Page last updated: 2024-11-02

pinacidil and Arrhythmia

pinacidil has been researched along with Arrhythmia in 33 studies

Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)

Research Excerpts

ExcerptRelevanceReference
"It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias."7.73Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005)
" In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits."7.72Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003)
"Ranolazine has been reported to have an antiarrhythmic potential."5.43Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome. ( Bögeholz, N; Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Güner, F; Kochhäuser, S; Leitz, P; Pott, C, 2016)
"the arrhythmia score and the duration of arrhythmias were significantly reduced by HMR 1098, diazoxide, and pinacidil in male rats."3.76Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats. ( Bozdogan, O; Gonca, E, 2010)
"It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias."3.73Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005)
" In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits."3.72Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003)
"We investigated the effect of ATP-sensitive K+ channel (KATP) openers (pinacidil and cromakalim), and a KATP blocker (glibenclamide) on reperfusion-induced arrhythmias in pentobarbitone-anaesthetized rats."3.69KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats. ( Baczkó, I; Leprán, I; Papp, JG, 1997)
"Antazoline is a first-generation antihistamine with antiarrhythmic properties."1.48Antiarrhythmic effect of antazoline in experimental models of acquired short- and long-QT-syndromes. ( Dechering, DG; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Kochhäuser, S; Sterneberg, M, 2018)
"Ranolazine has been reported to have an antiarrhythmic potential."1.43Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome. ( Bögeholz, N; Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Güner, F; Kochhäuser, S; Leitz, P; Pott, C, 2016)
"Glibenclamide (10 μM) terminated these arrhythmias and restored APDs to control values."1.37Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. ( Ambrosi, CM; Chang, R; Efimov, IR; Fedorov, VV; Glukhov, AV; Janks, D; Kostecki, G; Moazami, N; Nichols, CG; Schuessler, RB, 2011)
"Importantly, increased arrhythmia propensity during DI-ATS1 was associated with diastolic [Ca(2+)](i) accumulation and increased [Ca(2+)](i) transient amplitudes."1.36Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in a guinea pig model of Andersen-Tawil syndrome. ( Poelzing, S; Radwański, PB; Veeraraghavan, R, 2010)
"Sotalol (220 microM) was infused in the aortic cannula, and pinacidil (20 microM) was infused through the LAD, causing a gradient in repolarization time between the two myocardial regions."1.35Dispersion of repolarization and arrhythmogenesis. ( Coronel, R; Janse, MJ; Opthof, T; Wilms-Schopman, FJ, 2009)
" The chronic use of mitochondrial K(ATP) channel agonists after infarction may attenuate the arrhythmogenic response to programmed electrical stimulation."1.35Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts. ( Chang, NC; Chen, CC; Kang, CS; Lee, TM; Lin, CC, 2009)
"Pinacidil pretreatment induced VF (12 of 14; p = 0."1.32Risk of ventricular proarrhythmia with selective opening of the myocardial sarcolemmal versus mitochondrial ATP-gated potassium channel. ( Barrett, TD; Fischbach, PS; Lucchesi, BR; White, A, 2004)
"Pinacidil pretreatment resulted in significantly fewer total ventricular ectopic beats (168 +/- 157 versus 582 +/- 448, p less than 0."1.28Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators. ( Fish, FA; Prakash, C; Roden, DM, 1990)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.03)18.7374
1990's10 (30.30)18.2507
2000's11 (33.33)29.6817
2010's11 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Limprasutr, V1
Saengklub, N1
Meedech, P1
Kijtawornrat, A1
Hamlin, RL1
Patocskai, B1
Yoon, N1
Antzelevitch, C4
Ellermann, C2
Sterneberg, M1
Kochhäuser, S2
Dechering, DG2
Fehr, M1
Eckardt, L3
Frommeyer, G2
Bögeholz, N1
Güner, F1
Leitz, P1
Pott, C1
Coronel, R1
Wilms-Schopman, FJ1
Opthof, T1
Janse, MJ1
Gilmour, RF1
Kang, CS1
Chen, CC1
Lin, CC1
Chang, NC1
Lee, TM1
Weinberg, S1
Malhotra, N1
Tung, L1
Radwański, PB1
Veeraraghavan, R1
Poelzing, S1
Gonca, E2
Bozdogan, O2
Fedorov, VV1
Glukhov, AV1
Ambrosi, CM1
Kostecki, G1
Chang, R1
Janks, D1
Schuessler, RB1
Moazami, N1
Nichols, CG1
Efimov, IR1
Lin, YK1
Lai, MS1
Chen, YC1
Cheng, CC1
Huang, JH1
Chen, SA1
Chen, YJ1
Lin, CI1
Chang, MG1
de Lange, E1
Calmettes, G1
Garfinkel, A1
Qu, Z1
Weiss, JN1
Boyden, P1
Di Diego, JM2
Cordeiro, JM1
Goodrow, RJ1
Fish, JM2
Zygmunt, AC1
Pérez, GJ1
Scornik, FS1
Das, B1
Sarkar, C1
Fischbach, PS1
White, A1
Barrett, TD1
Lucchesi, BR2
Ferrier, GR1
Howlett, SE1
Trénor, B1
Ferrero, JM1
Rodríguez, B1
Montilla, F1
Nebigil, M1
Tiryaki, ES1
Welchons, DR1
Kim, YS1
Lee, SH1
Ho, WK1
Milberg, P1
Tegelkamp, R1
Osada, N1
Schimpf, R1
Wolpert, C1
Breithardt, G1
Borggrefe, M1
D'Alonzo, AJ3
Hess, TA2
Darbenzio, RB3
Sewter, JC2
Sleph, PG1
Grover, GJ2
Black, SC1
Nakaya, H1
Baczkó, I1
Leprán, I1
Papp, JG1
Zhu, JL1
Dorso, CR1
Jayawant, M1
Stephenson, ER1
Damiano, RJ1
Padrini, R1
Bova, S1
Cargnelli, G1
Piovan, D1
Ferrari, M1
Fish, FA1
Prakash, C1
Roden, DM1
Wolleben, CD1
Sanguinetti, MC1
Siegl, PK1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Invasive and Clinical Features in Patients With Brugada Syndrome Undergoing Catheter Ablation: a Prospective, Single-centre, Randomized, Sham-controlled, and Masked Pilot Study[NCT05685134]12 participants (Anticipated)Interventional2020-11-03Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for pinacidil and Arrhythmia

