pinacidil has been researched along with Arrhythmias, Cardiac in 33 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias." | 7.73 | Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 7.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| "Ranolazine has been reported to have an antiarrhythmic potential." | 5.43 | Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome. ( Bögeholz, N; Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Güner, F; Kochhäuser, S; Leitz, P; Pott, C, 2016) |
| "the arrhythmia score and the duration of arrhythmias were significantly reduced by HMR 1098, diazoxide, and pinacidil in male rats." | 3.76 | Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats. ( Bozdogan, O; Gonca, E, 2010) |
| "It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias." | 3.73 | Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| "We investigated the effect of ATP-sensitive K+ channel (KATP) openers (pinacidil and cromakalim), and a KATP blocker (glibenclamide) on reperfusion-induced arrhythmias in pentobarbitone-anaesthetized rats." | 3.69 | KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats. ( Baczkó, I; Leprán, I; Papp, JG, 1997) |
| "Antazoline is a first-generation antihistamine with antiarrhythmic properties." | 1.48 | Antiarrhythmic effect of antazoline in experimental models of acquired short- and long-QT-syndromes. ( Dechering, DG; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Kochhäuser, S; Sterneberg, M, 2018) |
| "Ranolazine has been reported to have an antiarrhythmic potential." | 1.43 | Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome. ( Bögeholz, N; Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Güner, F; Kochhäuser, S; Leitz, P; Pott, C, 2016) |
| "Glibenclamide (10 μM) terminated these arrhythmias and restored APDs to control values." | 1.37 | Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. ( Ambrosi, CM; Chang, R; Efimov, IR; Fedorov, VV; Glukhov, AV; Janks, D; Kostecki, G; Moazami, N; Nichols, CG; Schuessler, RB, 2011) |
| "Importantly, increased arrhythmia propensity during DI-ATS1 was associated with diastolic [Ca(2+)](i) accumulation and increased [Ca(2+)](i) transient amplitudes." | 1.36 | Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in a guinea pig model of Andersen-Tawil syndrome. ( Poelzing, S; Radwański, PB; Veeraraghavan, R, 2010) |
| "Sotalol (220 microM) was infused in the aortic cannula, and pinacidil (20 microM) was infused through the LAD, causing a gradient in repolarization time between the two myocardial regions." | 1.35 | Dispersion of repolarization and arrhythmogenesis. ( Coronel, R; Janse, MJ; Opthof, T; Wilms-Schopman, FJ, 2009) |
| " The chronic use of mitochondrial K(ATP) channel agonists after infarction may attenuate the arrhythmogenic response to programmed electrical stimulation." | 1.35 | Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts. ( Chang, NC; Chen, CC; Kang, CS; Lee, TM; Lin, CC, 2009) |
| "Pinacidil pretreatment induced VF (12 of 14; p = 0." | 1.32 | Risk of ventricular proarrhythmia with selective opening of the myocardial sarcolemmal versus mitochondrial ATP-gated potassium channel. ( Barrett, TD; Fischbach, PS; Lucchesi, BR; White, A, 2004) |
| "Pinacidil pretreatment resulted in significantly fewer total ventricular ectopic beats (168 +/- 157 versus 582 +/- 448, p less than 0." | 1.28 | Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators. ( Fish, FA; Prakash, C; Roden, DM, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.03) | 18.7374 |
