pinacidil has been researched along with Cerebral Ischemia in 4 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate effect of pinacidil, an ATP sensitive potassium channel (K(ATP)) opener, on the neuronal apoptosis and its signaling transduction mechanism following focal cerebral ischemia-reperfusion in rats." | 7.74 | Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways. ( Liu, YY; Lu, YL; Ma, Y; Song, LC; Zhang, H, 2007) |
| "To investigate effect of pinacidil, an ATP sensitive potassium channel (K(ATP)) opener, on the neuronal apoptosis and its signaling transduction mechanism following focal cerebral ischemia-reperfusion in rats." | 3.74 | Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways. ( Liu, YY; Lu, YL; Ma, Y; Song, LC; Zhang, H, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 2 |
| Song, LC | 2 |
| Liu, YY | 1 |
| Ma, Y | 1 |
| Lu, YL | 2 |
| Jia, CH | 1 |
| Heurteaux, C | 1 |
| Bertaina, V | 1 |
| Widmann, C | 1 |
| Lazdunski, M | 1 |
| Nishimura, M | 1 |
| Takahashi, H | 1 |
| Nanbu, A | 1 |
| Sakamoto, M | 1 |
| Nakanishi, T | 1 |
| Yoshimura, M | 1 |
4 other studies available for pinacidil and Cerebral Ischemia
| Article | Year |
|---|---|
Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways.
Topics: Animals; Antihypertensive Agents; Apoptosis; Brain Ischemia; Caspases; Gene Expression Regulation; I | 2007 |
Effects of ATP sensitive potassium channel opener on the mRNA and protein expressions of caspase-12 after cerebral ischemia-reperfusion in rats.
Topics: Animals; Brain Ischemia; Caspase 12; Endoplasmic Reticulum Stress; Infarction, Middle Cerebral Arter | 2008 |
K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus.
Topics: Alternative Splicing; Amyloid beta-Protein Precursor; Animals; Base Sequence; Benzopyrans; Brain Isc | 1993 |
Cerebral adenosine triphosphate-sensitive K+ channels may be impaired during acute cerebral ischemia in spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Antidiuretic Hormone Receptor Antagon | 1996 |