Page last updated: 2024-08-23

pimonidazole and Hypoxia

pimonidazole has been researched along with Hypoxia in 97 studies

Research

Studies (97)

TimeframeStudies, this research(%)All Research%
pre-19902 (2.06)18.7374
1990's6 (6.19)18.2507
2000's45 (46.39)29.6817
2010's39 (40.21)24.3611
2020's5 (5.15)2.80

Authors

AuthorsStudies
de Bree, R; H A M Kaanders, J; Philippens, MEP; Smits, HJG; Swartz, JE; Willems, SM1
Labiano, S; Rodriguez-Ruiz, ME; Serrano-Mendioroz, I1
Ahn, YB; Ko, SH; Lee, E; Ryu, GR; Song, KH1
Kanazawa, K; Maruyama, H; Uchiyama, Y; Yamagishi, S; Yamaura, T1
Fukatsu, A; Inada, A1
Arias, SCA; Ávila, VF; Câmara, NOS; Fanelli, C; Faustino, VD; Foresto-Neto, O; Fujihara, CK; Malheiros, DMAC; Moreira, GCDS; Nascimento, TF; Rempel, LCT; Zatz, R1
Elias, AA; Maki, Y; Matushewski, B; Nygard, K; Regnault, TRH; Richardson, BS1
Asada, Y; Iwakiri, T; Kawai, K; Kitamura, K; Koshimoto, C; Kuge, Y; Matsuura, Y; Sugita, C; Tamaki, N; Yamasaki, K; Yamashita, A; Zhao, S; Zhao, Y1
Andersen, LMK; Galappathi, K; Gaustad, JV; Hauge, A; Rofstad, EK; Simonsen, TG; Wegner, CS1
Jayagopal, A; McCollum, GW; Penn, JS; Uddin, MI; Yang, R1
Bayin, NS; Placantonakis, DG1
Aminuddin, A; Fujisaka, S; Goda, N; Ikutani, M; Mahmood, A; Nagai, Y; Takatsu, K; Takikawa, A; Tobe, K; Tsuneyama, K; Usui, I1
Ababneh, DH; Oakes, DJ; Power, CA; Ritchie, HE; Webster, WS1
Busk, M; Horsman, MR; Iversen, AB; Jakobsen, S; Ji, X; Lee, DY; Mortensen, LS; Nordsmark, M; Overgaard, J; Raleigh, JR1
Capozzi, ME; Craft, JR; Evans, SM; Jayagopal, A; Kim, K; Moore, CE; Sulikowski, GA; Uddin, MI1
Andreeff, M; Benito, J; Borthakur, G; Bueso-Ramos, C; Cortes, J; Coveler, A; Daver, N; Estey, EH; Faderl, S; Feliu, J; Gu, Y; Gutheil, JC; Jabbour, E; Kadia, T; Kantarjian, H; Konoplev, S; Konopleva, M; Kornblau, S; Lu, H; Melink, TJ; Nguyen, HQ; Pemmaraju, N; Ravandi, F; Thall, PF; Thomas, D; Wei, C; Wilson, WR; Yi, CA1
Duan, X; Li, J; Li, XF; Ma, Y; Postel, GC; Wang, F; Wang, X; Yin, X; Zhang, G; Zheng, H1
Chae, JR; Cho, A; Cho, YL; Chung, KY; Kang, WJ; Kim, JY; Lee, JW; Park, SY1
Bollineni, VR; Bruine de Bruin, L; de Bock, GH; Halmos, GB; Langendijk, JA; Pruim, J; Schuuring, E; Slagter-Menkema, L; Steenbakkers, RJ; van der Laan, BF; van der Wal, JE; van Hemel, BM; Wachters, JE1
Bar-Sagi, D; Grabocka, E; Mishra, B; Sundstrom, A1
Fourcade, O; Geeraerts, T; Gonzalez, L; Kerhuel, L; Luzi, A; Mrozek, S1
Baumann, M; Mönnich, D; Thorwarth, D; Wack, LJ; Yaromina, A; Zips, D1
He, T; Xing, Y; Yang, N; Zhang, W1
Crukley, C; Desjardins, L; Hadway, J; Lee, TY; Morrison, L; Stewart, E; Wang, Y1
Brader, P; Carlin, S; Chun, YS; Fong, Y; Hricak, H; Ling, CC; Riedl, CC; Singh, P; Wen, B; Woo, Y; Zanzonico, PB1
Gilbert, RE; Kelly, DJ; Langham, RG; Tiauw, V; Wiggins, KJ; Zhang, Y1
Cui, P; Dai, M; Han, J; Li, H; Liu, Q; Xiu, R; Yu, M; Zhang, J1
Cui, P; Dai, M; Han, J; Li, H; Liu, Q; Xiu, R; Yu, M1
Heyman, SN; Paliege, A; Rosen, S; Rosenberger, C1
Fujibayashi, Y; Fujieda, S; Furukawa, T; Kobayashi, M; Kudo, T; Mori, T; Oh, M; Tanaka, T1
Boutrid, H; Cebulla, CM; Feuer, WJ; Jockovich, ME; Lampidis, TJ; Murray, TG; Piña, Y1
Baumann, M; Eckardt, A; Eicheler, W; Schuetze, C; Thames, H; Yaromina, A; Zips, D1
Cho, H; Koutcher, JA; Li, XF; Ling, CC; Lupu, ME; Russell, J; Yang, KM1
Busk, M; Bussink, J; Hansen, KV; Horsman, MR; Jakobsen, S; Overgaard, J; van der Kogel, A1
Baumann, M; Meyer, S; Mueller-Klieser, W; Quennet, V; Shakirin, G; Walenta, S; Yaromina, A; Zips, D1
Möller, A; Young, RJ1
McPhail, LD; Robinson, SP1
Bengtsson, E; Blomgren, B; Danielsson, BR; Danielsson, C; Johansson, A; Khan, KM; Kultima, K; Nilsson, MF; Sköld, AC; Webster, WS; Wilson, J1
Humm, JL; Li, XF; Ling, CC; Ma, Y; O'Donoghue, JA; Sun, X1
Boerman, OC; Bussink, J; Franssen, GM; Hoeben, BA; Kaanders, JH; Oosterwijk, E; Oyen, WJ; Rijken, PF; Troost, EG; van Dongen, GA1
Baumann, M; Beuthien-Baumann, B; Bussink, J; Eicheler, W; Krause, M; Rijken, P; Santiago, A; van der Kogel, AJ; Yaromina, A1
Boutrid, H; Celdran, M; Feuer, W; Hernandez, E; Houston, SK; Lampidis, TJ; Murray, TG; Piña, Y; Shi, W1
Babaev, AA; Golubiatnikov, GY; Ivanova, IP; Kamensky, VA; Maslennikova, AV; Orlova, AG; Plekhanov, VI; Prianikova, TI; Shakhova, NM; Snopova, LB; Turchin, IV1
Gorodkin, R; Herrick, AL; Jeziorska, M; Stratford, IJ1
Batlle, D; Cabray, J; Halter, S; Li, LP; Prasad, P; Ye, M1
Chaudhuri, S; Hennings, L; Hinson, JA; James, LP; Letzig, L; McCullough, SS; Simpson, PM1
