pinacidil has been researched along with Disease Models, Animal in 51 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias." | 7.73 | Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005) |
| "Pre-treatment of brain dead rabbits with pinacidil before prolonged cold-storage with STH solution significantly impaired endothelium-dependent vasorelaxation in comparison to storage with STH solution." | 7.70 | Pretreatment of brain dead rabbits with pinacidil before prolonged cold-storage with an extracellular solution alters aortic endothelial function. ( Berdeaux, A; Bévérelli, F; Kirsch, M; Lesurtel, M; Loisance, D, 2000) |
| "To investigate the protective and therapeutic effects of pinacidil on hypoxia-induced pulmonary hypertension(HPH) and pulmonary vascular remodeling." | 7.70 | [Laboratory study on protective and therapeutic effects of pinacidil on pulmonary vascular remodeling in rats with hypoxia-induced pulmonary hypertension]. ( He, Z; Liang, G; Zhong, X, 2000) |
| "We studied the electrophysiologic and antifibrillatory effects of the class III agent MS-551 in a rabbit isolated heart model in which ventricular fibrillation (VF) occurs reproducibly under conditions of hypoxia/reoxygenation in the presence of the ATP-dependent potassium channel opener, pinacidil." | 7.69 | Antiarrhythmic agent, MS-551, protects against pinacidil + hypoxia-induced ventricular fibrillation in Langendorff-perfused rabbit isolated heart. ( Black, SC; Chi, L; Friedrichs, GS; Lucchesi, BR; Manley, PJ, 1994) |
| "Ranolazine has been reported to have an antiarrhythmic potential." | 5.43 | Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome. ( Bögeholz, N; Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Güner, F; Kochhäuser, S; Leitz, P; Pott, C, 2016) |
| "Hydrogen sulfide (H(2)S) is an endogenous gaseous mediator of mucosal defense with antiinflammatory effects that promote ulcer healing." | 5.35 | Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats. ( Dicay, M; Martin, GR; McKnight, W; Vong, L; Wallace, JL, 2009) |
| "Melatonin was tested in two experimental groups, one of which underwent common bile duct ligation for 2 days and another that was later de-ligated for 2 days." | 5.35 | Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2008) |
| "Celikalim inhibited white thrombus formation at i." | 5.29 | Analysis of the potassium channel openers celikalim, pinacidil and cromakalim in platelet models of thrombosis. ( Carmint, WJ; Colatsky, TJ; Fenichel, RL; Patelunas-Hoffman, DM, 1994) |
| "We investigated the beneficial effect of pinacidil pretreatment on vascular reactivity, calcium sensitivity, and animal survival after hemorrhagic shock, its relationship to protein kinase Cα (PKCα), protein kinase Cε (PKCε), and adenosine." | 3.78 | Pinacidil pretreatment improves vascular reactivity after shock through PKCα and PKCε in rats. ( Li, T; Liu, L; Xu, J; Yang, G, 2012) |
| "A loss of 5%-10% blood for preconditioning could not improve the survival rate of rat after hemorrhagic shock, while pinacidil preconditioning significantly increased the survival rate of rats with hemorrhagic shock lasting for 120 minutes." | 3.74 | [Effects of preconditioning on the responsiveness of superior mesenteric artery after hemorrhagic shock in rats]. ( Liu, LM; Zhou, R, 2007) |
