pinacidil has been researched along with Arrhythmia in 33 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias." | 7.73 | Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 7.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| "Ranolazine has been reported to have an antiarrhythmic potential." | 5.43 | Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome. ( Bögeholz, N; Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Güner, F; Kochhäuser, S; Leitz, P; Pott, C, 2016) |
| "the arrhythmia score and the duration of arrhythmias were significantly reduced by HMR 1098, diazoxide, and pinacidil in male rats." | 3.76 | Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats. ( Bozdogan, O; Gonca, E, 2010) |
| "It is not clear whether activation of ATP-sensitive potassium channels (K(ATP)) with pinacidil in advance of ischemia and reperfusion promotes or suppresses arrhythmias." | 3.73 | Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion. ( Ferrier, GR; Howlett, SE, 2005) |
| " In the present study, we investigated the effects of the administration of non-hypotensive doses of ATP-sensitive K+ channel (KATP) openers (nicorandil and 3-pyridyl pinacidil), a specific mitochondrial KATP channel blocker (5-hydroxydecanoate) and a specific sarcolemmal KATP channel blocker (HMR 1883; 1-[5-[2-(5-chloro-o-anisamido)ethyl]-2-methoxyphenyl]sulfonyl-3- methylthiourea) prior to and during coronary occlusion, as well as prior to and during post-ischemic reperfusion, on survival rate, ischemia-induced and reperfusion-induced arrhythmias and myocardial infarct size in anesthetized albino rabbits." | 3.72 | Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion. ( Das, B; Sarkar, C, 2003) |
| "We investigated the effect of ATP-sensitive K+ channel (KATP) openers (pinacidil and cromakalim), and a KATP blocker (glibenclamide) on reperfusion-induced arrhythmias in pentobarbitone-anaesthetized rats." | 3.69 | KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats. ( Baczkó, I; Leprán, I; Papp, JG, 1997) |
| "Antazoline is a first-generation antihistamine with antiarrhythmic properties." | 1.48 | Antiarrhythmic effect of antazoline in experimental models of acquired short- and long-QT-syndromes. ( Dechering, DG; Eckardt, L; Ellermann, C; Fehr, M; Frommeyer, G; Kochhäuser, S; Sterneberg, M, 2018) |
| "Ranolazine has been reported to have an antiarrhythmic potential." | 1.43 | Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome. ( Bögeholz, N; Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Güner, F; Kochhäuser, S; Leitz, P; Pott, C, 2016) |
| "Glibenclamide (10 μM) terminated these arrhythmias and restored APDs to control values." | 1.37 | Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. ( Ambrosi, CM; Chang, R; Efimov, IR; Fedorov, VV; Glukhov, AV; Janks, D; Kostecki, G; Moazami, N; Nichols, CG; Schuessler, RB, 2011) |
| "Importantly, increased arrhythmia propensity during DI-ATS1 was associated with diastolic [Ca(2+)](i) accumulation and increased [Ca(2+)](i) transient amplitudes." | 1.36 | Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in a guinea pig model of Andersen-Tawil syndrome. ( Poelzing, S; Radwański, PB; Veeraraghavan, R, 2010) |
| "Sotalol (220 microM) was infused in the aortic cannula, and pinacidil (20 microM) was infused through the LAD, causing a gradient in repolarization time between the two myocardial regions." | 1.35 | Dispersion of repolarization and arrhythmogenesis. ( Coronel, R; Janse, MJ; Opthof, T; Wilms-Schopman, FJ, 2009) |
| " The chronic use of mitochondrial K(ATP) channel agonists after infarction may attenuate the arrhythmogenic response to programmed electrical stimulation." | 1.35 | Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts. ( Chang, NC; Chen, CC; Kang, CS; Lee, TM; Lin, CC, 2009) |