Forsback, S; Heinonen, SE; Knuuti, J; Laine, VJ; Roivainen, A; Saraste, A; Saukko, P; Silvola, JM; Ylä-Herttuala, S1
Bifani, P; Dartois, V; Heng, Y; Hervé, M; Kiass, M; Mathys, V; Seah, PG; Siew, JY; Singhal, A; Tay, HC1
Combes, V; Grau, GE; Hempel, C; Hunt, NH; Kurtzhals, JA1
Hagtvet, E; Olsen, DR; Røe, K1
Griffin, RJ; Koonce, NA; Przybyla, BD; Shafirstein, G; Webber, JS1
Barber, PR; Bell, A; Burke, M; Daley, FM; Finch, J; Goh, V; Hoskin, PJ; Kozarski, R; Mandeville, HC; Ng, QS; Pierce, G; Townsend, ER; Vojnovic, B1
Bussink, J; Grénman, R; Iida, M; Kaanders, JH; Span, PN; Stegeman, H; van der Kogel, AJ; Verheijen, MM; Waaijer, SJ; Wheeler, DL1
Bachmann, S; Dietrich, A; Kaminski, H; Mathia, S; Mrowka, R; Mutig, K; Paliege, A; Rosenberger, C1
Kertscho, H; Lauscher, P; Meier, J; Rosenberger, P; Schmidt, O; Zacharowski, K; Zimmermann, R1
Basile, DP; Donohoe, DL; Mattson, DL; Roethe, K1
Balm, AJ; Begg, AC; Blijweert, E; Blommestijn, G; Delaere, P; Haustermans, KM; Hoebers, FJ; Hofland, I; Janssen, HL; Raleigh, JA; Sciot, R; Semenza, GL; Sprong, D; van Velthuysen, ML; Varia, MA1
Bachmann, S; Eckardt, KU; Frei, U; Griethe, W; Gruber, G; Rosenberger, C; Wiesener, M1
Azuma, Y; Chou, SC; Lininger, RA; Murphy, BJ; Raleigh, JA; Varia, MA1
Frischer, JS; Holash, J; Huang, J; Kadenhe-Chiwishe, A; Kandel, JJ; Kim, ES; Lee, A; New, T; Pollyea, DA; Serur, A; Yamashiro, DJ; Yancopoulos, GD; Yokoi, A1
Balm, AJ; Begg, AC; Goethals, L; Haustermans, KM; Hoebers, FJ; Janssen, HL; Sprong, D; Stratford, IJ; Williams, KJ1
Davidson, SE; Harris, AL; Hunter, RD; Hutchison, GJ; Loncaster, JA; Price, PM; Roberts, SA; Stratford, IJ; Valentine, HR; West, CM1
Amin, K; Arcasoy, MO; Chou, SC; Haroon, ZA; Raleigh, JA; Varia, M1
Doege, K; Heine, S; Jelkmann, W; Jensen, I; Metzen, E1
Asosingh, K; De Raeve, H; de Ridder, M; Storme, GA; Van Camp, B; Van Riet, I; Vanderkerken, K; Willems, A1
Céspedes, C; Villanueva, S; Vio, CP1
Bernhardt, W; Eckardt, KU; Frei, U; Heyman, SN; Rosen, S; Rosenberger, C; Shina, A; Wiesener, MS1
Aly, S; Bange, FC; Brandau, S; Ehlers, S; Keller, C; Malm, S; Malzan, A; Wagner, K1
Curtis, TM; de Gooyer, TE; Gardiner, TA; Humphries, P; Simpson, DA; Stevenson, KA; Stitt, AW1
Donadieu, E; Lavieille, JP; Magnan, J; Riva, C1
Deveze, A; Donadieu, E; Hamdi, W; Lavieille, JP; Lucciano, M; Magnan, J; Riva, C1
Down, JD; Mauch, P; Parmar, K; Sackstein, R; Vergilio, JA1
Aly, S; Andries, K; Basaraba, RJ; Cantarero, L; Ehlers, S; Hoff, D; Lenaerts, AJ; Orme, IM1
Echevarría, M; López-Barneo, J; Muñoz-Cabello, AM; Sánchez-Silva, R; Toledo-Aral, JJ1
Ohno, N; Ohno, S; Saitoh, S; Terada, N1
Cheluvappa, R; Cogger, VC; Hilmer, SN; Kwun, SY; LE Couteur, DG1
Abassi, Z; Eckardt, KU; Goldfarb, M; Heyman, SN; Khamaisi, M; Rosen, S; Rosenberger, C; Shilo, V; Shina, A; Weksler-Zangen, S; Zibertrest, F1
Chastagner, P; Fouyssac, F; Karcher, G; Pinel, S; Plenat, F; Poussier, S; Scigliano, S1
Allen, SS; Barry, CE; Carrillo, J; Cho, SN; Eum, SY; Flynn, JL; Gonzales, J; Klein, E; Lee, EG; Lin, PL; Manjunatha, U; McMurray, DN; Park, SK; Raleigh, JA; Ray, SM; Taylor, K; Via, LE1
Bijnens, AP; Cleutjens, JP; Corvol, P; Daemen, MJ; Gasc, JM; Groeneweg, M; Kisters, N; Sluimer, JC; Sollewijn Gelpke, MD; van den Akker, LH; van Wanroij, JL; Wouters, BG1
Mayr, M; Sidibe, A; Zampetaki, A1
Azuma, C; Raleigh, JA; Thrall, DE1
Arteel, GE; Raleigh, JA; Thurman, RG1
Arteel, GE; Connor, HD; Frankenberg, MV; Mason, RP; Raleigh, JA; Stachlewitz, RF; Thurman, RG; Yin, M; Zhong, Z1
Bunzendahl, H; Raleigh, JA; Schemmer, P; Thurman, RG1
Arteel, GE; Bunzendahl, H; Connor, HD; Mason, RP; Raleigh, JA; Schemmer, P; Thurman, RG1
Bakker, JH; Bernsen, HJ; Boerman, RH; Peters, JP; Rijken, PF; van der Kogel, AJ; Wesseling, P1
Bussink, J; de Wilde, PC; Kaanders, JH; Marres, HA; Raleigh, JA; Rijken, PF; van den Hoogen, FJ; van der Kogel, AJ; Wijffels, KI1
Bernsen, HJ; Jeuken, JW; Peters, H; Raleigh, JA; Rijken, PF; van der Kogel, AJ; Wesseling, P1
Beasley, NJ; Harris, AL; Maxwell, PH; Pastorek, J; Pugh, CW; Ratcliffe, PJ; Sibtain, A; Talks, KL; Turley, H; Turner, KJ; Watson, PH; Wilson, GD; Wykoff, CC1
Bae, SK; Chung, HY; Jeong, CH; Kim, KW; Koo, SY; Lee, YM; Raleigh, JA; Son, MJ; Song, HS; Yoo, MA1
Aquino-Parsons, C; Banáth, JP; Olive, PL1
Balm, A; Begg, AC; Blommestijn, G; Delaere, P; Hofland, I; Janssen, H; Raleigh, JA; Sciot, R; Sprong, D; Van Velthuyzen, L; Varia, M1
Braun, RD; Dewhirst, MW; Greer, PK; Gwinn, WM; Hale, LP1
Peters, JP; Rijken, PF; Van der Kogel, AJ1
Dische, S1
Adams, GE; Stratford, IJ1