| "We assessed whether pravastatin attenuates cardiac sympathetic reinnervation after myocardial infarction through the activation of ATP-sensitive K(+) (K(ATP)) channels." | 3.74 | Effect of pravastatin on sympathetic reinnervation in postinfarcted rats. ( Chang, NC; Lee, TM; Lin, MS, 2007) |
| "It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias." | 3.73 | Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005) |
| "Potassium channel openers with pinacidil can provide pulmonary protection against warm ischemia reperfusion injury." | 3.72 | Warm ischemia lung protection with pinacidil: an ATP regulated potassium channel opener. ( Cohen, NM; Holwitt, DM; Mouria, MM; Pavot, DR; Tang, DG, 2003) |
| "Posthypothermic rapid rewarming caused cerebral vascular abnormalities, including a diminished response to acetylcholine, hypercapnia, pinacidil, and SNP." | 3.72 | Uncomplicated rapid posthypothermic rewarming alters cerebrovascular responsiveness. ( Kontos, HA; Povlishock, JT; Suehiro, E; Ueda, Y; Wei, EP, 2004) |
| "Pre-treatment of brain dead rabbits with pinacidil before prolonged cold-storage with STH solution significantly impaired endothelium-dependent vasorelaxation in comparison to storage with STH solution." | 3.70 | Pretreatment of brain dead rabbits with pinacidil before prolonged cold-storage with an extracellular solution alters aortic endothelial function. ( Berdeaux, A; Bévérelli, F; Kirsch, M; Lesurtel, M; Loisance, D, 2000) |
| "To investigate the protective and therapeutic effects of pinacidil on hypoxia-induced pulmonary hypertension(HPH) and pulmonary vascular remodeling." | 3.70 | [Laboratory study on protective and therapeutic effects of pinacidil on pulmonary vascular remodeling in rats with hypoxia-induced pulmonary hypertension]. ( He, Z; Liang, G; Zhong, X, 2000) |
| "We studied the electrophysiologic and antifibrillatory effects of the class III agent MS-551 in a rabbit isolated heart model in which ventricular fibrillation (VF) occurs reproducibly under conditions of hypoxia/reoxygenation in the presence of the ATP-dependent potassium channel opener, pinacidil." | 3.69 | Antiarrhythmic agent, MS-551, protects against pinacidil + hypoxia-induced ventricular fibrillation in Langendorff-perfused rabbit isolated heart. ( Black, SC; Chi, L; Friedrichs, GS; Lucchesi, BR; Manley, PJ, 1994) |
| "We investigated the effect of ATP-sensitive K+ channel (KATP) openers (pinacidil and cromakalim), and a KATP blocker (glibenclamide) on reperfusion-induced arrhythmias in pentobarbitone-anaesthetized rats." | 3.69 | KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats. ( Baczkó, I; Leprán, I; Papp, JG, 1997) |
| "Antazoline is a first-generation antihistamine with antiarrhythmic properties." | 1.48 | Antiarrhythmic effect of antazoline in experimental models of acquired short- and long-QT-syndromes. ( Dechering, DG; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Kochhäuser, S; Sterneberg, M, 2018) |
