pinacidil has been researched along with Diarrhea in 1 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of pinacidil and cromakalim, two KATP channel openers, on intestinal transit and castor oil-induced diarrhea was studied in mice." | 3.69 | K+ channel openers delay intestinal transit and have antidiarrheal activity. ( Arletti, R; Benelli, A; Bertolini, A; Cavazzuti, E; Poggioli, R, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Poggioli, R | 1 |
| Benelli, A | 1 |
| Arletti, R | 1 |
| Cavazzuti, E | 1 |
| Bertolini, A | 1 |
1 other study available for pinacidil and Diarrhea
| Article | Year |
|---|---|
K+ channel openers delay intestinal transit and have antidiarrheal activity.
Topics: Animals; Benzopyrans; Cromakalim; Diarrhea; Dose-Response Relationship, Drug; Gastrointestinal Motil | 1995 |