Reviews

1 review(s) available for pimonidazole and Hypoxia

ArticleYear
Hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer. An overview.
    Biochemical pharmacology, 1986, Jan-01, Volume: 35, Issue:1

    Topics: Alkylating Agents; Animals; Cell Survival; Drug Synergism; Etanidazole; Hypoxia; Misonidazole; Neoplasms, Experimental; Nitrofurans; Nitrofurazone; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents; Structure-Activity Relationship

1986

Trials

3 trial(s) available for pimonidazole and Hypoxia

ArticleYear
Correlation and colocalization of HIF-1α and pimonidazole staining for hypoxia in laryngeal squamous cell carcinomas: A digital, single-cell-based analysis.
    Oral oncology, 2022, Volume: 128

    Topics: Biomarkers; Biomarkers, Tumor; Cell Hypoxia; Head and Neck Neoplasms; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Laryngeal Neoplasms; Nitroimidazoles; Prognosis; Squamous Cell Carcinoma of Head and Neck; Staining and Labeling

2022
Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia.
    Haematologica, 2015, Volume: 100, Issue:7

    Topics: Adult; Aged; Anemia; Antigens, Neoplasm; Antineoplastic Agents, Alkylating; Biomarkers; Bone Marrow; Carbonic Anhydrase IX; Carbonic Anhydrases; Enterocolitis; Female; Gene Expression; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Myeloid, Acute; Male; Middle Aged; Neutropenia; Nitrogen Mustard Compounds; Nitroimidazoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prodrugs; Recurrence; Remission Induction; Thrombocytopenia

2015
Hypoxia and perfusion measurements in human tumors--initial experience with pimonidazole and IUdR.
    Acta oncologica (Stockholm, Sweden), 2001, Volume: 40, Issue:8

    Topics: Antibodies; Biopsy; Diffusion; Esophageal Neoplasms; Female; Head and Neck Neoplasms; Humans; Hypoxia; Idoxuridine; Kinetics; Male; Nitroimidazoles; Nucleic Acid Synthesis Inhibitors; Radiation-Sensitizing Agents; Rectal Neoplasms; Regional Blood Flow; Specimen Handling; Uterine Cervical Neoplasms

2001

Other Studies

93 other study(ies) available for pimonidazole and Hypoxia

ArticleYear
Assessment of hypoxia by pimonidazole staining following radiotherapy.
    Methods in cell biology, 2022, Volume: 172

    Topics: Biomarkers; Cell Hypoxia; Humans; Hypoxia; Neoplasms; Nitroimidazoles; Oxygen; Staining and Labeling; Tumor Microenvironment

2022
Pancreatic stellate cells promote pancreatic β-cell death through exosomal microRNA transfer in hypoxia.
    Molecular and cellular endocrinology, 2023, 07-15, Volume: 572

    Topics: Animals; Cell Death; Diabetes Mellitus, Type 2; Glucose; Hypoxia; Insulin; Islets of Langerhans; Mice; MicroRNAs; Pancreatic Stellate Cells

2023
In Vivo Imaging of Tumor Hypoxia by Maintaining Green Fluorescence of 9-Aminoanthracene Under Hypoxic Conditions.
    Bioorganic & medicinal chemistry, 2023, 08-15, Volume: 91

    Topics: Animals; Anthracenes; Cell Hypoxia; Diagnostic Imaging; Fluorescence; Hypoxia; Mice; Neoplasms; Tumor Hypoxia

2023
Persistence and expansion of hypoxia detected by pimonidazole adduct immunostaining during progression of diabetic nephropathy in diabetic mice.
    American journal of physiology. Renal physiology, 2023, 11-01, Volume: 325, Issue:5

    Topics: Animals; Child, Preschool; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Nitroimidazoles

2023
Chronic exposure to hypoxia attenuates renal injury and innate immunity activation in the remnant kidney model.
    American journal of physiology. Renal physiology, 2019, 11-01, Volume: 317, Issue:5

    Topics: Animals; Gene Expression Regulation; Hypoxia; Immunity, Innate; Kidney; Male; Nephrectomy; Nitroimidazoles; Organ Size; Oxygen; Radiation-Sensitizing Agents; Rats; Renal Insufficiency, Chronic

2019
Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with evidence for chronic hypoxia.
    Pediatric research, 2017, Volume: 82, Issue:1

    Topics: Animals; Cohort Studies; Erythropoietin; Female; Fetal Development; Fetal Growth Retardation; Guinea Pigs; Hypoxia; Immunohistochemistry; Male; Maternal Nutritional Physiological Phenomena; Maternal-Fetal Exchange; Nitroimidazoles; Placenta; Pregnancy; Signal Transduction; Vascular Endothelial Growth Factor A

2017
Altered glucose metabolism and hypoxic response in alloxan-induced diabetic atherosclerosis in rabbits.
    PloS one, 2017, Volume: 12, Issue:4

    Topics: Alloxan; Animals; Apoptosis; Atherosclerosis; Autoradiography; Body Weight; Cluster Analysis; Diabetes Mellitus, Experimental; Diet, High-Fat; Electrophoresis, Capillary; Femoral Artery; Fluorodeoxyglucose F18; Glucose; Glycolysis; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Macrophages; Mass Spectrometry; Metabolomics; Microscopy, Fluorescence; Nitroimidazoles; Principal Component Analysis; Rabbits

2017
Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts.
    Acta oncologica (Stockholm, Sweden), 2017, Volume: 56, Issue:12

    Topics: Animals; Carcinoma, Pancreatic Ductal; Contrast Media; Extracellular Fluid; Female; Heterocyclic Compounds; Heterografts; Humans; Hypoxia; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Nude; Microvessels; Neoplasm Transplantation; Nitroimidazoles; Organometallic Compounds; Pancreatic Neoplasms; Platelet Endothelial Cell Adhesion Molecule-1; Pressure; Tumor Microenvironment

2017
In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO).
    Investigative ophthalmology & visual science, 2017, 07-01, Volume: 58, Issue:9

    Topics: Animals; Disease Models, Animal; Fluorescein Angiography; Fluoresceins; Fluorescent Dyes; Hypoxia; Image Processing, Computer-Assisted; Macular Edema; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Radiation-Sensitizing Agents; Retinal Neovascularization; Retinal Vein; Retinal Vein Occlusion; Tomography, Optical Coherence