| "Ranolazine has been reported to have an antiarrhythmic potential." | 1.43 | Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome. ( Bögeholz, N; Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Güner, F; Kochhäuser, S; Leitz, P; Pott, C, 2016) |
| "Bone cancer pain is a major clinical problem and remains difficult to treat." | 1.40 | Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain. ( Fan, L; Pan, HL; Ren, J; Tian, Y; Wang, X; Wang, Y; Wu, J; Xia, H; Xu, L; Yang, S; Yao, W; Zhang, C; Zhang, D, 2014) |
| " The DFT, 90% action potential duration (APD(90)) and activation recovery interval (ARI) were evaluated before and after pinacidil administration (loading dosage 0." | 1.38 | The effect of pinacidil on postshock activation and ventricular defibrillation threshold in canine hearts. ( Gu, G; Jin, Q; Lin, CJ; Pang, Y; Shen, WF; Wu, LQ; Zhang, N; Zhou, J, 2012) |
| "Hydrogen sulfide (H(2)S) is an endogenous gaseous mediator of mucosal defense with antiinflammatory effects that promote ulcer healing." | 1.35 | Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats. ( Dicay, M; Martin, GR; McKnight, W; Vong, L; Wallace, JL, 2009) |
| "Melatonin was tested in two experimental groups, one of which underwent common bile duct ligation for 2 days and another that was later de-ligated for 2 days." | 1.35 | Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis. ( Camello, PJ; Gomez-Pinilla, PJ; Pozo, MJ, 2008) |
| "The Brugada syndrome is characterized by ST-segment elevation on the ECG, especially in the right precordial leads sensitive to the right ventricular outflow tract (RVOT)." | 1.34 | Differences in arrhythmogenicity between the canine right ventricular outflow tract and anteroinferior right ventricle in a model of Brugada syndrome. ( Morita, H; Morita, ST; Wu, J; Zipes, DP, 2007) |
| "Myocardial infarction was produced in dogs by ligation of the left anterior descending coronary artery." | 1.31 | Effects of pinacidil on electrophysiological properties of epicardial border zone of healing canine infarcts: possible effects of K(ATP) channel activation. ( Coromilas, J; Costeas, C; Deruyter, B; Dillon, SM; Peters, NS; Wit, AL, 2002) |
| "Celikalim inhibited white thrombus formation at i." | 1.29 | Analysis of the potassium channel openers celikalim, pinacidil and cromakalim in platelet models of thrombosis. ( Carmint, WJ; Colatsky, TJ; Fenichel, RL; Patelunas-Hoffman, DM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (17.65) | 18.2507 |
| 2000's | 25 (49.02) | 29.6817 |
| 2010's | 15 (29.41) | 24.3611 |
| 2020's | 2 (3.92) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, X | 1 |
| Qiu, Y | 1 |
| Li, X | 1 |
| Bhattacharjee, S | 1 |
| Woods, M | 1 |
| Kraft, P | 1 |
| Lundeen, SG | 1 |
| Sui, Z | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Limprasutr, V | 1 |
| Saengklub, N | 1 |
| Meedech, P | 1 |
| Kijtawornrat, A | 1 |
| Hamlin, RL | 1 |
| Patocskai, B | 1 |
| Yoon, N | 1 |
| Antzelevitch, C | 1 |
| Ellermann, C | 2 |
| Sterneberg, M | 1 |
| Kochhäuser, S | 2 |
| Dechering, DG | 2 |
| Fehr, M | 1 |
| Eckardt, L | 3 |
| Frommeyer, G | 2 |
| Sun, W | 1 |
| Li, T | 2 |
| Ma, H | 1 |
| Lin, S | 1 |
| Xie, M | 1 |
| Luo, Y | 1 |
| Tian, R | 1 |
| Tang, S | 1 |
| Xia, H | 1 |
| Zhang, D | 1 |
| Yang, S | 1 |
| Wang, Y | 1 |
| Xu, L | 1 |
