pinacidil has been researched along with Ache in 7 studies
Pinacidil: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " injected at doses of 50, 100 or 150 micrograms/rat, significantly increases and prolongs the effect of morphine on the thermal pain threshold (hot-plate and tail-flick tests)." | 3.68 | Pinacidil potentiates morphine analgesia. ( Bertolini, A; Scarano, A; Vergoni, AV, 1992) |
| "Bone cancer pain is a major clinical problem and remains difficult to treat." | 1.40 | Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain. ( Fan, L; Pan, HL; Ren, J; Tian, Y; Wang, X; Wang, Y; Wu, J; Xia, H; Xu, L; Yang, S; Yao, W; Zhang, C; Zhang, D, 2014) |
| "Pinacidil activity was not blocked by L-NAME, D-NAME, 7-nitroindazole, ODQ, KT-5823 or okadaic acid." | 1.33 | The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin. ( Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T, 2006) |
| "pinacidil was significantly antagonized by i." | 1.31 | Effect of diabetes on pinacidil-induced antinociception in mice. ( Kamei, J; Onodera, K; Zushida, K, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xia, H | 1 |
| Zhang, D | 1 |
| Yang, S | 1 |
| Wang, Y | 1 |
| Xu, L | 1 |
| Wu, J | 1 |
| Ren, J | 1 |
| Yao, W | 1 |
| Fan, L | 1 |
| Zhang, C | 1 |
| Tian, Y | 1 |
| Pan, HL | 1 |
| Wang, X | 1 |
| Du, X | 1 |
| Wang, C | 1 |
| Zhang, H | 1 |
| Zushida, K | 1 |
| Onodera, K | 1 |
| Kamei, J | 1 |
| Sarantopoulos, C | 1 |
| McCallum, B | 1 |
| Sapunar, D | 1 |
| Kwok, WM | 1 |
| Hogan, Q | 1 |
| Mixcoatl-Zecuatl, T | 1 |
| Flores-Murrieta, FJ | 1 |
| Granados-Soto, V | 2 |
| Ortiz, MI | 1 |
| Torres-López, JE | 1 |
| Castañeda-Hernández, G | 1 |
| Rosas, R | 1 |
| Vidal-Cantú, GC | 1 |
| Vergoni, AV | 1 |
| Scarano, A | 1 |
| Bertolini, A | 1 |
7 other studies available for pinacidil and Ache
| Article | Year |
|---|---|
Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Glyburide; Hyperalgesia; | 2014 |
Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats.
Topics: Animals; Behavior, Animal; Bradykinin; Diazoxide; Ganglia, Spinal; Glyburide; Ion Channel Gating; KA | 2011 |
Effect of diabetes on pinacidil-induced antinociception in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glyburide; Injections, I | 2002 |
ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin.
Topics: Acetates; Amines; Animals; ATP-Binding Cassette Transporters; Basal Ganglia; Cyclohexanecarboxylic A | 2003 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Pro | 2006 |
Pharmacological evidence for the activation of K(+) channels by diclofenac.
Topics: 4-Aminopyridine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; A | 2002 |
Pinacidil potentiates morphine analgesia.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Synergism; Guanidines; Ion Channel Gating | 1992 |