2017
Evaluation of Vascularity, Blood Perfusion, and Oxygen Tension in Tumor Xenografts with Fluorescent Microscopy.
    Methods in molecular biology (Clifton, N.J.), 2018, Volume: 1741

    Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; Heterografts; Humans; Hypoxia; Mice; Microscopy, Fluorescence; Neoplasm Staging; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; Oxygen

2018
Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice.
    Diabetologia, 2013, Volume: 56, Issue:6

    Topics: Adipose Tissue; Alleles; Animals; Bone Marrow Cells; Cell Polarity; Flow Cytometry; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Nitroimidazoles; Phenotype

2013
The teratogenic effect of dofetilide during rat limb development and association with drug-induced bradycardia and hypoxia in the embryo.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2013, Volume: 98, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Heart; Hypoxia; Limb Deformities, Congenital; Nitroimidazoles; Phenethylamines; Rats; Rats, Sprague-Dawley; Sulfonamides; Teratogens

2013
PET imaging of tumor hypoxia using 18F-labeled pimonidazole.
    Acta oncologica (Stockholm, Sweden), 2013, Volume: 52, Issue:7

    Topics: Animals; Carcinoma, Squamous Cell; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Hypoxia; Mammary Neoplasms, Animal; Mice; Mice, Inbred C3H; Mice, Nude; Nitroimidazoles; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tumor Cells, Cultured

2013
Molecular probes for imaging of hypoxia in the retina.
    Bioconjugate chemistry, 2014, Nov-19, Volume: 25, Issue:11

    Topics: Animals; Cell Line; Cell Survival; Fluorescein-5-isothiocyanate; Humans; Hypoxia; Mice; Molecular Imaging; Molecular Probes; Nitroimidazoles; Retina; Retinal Neurons

2014
The reverse Warburg effect and 18F-FDG uptake in non-small cell lung cancer A549 in mice: a pilot study.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2015, Volume: 56, Issue:4

    Topics: Animals; Blood Glucose; Body Weight; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diet; Female; Fluorodeoxyglucose F18; Glucose; Humans; Hypoxia; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Radiopharmaceuticals; Tumor Microenvironment

2015
64Cu-ATSM Hypoxia Positron Emission Tomography for Detection of Conduit Ischemia in an Experimental Rat Esophagectomy Model.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Anastomotic Leak; Animals; Autoradiography; Coordination Complexes; Copper Radioisotopes; Esophagectomy; Esophagogastric Junction; Gastric Fundus; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Ischemia; Male; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Thiosemicarbazones

2015
Assessment of hypoxic subvolumes in laryngeal cancer with (18)F-fluoroazomycinarabinoside ((18)F-FAZA)-PET/CT scanning and immunohistochemistry.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2015, Volume: 117, Issue:1

    Topics: Aged; Aged, 80 and over; Biomarkers; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Hypoxia; Laryngeal Neoplasms; Laryngectomy; Male; Middle Aged; Multimodal Imaging; Neoplasm Recurrence, Local; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Squamous Cell Carcinoma of Head and Neck; Tomography, X-Ray Computed

2015
Histological Image Processing Features Induce a Quantitative Characterization of Chronic Tumor Hypoxia.
    PloS one, 2016, Volume: 11, Issue:4

    Topics: Algorithms; Animals; Cell Line, Tumor; Colonic Neoplasms; Humans; Hypoxia; Image Processing, Computer-Assisted; Mice; Mice, Nude; Nitroimidazoles

2016
Cerebral and extracerebral vulnerability to hypoxic insults after diffuse traumatic brain injury in rats.
    Brain research, 2016, 09-01, Volume: 1646

    Topics: Animals; Arterial Pressure; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Hypotension; Hypoxia; Hypoxia, Brain; Kidney; Liver; Male; Myocardium; Nitroimidazoles; Rats; Rats, Sprague-Dawley

2016
Correlation of FMISO simulations with pimonidazole-stained tumor xenografts: A question of O2 consumption?
    Medical physics, 2016, Volume: 43, Issue:7

    Topics: Animals; Benzimidazoles; Carcinoma, Squamous Cell; Cell Line, Tumor; Computer Simulation; Feasibility Studies; Fluorescent Antibody Technique; Head and Neck Neoplasms; Humans; Hypoxia; Mice, Nude; Misonidazole; Models, Biological; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Platelet Endothelial Cell Adhesion Molecule-1; Tumor Microenvironment

2016
Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy.
    Experimental eye research, 2017, Volume: 159

    Topics: Animals; Animals, Newborn; Blotting, Western; Disease Models, Animal; Galectin 1; Gene Silencing; Hypoxia; Intravitreal Injections; Ischemia; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Real-Time Polymerase Chain Reaction; Retinal Neovascularization; RNA; RNA, Messenger

2017
Assessment of intratumor hypoxia by integrated 18F-FDG PET / perfusion CT in a liver tumor model.
    PloS one, 2017, Volume: 12, Issue:3

    Topics: Animals; Disease Models, Animal; Fluorodeoxyglucose F18; Glucose; Humans; Hypoxia; Liver Neoplasms; Male; Neovascularization, Pathologic; Nitroimidazoles; Oxygen Consumption; Perfusion; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Rabbits

2017
Imaging hypoxia in orthotopic rat liver tumors with iodine 124-labeled iodoazomycin galactopyranoside PET.
    Radiology, 2008, Volume: 248, Issue:2

    Topics: Animals; Carcinoma, Hepatocellular; Hypoxia; Image Processing, Computer-Assisted; Iodine Radioisotopes; Liver Neoplasms; Monosaccharides; Nitroimidazoles; Positron-Emission Tomography; Rats; Rats, Nude

2008
Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats.
    Nephrology (Carlton, Vic.), 2008, Volume: 13, Issue:8

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Fibrosis; Hypoxia; Immunohistochemistry; Inflammation; Kidney Tubules; Macrophages; Nitroimidazoles; Osteopontin; Perindopril; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Renin-Angiotensin System; Time Factors

2008
Effect of artificial oxygen carrier with chemotherapy on tumor hypoxia and neovascularization.
    Artificial cells, blood substitutes, and immobilization biotechnology, 2008, Volume: 36, Issue:5

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Cricetinae; HeLa Cells; Hemoglobins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mesocricetus; Microvessels; Neoplasms, Experimental; Neovascularization, Pathologic; Nitroimidazoles; Oxygen; Oxygen Inhalation Therapy; Polyethylene Glycols; Tumor Burden

2008
Influence of PEG-conjugated hemoglobin on tumor oxygenation and response to chemotherapy.
    Artificial cells, blood substitutes, and immobilization biotechnology, 2008, Volume: 36, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Substitutes; Cisplatin; Drug Synergism; Female; Hemoglobins; Hypoxia; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oxygen Consumption; Polyethylene Glycols; Treatment Outcome; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

2008
Pimonidazole adduct immunohistochemistry in the rat kidney: detection of tissue hypoxia.
    Methods in molecular biology (Clifton, N.J.), 2009, Volume: 466