| Wu, J | 3 |
| Ren, J | 1 |
| Yao, W | 1 |
| Fan, L | 1 |
| Zhang, C | 1 |
| Tian, Y | 1 |
| Pan, HL | 1 |
| Wang, X | 1 |
| Aziz, Q | 1 |
| Thomas, AM | 1 |
| Gomes, J | 1 |
| Ang, R | 1 |
| Sones, WR | 1 |
| Li, Y | 2 |
| Ng, KE | 1 |
| Gee, L | 1 |
| Tinker, A | 1 |
| Hozhenko, AI | 1 |
| Filipets', ND | 1 |
| Cao, S | 2 |
| Qin, Y | 1 |
| Chen, J | 1 |
| Shen, S | 2 |
| Zhu, X | 1 |
| Liu, J | 1 |
| Gao, Y | 1 |
| Kojima, A | 1 |
| Matsumoto, A | 1 |
| Nishida, H | 1 |
| Reien, Y | 1 |
| Iwata, K | 1 |
| Shirayama, T | 1 |
| Yabe-Nishimura, C | 1 |
| Nakaya, H | 1 |
| Bögeholz, N | 1 |
| Güner, F | 1 |
| Leitz, P | 1 |
| Pott, C | 1 |
| Wallace, JL | 1 |
| Vong, L | 1 |
| McKnight, W | 1 |
| Dicay, M | 1 |
| Martin, GR | 1 |
| Strutyns'kyĭ, RB | 3 |
| Neshcheret, OP | 3 |
| Tumanovs'ka, LV | 2 |
| Rovenets', RA | 3 |
| Moĭbenko, OO | 3 |
| Kotsiuruba, AV | 1 |
| Shysh, AM | 1 |
| Boĭchuk, TM | 1 |
| Dzhuran, BV | 1 |
| Xu, J | 1 |
| Yang, G | 1 |
| Liu, L | 1 |
| Jin, Q | 1 |
| Zhang, N | 1 |
| Zhou, J | 1 |
| Lin, CJ | 1 |
| Pang, Y | 1 |
| Gu, G | 1 |
| Shen, WF | 1 |
| Wu, LQ | 1 |
| Chang, MG | 1 |
| de Lange, E | 1 |
| Calmettes, G | 1 |
| Garfinkel, A | 1 |
| Qu, Z | 1 |
| Weiss, JN | 1 |
| Tang, DG | 1 |
| Pavot, DR | 1 |
| Mouria, MM | 1 |
| Holwitt, DM | 1 |
| Cohen, NM | 1 |
| Kimura, M | 1 |
| Kobayashi, T | 1 |
| Owada, S | 1 |
| Ashikaga, K | 1 |
| Higuma, T | 1 |
| Sasaki, S | 1 |
| Iwasa, A | 1 |
| Motomura, S | 1 |
| Okumura, K | 1 |
| Fields, AM | 1 |
| Richards, TA | 1 |
| Felton, JA | 1 |
| Felton, SK | 1 |
| Bayer, EZ | 1 |
| Ibrahim, IN | 1 |
| Kaye, AD | 1 |
| Ueda, Y | 1 |
| Suehiro, E | 1 |
| Wei, EP | 1 |
| Kontos, HA | 1 |
| Povlishock, JT | 1 |
| Ferrier, GR | 1 |
| Howlett, SE | 1 |
| Peng, NY | 1 |
| Zhou, H | 1 |
| Si, LY | 1 |
| Wang, S | 1 |
| Hu, LF | 1 |
| Zhang, Y | 1 |
| Sun, T | 1 |
| Sun, YH | 1 |
| Liu, SY | 1 |
| Ding, JH | 1 |
| Hu, G | 1 |
| Aiba, T | 1 |
| Shimizu, W | 1 |
| Hidaka, I | 1 |
| Uemura, K | 1 |
| Noda, T | 1 |
| Zheng, C | 1 |
| Kamiya, A | 1 |
| Inagaki, M | 1 |
| Sugimachi, M | 1 |
| Sunagawa, K | 1 |
| Morita, H | 1 |
| Zipes, DP | 1 |
| Morita, ST | 1 |
| Traverse, JH | 1 |
| Chen, Y | 1 |
| Hou, M | 1 |
| Bache, RJ | 1 |
| Zhou, R | 1 |
| Liu, LM | 1 |
| Milberg, P | 1 |
| Tegelkamp, R | 1 |
| Osada, N | 1 |
| Schimpf, R | 1 |
| Wolpert, C | 1 |
| Breithardt, G | 1 |
| Borggrefe, M | 1 |
| Lee, TM | 1 |
| Lin, MS | 1 |
| Chang, NC | 1 |
| Reyes, S | 1 |
| Kane, GC | 1 |
| Miki, T | 1 |
| Seino, S | 1 |
| Terzic, A | 1 |
| Gomez-Pinilla, PJ | 1 |
| Camello, PJ | 1 |
| Pozo, MJ | 1 |
| Friedrichs, GS | 1 |
| Chi, L | 1 |
| Black, SC | 1 |
| Manley, PJ | 1 |
| Lucchesi, BR | 1 |
| Grover, GJ | 1 |
| Patelunas-Hoffman, DM | 1 |
| Carmint, WJ | 1 |
| Colatsky, TJ | 1 |
| Fenichel, RL | 1 |
| Lawton, JS | 1 |
| Hsia, PW | 1 |
| Allen, CT | 1 |
| Damiano, RJ | 2 |
| Baczkó, I | 1 |
| Leprán, I | 1 |
| Papp, JG | 1 |
| Critz, SD | 1 |
| Liu, GS | 1 |
| Chujo, M | 1 |
| Downey, JM | 1 |
| Jayawant, M | 1 |
| Stephenson, ER | 1 |
| Kirsch, M | 1 |
| Lesurtel, M | 1 |
| Berdeaux, A | 1 |
| Bévérelli, F | 1 |
| Loisance, D | 1 |
| Morita, K | 1 |
| Kamei, J | 1 |
| Honchar, OO | 1 |
| Rozova, KV | 1 |