ArticleYear
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
    Kokyu to junkan. Respiration & circulation, 1993, Volume: 41, Issue:6

    Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; G

1993

Other Studies

32 other studies available for pinacidil and Arrhythmia

ArticleYear
Characteristics of electromechanical window in anesthetized rabbit models of short QT and long QT syndromes.
    The Journal of toxicological sciences, 2017, Volume: 42, Issue:5

    Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Benzopyrans; Biomarkers; Biomarkers, Pharmacological; Cro

2017
Mechanisms Underlying Epicardial Radiofrequency Ablation to Suppress Arrhythmogenesis in Experimental Models of Brugada Syndrome.
    JACC. Clinical electrophysiology, 2017, Volume: 3, Issue:4

    Topics: Action Potentials; Ajmaline; Animals; Arrhythmias, Cardiac; Brugada Syndrome; Disease Models, Animal

2017
Antiarrhythmic effect of antazoline in experimental models of acquired short- and long-QT-syndromes.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2018, 10-01, Volume: 20, Issue:10

    Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Antazoline; Anti-Bacterial Agents; Arrhythm

2018
Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome.
    Journal of cardiovascular electrophysiology, 2016, Volume: 27, Issue:10

    Topics: Action Potentials; Animals; Anisoles; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing,

2016
Dispersion of repolarization and arrhythmogenesis.
    Heart rhythm, 2009, Volume: 6, Issue:4

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Electrocardiography; Electrophysiologic Techniques

2009
Restitution, heterogeneity and unidirectional conduction block: New roles for old players.
    Heart rhythm, 2009, Volume: 6, Issue:4

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Electrocardiography; Electrophysiologic Techniques

2009
Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Echocardiography; Endothelin-1; Glyburide; Heart; Hypoglycemic Agents

2009
Vulnerable windows define susceptibility to alternans and spatial discordance.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:6

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Calcium; Cells, Cultured; Dogs; Electrophysiologic

2010
Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in a guinea pig model of Andersen-Tawil syndrome.
    Heart rhythm, 2010, Volume: 7, Issue:10

    Topics: Action Potentials; Andersen Syndrome; Animals; Arrhythmias, Cardiac; Calcium; Cardiac Pacing, Artifi

