pinacidil has been researched along with Coronary Heart Disease in 10 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effect of ATP-sensitive K+ channel (KATP) openers (pinacidil and cromakalim), and a KATP blocker (glibenclamide) on reperfusion-induced arrhythmias in pentobarbitone-anaesthetized rats." | 3.69 | KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats. ( Baczkó, I; Leprán, I; Papp, JG, 1997) |
| " In order to determine whether activation of adenosine triphosphate (ATP)-sensitive K+ channels exclusively explains the hypoxia- and ischaemia-induced action potential shortening, effects of tolbutamide and glibenclamide on changes in action potential duration (APD) during hypoxia, metabolic blockade or experimental ischaemia were examined in guinea-pig and canine isolated myocardium by standard microelectrode techniques." | 3.68 | Effects of ATP-sensitive K+ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium. ( Kanno, M; Nakaya, H; Takeda, Y; Tohse, N, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miura, T | 1 |
| Miki, T | 1 |
| Baczkó, I | 1 |
| Leprán, I | 1 |
| Papp, JG | 1 |
| Gojkoviíc Bukarica, L | 1 |
| Kazić, T | 1 |
| Sajić, Z | 1 |
| Djukanović, B | 1 |
| Panić, G | 1 |
| Perić, M | 1 |
| Bojić, M | 1 |
| Chi, L | 1 |
| Uprichard, AC | 1 |
| Lucchesi, BR | 1 |
| Bache, RJ | 1 |
| Dai, XZ | 1 |
| Baran, KW | 1 |
| Cole, WC | 1 |
| McPherson, CD | 1 |
| Sontag, D | 1 |
| Nakaya, H | 1 |
| Takeda, Y | 1 |
| Tohse, N | 1 |
| Kanno, M | 1 |
| Wolleben, CD | 1 |
| Sanguinetti, MC | 1 |
| Siegl, PK | 1 |
| Grover, GJ | 1 |
| McCullough, JR | 1 |
| Henry, DE | 1 |
| Conder, ML | 1 |
| Sleph, PG | 1 |
| Rockhold, FW | 1 |
| Goldberg, MR | 1 |
| Thompson, WL | 1 |
1 review available for pinacidil and Coronary Heart Disease
| Article | Year |
|---|---|
ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Diazoxide; Glyburide; Human | 2003 |
1 trial available for pinacidil and Coronary Heart Disease
| Article | Year |
|---|---|
Beneficial effects of pinacidil on blood lipids: comparisons with prazosin and placebo in patients with hypertension. Pinacidil-Prazosin and Pinacidil-Placebo Research Groups, Lilly Research Laboratories.
Topics: Antihypertensive Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic; | 1989 |
8 other studies available for pinacidil and Coronary Heart Disease
| Article | Year |
|---|---|
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Ar | 1997 |
The effects of levcromakalim and pinacidil on the human internal mammary artery.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Apamin; Charybdotoxin; Coronary Artery Bypass; Coronary Dis | 1997 |
Profibrillatory actions of pinacidil in a conscious canine model of sudden coronary death.
Topics: Action Potentials; Animals; Blood Pressure; Coronary Disease; Death, Sudden; Dogs; Dose-Response Rel | 1990 |
Effect of pinacidil on myocardial blood flow in the presence of a coronary artery stenosis.
Topics: Animals; Antihypertensive Agents; Coronary Circulation; Coronary Disease; Dogs; Dose-Response Relati | 1990 |
ATP-regulated K+ channels protect the myocardium against ischemia/reperfusion damage.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Coronary Disease; Glyburide; Guanidines; Guinea | 1991 |
Effects of ATP-sensitive K+ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dogs; Fe | 1991 |
Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Coronar | 1989 |
Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Coronary Disease; Cromakalim; Glyburide; Guanidines; | 1989 |