    Topics: Animals; Hypoxia; Immunohistochemistry; Kidney; Molecular Structure; Nitroimidazoles; Rats; Tissue Fixation

2009
Radio-copper-labeled Cu-ATSM: an indicator of quiescent but clonogenic cells under mild hypoxia in a Lewis lung carcinoma model.
    Nuclear medicine and biology, 2009, Volume: 36, Issue:4

    Topics: Animals; Autoradiography; Bromodeoxyuridine; Carcinoma, Lewis Lung; Cell Proliferation; Colony-Forming Units Assay; Coordination Complexes; Copper Radioisotopes; Disease Models, Animal; Fluorodeoxyglucose F18; Hypoxia; Image Processing, Computer-Assisted; Immunohistochemistry; Ki-67 Antigen; Male; Mice; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Staining and Labeling; Thiosemicarbazones

2009
Increased hypoxia following vessel targeting in a murine model of retinoblastoma.
    Investigative ophthalmology & visual science, 2009, Volume: 50, Issue:12

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carboplatin; Disease Models, Animal; Hypoxia; Mice; Mice, Transgenic; Microscopy, Confocal; Neovascularization, Pathologic; Nitroimidazoles; Pregnadienediols; Retinal Neoplasms; Retinoblastoma

2009
Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studies.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2009, Volume: 92, Issue:3

    Topics: Animals; Biopsy, Needle; Carcinoma, Squamous Cell; Confidence Intervals; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Environment; Female; Humans; Hypoxia; Immunohistochemistry; Longitudinal Studies; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Probability; Radiobiology; Random Allocation; Reference Values

2009
Atrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model.
    Cancer biology & therapy, 2009, Volume: 8, Issue:20

    Topics: Adenocarcinoma; Animals; Atrasentan; Colonic Neoplasms; Combined Modality Therapy; Etanidazole; Gadolinium DTPA; HT29 Cells; Humans; Hydrocarbons, Fluorinated; Hypoxia; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Nitroimidazoles; Perfusion; Pyrrolidines; Radiation-Sensitizing Agents; Radiotherapy; Treatment Outcome; Xenograft Model Antitumor Assays

2009
Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2009, Volume: 92, Issue:3

    Topics: Animals; Carcinoma, Squamous Cell; Cell Count; Cell Hypoxia; Disease Models, Animal; Female; Hypoxia; Mice; Mice, Inbred C3H; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Random Allocation; Sensitivity and Specificity; Tissue Distribution

2009
Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.
    International journal of radiation biology, 2009, Volume: 85, Issue:11

    Topics: Animals; Benzimidazoles; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Female; Fluorescent Dyes; Glucose; Humans; Hypoxia; Lactic Acid; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Transplantation, Heterologous

2009
Immunohistochemical detection of tumour hypoxia.
    Methods in molecular biology (Clifton, N.J.), 2010, Volume: 611

    Topics: Animals; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mice; Neoplasms; Nitroimidazoles

2010
Intrinsic susceptibility MR imaging of chemically induced rat mammary tumors: relationship to histologic assessment of hypoxia and fibrosis.
    Radiology, 2010, Volume: 254, Issue:1

    Topics: Animals; Biomarkers, Tumor; Carbon Dioxide; Female; Fibrosis; Hypoxia; Keratin-14; Linear Models; Magnetic Resonance Imaging; Mammary Neoplasms, Experimental; Methylnitrosourea; Necrosis; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Rats; Rats, Wistar

2010
Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs.
    Reproductive toxicology (Elmsford, N.Y.), 2010, Volume: 29, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Astemizole; Cetirizine; Drug Evaluation, Preclinical; Embryo Culture Techniques; Embryo, Mammalian; Embryonic Development; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart Rate; Histamine H1 Antagonists, Non-Sedating; Hypoxia; Image Processing, Computer-Assisted; Maternal Exposure; Nitroimidazoles; Potassium Channels, Inwardly Rectifying; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens

2010
High 18F-FDG uptake in microscopic peritoneal tumors requires physiologic hypoxia.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010, Volume: 51, Issue:4

    Topics: Air; Animals; Autoradiography; Biological Transport; Carbon Dioxide; Cell Proliferation; Female; Fluorescent Antibody Technique; Fluorodeoxyglucose F18; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; HT29 Cells; Humans; Hypoxia; Mice; Nitroimidazoles; Oxygen; Peritoneal Neoplasms; Respiration

2010
PET of hypoxia with 89Zr-labeled cG250-F(ab')2 in head and neck tumors.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2010, Volume: 51, Issue:7

    Topics: Animals; Antibodies, Monoclonal; Autoradiography; Carbonic Anhydrase Inhibitors; Head and Neck Neoplasms; Hypoxia; Image Processing, Computer-Assisted; Immunoglobulin Fab Fragments; Immunoglobulin G; Immunohistochemistry; Isotope Labeling; Mice; Mice, Inbred BALB C; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Quality Control; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tissue Distribution; Xenograft Model Antitumor Assays; Zirconium

2010
Effect of cetuximab and fractionated irradiation on tumour micro-environment.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2010, Volume: 97, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Combined Modality Therapy; Dose Fractionation, Radiation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Male; Mice; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Signal Transduction; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2010
Focal, periocular delivery of 2-deoxy-D-glucose as adjuvant to chemotherapy for treatment of advanced retinoblastoma.
    Investigative ophthalmology & visual science, 2010, Volume: 51, Issue:12

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Deoxyglucose; Disease Models, Animal; Drug Delivery Systems; Hypoxia; Mice; Mice, Transgenic; Microscopy, Fluorescence; Nitroimidazoles; Retinal Neoplasms; Retinoblastoma; Tumor Burden

2010
Comparative study of tumor hypoxia by diffuse optical spectroscopy and immunohistochemistry in two tumor models.
    Journal of biophotonics, 2010, Volume: 3, Issue:12

    Topics: Animals; Biomarkers, Tumor; Brain Neoplasms; Diffusion; Disease Models, Animal; Female; Hemoglobins; Hypoxia; Immunohistochemistry; Lymph Nodes; Male; Medical Oncology; Nitroimidazoles; Optical Devices; Oxygen; Radiation-Sensitizing Agents; Rats; Spectrum Analysis

2010
Testing for hypoxia in forearm skin of patients with systemic sclerosis, assessed by pimonidazole.
    The Journal of rheumatology, 2010, Volume: 37, Issue:9

    Topics: Adult; Aged; Female; Forearm; Humans; Hypoxia; Male; Middle Aged; Nitroimidazoles; Radiation-Sensitizing Agents; Scleroderma, Systemic; Skin

2010
Evaluation of renal hypoxia in diabetic mice by BOLD MRI.
    Investigative radiology, 2010, Volume: 45, Issue:12

    Topics: Age Factors; Animals; Diabetic Nephropathies; Hypoxia; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Staining and Labeling

2010
Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia.
    Toxicology and applied pharmacology, 2011, May-01, Volume: 252, Issue:3

    Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Dose-Response Relationship, Drug; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Nitroimidazoles; Oxidative Stress; Statistics, Nonparametric

2011
Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.
    Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:5

    Topics: Analysis of Variance; Animals; Aorta; Apolipoprotein B-100; Atherosclerosis; Autoradiography; Disease Models, Animal; Etanidazole; Female; Fluorine Radioisotopes; Genotype; Hydrocarbons, Fluorinated; Hypoxia; Immunohistochemistry; Insulin-Like Growth Factor II; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitroimidazoles; Phenotype; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, LDL; Tissue Distribution

2011
Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat.
    Tuberculosis (Edinburgh, Scotland), 2011, Volume: 91, Issue:4

    Topics: Animals; Disease Models, Animal; Female; Granuloma; Hypoxia; Immunohistochemistry; Lung; Mycobacterium tuberculosis; Nitroimidazoles; Rats; Tuberculosis, Pulmonary

2011
CNS hypoxia is more pronounced in murine cerebral than noncerebral malaria and is reversed by erythropoietin.
    The American journal of pathology, 2011, Volume: 179, Issue:4

    Topics: Animals; Brain; Disease Models, Animal; Erythropoietin; Female; Fluorescent Dyes; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Malaria, Cerebral; Mice; Nitroimidazoles; Parasitemia; Plasmodium berghei; Poly(ADP-ribose) Polymerases; Survival Analysis; Treatment Outcome

2011
Liposomal doxorubicin improves radiotherapy response in hypoxic prostate cancer xenografts.
    Radiation oncology (London, England), 2011, Oct-07, Volume: 6

    Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Combined Modality Therapy; Contrast Media; Doxorubicin; Humans; Hypoxia; Immunohistochemistry; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Theoretical; Neoplasm Transplantation; Nitroimidazoles; Prostatic Neoplasms; Treatment Outcome

2011
Conductive thermal ablation of 4T1 murine breast carcinoma reduces severe hypoxia in surviving tumour.
    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2012, Volume: 28, Issue:2

    Topics: Animals; Combined Modality Therapy; Female; Hyperthermia, Induced; Hypoxia; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Nitroimidazoles; Radiation-Sensitizing Agents

2012
Operable non-small cell lung cancer: correlation of volumetric helical dynamic contrast-enhanced CT parameters with immunohistochemical markers of tumor hypoxia.
    Radiology, 2012, Volume: 264, Issue:2

    Topics: Aged; Biomarkers, Tumor; Blood Volume; Carcinoma, Non-Small-Cell Lung; Contrast Media; Female; Humans; Hypoxia; Immunohistochemistry; Iohexol; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Nitroimidazoles; Prospective Studies; Radiation-Sensitizing Agents; Radiographic Image Interpretation, Computer-Assisted; Statistics, Nonparametric; Tomography, Spiral Computed

2012
Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck.
    BMC cancer, 2012, Oct-10, Volume: 12

    Topics: Animals; Blotting, Western; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; ErbB Receptors; Fluorescent Antibody Technique; Head and Neck Neoplasms; Heterocyclic Compounds, 3-Ring; Humans; Hypoxia; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Radiation-Sensitizing Agents; Radiotherapy; Receptor, ErbB-2; Signal Transduction; Tumor Microenvironment; Xenograft Model Antitumor Assays

2012
Chronic activation of vasopressin V2 receptor signalling lowers renal medullary oxygen levels in rats.
    Acta physiologica (Oxford, England), 2013, Volume: 207, Issue:4

    Topics: Animals; Deamino Arginine Vasopressin; Disease Models, Animal; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Medulla; Nitroimidazoles; Oxygen; Rats; Rats, Brattleboro; Rats, Sprague-Dawley; Receptors, Vasopressin; Signal Transduction; Vasopressins

2013
Determination of organ-specific anemia tolerance.
    Critical care medicine, 2013, Volume: 41, Issue:4

    Topics: Acute Disease; Anemia; Animals; Brain; Cell Hypoxia; Female; Hemodilution; Hemodynamics; Hypoxia; Hypoxia, Brain; Immune Tolerance; Intestine, Small; Kidney; Liver; Male; Muscle, Skeletal; Nitroimidazoles; Oxygen Consumption; Random Allocation; Swine; Vascular Endothelial Growth Factor A

2013
Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage.
    American journal of physiology. Renal physiology, 2003, Volume: 284, Issue:2

    Topics: Acute Kidney Injury; Animals; Arginine; Chronic Disease; Disease Progression; Hypoxia; Ischemia; Kidney; Kidney Diseases; Kidney Failure, Chronic; Male; Nephrectomy; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Time Factors

2003
HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors.
    International journal of radiation oncology, biology, physics, 2002, Dec-01, Volume: 54, Issue:5

    Topics: Carcinoma, Squamous Cell; Dimerization; Dose-Response Relationship, Drug; Head and Neck Neoplasms; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Idoxuridine; Immunohistochemistry; Ki-67 Antigen; Neovascularization, Pathologic; Nitroimidazoles; Nucleic Acid Synthesis Inhibitors; Perfusion; Transcription Factors; Treatment Outcome

2002
Cellular responses to hypoxia after renal segmental infarction.
    Kidney international, 2003, Volume: 64, Issue:3

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Division; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Infarction; Kidney; Male; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Trans-Activators; Transcription Factors; Vascular Endothelial Growth Factor A

2003
Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: pimonidazole and involucrin.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Oct-15, Volume: 9, Issue:13

    Topics: Biopsy; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line, Tumor; Female; Humans; Hypoxia; Immunohistochemistry; In Situ Hybridization; Metallothionein; Nitroimidazoles; Oxygen; Prognosis; Protein Precursors; Radiation-Sensitizing Agents; RNA, Messenger; Transcription, Genetic; Uterine Cervical Neoplasms

2003
TNP-470 promotes initial vascular sprouting in xenograft tumors.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:3

    Topics: Angiogenesis Inhibitors; Angiography; Animals; Antibiotics, Antineoplastic; Apoptosis; Capillaries; Cell Line, Tumor; Cyclohexanes; Fluorescein; Humans; Hypoxia; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Lectins; Mice; Mice, Nude; Microcirculation; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; O-(Chloroacetylcarbamoyl)fumagillol; Radiation-Sensitizing Agents; Sesquiterpenes; Vascular Endothelial Growth Factor A; Wilms Tumor

2004
Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2004, Volume: 70, Issue:1

    Topics: Antibodies, Anti-Idiotypic; Biomarkers; Carcinoma, Squamous Cell; Flow Cytometry; Frozen Sections; Head and Neck Neoplasms; Humans; Hypoxia; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Staining and Labeling

2004
Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Dec-15, Volume: 10, Issue:24

    Topics: Antigens, Neoplasm; Biomarkers, Tumor; Carbonic Anhydrase IX; Carbonic Anhydrases; Disease-Free Survival; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ion-Selective Electrodes; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Oxygen; Prognosis; Radiation-Sensitizing Agents; Survival Rate; Transcription Factors; Treatment Outcome; Uterine Cervical Neoplasms