2010
Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats.
    Journal of cardiovascular pharmacology and therapeutics, 2010, Volume: 15, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzamides; Diazoxid

2010
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.
    Journal of molecular and cellular cardiology, 2011, Volume: 51, Issue:2

    Topics: Action Potentials; Adolescent; Adult; Arrhythmias, Cardiac; Coronary Vessels; Diazoxide; Female; Gen

2011
Hypoxia and reoxygenation modulate the arrhythmogenic activity of the pulmonary vein and atrium.
    Clinical science (London, England : 1979), 2012, Volume: 122, Issue:3

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Blotting, Western; Chloramphe

2012
Pro- and antiarrhythmic effects of ATP-sensitive potassium current activation on reentry during early afterdepolarization-mediated arrhythmias.
    Heart rhythm, 2013, Volume: 10, Issue:4

    Topics: Action Potentials; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Body Sur

2013
Whirling dervishes from Pinacidil to pinwheels.
    Heart rhythm, 2013, Volume: 10, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; KATP Channels; Pinacidil

2013
Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males.
    Circulation, 2002, Oct-08, Volume: 106, Issue:15

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cells, Cultured; Culture Techniques; Dogs; Female;

2002
Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion.
    Methods and findings in experimental and clinical pharmacology, 2003, Volume: 25, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Arrhythmias, Cardiac; Blood Pressure; Decanoic Acids;

2003
Risk of ventricular proarrhythmia with selective opening of the myocardial sarcolemmal versus mitochondrial ATP-gated potassium channel.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Heart; Hypoxia; Imidazoles; Male; Membrane Proteins; Mit

2004
Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Guinea Pigs; Heart Ventricles; In Vitro Techn

2005
Effects of pinacidil on reentrant arrhythmias generated during acute regional ischemia: a simulation study.
    Annals of biomedical engineering, 2005, Volume: 33, Issue:7

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Computer Simulation; Heart

2005
Effect of thimerosal on arrhythmia induced by coronary ligation: the involvement of ATP-dependent potassium channels.
    International heart journal, 2005, Volume: 46, Issue:4

    Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Electrocard

2005
Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome.
    Circulation, 2006, Mar-21, Volume: 113, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; Biological Transport; Calcium Channel Blockers; Dogs; Drug Evaluation

2006
Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome.
    Journal of cardiovascular electrophysiology, 2007, Volume: 18, Issue:6

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Do

2007
Effects of intracoronary cromakalim, pinacidil, or diltiazem on cesium chloride-induced arrhythmias in anesthetized dogs under conditions of controlled coronary blood flow.
    Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Cesium; Chlorides; Coronary Circulation;

1993
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.
    Cardiovascular research, 1994, Volume: 28, Issue:6

    Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; My

1994
Potassium channel openers are likely to be proarrhythmic in the diseased human heart.
    Cardiovascular research, 1994, Volume: 28, Issue:6

    Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Dogs; Guanidines; Heart; H

1994
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
    European journal of pharmacology, 1997, Apr-11, Volume: 324, Issue:1

    Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Ar

1997
Proarrhythmic effects of pinacidil are partially mediated through enhancement of catecholamine release in isolated perfused guinea-pig hearts.
    Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:2

    Topics: Adenosine Triphosphate; Adrenergic Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Card

1998
Advantages of continuous hyperpolarized arrest with pinacidil over St. Thomas' Hospital solution during prolonged ischemia.
    The Journal of thoracic and cardiovascular surgery, 1998, Volume: 116, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Bicarbonates; Body Water; Calcium Chloride; Cardioplegic Solutions; C

1998
Role of K+ channel activators in cardiac electrophysiology and arrhythmias.
    Circulation, 1992, Volume: 85, Issue:4

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Guanidines; Heart Conduction System; Pi

1992
Effects of pinacidil on guinea-pig isolated perfused heart with particular reference to the proarrhythmic effect.
    British journal of pharmacology, 1992, Volume: 105, Issue:3

    Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Electric Stimulation; Electrocardiography; Fema

1992
Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators.
    Circulation, 1990, Volume: 82, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cardiac Complexes, Premature; Cesium; Chlorides; Cromaka

1990
Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts.
    Journal of molecular and cellular cardiology, 1989, Volume: 21, Issue:8

    Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Coronar

1989