pimonidazole has been researched along with Hypoxia in 97 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.06) | 18.7374 |
| 1990's | 6 (6.19) | 18.2507 |
| 2000's | 45 (46.39) | 29.6817 |
| 2010's | 39 (40.21) | 24.3611 |
| 2020's | 5 (5.15) | 2.80 |
| Authors | Studies |
|---|---|
| de Bree, R; H A M Kaanders, J; Philippens, MEP; Smits, HJG; Swartz, JE; Willems, SM | 1 |
| Labiano, S; Rodriguez-Ruiz, ME; Serrano-Mendioroz, I | 1 |
| Ahn, YB; Ko, SH; Lee, E; Ryu, GR; Song, KH | 1 |
| Kanazawa, K; Maruyama, H; Uchiyama, Y; Yamagishi, S; Yamaura, T | 1 |
| Fukatsu, A; Inada, A | 1 |
| Arias, SCA; Ávila, VF; Câmara, NOS; Fanelli, C; Faustino, VD; Foresto-Neto, O; Fujihara, CK; Malheiros, DMAC; Moreira, GCDS; Nascimento, TF; Rempel, LCT; Zatz, R | 1 |
| Elias, AA; Maki, Y; Matushewski, B; Nygard, K; Regnault, TRH; Richardson, BS | 1 |
| Asada, Y; Iwakiri, T; Kawai, K; Kitamura, K; Koshimoto, C; Kuge, Y; Matsuura, Y; Sugita, C; Tamaki, N; Yamasaki, K; Yamashita, A; Zhao, S; Zhao, Y | 1 |
| Andersen, LMK; Galappathi, K; Gaustad, JV; Hauge, A; Rofstad, EK; Simonsen, TG; Wegner, CS | 1 |
| Jayagopal, A; McCollum, GW; Penn, JS; Uddin, MI; Yang, R | 1 |
| Bayin, NS; Placantonakis, DG | 1 |
| Aminuddin, A; Fujisaka, S; Goda, N; Ikutani, M; Mahmood, A; Nagai, Y; Takatsu, K; Takikawa, A; Tobe, K; Tsuneyama, K; Usui, I | 1 |
| Ababneh, DH; Oakes, DJ; Power, CA; Ritchie, HE; Webster, WS | 1 |
| Busk, M; Horsman, MR; Iversen, AB; Jakobsen, S; Ji, X; Lee, DY; Mortensen, LS; Nordsmark, M; Overgaard, J; Raleigh, JR | 1 |
| Capozzi, ME; Craft, JR; Evans, SM; Jayagopal, A; Kim, K; Moore, CE; Sulikowski, GA; Uddin, MI | 1 |
| Andreeff, M; Benito, J; Borthakur, G; Bueso-Ramos, C; Cortes, J; Coveler, A; Daver, N; Estey, EH; Faderl, S; Feliu, J; Gu, Y; Gutheil, JC; Jabbour, E; Kadia, T; Kantarjian, H; Konoplev, S; Konopleva, M; Kornblau, S; Lu, H; Melink, TJ; Nguyen, HQ; Pemmaraju, N; Ravandi, F; Thall, PF; Thomas, D; Wei, C; Wilson, WR; Yi, CA | 1 |
| Duan, X; Li, J; Li, XF; Ma, Y; Postel, GC; Wang, F; Wang, X; Yin, X; Zhang, G; Zheng, H | 1 |
| Chae, JR; Cho, A; Cho, YL; Chung, KY; Kang, WJ; Kim, JY; Lee, JW; Park, SY | 1 |
| Bollineni, VR; Bruine de Bruin, L; de Bock, GH; Halmos, GB; Langendijk, JA; Pruim, J; Schuuring, E; Slagter-Menkema, L; Steenbakkers, RJ; van der Laan, BF; van der Wal, JE; van Hemel, BM; Wachters, JE | 1 |
| Bar-Sagi, D; Grabocka, E; Mishra, B; Sundstrom, A | 1 |
| Fourcade, O; Geeraerts, T; Gonzalez, L; Kerhuel, L; Luzi, A; Mrozek, S | 1 |
| Baumann, M; Mönnich, D; Thorwarth, D; Wack, LJ; Yaromina, A; Zips, D | 1 |
| He, T; Xing, Y; Yang, N; Zhang, W | 1 |
| Crukley, C; Desjardins, L; Hadway, J; Lee, TY; Morrison, L; Stewart, E; Wang, Y | 1 |
| Brader, P; Carlin, S; Chun, YS; Fong, Y; Hricak, H; Ling, CC; Riedl, CC; Singh, P; Wen, B; Woo, Y; Zanzonico, PB | 1 |
| Gilbert, RE; Kelly, DJ; Langham, RG; Tiauw, V; Wiggins, KJ; Zhang, Y | 1 |
| Cui, P; Dai, M; Han, J; Li, H; Liu, Q; Xiu, R; Yu, M; Zhang, J | 1 |
| Cui, P; Dai, M; Han, J; Li, H; Liu, Q; Xiu, R; Yu, M | 1 |
| Heyman, SN; Paliege, A; Rosen, S; Rosenberger, C | 1 |
| Fujibayashi, Y; Fujieda, S; Furukawa, T; Kobayashi, M; Kudo, T; Mori, T; Oh, M; Tanaka, T | 1 |
