pinacidil has been researched along with Body Weight in 8 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic responses of systemic hemodynamics and blood pressure counterregulatory ("pseudo-tolerance") mechanisms were investigated in matched groups of patients with essential hypertension after 1 month of vasodilator therapy with pinacidil (a direct arterial dilator), prazosin (an alpha 1-adrenergic blocking drug) or captopril (an angiotensin-converting enzyme inhibitor)." | 9.06 | Chronic effects of direct vasodilation (pinacidil), alpha-adrenergic blockade (prazosin) and angiotensin-converting enzyme inhibition (captopril) in systemic hypertension. ( Izzo, JL; Kallay, MC; Larrabee, PS; Licht, MR; Radke, KJ; Smith, RJ, 1987) |
| "Patients with essential hypertension were randomized to treatment with either prazosin or pinacidil, a new direct-acting vasodilator." | 9.06 | Comparative effects of pinacidil and prazosin on blood pressure, weight, plasma volume, the renin-angiotensin-aldosterone system, and the renal kallikrein-kinin system in patients with essential hypertension. ( Solomon, RJ; Weinberg, MS, 1987) |
| "Ten patients with mild to moderate hypertension were treated for 9 weeks with a tablet formulation of pinacidil." | 7.67 | Pinacidil monotherapy for hypertension. ( Ward, JW, 1984) |
| "Chronic responses of systemic hemodynamics and blood pressure counterregulatory ("pseudo-tolerance") mechanisms were investigated in matched groups of patients with essential hypertension after 1 month of vasodilator therapy with pinacidil (a direct arterial dilator), prazosin (an alpha 1-adrenergic blocking drug) or captopril (an angiotensin-converting enzyme inhibitor)." | 5.06 | Chronic effects of direct vasodilation (pinacidil), alpha-adrenergic blockade (prazosin) and angiotensin-converting enzyme inhibition (captopril) in systemic hypertension. ( Izzo, JL; Kallay, MC; Larrabee, PS; Licht, MR; Radke, KJ; Smith, RJ, 1987) |
| "Patients with essential hypertension were randomized to treatment with either prazosin or pinacidil, a new direct-acting vasodilator." | 5.06 | Comparative effects of pinacidil and prazosin on blood pressure, weight, plasma volume, the renin-angiotensin-aldosterone system, and the renal kallikrein-kinin system in patients with essential hypertension. ( Solomon, RJ; Weinberg, MS, 1987) |
| "Ten patients with mild to moderate hypertension were treated for 9 weeks with a tablet formulation of pinacidil." | 3.67 | Pinacidil monotherapy for hypertension. ( Ward, JW, 1984) |
| "Pinacidil is a direct vasodilator with good absorption, a half-life of 2 to 4 hours, and side effects similar to those of other vasodilators." | 2.66 | A double-blind, randomized, controlled trial comparing pinacidil to hydralazine in essential hypertension. ( Byyny, RL; LoVerde, ME; Mitchell, WD; Nies, AS, 1987) |
| "Obesity was induced by 24 weeks of high-fat diet feeding in male Sprague-Dawley rats." | 1.35 | Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure. ( Cao, YX; Fan, LH; Hu, Z; Huo, JH; Ma, AQ; Tian, HY, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fan, LH | 1 |
| Tian, HY | 1 |
| Ma, AQ | 1 |
| Hu, Z | 1 |
| Huo, JH | 1 |
| Cao, YX | 1 |
| Ward, JW | 1 |
| Gaudette, GR | 1 |
| Krukenkamp, IB | 1 |
| Saltman, AE | 1 |
| Horimoto, H | 1 |
| Levitsky, S | 1 |
| Bache, RJ | 1 |
| Dai, XZ | 1 |
| Baran, KW | 1 |
| Izzo, JL | 1 |
| Licht, MR | 1 |
| Smith, RJ | 1 |
| Larrabee, PS | 1 |
| Radke, KJ | 1 |
| Kallay, MC | 1 |
| Byyny, RL | 1 |
| Nies, AS | 1 |
| LoVerde, ME | 1 |
| Mitchell, WD | 1 |
| Solomon, RJ | 1 |
| Weinberg, MS | 1 |
| Muiesan, G | 1 |
| Fariello, R | 1 |
| Muiesan, ML | 1 |
| Christensen, OE | 1 |
4 trials available for pinacidil and Body Weight
| Article | Year |
|---|---|
Chronic effects of direct vasodilation (pinacidil), alpha-adrenergic blockade (prazosin) and angiotensin-converting enzyme inhibition (captopril) in systemic hypertension.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensiv | 1987 |
A double-blind, randomized, controlled trial comparing pinacidil to hydralazine in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Body Weight; Clinical Trials as Topic; Delayed-Action Preparations; Dou | 1987 |
Comparative effects of pinacidil and prazosin on blood pressure, weight, plasma volume, the renin-angiotensin-aldosterone system, and the renal kallikrein-kinin system in patients with essential hypertension.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Weight; Clinical Trials as To | 1987 |
Effect of pinacidil on blood pressure, plasma catecholamines and plasma renin activity in essential hypertension.
Topics: Adult; Aged; Amiloride; Antihypertensive Agents; Blood Pressure; Body Weight; Catecholamines; Chloro | 1985 |
4 other studies available for pinacidil and Body Weight
| Article | Year |
|---|---|
Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Body Weight; Dietary Fats; Electr | 2008 |
Pinacidil monotherapy for hypertension.
Topics: Adult; Antihypertensive Agents; Body Weight; Female; Guanidines; Humans; Hypertension; Male; Middle | 1984 |
Preconditioning with PKC and the ATP-sensitive potassium channels: a codependent relationship.
Topics: Animals; Body Weight; Female; Heart Rate; Ischemic Preconditioning, Myocardial; Male; Pinacidil; Pot | 2000 |
Effect of pinacidil on myocardial blood flow in the chronically pressure overloaded hypertrophied left ventricle.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Coronary Circulation; Dogs; Guanidines; Heart Ra | 1990 |