pinacidil has been researched along with Brain Ischemia in 4 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate effect of pinacidil, an ATP sensitive potassium channel (K(ATP)) opener, on the neuronal apoptosis and its signaling transduction mechanism following focal cerebral ischemia-reperfusion in rats." | 7.74 | Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways. ( Liu, YY; Lu, YL; Ma, Y; Song, LC; Zhang, H, 2007) |
| "To investigate effect of pinacidil, an ATP sensitive potassium channel (K(ATP)) opener, on the neuronal apoptosis and its signaling transduction mechanism following focal cerebral ischemia-reperfusion in rats." | 3.74 | Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways. ( Liu, YY; Lu, YL; Ma, Y; Song, LC; Zhang, H, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 2 |
| Song, LC | 2 |
| Liu, YY | 1 |
| Ma, Y | 1 |
| Lu, YL | 2 |
| Jia, CH | 1 |
| Heurteaux, C | 1 |
| Bertaina, V | 1 |
| Widmann, C | 1 |
| Lazdunski, M | 1 |
| Nishimura, M | 1 |
| Takahashi, H | 1 |
| Nanbu, A | 1 |
| Sakamoto, M | 1 |
| Nakanishi, T | 1 |
| Yoshimura, M | 1 |
4 other studies available for pinacidil and Brain Ischemia
| Article | Year |
|---|---|
Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways.
Topics: Animals; Antihypertensive Agents; Apoptosis; Brain Ischemia; Caspases; Gene Expression Regulation; I | 2007 |
Effects of ATP sensitive potassium channel opener on the mRNA and protein expressions of caspase-12 after cerebral ischemia-reperfusion in rats.
Topics: Animals; Brain Ischemia; Caspase 12; Endoplasmic Reticulum Stress; Infarction, Middle Cerebral Arter | 2008 |
K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus.
Topics: Alternative Splicing; Amyloid beta-Protein Precursor; Animals; Base Sequence; Benzopyrans; Brain Isc | 1993 |
Cerebral adenosine triphosphate-sensitive K+ channels may be impaired during acute cerebral ischemia in spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Antidiuretic Hormone Receptor Antagon | 1996 |