| 1990's | 10 (30.30) | 18.2507 |
| 2000's | 11 (33.33) | 29.6817 |
| 2010's | 11 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Limprasutr, V | 1 |
| Saengklub, N | 1 |
| Meedech, P | 1 |
| Kijtawornrat, A | 1 |
| Hamlin, RL | 1 |
| Patocskai, B | 1 |
| Yoon, N | 1 |
| Antzelevitch, C | 4 |
| Ellermann, C | 2 |
| Sterneberg, M | 1 |
| Kochhäuser, S | 2 |
| Dechering, DG | 2 |
| Fehr, M | 1 |
| Eckardt, L | 3 |
| Frommeyer, G | 2 |
| Bögeholz, N | 1 |
| Güner, F | 1 |
| Leitz, P | 1 |
| Pott, C | 1 |
| Coronel, R | 1 |
| Wilms-Schopman, FJ | 1 |
| Opthof, T | 1 |
| Janse, MJ | 1 |
| Gilmour, RF | 1 |
| Kang, CS | 1 |
| Chen, CC | 1 |
| Lin, CC | 1 |
| Chang, NC | 1 |
| Lee, TM | 1 |
| Weinberg, S | 1 |
| Malhotra, N | 1 |
| Tung, L | 1 |
| Radwański, PB | 1 |
| Veeraraghavan, R | 1 |
| Poelzing, S | 1 |
| Gonca, E | 2 |
| Bozdogan, O | 2 |
| Fedorov, VV | 1 |
| Glukhov, AV | 1 |
| Ambrosi, CM | 1 |
| Kostecki, G | 1 |
| Chang, R | 1 |
| Janks, D | 1 |
| Schuessler, RB | 1 |
| Moazami, N | 1 |
| Nichols, CG | 1 |
| Efimov, IR | 1 |
| Lin, YK | 1 |
| Lai, MS | 1 |
| Chen, YC | 1 |
| Cheng, CC | 1 |
| Huang, JH | 1 |
| Chen, SA | 1 |
| Chen, YJ | 1 |
| Lin, CI | 1 |
| Chang, MG | 1 |
| de Lange, E | 1 |
| Calmettes, G | 1 |
| Garfinkel, A | 1 |
| Qu, Z | 1 |
| Weiss, JN | 1 |
| Boyden, P | 1 |
| Di Diego, JM | 2 |
| Cordeiro, JM | 1 |
| Goodrow, RJ | 1 |
| Fish, JM | 2 |
| Zygmunt, AC | 1 |
| Pérez, GJ | 1 |
| Scornik, FS | 1 |
| Das, B | 1 |
| Sarkar, C | 1 |
| Fischbach, PS | 1 |
| White, A | 1 |
| Barrett, TD | 1 |
| Lucchesi, BR | 2 |
| Ferrier, GR | 1 |
| Howlett, SE | 1 |
| Trénor, B | 1 |
| Ferrero, JM | 1 |
| Rodríguez, B | 1 |
| Montilla, F | 1 |
| Nebigil, M | 1 |
| Tiryaki, ES | 1 |
| Welchons, DR | 1 |
| Kim, YS | 1 |
| Lee, SH | 1 |
| Ho, WK | 1 |
| Milberg, P | 1 |
| Tegelkamp, R | 1 |
| Osada, N | 1 |
| Schimpf, R | 1 |
| Wolpert, C | 1 |
| Breithardt, G | 1 |
| Borggrefe, M | 1 |
| D'Alonzo, AJ | 3 |
| Hess, TA | 2 |
| Darbenzio, RB | 3 |
| Sewter, JC | 2 |
| Sleph, PG | 1 |
| Grover, GJ | 2 |
| Black, SC | 1 |
| Nakaya, H | 1 |
| Baczkó, I | 1 |
| Leprán, I | 1 |
| Papp, JG | 1 |
| Zhu, JL | 1 |
| Dorso, CR | 1 |
| Jayawant, M | 1 |
| Stephenson, ER | 1 |
| Damiano, RJ | 1 |
| Padrini, R | 1 |
| Bova, S | 1 |
| Cargnelli, G | 1 |
| Piovan, D | 1 |
| Ferrari, M | 1 |
| Fish, FA | 1 |
| Prakash, C | 1 |
| Roden, DM | 1 |
| Wolleben, CD | 1 |
| Sanguinetti, MC | 1 |
| Siegl, PK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Invasive and Clinical Features in Patients With Brugada Syndrome Undergoing Catheter Ablation: a Prospective, Single-centre, Randomized, Sham-controlled, and Masked Pilot Study[NCT05685134] | 12 participants (Anticipated) | Interventional | 2020-11-03 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pinacidil and Arrhythmias, Cardiac
| Article | Year |
|---|---|
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; G | 1993 |
32 other studies available for pinacidil and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Characteristics of electromechanical window in anesthetized rabbit models of short QT and long QT syndromes.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Benzopyrans; Biomarkers; Biomarkers, Pharmacological; Cro | 2017 |
Mechanisms Underlying Epicardial Radiofrequency Ablation to Suppress Arrhythmogenesis in Experimental Models of Brugada Syndrome.
