pimonidazole has been researched along with Melanoma in 12 studies
*Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Denny, WA; Hay, MP; Lee, HH; Roberts, PB; Wilson, WR | 1 |
| Gaustad, JV; Rofstad, EK; Simonsen, TG | 1 |
| Ellingsen, C; Galappathi, K; Mathiesen, B; Ovrebø, KM; Rofstad, EK | 1 |
| Kageyama, K; Kato, S; Kimura, M; Miwa, N; Tanaka, H | 1 |
| el Gamoussi, R; Guichard, M; Stratford, IJ | 1 |
| el Gamoussi, R; Guichard, M; Prade, M; Stratford, IJ; Threadgill, MD | 1 |
| Galappathi, K; Graff, BA; Mathiesen, B; Nilsen, K; Rasmussen, H; Rofstad, EK | 1 |
| Guichard, ME; Lespinasse, F; Taghian, A | 1 |
| Dische, S | 1 |
| Bennett, MH; Dische, S; Orchard, R; Stratford, MR; Wardman, P | 1 |
| Bleehen, NM; Newman, HF; Workman, P | 1 |
| Bennett, MH; Des Rochers, C; Dische, S; Dunphy, EP; Minchinton, AI; Saunders, MI; Stratford, MR; Wardman, P | 1 |
12 other study(ies) available for pimonidazole and Melanoma
| Article | Year |
|---|---|
Hypoxia-selective antitumor agents. 10. bis(nitroimidazoles) and related Bis(nitroheterocycles): development of derivatives with higher rates of metabolic activation under hypoxia and improved aqueous solubility.
Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Hypoxia; Cell Line; Chemical Phenomena; Chemistry, Physical; Cricetinae; Cricetulus; Heterocyclic Compounds; Humans; Mammary Neoplasms, Experimental; Melanoma; Mice; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Solubility; Structure-Activity Relationship; Water | 1995 |
Development of hypoxia in a preclinical model of tumor micrometastases.
Topics: Animals; Blood Flow Velocity; Cell Hypoxia; Female; Humans; Melanoma; Mice; Mice, Inbred A; Mice, Nude; Nitroimidazoles; Rhodamines; Xenograft Model Antitumor Assays | 2010 |
pO₂ fluctuation pattern and cycling hypoxia in human cervical carcinoma and melanoma xenografts.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Coloring Agents; Connective Tissue; Female; Humans; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Microvessels; Nitroimidazoles; Oxygen; Oxygen Consumption; Partial Pressure; Transplantation, Heterologous; Uterine Cervical Neoplasms | 2012 |
Enhanced radiosensitization by liposome-encapsulated pimonidazole for anticancer effects on human melanoma cells.
Topics: Cell Line; Cell Survival; Humans; Liposomes; Materials Testing; Melanoma; Nanocapsules; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents | 2012 |
Relationship between intracellular concentration and radiosensitizing effect of pimonidazole and etanidazole on two human melanoma cell lines.
Topics: Etanidazole; Humans; In Vitro Techniques; Melanoma; Nitroimidazoles; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1993 |
Relationship between the melanin content of a human melanoma cell line and its radiosensitivity and uptake of pimonidazole.
Topics: Animals; Autoradiography; Cell Line; Etanidazole; Humans; Melanins; Melanoma; Mice; Mice, Nude; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1993 |
Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor.
Topics: Animals; Cell Hypoxia; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Melanoma; Mice; Mice, Inbred BALB C; Nitroimidazoles; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Transplantation, Heterologous; Tumor Cells, Cultured; Up-Regulation | 2002 |
Radiosensitization by the combination of etanidazole (SR-2508) and pimonidazole (Ro 03-8799) in human tumor xenografts.
Topics: Adenocarcinoma; Animals; Cell Survival; Drug Synergism; Etanidazole; Female; Humans; Melanoma; Mice; Mice, Nude; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Radiotherapy Dosage; Rectal Neoplasms | 1991 |
Radiotherapy using the hypoxic cell sensitizer Ro 03-8799 in malignant melanoma.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypoxia; Lymph Nodes; Male; Melanoma; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Palliative Care; Radiation Tolerance; Radiation-Sensitizing Agents; Skin Neoplasms | 1987 |
The uptake of the radiosensitizing compound Ro 03-8799 (Pimonidazole) in human tumors.
Topics: Breast Neoplasms; Female; Humans; Melanoma; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Rectal Neoplasms; Uterine Cervical Neoplasms | 1989 |
A phase I study of the combined hypoxic cell radiosensitizers, Ro 03-8799 and SR 2508: a preliminary report of single-dose toxicity, pharmacokinetics and tumour concentrations.
Topics: Adenocarcinoma; Drug Combinations; Drug Evaluation; Etanidazole; Humans; Melanoma; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
A comparison of the tumour concentrations obtainable with misonidazole and Ro 03-8799.
Topics: Adult; Aged; Animals; Carcinoma, Squamous Cell; Cricetinae; Cricetulus; Female; Humans; Male; Melanoma; Mice; Middle Aged; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms | 1986 |