| Seredenko, MM | 1 |
| Zhong, X | 1 |
| Liang, G | 1 |
| He, Z | 1 |
| Coromilas, J | 1 |
| Costeas, C | 1 |
| Deruyter, B | 1 |
| Dillon, SM | 1 |
| Peters, NS | 1 |
| Wit, AL | 1 |
| Fukuse, T | 1 |
| Hirata, T | 1 |
| Omasa, M | 1 |
| Wada, H | 1 |
| Kamijo, T | 1 |
| Tomaru, T | 1 |
| Miwa, A | 1 |
| Nakamura, F | 1 |
| Kido, H | 1 |
| Sugimoto, T | 1 |
| Uchida, Y | 1 |
| Longman, SD | 1 |
| Hamilton, TC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Invasive and Clinical Features in Patients With Brugada Syndrome Undergoing Catheter Ablation: a Prospective, Single-centre, Randomized, Sham-controlled, and Masked Pilot Study[NCT05685134] | 12 participants (Anticipated) | Interventional | 2020-11-03 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pinacidil and Disease Models, Animal
| Article | Year |
|---|---|
Protective effects of ATP-sensitive potassium-channel openers in experimental myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dihydropyridines; Disea | 1994 |
Potassium channel activator drugs: mechanism of action, pharmacological properties, and therapeutic potential.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cardiovascular System; Central Nervous System; Clinic | 1992 |
49 other studies available for pinacidil and Disease Models, Animal
| Article | Year |
|---|---|
Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence.
Topics: Animals; Benzopyrans; Disease Models, Animal; Potassium Channels, Inwardly Rectifying; Rats; Structu | 2009 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Characteristics of electromechanical window in anesthetized rabbit models of short QT and long QT syndromes.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Benzopyrans; Biomarkers; Biomarkers, Pharmacological; Cro | 2017 |
Mechanisms Underlying Epicardial Radiofrequency Ablation to Suppress Arrhythmogenesis in Experimental Models of Brugada Syndrome.
Topics: Action Potentials; Ajmaline; Animals; Arrhythmias, Cardiac; Brugada Syndrome; Disease Models, Animal | 2017 |
Antiarrhythmic effect of antazoline in experimental models of acquired short- and long-QT-syndromes.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Antazoline; Anti-Bacterial Agents; Arrhythm | 2018 |
The effect of K+ channel opener pinacidil on the transmembrane potassi channel protein Kir4.1 of retinal Müller cells in vitro and diabetic rats.
Topics: Animals; Capillary Permeability; Cells, Cultured; Diabetic Retinopathy; Disease Models, Animal; Epen | 2020 |
Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Glyburide; Hyperalgesia; | 2014 |
The ATP-sensitive potassium channel subunit, Kir6.1, in vascular smooth muscle plays a major role in blood pressure control.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hypertension; In V | 2014 |
[The functional state of the kidneys after adenosine triphosphate-sensitive potassium channels activation in experimental acute hypoxia].
Topics: Acute Disease; Animals; Disease Models, Animal; Hypoxia; Ion Channel Gating; KATP Channels; Kidney; | 2014 |
Effects of pinacidil on changes to the microenvironment around the incision site, of a skin/muscle incision and retraction, in a rat model of postoperative pain.