| "Pinacidil pretreatment induced VF (12 of 14; p = 0." | 1.32 | Risk of ventricular proarrhythmia with selective opening of the myocardial sarcolemmal versus mitochondrial ATP-gated potassium channel. ( Barrett, TD; Fischbach, PS; Lucchesi, BR; White, A, 2004) |
| "Pinacidil pretreatment resulted in significantly fewer total ventricular ectopic beats (168 +/- 157 versus 582 +/- 448, p less than 0." | 1.28 | Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators. ( Fish, FA; Prakash, C; Roden, DM, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.03) | 18.7374 |
| 1990's | 10 (30.30) | 18.2507 |
| 2000's | 11 (33.33) | 29.6817 |
| 2010's | 11 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Limprasutr, V | 1 |
| Saengklub, N | 1 |
| Meedech, P | 1 |
| Kijtawornrat, A | 1 |
| Hamlin, RL | 1 |
| Patocskai, B | 1 |
| Yoon, N | 1 |
| Antzelevitch, C | 4 |
| Ellermann, C | 2 |
| Sterneberg, M | 1 |
| Kochhäuser, S | 2 |
| Dechering, DG | 2 |
| Fehr, M | 1 |
| Eckardt, L | 3 |
| Frommeyer, G | 2 |
| Bögeholz, N | 1 |
| Güner, F | 1 |
| Leitz, P | 1 |
| Pott, C | 1 |
| Coronel, R | 1 |
| Wilms-Schopman, FJ | 1 |
| Opthof, T | 1 |
| Janse, MJ | 1 |
| Gilmour, RF | 1 |
| Kang, CS | 1 |
| Chen, CC | 1 |
| Lin, CC | 1 |
| Chang, NC | 1 |
| Lee, TM | 1 |
| Weinberg, S | 1 |
| Malhotra, N | 1 |
| Tung, L | 1 |
| Radwański, PB | 1 |
| Veeraraghavan, R | 1 |
| Poelzing, S | 1 |
| Gonca, E | 2 |
| Bozdogan, O | 2 |
| Fedorov, VV | 1 |
| Glukhov, AV | 1 |
| Ambrosi, CM | 1 |
| Kostecki, G | 1 |
| Chang, R | 1 |
| Janks, D | 1 |
| Schuessler, RB | 1 |
| Moazami, N | 1 |
| Nichols, CG | 1 |
| Efimov, IR | 1 |
| Lin, YK | 1 |
| Lai, MS | 1 |
| Chen, YC | 1 |
| Cheng, CC | 1 |
| Huang, JH | 1 |
| Chen, SA | 1 |
| Chen, YJ | 1 |
| Lin, CI | 1 |
| Chang, MG | 1 |
| de Lange, E | 1 |
| Calmettes, G | 1 |
| Garfinkel, A | 1 |
| Qu, Z | 1 |
| Weiss, JN | 1 |
| Boyden, P | 1 |
| Di Diego, JM | 2 |
| Cordeiro, JM | 1 |
| Goodrow, RJ | 1 |
| Fish, JM | 2 |
| Zygmunt, AC | 1 |
| Pérez, GJ | 1 |
| Scornik, FS | 1 |
| Das, B | 1 |
| Sarkar, C | 1 |
| Fischbach, PS | 1 |
| White, A | 1 |
| Barrett, TD | 1 |
| Lucchesi, BR | 2 |
| Ferrier, GR | 1 |
| Howlett, SE | 1 |
| Trénor, B | 1 |
| Ferrero, JM | 1 |
| Rodríguez, B | 1 |
| Montilla, F | 1 |
| Nebigil, M | 1 |
| Tiryaki, ES | 1 |
| Welchons, DR | 1 |
| Kim, YS | 1 |
| Lee, SH | 1 |
| Ho, WK | 1 |
| Milberg, P | 1 |
| Tegelkamp, R | 1 |
| Osada, N | 1 |
| Schimpf, R | 1 |
| Wolpert, C | 1 |
| Breithardt, G | 1 |
| Borggrefe, M | 1 |
| D'Alonzo, AJ | 3 |
| Hess, TA | 2 |
| Darbenzio, RB | 3 |
| Sewter, JC | 2 |
| Sleph, PG | 1 |
| Grover, GJ | 2 |
| Black, SC | 1 |
| Nakaya, H | 1 |
| Baczkó, I | 1 |
| Leprán, I | 1 |
| Papp, JG | 1 |
| Zhu, JL | 1 |
| Dorso, CR | 1 |
| Jayawant, M | 1 |
| Stephenson, ER | 1 |
| Damiano, RJ | 1 |
| Padrini, R | 1 |
| Bova, S | 1 |
| Cargnelli, G | 1 |
| Piovan, D | 1 |
| Ferrari, M | 1 |
| Fish, FA | 1 |
| Prakash, C | 1 |
| Roden, DM | 1 |
| Wolleben, CD | 1 |
| Sanguinetti, MC | 1 |
| Siegl, PK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Invasive and Clinical Features in Patients With Brugada Syndrome Undergoing Catheter Ablation: a Prospective, Single-centre, Randomized, Sham-controlled, and Masked Pilot Study[NCT05685134] | 12 participants (Anticipated) | Interventional | 2020-11-03 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pinacidil and Arrhythmia
| Article | Year |
|---|---|
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; G | 1993 |
32 other studies available for pinacidil and Arrhythmia
| Article | Year |
|---|---|
Characteristics of electromechanical window in anesthetized rabbit models of short QT and long QT syndromes.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Benzopyrans; Biomarkers; Biomarkers, Pharmacological; Cro | 2017 |
Mechanisms Underlying Epicardial Radiofrequency Ablation to Suppress Arrhythmogenesis in Experimental Models of Brugada Syndrome.
