pinacidil has been researched along with Cardiac Hypertrophy in 2 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After dosage titration from the age of 1 month to the age of 3 months, spontaneously hypertensive rats (SHR) were treated with pinacidil 10 mg/kg daily until the age of 6 or 12 months." | 1.27 | Aggressive long-term antihypertensive therapy with pinacidil does not cause regression of cardiovascular hypertrophy in the spontaneously hypertensive rat. ( Baandrup, U; Jespersen, LT; Lederballe, O; Mikkelsen, EO; Nyborg, NC, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bache, RJ | 1 |
| Dai, XZ | 1 |
| Baran, KW | 1 |
| Jespersen, LT | 1 |
| Baandrup, U | 1 |
| Nyborg, NC | 1 |
| Mikkelsen, EO | 1 |
| Lederballe, O | 1 |
2 other studies available for pinacidil and Cardiac Hypertrophy
| Article | Year |
|---|---|
Effect of pinacidil on myocardial blood flow in the chronically pressure overloaded hypertrophied left ventricle.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Coronary Circulation; Dogs; Guanidines; Heart Ra | 1990 |
Aggressive long-term antihypertensive therapy with pinacidil does not cause regression of cardiovascular hypertrophy in the spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Guanidines; Hypertension; Male; Pina | 1986 |