Topics: Action Potentials; Ajmaline; Animals; Arrhythmias, Cardiac; Brugada Syndrome; Disease Models, Animal | 2017 |
Antiarrhythmic effect of antazoline in experimental models of acquired short- and long-QT-syndromes.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Antazoline; Anti-Bacterial Agents; Arrhythm | 2018 |
Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome.
Topics: Action Potentials; Animals; Anisoles; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, | 2016 |
Dispersion of repolarization and arrhythmogenesis.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Electrocardiography; Electrophysiologic Techniques | 2009 |
Restitution, heterogeneity and unidirectional conduction block: New roles for old players.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Electrocardiography; Electrophysiologic Techniques | 2009 |
Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Echocardiography; Endothelin-1; Glyburide; Heart; Hypoglycemic Agents | 2009 |
Vulnerable windows define susceptibility to alternans and spatial discordance.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Calcium; Cells, Cultured; Dogs; Electrophysiologic | 2010 |
Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in a guinea pig model of Andersen-Tawil syndrome.
Topics: Action Potentials; Andersen Syndrome; Animals; Arrhythmias, Cardiac; Calcium; Cardiac Pacing, Artifi | 2010 |
Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzamides; Diazoxid | 2010 |
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.
Topics: Action Potentials; Adolescent; Adult; Arrhythmias, Cardiac; Coronary Vessels; Diazoxide; Female; Gen | 2011 |
Hypoxia and reoxygenation modulate the arrhythmogenic activity of the pulmonary vein and atrium.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Blotting, Western; Chloramphe | 2012 |
Pro- and antiarrhythmic effects of ATP-sensitive potassium current activation on reentry during early afterdepolarization-mediated arrhythmias.
Topics: Action Potentials; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Body Sur | 2013 |
Whirling dervishes from Pinacidil to pinwheels.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; KATP Channels; Pinacidil | 2013 |
Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cells, Cultured; Culture Techniques; Dogs; Female; | 2002 |
Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Arrhythmias, Cardiac; Blood Pressure; Decanoic Acids; | 2003 |
Risk of ventricular proarrhythmia with selective opening of the myocardial sarcolemmal versus mitochondrial ATP-gated potassium channel.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Heart; Hypoxia; Imidazoles; Male; Membrane Proteins; Mit | 2004 |
Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Guinea Pigs; Heart Ventricles; In Vitro Techn | 2005 |
Effects of pinacidil on reentrant arrhythmias generated during acute regional ischemia: a simulation study.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Computer Simulation; Heart | 2005 |
Effect of thimerosal on arrhythmia induced by coronary ligation: the involvement of ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Electrocard | 2005 |
Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome.
Topics: Animals; Arrhythmias, Cardiac; Biological Transport; Calcium Channel Blockers; Dogs; Drug Evaluation | 2006 |
Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Do | 2007 |
Effects of intracoronary cromakalim, pinacidil, or diltiazem on cesium chloride-induced arrhythmias in anesthetized dogs under conditions of controlled coronary blood flow.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Cesium; Chlorides; Coronary Circulation; | 1993 |
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; My | 1994 |
Potassium channel openers are likely to be proarrhythmic in the diseased human heart.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Dogs; Guanidines; Heart; H | 1994 |
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Ar | 1997 |
Proarrhythmic effects of pinacidil are partially mediated through enhancement of catecholamine release in isolated perfused guinea-pig hearts.
Topics: Adenosine Triphosphate; Adrenergic Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Card | 1998 |
Advantages of continuous hyperpolarized arrest with pinacidil over St. Thomas' Hospital solution during prolonged ischemia.
Topics: Animals; Arrhythmias, Cardiac; Bicarbonates; Body Water; Calcium Chloride; Cardioplegic Solutions; C | 1998 |
Role of K+ channel activators in cardiac electrophysiology and arrhythmias.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Guanidines; Heart Conduction System; Pi | 1992 |
Effects of pinacidil on guinea-pig isolated perfused heart with particular reference to the proarrhythmic effect.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Electric Stimulation; Electrocardiography; Fema | 1992 |
Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cardiac Complexes, Premature; Cesium; Chlorides; Cromaka | 1990 |
Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Coronar | 1989 |