pinacidil has been researched along with Cardiomegaly in 2 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After dosage titration from the age of 1 month to the age of 3 months, spontaneously hypertensive rats (SHR) were treated with pinacidil 10 mg/kg daily until the age of 6 or 12 months." | 1.27 | Aggressive long-term antihypertensive therapy with pinacidil does not cause regression of cardiovascular hypertrophy in the spontaneously hypertensive rat. ( Baandrup, U; Jespersen, LT; Lederballe, O; Mikkelsen, EO; Nyborg, NC, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bache, RJ | 1 |
| Dai, XZ | 1 |
| Baran, KW | 1 |
| Jespersen, LT | 1 |
| Baandrup, U | 1 |
| Nyborg, NC | 1 |
| Mikkelsen, EO | 1 |
| Lederballe, O | 1 |
2 other studies available for pinacidil and Cardiomegaly
| Article | Year |
|---|---|
Effect of pinacidil on myocardial blood flow in the chronically pressure overloaded hypertrophied left ventricle.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Coronary Circulation; Dogs; Guanidines; Heart Ra | 1990 |
Aggressive long-term antihypertensive therapy with pinacidil does not cause regression of cardiovascular hypertrophy in the spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Guanidines; Hypertension; Male; Pina | 1986 |