Topics: Action Potentials; Ajmaline; Animals; Arrhythmias, Cardiac; Brugada Syndrome; Disease Models, Animal | 2017 |
Antiarrhythmic effect of antazoline in experimental models of acquired short- and long-QT-syndromes.
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Antazoline; Anti-Bacterial Agents; Arrhythm | 2018 |
Ranolazine and Vernakalant Prevent Ventricular Arrhythmias in an Experimental Whole-Heart Model of Short QT Syndrome.
Topics: Action Potentials; Animals; Anisoles; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, | 2016 |
Dispersion of repolarization and arrhythmogenesis.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Electrocardiography; Electrophysiologic Techniques | 2009 |
Restitution, heterogeneity and unidirectional conduction block: New roles for old players.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Electrocardiography; Electrophysiologic Techniques | 2009 |
Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Echocardiography; Endothelin-1; Glyburide; Heart; Hypoglycemic Agents | 2009 |
Vulnerable windows define susceptibility to alternans and spatial discordance.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Calcium; Cells, Cultured; Dogs; Electrophysiologic | 2010 |
Cytosolic calcium accumulation and delayed repolarization associated with ventricular arrhythmias in a guinea pig model of Andersen-Tawil syndrome.
Topics: Action Potentials; Andersen Syndrome; Animals; Arrhythmias, Cardiac; Calcium; Cardiac Pacing, Artifi | 2010 |
Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats.
Topics: Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Benzamides; Diazoxid | 2010 |
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.
Topics: Action Potentials; Adolescent; Adult; Arrhythmias, Cardiac; Coronary Vessels; Diazoxide; Female; Gen | 2011 |
Hypoxia and reoxygenation modulate the arrhythmogenic activity of the pulmonary vein and atrium.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Blotting, Western; Chloramphe | 2012 |
Pro- and antiarrhythmic effects of ATP-sensitive potassium current activation on reentry during early afterdepolarization-mediated arrhythmias.
Topics: Action Potentials; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Body Sur | 2013 |
Whirling dervishes from Pinacidil to pinwheels.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; KATP Channels; Pinacidil | 2013 |
Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cells, Cultured; Culture Techniques; Dogs; Female; | 2002 |
Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Antioxidants; Arrhythmias, Cardiac; Blood Pressure; Decanoic Acids; | 2003 |
Risk of ventricular proarrhythmia with selective opening of the myocardial sarcolemmal versus mitochondrial ATP-gated potassium channel.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Heart; Hypoxia; Imidazoles; Male; Membrane Proteins; Mit | 2004 |
Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion.
Topics: Animals; Arrhythmias, Cardiac; Disease Models, Animal; Guinea Pigs; Heart Ventricles; In Vitro Techn | 2005 |
Effects of pinacidil on reentrant arrhythmias generated during acute regional ischemia: a simulation study.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Computer Simulation; Heart | 2005 |
Effect of thimerosal on arrhythmia induced by coronary ligation: the involvement of ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Electrocard | 2005 |
Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome.
Topics: Animals; Arrhythmias, Cardiac; Biological Transport; Calcium Channel Blockers; Dogs; Drug Evaluation | 2006 |
Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Do | 2007 |
Effects of intracoronary cromakalim, pinacidil, or diltiazem on cesium chloride-induced arrhythmias in anesthetized dogs under conditions of controlled coronary blood flow.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Blood Pressure; Cesium; Chlorides; Coronary Circulation; | 1993 |
Effect of potassium on the action of the KATP modulators cromakalim, pinacidil, or glibenclamide on arrhythmias in isolated perfused rat heart subjected to regional ischaemia.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; My | 1994 |
Potassium channel openers are likely to be proarrhythmic in the diseased human heart.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Dogs; Guanidines; Heart; H | 1994 |
KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats.
Topics: Action Potentials; Adenosine Triphosphate; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Ar | 1997 |
Proarrhythmic effects of pinacidil are partially mediated through enhancement of catecholamine release in isolated perfused guinea-pig hearts.
Topics: Adenosine Triphosphate; Adrenergic Agonists; Adrenergic beta-Antagonists; Animals; Arrhythmias, Card | 1998 |
Advantages of continuous hyperpolarized arrest with pinacidil over St. Thomas' Hospital solution during prolonged ischemia.
Topics: Animals; Arrhythmias, Cardiac; Bicarbonates; Body Water; Calcium Chloride; Cardioplegic Solutions; C | 1998 |
Role of K+ channel activators in cardiac electrophysiology and arrhythmias.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Guanidines; Heart Conduction System; Pi | 1992 |
Effects of pinacidil on guinea-pig isolated perfused heart with particular reference to the proarrhythmic effect.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Electric Stimulation; Electrocardiography; Fema | 1992 |
Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators.
Topics: Animals; Arrhythmias, Cardiac; Benzopyrans; Cardiac Complexes, Premature; Cesium; Chlorides; Cromaka | 1990 |
Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Coronar | 1989 |