Topics: Animals; Cellular Microenvironment; Dermatologic Surgical Procedures; Disease Models, Animal; Gene E | 2015 |
ATP-sensitive potassium channels alleviate postoperative pain through JNK-dependent MCP-1 expression in spinal cord.
Topics: Animals; Astrocytes; Chemokine CCL2; Disease Models, Animal; Enzyme Activation; Gene Expression Regu | 2015 |
A protective role of Nox1/NADPH oxidase in a mouse model with hypoxia-induced bradycardia.
Topics: Action Potentials; Animals; Bradycardia; Calcium Channel Blockers; Disease Models, Animal; Electroca | 2015 |
Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome.
Topics: Action Potentials; Animals; Anisoles; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, | 2016 |
Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats.
Topics: Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Colitis; Cyclooxygenase 1; Cyclooxygenase | 2009 |
[Cardioprotective effects of flokalin in experiments in vivo: influence on hemodynamic and myocardial lesions in ischemia-reperfusion].
Topics: Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Disease Models, Animal; Dogs; Heart Rat | 2009 |
[Cardioprotective effects of activation of ATP-sensitive potassium channels in experiments in vivo: influence on blood biochemical parameters following ischemia-reperfusion of the myocardium].
Topics: Animals; Antioxidants; Cardiotonic Agents; Disease Models, Animal; Dogs; Free Radicals; Hemodynamics | 2009 |
[Effect of medical form of flocalin on the course of myocardial reperfusion injury].
Topics: Animals; Cardiotonic Agents; Coronary Circulation; Disease Models, Animal; Dogs; Hemodynamics; Ische | 2011 |
Pinacidil pretreatment improves vascular reactivity after shock through PKCα and PKCε in rats.
Topics: Adenosine; Animals; Calcium; Disease Models, Animal; Female; Fluid Therapy; Male; Mesenteric Artery, | 2012 |
The effect of pinacidil on postshock activation and ventricular defibrillation threshold in canine hearts.
Topics: Action Potentials; Animals; Differential Threshold; Disease Models, Animal; Dogs; Electric Countersh | 2012 |
Pro- and antiarrhythmic effects of ATP-sensitive potassium current activation on reentry during early afterdepolarization-mediated arrhythmias.
Topics: Action Potentials; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Body Sur | 2013 |
Warm ischemia lung protection with pinacidil: an ATP regulated potassium channel opener.
Topics: Animals; Disease Models, Animal; Female; Graft Rejection; Graft Survival; Lung Transplantation; Male | 2003 |
Mechanism of ST elevation and ventricular arrhythmias in an experimental Brugada syndrome model.
Topics: Animals; Disease Models, Animal; Dogs; Electrocardiography; Female; In Vitro Techniques; Lidocaine; | 2004 |
Analysis of responses to valerian root extract in the feline pulmonary vascular bed.
Topics: Acetylcholine; Animals; Arachidonic Acid; Bradykinin; Calcium Channel Agonists; Cats; Disease Models | 2003 |
Uncomplicated rapid posthypothermic rewarming alters cerebrovascular responsiveness.
Topics: Acetylcholine; Animals; Carbon Dioxide; Cerebrovascular Circulation; Disease Models, Animal; Hyperca | 2004 |
Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Guinea Pigs; Heart Ventricles; In Vitro Techn | 2005 |
[Influence of pinacidil on the myocardial mitochondrial structure and the respiratory function in scalded rats].
Topics: Animals; Burns; Cell Respiration; Disease Models, Animal; Mitochondria, Heart; Pinacidil; Rats; Rats | 2005 |
Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Apomorphine; Astrocytes; Cells, Cultured; | 2006 |
Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study.
Topics: Action Potentials; Animals; Cardiovascular Agents; Disease Models, Animal; Dogs; Electrocardiography | 2006 |
Differences in arrhythmogenicity between the canine right ventricular outflow tract and anteroinferior right ventricle in a model of Brugada syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Brugada Syndrome; Disease Models, Animal; Dogs; | 2007 |
Effect of K+ATP channel and adenosine receptor blockade during rest and exercise in congestive heart failure.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Cardiac Pacing, Artifi | 2007 |
[Effects of preconditioning on the responsiveness of superior mesenteric artery after hemorrhagic shock in rats].
