pinacidil and Ache
pinacidil has been researched along with Ache in 7 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " injected at doses of 50, 100 or 150 micrograms/rat, significantly increases and prolongs the effect of morphine on the thermal pain threshold (hot-plate and tail-flick tests)." | 3.68 | Pinacidil potentiates morphine analgesia. ( Bertolini, A; Scarano, A; Vergoni, AV, 1992) |
| "Bone cancer pain is a major clinical problem and remains difficult to treat." | 1.40 | Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain. ( Fan, L; Pan, HL; Ren, J; Tian, Y; Wang, X; Wang, Y; Wu, J; Xia, H; Xu, L; Yang, S; Yao, W; Zhang, C; Zhang, D, 2014) |
| "Pinacidil activity was not blocked by L-NAME, D-NAME, 7-nitroindazole, ODQ, KT-5823 or okadaic acid." | 1.33 | The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin. ( Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T, 2006) |
| "pinacidil was significantly antagonized by i." | 1.31 | Effect of diabetes on pinacidil-induced antinociception in mice. ( Kamei, J; Onodera, K; Zushida, K, 2002) |
Research
Studies (7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Xia, H | 1 |
| Zhang, D | 1 |
| Yang, S | 1 |
| Wang, Y | 1 |
| Xu, L | 1 |
| Wu, J | 1 |
| Ren, J | 1 |
| Yao, W | 1 |
| Fan, L | 1 |
| Zhang, C | 1 |
| Tian, Y | 1 |
| Pan, HL | 1 |
| Wang, X | 1 |
| Du, X | 1 |
| Wang, C | 1 |
| Zhang, H | 1 |
| Zushida, K | 1 |
| Onodera, K | 1 |
| Kamei, J | 1 |
| Sarantopoulos, C | 1 |
| McCallum, B | 1 |
| Sapunar, D | 1 |
| Kwok, WM | 1 |
| Hogan, Q | 1 |
| Mixcoatl-Zecuatl, T | 1 |
| Flores-Murrieta, FJ | 1 |
| Granados-Soto, V | 2 |
| Ortiz, MI | 1 |
| Torres-López, JE | 1 |
| Castañeda-Hernández, G | 1 |
| Rosas, R | 1 |
| Vidal-Cantú, GC | 1 |
| Vergoni, AV | 1 |
| Scarano, A | 1 |
| Bertolini, A | 1 |
Other Studies
7 other studies available for pinacidil and Ache
| Article | Year |
|---|---|
Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Glyburide; Hyperalgesia; | 2014 |
Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats.
Topics: Animals; Behavior, Animal; Bradykinin; Diazoxide; Ganglia, Spinal; Glyburide; Ion Channel Gating; KA | 2011 |
Effect of diabetes on pinacidil-induced antinociception in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glyburide; Injections, I | 2002 |
ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin.
Topics: Acetates; Amines; Animals; ATP-Binding Cassette Transporters; Basal Ganglia; Cyclohexanecarboxylic A | 2003 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Pro | 2006 |
Pharmacological evidence for the activation of K(+) channels by diclofenac.
Topics: 4-Aminopyridine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; A | 2002 |
Pinacidil potentiates morphine analgesia.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Synergism; Guanidines; Ion Channel Gating | 1992 |