pinacidil has been researched along with Alloxan Diabetes in 12 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to determine the effect of pinacidil, a nonselective KATP channel opener, on diabetes-induced retinal gliosis and inflammation." | 4.02 | KATP Opener Attenuates Diabetic-Induced Müller Gliosis and Inflammation by Modulating Kir6.1 in Microglia. ( Chen, D; Chen, J; Li, H; Luo, C; Ma, JH; Sun, W; Tang, S; Xu, H, 2021) |
| "Adenosine is a potent vasodilator of retinal blood vessels and is implicated to be a major regulator of retinal blood flow during metabolic stress, but little is known about the impact of diabetes on the role of adenosine in regulation of retinal hemodynamics." | 1.35 | Vasodilator effects of adenosine on retinal arterioles in streptozotocin-induced diabetic rats. ( Ishii, K; Mori, A; Nakahara, T; Nakazawa, T; Saito, M; Sakamoto, K, 2008) |
| "pinacidil was significantly antagonized by i." | 1.31 | Effect of diabetes on pinacidil-induced antinociception in mice. ( Kamei, J; Onodera, K; Zushida, K, 2002) |
| "IDDM was induced in rats by streptozotocin (STZ) injection, and adequate insulin was provided to maintain moderate hyperglycemia." | 1.31 | Exaggerated impact of ATP-sensitive K(+) channels on afferent arteriolar diameter in diabetes mellitus. ( Bast, JP; Carmines, PK; Fallet, RW; Ikenaga, H, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Chen, D | 1 |
| Sun, W | 1 |
| Chen, J | 1 |
| Luo, C | 1 |
| Xu, H | 1 |
| Ma, JH | 1 |
| Tang, S | 1 |
| Miller, BS | 1 |
| Blumenthal, SR | 1 |
| Shalygin, A | 1 |
| Wright, KD | 1 |
| Staruschenko, A | 1 |
| Imig, JD | 1 |
| Sorokin, A | 1 |
| Ishizaki, E | 1 |
| Fukumoto, M | 1 |
| Puro, DG | 1 |
| Mori, A | 2 |
| Suzuki, S | 1 |
| Sakamoto, K | 2 |
| Nakahara, T | 2 |
| Ishii, K | 2 |
| Zushida, K | 1 |
| Onodera, K | 1 |
| Kamei, J | 1 |
| Khanam, R | 1 |
| Pillai, KK | 1 |
| Nakazawa, T | 1 |
| Saito, M | 1 |
| Smith, JM | 1 |
| Wahler, GM | 1 |
| Zimmermann, PA | 1 |
| Knot, HJ | 1 |
| Stevenson, AS | 1 |
| Nelson, MT | 1 |
| Ikenaga, H | 1 |
| Bast, JP | 1 |
| Fallet, RW | 1 |
| Carmines, PK | 1 |
| Karicheti, V | 1 |
| Santizo, C | 1 |
| Zhao, W | 1 |
| Kuo, E | 1 |
| Shenk, G | 1 |
| Melman, A | 1 |
| Christ, GJ | 1 |
| Brown, RA | 1 |
| Petrovski, P | 1 |
| Savage, AO | 1 |
| Ren, J | 1 |
12 other studies available for pinacidil and Alloxan Diabetes
| Article | Year |
|---|---|
KATP Opener Attenuates Diabetic-Induced Müller Gliosis and Inflammation by Modulating Kir6.1 in Microglia.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; DNA; Gene Expression Regulation; Gliosis; | 2021 |
Inactivation of p66Shc Decreases Afferent Arteriolar K
Topics: Animals; Arterioles; Diabetes Mellitus, Experimental; Diabetic Nephropathies; KATP Channels; Kidney; | 2018 |
Functional K(ATP) channels in the rat retinal microvasculature: topographical distribution, redox regulation, spermine modulation and diabetic alteration.
Topics: Adenosine; Animals; Arterioles; Capillaries; Diabetes Mellitus, Experimental; Dithionitrobenzoic Aci | 2009 |
Vasodilation of retinal arterioles induced by activation of BKCa channels is attenuated in diabetic rats.
Topics: Acetylcholine; Animals; Blood Glucose; Blood Pressure; Cyclooxygenase Inhibitors; Diabetes Mellitus, | 2011 |
Effect of diabetes on pinacidil-induced antinociception in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glyburide; Injections, I | 2002 |
Involvement of potassium channels in hypoglycemic effect of sertraline.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucose; Hyperglycemia; | 2006 |
Vasodilator effects of adenosine on retinal arterioles in streptozotocin-induced diabetic rats.
Topics: Acetylcholine; Adenosine; Animals; Arterioles; Blood Pressure; Diabetes Mellitus, Experimental; Enzy | 2008 |
ATP-sensitive potassium channels are altered in ventricular myocytes from diabetic rats.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Diabetes Mellitus, Experimental; Electrophysiolo | 1996 |
Increased myogenic tone and diminished responsiveness to ATP-sensitive K+ channel openers in cerebral arteries from diabetic rats.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Cerebral Arteries; Diabetes Mellitus, Experimental; | 1997 |
Exaggerated impact of ATP-sensitive K(+) channels on afferent arteriolar diameter in diabetes mellitus.
Topics: Adenosine Triphosphate; Animals; Arterioles; Benzopyrans; Cyclopentanes; Diabetes Mellitus, Experime | 2000 |
Changes in electrical properties of detrusor smooth muscle in the STZ (streptozotocin)-diabetic rat.
Topics: Action Potentials; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Diabetes Mellitus, Exper | 2001 |
Influence of ATP-sensitive K+ channel modulation on the mechanical properties of diabetic myocardium.
Topics: Adenosine Triphosphate; Animals; Biomechanical Phenomena; Blood Glucose; Cromakalim; Depression, Che | 2001 |