Topics: Animals; Disease Models, Animal; Female; Ischemic Preconditioning; Male; Mesenteric Artery, Superior | 2007 |
Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Do | 2007 |
Effect of pravastatin on sympathetic reinnervation in postinfarcted rats.
Topics: Animals; Blotting, Western; Cardiac Pacing, Artificial; Coronary Vessels; Disease Models, Animal; GA | 2007 |
KATP channels confer survival advantage in cocaine overdose.
Topics: Animals; Behavior, Animal; Cocaine; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Overdos | 2007 |
Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis.
Topics: Acalculous Cholecystitis; Animals; Caffeine; Calcium; Cholecystitis, Acute; Common Bile Duct; Diseas | 2008 |
Antiarrhythmic agent, MS-551, protects against pinacidil + hypoxia-induced ventricular fibrillation in Langendorff-perfused rabbit isolated heart.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dogs; Guanidines; Heart; Heart Atria; Hypox | 1994 |
Analysis of the potassium channel openers celikalim, pinacidil and cromakalim in platelet models of thrombosis.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Blood Coagulation; Cromakalim; Disease Models, Animal | 1994 |
Myocardial protection in the acutely injured heart: hyperpolarizing versus depolarizing hypothermic cardioplegia.
Topics: Animals; Cardioplegic Solutions; Coronary Circulation; Disease Models, Animal; Female; Glucose; Glyb | 1997 |
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Ar | 1997 |
Pinacidil but not nicorandil opens ATP-sensitive K+ channels and protects against simulated ischemia in rabbit myocytes.
Topics: Adenosine Triphosphate; Animals; Cell Death; Disease Models, Animal; Electrophysiology; Female; Guan | 1997 |
Advantages of continuous hyperpolarized arrest with pinacidil over St. Thomas' Hospital solution during prolonged ischemia.
Topics: Animals; Arrhythmias, Cardiac; Bicarbonates; Body Water; Calcium Chloride; Cardioplegic Solutions; C | 1998 |
Pretreatment of brain dead rabbits with pinacidil before prolonged cold-storage with an extracellular solution alters aortic endothelial function.
Topics: Analysis of Variance; Animals; Aorta, Abdominal; Brain Death; Cardioplegic Solutions; Cryopreservati | 2000 |
Involvement of ATP-sensitive K(+) channels in the anti-tussive effect of moguisteine.
Topics: Animals; Antitussive Agents; ATP-Binding Cassette Transporters; Cough; Disease Models, Animal; Drug | 2000 |
[Effect of potassium channel openers on lysosomal function and morphology during acute hypoxic hypoxia].
Topics: Acid Phosphatase; Acute Disease; Animals; Cathepsin D; Disease Models, Animal; Heart; Hypoxia; Lung; | 2001 |
[Laboratory study on protective and therapeutic effects of pinacidil on pulmonary vascular remodeling in rats with hypoxia-induced pulmonary hypertension].
Topics: Animals; Antihypertensive Agents; Disease Models, Animal; Hypertension, Pulmonary; Hypertrophy, Righ | 2000 |
Effects of pinacidil on electrophysiological properties of epicardial border zone of healing canine infarcts: possible effects of K(ATP) channel activation.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electric St | 2002 |
Effect of adenosine triphosphate-sensitive potassium channel openers on lung preservation.
Topics: Adenosine Triphosphate; Animals; Disease Models, Animal; Glyburide; Hypertension, Pulmonary; Lung; P | 2002 |
[The vasospasmolytic effects of nicorandil, cromakalim and pinacidil on 3,4-diaminopyridine-induced phasic contractions in canine coronary arteries as an experimental vasospasm model].
Topics: 4-Aminopyridine; Amifampridine; Animals; Benzopyrans; Coronary Vasospasm; Cromakalim; Disease Models | 1992 |