pinacidil has been researched along with Cardiovascular Stroke in 23 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assessed whether pravastatin attenuates cardiac sympathetic reinnervation after myocardial infarction through the activation of ATP-sensitive K(+) (K(ATP)) channels." | 3.74 | Effect of pravastatin on sympathetic reinnervation in postinfarcted rats. ( Chang, NC; Lee, TM; Lin, MS, 2007) |
| "Male Wistar rats after induction of myocardial infarction were randomized to either vehicle, agonists of K(ATP) channels nicorandil and pinacidil, an antagonist of K(ATP) channels glibenclamide, or a combination of nicorandil and glibenclamide or pinacidil and glibenclamide for 4 weeks." | 3.74 | Effect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts. ( Chang, NC; Lee, TM; Lin, MS, 2008) |
| "Treatment with pinacidil decreased APD (26%) in co-cultures with sMI-Fb." | 1.39 | Fibroblast KATP currents modulate myocyte electrophysiology in infarcted hearts. ( Benamer, N; Coetzee, WA; Mahoney, VM; Morley, GE; Steinhardt, MJ; Vasquez, C, 2013) |
| " The chronic use of mitochondrial K(ATP) channel agonists after infarction may attenuate the arrhythmogenic response to programmed electrical stimulation." | 1.35 | Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts. ( Chang, NC; Chen, CC; Kang, CS; Lee, TM; Lin, CC, 2009) |
| "Myocardial infarction was produced in dogs by ligation of the left anterior descending coronary artery." | 1.31 | Effects of pinacidil on electrophysiological properties of epicardial border zone of healing canine infarcts: possible effects of K(ATP) channel activation. ( Coromilas, J; Costeas, C; Deruyter, B; Dillon, SM; Peters, NS; Wit, AL, 2002) |
| "Cromakalim pretreatment (both when given throughout the experiment and when not present in the reperfusion buffer) resulted in significant improvements in the reperfusion function." | 1.28 | The protective effects of cromakalim and pinacidil on reperfusion function and infarct size in isolated perfused rat hearts and anesthetized dogs. ( Dzwonczyk, S; Grover, GJ; Parham, CS; Sleph, PG, 1990) |
| "Pinacidil was titrated to decrease mean aortic pressure 25 mm Hg, which resulted in an increase in heart rate (HR), cardiac output (CO), and left ventricular (LV) dP/dt and LVdP/dt/P." | 1.28 | Effects of pinacidil on myocardial blood flow and infarct size after acute left anterior descending coronary artery occlusion and reperfusion in awake dogs with and without a coexisting left circumflex coronary artery stenosis. ( Hood, WB; Liang, CS; Sakamoto, S; Stone, CK, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.70) | 18.7374 |
| 1990's | 10 (43.48) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benamer, N | 1 |
| Vasquez, C | 1 |
| Mahoney, VM | 1 |
| Steinhardt, MJ | 1 |
| Coetzee, WA | 1 |
| Morley, GE | 1 |
| Kang, CS | 1 |
| Chen, CC | 1 |
| Lin, CC | 1 |
| Chang, NC | 3 |
| Lee, TM | 3 |
| Strutyns'kyĭ, RB | 2 |
| Neshcheret, OP | 2 |
| Tumanovs'ka, LV | 1 |
| Rovenets', RA | 2 |
| Moĭbenko, OO | 2 |
| Kotsiuruba, AV | 1 |
| Shysh, AM | 1 |
| Kupriyanov, VV | 1 |
| Xiang, B | 1 |
| Sun, J | 1 |
| Jilkina, O | 1 |
| Fischbach, PS | 1 |
| Barrett, TD | 1 |
| Reed, NJ | 1 |
| Lucchesi, BR | 2 |
| Lin, MS | 2 |
| Smallwood, JK | 1 |
| Schelm, JA | 1 |
| Bemis, KG | 1 |
| Simpson, PJ | 1 |
| Grover, GJ | 3 |
| Black, SC | 1 |
| Walsh, RS | 1 |
| Tsuchida, A | 2 |
| Daly, JJ | 1 |
| Thornton, JD | 2 |
| Cohen, MV | 1 |
| Downey, JM | 2 |
| Ito, M | 1 |
| Pride, HP | 1 |
| Zipes, DP | 1 |
| Ren, XL | 1 |
| Hoffman, BF | 1 |
| Thornton, CS | 1 |
| Sterling, DL | 1 |
| Leprán, I | 1 |
| Baczkó, I | 1 |
| Varró, A | 1 |
| Papp, JG | 1 |
| Matsuyama, N | 1 |
| Leavens, JE | 1 |
| McKinnon, D | 1 |
| Gaudette, GR | 1 |
| Aksehirli, TO | 1 |
| Krukenkamp, IB | 1 |
| Tanno, M | 1 |
| Miura, T | 1 |
| Miki, T | 1 |
| Nishino, Y | 1 |
| Ohnuma, Y | 1 |
| Shimamoto, K | 1 |
| Coromilas, J | 1 |
| Costeas, C | 1 |
| Deruyter, B | 1 |
| Dillon, SM | 1 |
| Peters, NS | 1 |
| Wit, AL | 1 |
| Dzwonczyk, S | 1 |
| Parham, CS | 1 |
| Sleph, PG | 1 |
| Sakamoto, S | 2 |
| Liang, CS | 2 |
| Stone, CK | 2 |
| Hood, WB | 2 |
| Imai, N | 1 |
1 review available for pinacidil and Cardiovascular Stroke
| Article | Year |
|---|---|
Protective effects of ATP-sensitive potassium-channel openers in experimental myocardial ischemia.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dihydropyridines; Disea | 1994 |
22 other studies available for pinacidil and Cardiovascular Stroke
| Article | Year |
|---|---|
Fibroblast KATP currents modulate myocyte electrophysiology in infarcted hearts.
