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pinacidil and Acidosis

pinacidil has been researched along with Acidosis in 3 studies

Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)

Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.

Research Excerpts

ExcerptRelevanceReference
" The aims of this study were to compare in the rat isolated perfused lung preparation, the dilator actions of nicorandil, pinacidil and nitroglycerin on the hypoxic pulmonary pressure response with or without hypercapnic acidosis and to investigate the possible involvement of K channels and EDRF in these effects."3.69Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat. ( Advenier, C; Dumas, JP; Dumas, M; Giudicelli, JF; Rochette, L, 1996)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lindauer, U1
Vogt, J1
Schuh-Hofer, S1
Dreier, JP1
Dirnagl, U1
Dumas, M1
Dumas, JP1
Rochette, L1
Advenier, C1
Giudicelli, JF1
Ishizaka, H1
Gudi, SR1
Frangos, JA1
Kuo, L1

Other Studies

3 other studies available for pinacidil and Acidosis

ArticleYear
Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2003, Volume: 23, Issue:10

    Topics: Acidosis; Adenosine Triphosphate; Animals; Benzimidazoles; Cerebrovascular Circulation; Enzyme Inhib

2003
Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat.
    British journal of pharmacology, 1996, Volume: 117, Issue:4

    Topics: Acidosis; Animals; Guanidines; Hypercapnia; Hypoxia; In Vitro Techniques; Lung; Male; Niacinamide; N

1996
Coronary arteriolar dilation to acidosis: role of ATP-sensitive potassium channels and pertussis toxin-sensitive G proteins.
    Circulation, 1999, Feb-02, Volume: 99, Issue:4

    Topics: Acidosis; Adenosine Triphosphate; Animals; Arterioles; Coronary Vessels; Female; Glyburide; GTP-Bind

1999