
| Schumacker, PT | 1 |
| Ghosh, S | 1 |
| Standen, NB | 1 |
| Galiñanes, M | 1 |
| Feng, J | 1 |
| Li, H | 1 |
| Rosenkranz, ER | 1 |
| Hoenicke, EM | 1 |
| Lin, R | 1 |
| Zhu, X | 1 |
| Zhang, Z | 1 |
| Kang, M | 1 |
| Xia, Q | 1 |
3 reviews available for pinacidil and Heart Disease, Ischemic
| Article | Year |
|---|---|
Protective effects of ATP-sensitive potassium-channel openers in experimental myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dihydropyridines; Disea | 1994 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; G | 1993 |
Pharmacology of ATP-sensitive potassium channel (KATP) openers in models of myocardial ischemia and reperfusion.
Topics: Animals; ATP-Binding Cassette Transporters; Benzopyrans; Cromakalim; Guanidines; Humans; Ischemic Pr | 1997 |
1 trial available for pinacidil and Heart Disease, Ischemic
| Article | Year |
|---|---|
Pharmacological modulation of the ATP sensitive potassium channels during repeated coronary occlusions: no effect on myocardial ischaemia or function.
Topics: Adenosine Triphosphate; Angina Pectoris; Anti-Arrhythmia Agents; Balloon Occlusion; Coronary Stenosi | 2004 |
43 other studies available for pinacidil and Heart Disease, Ischemic
| Article | Year |
|---|---|
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.
Topics: Action Potentials; Adolescent; Adult; Arrhythmias, Cardiac; Coronary Vessels; Diazoxide; Female; Gen | 2011 |
The effects of drugs modulating K(+) transport on Rb(+) uptake and distribution in pig hearts following regional ischemia: (87)Rb MRI study.
Topics: Animals; Bumetanide; Glyburide; In Vitro Techniques; Magnetic Resonance Imaging; Myocardial Infarcti | 2002 |
The role of myocardial KATP-channel blockade in the protective effects of glibenclamide against ischaemia in the rat heart.
Topics: Animals; Coronary Circulation; Diazoxide; Drug Interactions; Glyburide; Male; Myocardial Ischemia; P | 2002 |
Improved myocardial function with the addition of pinacidil to custadiol.
Topics: Animals; Blood Pressure; Coronary Circulation; Creatine Kinase; Glucose; Heart; Hypothermia, Induced | 2002 |
SNC-80-induced preconditioning: selective activation of the mitochondrial adenosine triphosphate-gated potassium channel.
Topics: Adenosine Triphosphate; Animals; Benzamides; Female; Heart; In Vitro Techniques; Ion Channel Gating; | 2003 |
Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Arrhythmias, Cardiac; Blood Pressure; Decanoic Acids; | 2003 |
Myocardial protection of immature rabbits: polarizing versus depolarizing.
Topics: Aging; Animals; Bicarbonates; Body Water; Calcium Chloride; Cardiotonic Agents; Coronary Circulation | 2003 |
ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.
Topics: Animals; Calcium; Decanoic Acids; Glyburide; Heart Ventricles; Hemodynamics; Hydroxy Acids; Hypoxia; | 2003 |
Pinacidil-induced opening, like glibenclamide-induced closure of cardiac KATP channels, protects cardiac function against ischemia in isolated, working, erythrocyte perfused rat hearts.
Topics: Animals; Glyburide; Heart; In Vitro Techniques; Ion Channel Gating; Male; Myocardial Ischemia; Pinac | 2003 |
Early reperfusion levels of Na(+) and Ca(2+) are strongly associated with postischemic functional recovery but are disassociated from K(ATP) channel-induced cardioprotection.
Topics: Animals; Calcium; Chlorides; Heart Ventricles; In Vitro Techniques; Membrane Proteins; Myocardial Is | 2004 |
Donor heart preservation with pinacidil: the role of the mitochondrial K ATP channel.
Topics: Adenosine; Allopurinol; Animals; Benzamides; Cardiotonic Agents; Coronary Circulation; Decanoic Acid | 2004 |
Testosterone induces cytoprotection by activating ATP-sensitive K+ channels in the cardiac mitochondrial inner membrane.
Topics: Adenosine Triphosphate; Androgen Receptor Antagonists; Androstenedione; Animals; Biological Transpor | 2004 |
Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Guinea Pigs; Heart Ventricles; In Vitro Techn | 2005 |
Fasudil prevents KATP channel-induced improvement in postischemic functional recovery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Heart; In Vitro Techniques; Magnetic Resonan | 2005 |
Effects of pinacidil on reentrant arrhythmias generated during acute regional ischemia: a simulation study.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Computer Simulation; Heart | 2005 |
Action potential duration and QT interval during pinacidil infusion in isolated rabbit hearts.
Topics: Action Potentials; Animals; Calcium; Electrocardiography; Heart; In Vitro Techniques; Myocardial Isc | 2005 |
Ischemic preconditioning attenuates capillary no-reflow induced by prolonged ischemia and reperfusion.
Topics: Adenosine Triphosphate; Animals; Capillaries; Dogs; Female; Glyburide; Guanidines; Male; Muscle, Ske | 1995 |
Reversibility of electrophysiological abnormalities in subacute ischemia.
Topics: Action Potentials; Animals; Dogs; Female; Guanidines; Male; Membrane Potentials; Myocardial Ischemia | 1994 |
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; My | 1994 |
Potassium channel openers are likely to be proarrhythmic in the diseased human heart.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Dogs; Guanidines; Heart; H | 1994 |
Ketamine-xylazine anaesthesia permits a KATP channel antagonist to attenuate preconditioning in rabbit myocardium.