Topics: Action Potentials; Animals; ATP-Binding Cassette Transporters; Fibroblasts; Glyburide; Heart Ventric | 2013 |
Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Echocardiography; Endothelin-1; Glyburide; Heart; Hypoglycemic Agents | 2009 |
[Cardioprotective effects of flokalin in experiments in vivo: influence on hemodynamic and myocardial lesions in ischemia-reperfusion].
Topics: Animals; Blood Pressure; Cardiac Output; Cardiotonic Agents; Disease Models, Animal; Dogs; Heart Rat | 2009 |
[Cardioprotective effects of activation of ATP-sensitive potassium channels in experiments in vivo: influence on blood biochemical parameters following ischemia-reperfusion of the myocardium].
Topics: Animals; Antioxidants; Cardiotonic Agents; Disease Models, Animal; Dogs; Free Radicals; Hemodynamics | 2009 |
The effects of drugs modulating K(+) transport on Rb(+) uptake and distribution in pig hearts following regional ischemia: (87)Rb MRI study.
Topics: Animals; Bumetanide; Glyburide; In Vitro Techniques; Magnetic Resonance Imaging; Myocardial Infarcti | 2002 |
SNC-80-induced preconditioning: selective activation of the mitochondrial adenosine triphosphate-gated potassium channel.
Topics: Adenosine Triphosphate; Animals; Benzamides; Female; Heart; In Vitro Techniques; Ion Channel Gating; | 2003 |
Effect of pravastatin on sympathetic reinnervation in postinfarcted rats.
Topics: Animals; Blotting, Western; Cardiac Pacing, Artificial; Coronary Vessels; Disease Models, Animal; GA | 2007 |
Effect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts.
Topics: Animals; Glyburide; Hemodynamics; Hypertrophy, Left Ventricular; Immunohistochemistry; KATP Channels | 2008 |
Effect of activation of ATP-dependent potassium channels with (-)-pinacidil and (-)-3-pyridyl pinacidil on infarct size in a canine model of ischemia-reperfusion injury.
Topics: Animals; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Guanidines; Hemodynamics; Mal | 1993 |
Potassium channel openers are likely to be proarrhythmic in the diseased human heart.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Dogs; Guanidines; Heart; H | 1994 |
Ketamine-xylazine anaesthesia permits a KATP channel antagonist to attenuate preconditioning in rabbit myocardium.
Topics: Animals; Glyburide; Guanidines; Ketamine; Myocardial Infarction; Myocardial Ischemia; Myocardium; Pi | 1994 |
Glibenclamide enhances but pinacidil reduces attenuation in sympathetic responsiveness after acute coronary artery occlusion.
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Coronary Vessels; Denervation; Dogs; Dose-Respo | 1994 |
Reversibility of electrophysiologic abnormalities of subendocardial Purkinje fibers induced by ischemia.
Topics: Adenosine Triphosphate; Animals; Diastole; Dogs; Electrophysiology; Endocardium; Female; Guanidines; | 1994 |
An explanation for the reported observation that ATP dependent potassium channel openers fail to mimic preconditioning.
Topics: Adenosine Triphosphate; Animals; Dogs; Guanidines; Ion Channel Gating; Myocardial Infarction; Myocar | 1993 |
Blockade of ATP-sensitive potassium channels increases infarct size but does not prevent preconditioning in rabbit hearts.
Topics: Animals; Female; Glyburide; Guanidines; Male; Myocardial Infarction; Myocardial Ischemia; Pinacidil; | 1993 |
ATP-sensitive potassium channel modulators: both pinacidil and glibenclamide produce antiarrhythmic activity during acute myocardial infarction in conscious rats.
Topics: Adenosine Triphosphate; Animals; Glyburide; Guanidines; Kinetics; Male; Myocardial Infarction; Pinac | 1996 |
Ischemic but not pharmacological preconditioning requires protein synthesis.
Topics: Action Potentials; Animals; Blood Flow Velocity; Blood Pressure; Coronary Vessels; Cycloheximide; Da | 2000 |
Contribution of both the sarcolemmal K(ATP) and mitochondrial K(ATP) channels to infarct size limitation by K(ATP) channel openers: differences from preconditioning in the role of sarcolemmal K(ATP) channels.
Topics: Analysis of Variance; Animals; Hemodynamics; Male; Mitochondria; Myocardial Infarction; Pinacidil; P | 2001 |
Effects of pinacidil on electrophysiological properties of epicardial border zone of healing canine infarcts: possible effects of K(ATP) channel activation.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electric St | 2002 |
The protective effects of cromakalim and pinacidil on reperfusion function and infarct size in isolated perfused rat hearts and anesthetized dogs.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Dogs; Female; Guanidines; In Vitro Techniques; L-L | 1990 |
Effects of pinacidil on myocardial blood flow and infarct size after acute left anterior descending coronary artery occlusion and reperfusion in awake dogs with and without a coexisting left circumflex coronary artery stenosis.
Topics: Animals; Blood Pressure; Cardiac Output; Coronary Circulation; Dogs; Guanidines; Heart Rate; Myocard | 1989 |
Comparative effects of nitroprusside and pinacidil on myocardial blood flow and infarct size in awake dogs with acute myocardial infarction.
Topics: Animals; Consciousness; Coronary Circulation; Coronary Vessels; Dogs; Ferricyanides; Guanidines; Myo | 1988 |