2004
Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jan-01, Volume: 11, Issue:1

    Topics: Disease-Free Survival; Erythropoietin; Head and Neck Neoplasms; Humans; Hypoxia; Immunohistochemistry; Ligands; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Receptors, Erythropoietin; Recombinant Proteins; Time Factors

2005
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact.
    Blood, 2005, Oct-01, Volume: 106, Issue:7

    Topics: Active Transport, Cell Nucleus; Cell Line, Tumor; Cell Nucleus; DNA, Mitochondrial; Electron Transport; Fluorescent Dyes; Gene Expression Regulation; Humans; Hypoxia; Microscopy, Fluorescence; Mitochondria; Models, Theoretical; Nitroimidazoles; Osteosarcoma; Oxygen; Oxygen Consumption; Vascular Endothelial Growth Factor A

2005
Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression.
    Haematologica, 2005, Volume: 90, Issue:6

    Topics: Animals; Apoptosis; Bone Marrow Cells; Caspase 3; Caspases; Cell Hypoxia; Disease Progression; Flow Cytometry; Hematopoiesis; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leukocyte Common Antigens; Mice; Multiple Myeloma; Neovascularization, Pathologic; Nitroimidazoles

2005
Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2006, Volume: 290, Issue:4

    Topics: Acute Kidney Injury; Animals; Biomarkers; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Carrier Proteins; Caspase 3; Caspases; Cell Death; Hypoxia; Immunohistochemistry; Kidney; Kidney Tubules; Male; Nitroimidazoles; Phosphorylation; Rats; Rats, Sprague-Dawley; Regeneration; Reperfusion Injury; Smad Proteins

2006
Hypoxia-inducible factors and tubular cell survival in isolated perfused kidneys.
    Kidney international, 2006, Volume: 70, Issue:1

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Survival; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Kidney Cortex; Kidney Medulla; Kidney Tubules, Collecting; Nitroimidazoles; Oxygen; Perfusion; Rats; Up-Regulation

2006
Oxygen status of lung granulomas in Mycobacterium tuberculosis-infected mice.
    The Journal of pathology, 2006, Volume: 210, Issue:3

    Topics: Animals; Biomarkers; Disease Models, Animal; Electrodes; Female; Granuloma; Hypoxia; Immunohistochemistry; Lung; Mice; Mice, Inbred C57BL; Mutation; Mycobacterium tuberculosis; Necrosis; Nitrates; Nitroimidazoles; Oxygen; Time Factors; Tuberculosis, Pulmonary

2006
Rod photoreceptor loss in Rho-/- mice reduces retinal hypoxia and hypoxia-regulated gene expression.
    Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:12

    Topics: Animals; Apyrase; Cyclic Nucleotide Phosphodiesterases, Type 6; Dark Adaptation; Diltiazem; Enzyme-Linked Immunosorbent Assay; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Light; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitroimidazoles; Oxygen Consumption; Phosphoric Diester Hydrolases; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Rhodopsin; RNA, Messenger; Transcriptional Activation; Vascular Endothelial Growth Factor A

2006
Age-related hearing loss in CD/1 mice is associated to ROS formation and HIF target proteins up-regulation in the cochlea.
    Experimental gerontology, 2007, Volume: 42, Issue:4

    Topics: Action Potentials; Aging; Animals; Apoptosis; Caspase 3; Cochlea; Cochlear Nerve; Coloring Agents; Hearing Loss; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Injections, Intravenous; Insulin-Like Growth Factor I; Mice; Nitroimidazoles; Reactive Oxygen Species; Schwann Cells; Spiral Ganglion; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Up-Regulation

2007
Improved cryosections and specific immunohistochemical methods for detecting hypoxia in mouse and rat cochleae.
    Acta histochemica, 2007, Volume: 109, Issue:3

    Topics: Animals; Animals, Outbred Strains; Biomarkers; Cochlear Diseases; Fluorescent Antibody Technique, Indirect; Frozen Sections; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Tissue Embedding

2007
Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Mar-27, Volume: 104, Issue:13

    Topics: Animals; Benzimidazoles; Bone Marrow Cells; Cell Differentiation; Hematopoietic Stem Cells; Hematopoietic System; Hypoxia; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Perfusion; Stem Cells; Tirapazamine; Triazines

2007
Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:9

    Topics: Animals; Antibiotics, Antitubercular; Antitubercular Agents; Colony Count, Microbial; Diarylquinolines; Female; Granuloma; Guinea Pigs; Hypoxia; Isoniazid; Lung; Mycobacterium tuberculosis; Nitroimidazoles; Pyrazinamide; Quinolines; Radiation-Sensitizing Agents; Rifampin; Spleen; Tuberculosis

2007
Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression.
    The Journal of biological chemistry, 2007, Oct-12, Volume: 282, Issue:41

    Topics: Animals; Aquaporin 1; Carbon Dioxide; Cell Membrane; Cytosol; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1; Lung; Microscopy, Confocal; Models, Biological; Nitroimidazoles; Oxygen; PC12 Cells; Permeability; Rats; Up-Regulation

2007
Immunohistochemical detection of hypoxia in mouse liver tissues treated with pimonidazole using "in vivo cryotechnique".
    Histochemistry and cell biology, 2007, Volume: 128, Issue:3

    Topics: Animals; Cryopreservation; Freeze Substitution; Hypoxia; Immunohistochemistry; Injections, Intraperitoneal; Liver; Mice; Mice, Inbred C57BL; Nitroimidazoles; Tissue Fixation

2007
Effects of old age on hepatocyte oxygenation.
    Annals of the New York Academy of Sciences, 2007, Volume: 1114

    Topics: Aging; Animals; Biomarkers; Hepatocytes; Hypoxia; Male; Mitochondria; Nitroimidazoles; Oxygen; Oxygen Consumption; Rats; Rats, Inbred F344

2007
Adaptation to hypoxia in the diabetic rat kidney.
    Kidney international, 2008, Volume: 73, Issue:1

    Topics: Adaptation, Physiological; Animals; Antioxidants; Basic Helix-Loop-Helix Transcription Factors; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomerular Filtration Rate; Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1; Insulin; Male; Nitroimidazoles; Rats; Rats, Inbred Strains; Spin Labels; Streptozocin

2008
Measurement of hypoxia using invasive oxygen-sensitive electrode, pimonidazole binding and 18F-FDG uptake in anaemic or erythropoietin-treated mice bearing human glioma xenografts.
    International journal of oncology, 2008, Volume: 32, Issue:1

    Topics: Anemia; Animals; Autoradiography; Electrodes; Erythropoietin; Fluorodeoxyglucose F18; Glioma; Hemoglobins; Humans; Hypoxia; Mice; Mice, Nude; Muscle, Skeletal; Neoplasm Transplantation; Nitroimidazoles; Recombinant Proteins; Transplantation, Heterologous

2008
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
    Infection and immunity, 2008, Volume: 76, Issue:6