Topics: Animals; Glyburide; Guanidines; Ketamine; Myocardial Infarction; Myocardial Ischemia; Myocardium; Pi | 1994 |
Ischemia potentiates the mechanosensitive modulation of atrial ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Guanidines; Heart Atria; Ion Channel Gating; Mechanoreceptors; Myoc | 1994 |
Reversibility of electrophysiologic abnormalities of subendocardial Purkinje fibers induced by ischemia.
Topics: Adenosine Triphosphate; Animals; Diastole; Dogs; Electrophysiology; Endocardium; Female; Guanidines; | 1994 |
ATP sensitive potassium channel openers are of potential benefit in ischaemic heart disease.
Topics: Benzopyrans; Cromakalim; Dihydropyridines; Guanidines; Humans; Myocardial Ischemia; Myocardium; Niac | 1994 |
Ischemic cardioprotection by ATP-sensitive K+ channels involves high-energy phosphate preservation.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Glyburide; Guanidines; Guinea Pigs; Heart; In Vi | 1993 |
An explanation for the reported observation that ATP dependent potassium channel openers fail to mimic preconditioning.
Topics: Adenosine Triphosphate; Animals; Dogs; Guanidines; Ion Channel Gating; Myocardial Infarction; Myocar | 1993 |
Blockade of ATP-sensitive potassium channels increases infarct size but does not prevent preconditioning in rabbit hearts.
Topics: Animals; Female; Glyburide; Guanidines; Male; Myocardial Infarction; Myocardial Ischemia; Pinacidil; | 1993 |
Role of ATP-sensitive K+ channel on ECG ST segment elevation during a bout of myocardial ischemia. A study on epicardial mapping in dogs.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Dogs; Electrocardiography; Glyburide; Guanidines | 1993 |
Potassium channels and preconditioning of isolated rabbit cardiomyocytes: effects of glyburide and pinacidil.
Topics: Analysis of Variance; Animals; Cells, Cultured; Glyburide; Guanidines; Heart; Hypoglycemic Agents; K | 1995 |
Synergistic modulation of ATP-sensitive K+ currents by protein kinase C and adenosine. Implications for ischemic preconditioning.
Topics: Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Drug Synergism; Enzyme Activation; Guan | 1996 |
Myocardial protection with pinacidil cardioplegia in the blood-perfused heart.
Topics: Animals; Blood; Blood Pressure; Cardiac Volume; Cardioplegic Solutions; Coronary Circulation; Dose-R | 1996 |
Enhanced microvascular relaxations to VEGF and bFGF in chronically ischemic porcine myocardium.
Topics: Adenosine Diphosphate; Animals; Chronic Disease; Coronary Circulation; Endothelial Growth Factors; F | 1996 |
Unanticipated lessening of the rise in extracellular potassium during ischemia by pinacidil.
Topics: Adenosine Triphosphate; Animals; Drug Evaluation, Preclinical; Female; Guanidines; Ion Channel Gatin | 1997 |
Pinacidil but not nicorandil opens ATP-sensitive K+ channels and protects against simulated ischemia in rabbit myocytes.
Topics: Adenosine Triphosphate; Animals; Cell Death; Disease Models, Animal; Electrophysiology; Female; Guan | 1997 |
Myocardial oxygen consumption in the rabbit heart after ischemia: hyperpolarized arrest with pinacidil versus depolarized hyperkalemic arrest.
Topics: Animals; Coronary Circulation; Diastole; Female; Guanidines; Heart Arrest, Induced; Hyperkalemia; Ma | 1997 |
Advantages of continuous hyperpolarized arrest with pinacidil over St. Thomas' Hospital solution during prolonged ischemia.
Topics: Animals; Arrhythmias, Cardiac; Bicarbonates; Body Water; Calcium Chloride; Cardioplegic Solutions; C | 1998 |
Protein kinase C-dependent activation of KATP channel enhances adenosine-induced cardioprotection.
Topics: Adenosine; Animals; Cells, Cultured; Chick Embryo; Enzyme Activation; Glyburide; Ischemic Preconditi | 1998 |
Preconditioning reduces tissue complement gene expression in the rabbit isolated heart.
Topics: Animals; Complement System Proteins; DNA Primers; Gene Expression Regulation; Glyburide; In Vitro Te | 1999 |
Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Cell Death; Cells, Cultured; Chick Embryo; Decanoic Acids; Hydrogen | 2000 |
Evidence for mitochondrial K ATP channels as effectors of human myocardial preconditioning.
Topics: Analysis of Variance; Cell Membrane; Decanoic Acids; Diazoxide; Dose-Response Relationship, Drug; Gl | 2000 |
Pinacidil pretreatment extends ischemia tolerance of neonatal rabbit hearts.
Topics: Animals; Animals, Newborn; Cardioplegic Solutions; Coronary Circulation; Diastole; Heart Arrest, Ind | 2000 |
Superior 12-hour heart preservation with pinacidil hyperpolarizing solution compared to University of Wisconsin solution.
Topics: Animals; Heart Transplantation; Hemodynamics; Myocardial Ischemia; Organ Preservation; Organ Preserv | 2001 |
Myocardial protection of immature rabbits with an ATP-sensitive K+ channel opener pinacidil.
Topics: Animals; Coronary Circulation; Diastole; Female; Male; Myocardial Ischemia; Myocardial Reperfusion I | 2001 |