    Topics: Animals; Antitubercular Agents; Disease Models, Animal; Granuloma; Guinea Pigs; Humans; Hypoxia; Immunohistochemistry; Lung; Macaca fascicularis; Metronidazole; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mycobacterium tuberculosis; Nitroimidazoles; Oxygen; Rabbits; Radiation-Sensitizing Agents; Tuberculosis, Pulmonary

2008
Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis.
    Journal of the American College of Cardiology, 2008, Apr-01, Volume: 51, Issue:13

    Topics: Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; Carotid Stenosis; Cross-Sectional Studies; Disease Progression; Endarterectomy, Carotid; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Immunohistochemistry; Macrophages; Male; Middle Aged; Neovascularization, Pathologic; Nitroimidazoles; Oxidative Stress; RNA, Messenger; Vascular Endothelial Growth Factor A

2008
The paradox of hypoxic and oxidative stress in atherosclerosis.
    Journal of the American College of Cardiology, 2008, Apr-01, Volume: 51, Issue:13

    Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Atherosclerosis; Biomarkers; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Macrophages; Neovascularization, Pathologic; Nitroimidazoles; Oxidative Stress; Reactive Oxygen Species

2008
Longevity of pimonidazole adducts in spontaneous canine tumors as an estimate of hypoxic cell lifetime.
    Radiation research, 1997, Volume: 148, Issue:1

    Topics: Animals; Cell Survival; DNA Adducts; DNA, Neoplasm; Dog Diseases; Dogs; Hypoxia; Neoplasms; Nitroimidazoles

1997
Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state.
    European journal of biochemistry, 1998, May-01, Volume: 253, Issue:3

    Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Eating; Enzyme-Linked Immunosorbent Assay; Fasting; Glycolysis; Hypoxia; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Nitroimidazoles; Oxidation-Reduction; Oxygen Consumption; Potassium Cyanide; Radiation-Sensitizing Agents; Rats

1998
Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine.
    The American journal of physiology, 1998, Volume: 275, Issue:4

    Topics: Animals; Creatinine; Cyclosporine; Food, Fortified; Free Radicals; Glomerular Filtration Rate; Glycine; Hypoxia; Kidney; Male; Models, Biological; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Time Factors; Vasoconstriction

1998
Graft survival is improved by hepatic denervation before organ harvesting.
    Transplantation, 1999, May-27, Volume: 67, Issue:10

    Topics: Animals; Antihypertensive Agents; Denervation; Female; Graft Survival; Hepatic Artery; Hexamethonium; Hypoxia; Liver; Liver Transplantation; Microcirculation; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Inbred Lew; Reperfusion Injury; Tissue and Organ Procurement

1999
Reperfusion injury in livers due to gentle in situ organ manipulation during harvest involves hypoxia and free radicals.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:1

    Topics: Animals; Cryopreservation; Enzyme-Linked Immunosorbent Assay; Female; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Free Radicals; Hypoxia; Immunohistochemistry; In Vitro Techniques; Liver; Microcirculation; Nitroimidazoles; Organ Preservation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Specimen Handling; Trypan Blue

1999
Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status.
    Journal of neuro-oncology, 1999, Volume: 44, Issue:2

    Topics: Animals; Antineoplastic Agents; Blood Vessels; Brain Neoplasms; Glioma; Humans; Hypoxia; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Staining and Labeling; Suramin; Transplantation, Heterologous

1999
Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas.
    British journal of cancer, 2000, Volume: 83, Issue:5

    Topics: Aged; Biomarkers; Biopsy; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Hypopharyngeal Neoplasms; Hypoxia; Image Processing, Computer-Assisted; Immunohistochemistry; Laryngeal Neoplasms; Male; Microscopy, Fluorescence; Middle Aged; Nitroimidazoles; Oropharyngeal Neoplasms; Prognosis

2000
Hypoxia in a human intracerebral glioma model.
    Journal of neurosurgery, 2000, Volume: 93, Issue:3

    Topics: Animals; Brain Neoplasms; Cell Division; Disease Models, Animal; Glioma; Hypoxia; Mice; Mice, Inbred BALB C; Microcirculation; Nitroimidazoles; Radiation-Sensitizing Agents

2000
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
    Cancer research, 2000, Dec-15, Volume: 60, Issue:24

    Topics: Blotting, Western; Carbonic Anhydrases; Carcinoma; Carcinoma, Renal Cell; DNA-Binding Proteins; Endothelial Growth Factors; Genes, Reporter; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunohistochemistry; In Situ Hybridization; Kidney Neoplasms; Lymphokines; Models, Genetic; Necrosis; Nitroimidazoles; Nuclear Proteins; Oxygen; Plasmids; Promoter Regions, Genetic; Radiation-Sensitizing Agents; RNA; RNA, Messenger; Skin Neoplasms; Transcription Factors; Tumor Cells, Cultured; Up-Regulation; Urinary Bladder Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2000
Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development.
    Developmental dynamics : an official publication of the American Association of Anatomists, 2001, Volume: 220, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Biomarkers; Blood Vessels; Brain; Bucladesine; Cell Differentiation; Cell Hypoxia; DNA-Binding Proteins; Embryonic and Fetal Development; Endothelial Growth Factors; Endothelium, Vascular; Gene Expression Regulation, Developmental; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Lymphokines; Mice; Mice, Inbred BALB C; Nitroimidazoles; Nuclear Proteins; Platelet Endothelial Cell Adhesion Molecule-1; Stem Cells; Teratoma; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2001
Measuring hypoxia in solid tumours--is there a gold standard?
    Acta oncologica (Stockholm, Sweden), 2001, Volume: 40, Issue:8

    Topics: Biopsy, Needle; Comet Assay; Humans; Hypoxia; Microelectrodes; Neoplasms; Nitroimidazoles; Palliative Care; Predictive Value of Tests; Radiation-Sensitizing Agents; Radiotherapy; Reference Values

2001
Hypoxia in the thymus: role of oxygen tension in thymocyte survival.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:4

    Topics: Animals; Cell Survival; Cyclooxygenase 2; DNA Primers; Exons; Gene Expression Regulation; Genetic Markers; Heme Oxygenase (Decyclizing); Hypoxia; In Vitro Techniques; Introns; Isoenzymes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Oxygen Consumption; Partial Pressure; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Radiation-Sensitizing Agents; RNA, Messenger; Thymus Gland; Transcription, Genetic

2002
Quantitative analysis of varying profiles of hypoxia in relation to functional vessels in different human glioma xenograft lines.
    Radiation research, 2002, Volume: 157, Issue:6

    Topics: Animals; Glioma; Humans; Hypoxia; Immunohistochemistry; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Perfusion; Transplantation, Heterologous; Tumor Cells, Cultured

2002
Radiotherapy using the hypoxic cell sensitizer Ro 03-8799 in malignant melanoma.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1987, Volume: 10, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypoxia; Lymph Nodes; Male; Melanoma; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Palliative Care; Radiation Tolerance; Radiation-Sensitizing Agents; Skin Neoplasms

1987