| Boutrid, H; Cebulla, CM; Feuer, WJ; Jockovich, ME; Lampidis, TJ; Murray, TG; Piña, Y | 1 |
| Baumann, M; Eckardt, A; Eicheler, W; Schuetze, C; Thames, H; Yaromina, A; Zips, D | 1 |
| Cho, H; Koutcher, JA; Li, XF; Ling, CC; Lupu, ME; Russell, J; Yang, KM | 1 |
| Busk, M; Bussink, J; Hansen, KV; Horsman, MR; Jakobsen, S; Overgaard, J; van der Kogel, A | 1 |
| Baumann, M; Meyer, S; Mueller-Klieser, W; Quennet, V; Shakirin, G; Walenta, S; Yaromina, A; Zips, D | 1 |
| Möller, A; Young, RJ | 1 |
| McPhail, LD; Robinson, SP | 1 |
| Bengtsson, E; Blomgren, B; Danielsson, BR; Danielsson, C; Johansson, A; Khan, KM; Kultima, K; Nilsson, MF; Sköld, AC; Webster, WS; Wilson, J | 1 |
| Humm, JL; Li, XF; Ling, CC; Ma, Y; O'Donoghue, JA; Sun, X | 1 |
| Boerman, OC; Bussink, J; Franssen, GM; Hoeben, BA; Kaanders, JH; Oosterwijk, E; Oyen, WJ; Rijken, PF; Troost, EG; van Dongen, GA | 1 |
| Baumann, M; Beuthien-Baumann, B; Bussink, J; Eicheler, W; Krause, M; Rijken, P; Santiago, A; van der Kogel, AJ; Yaromina, A | 1 |
| Boutrid, H; Celdran, M; Feuer, W; Hernandez, E; Houston, SK; Lampidis, TJ; Murray, TG; Piña, Y; Shi, W | 1 |
| Babaev, AA; Golubiatnikov, GY; Ivanova, IP; Kamensky, VA; Maslennikova, AV; Orlova, AG; Plekhanov, VI; Prianikova, TI; Shakhova, NM; Snopova, LB; Turchin, IV | 1 |
| Gorodkin, R; Herrick, AL; Jeziorska, M; Stratford, IJ | 1 |
| Batlle, D; Cabray, J; Halter, S; Li, LP; Prasad, P; Ye, M | 1 |
| Chaudhuri, S; Hennings, L; Hinson, JA; James, LP; Letzig, L; McCullough, SS; Simpson, PM | 1 |
| Forsback, S; Heinonen, SE; Knuuti, J; Laine, VJ; Roivainen, A; Saraste, A; Saukko, P; Silvola, JM; Ylä-Herttuala, S | 1 |
| Bifani, P; Dartois, V; Heng, Y; Hervé, M; Kiass, M; Mathys, V; Seah, PG; Siew, JY; Singhal, A; Tay, HC | 1 |
| Combes, V; Grau, GE; Hempel, C; Hunt, NH; Kurtzhals, JA | 1 |
| Hagtvet, E; Olsen, DR; Røe, K | 1 |
| Griffin, RJ; Koonce, NA; Przybyla, BD; Shafirstein, G; Webber, JS | 1 |
| Barber, PR; Bell, A; Burke, M; Daley, FM; Finch, J; Goh, V; Hoskin, PJ; Kozarski, R; Mandeville, HC; Ng, QS; Pierce, G; Townsend, ER; Vojnovic, B | 1 |
| Bussink, J; Grénman, R; Iida, M; Kaanders, JH; Span, PN; Stegeman, H; van der Kogel, AJ; Verheijen, MM; Waaijer, SJ; Wheeler, DL | 1 |
| Bachmann, S; Dietrich, A; Kaminski, H; Mathia, S; Mrowka, R; Mutig, K; Paliege, A; Rosenberger, C | 1 |
| Kertscho, H; Lauscher, P; Meier, J; Rosenberger, P; Schmidt, O; Zacharowski, K; Zimmermann, R | 1 |
| Basile, DP; Donohoe, DL; Mattson, DL; Roethe, K | 1 |
| Balm, AJ; Begg, AC; Blijweert, E; Blommestijn, G; Delaere, P; Haustermans, KM; Hoebers, FJ; Hofland, I; Janssen, HL; Raleigh, JA; Sciot, R; Semenza, GL; Sprong, D; van Velthuysen, ML; Varia, MA | 1 |
| Bachmann, S; Eckardt, KU; Frei, U; Griethe, W; Gruber, G; Rosenberger, C; Wiesener, M | 1 |
| Azuma, Y; Chou, SC; Lininger, RA; Murphy, BJ; Raleigh, JA; Varia, MA | 1 |
| Frischer, JS; Holash, J; Huang, J; Kadenhe-Chiwishe, A; Kandel, JJ; Kim, ES; Lee, A; New, T; Pollyea, DA; Serur, A; Yamashiro, DJ; Yancopoulos, GD; Yokoi, A | 1 |
| Balm, AJ; Begg, AC; Goethals, L; Haustermans, KM; Hoebers, FJ; Janssen, HL; Sprong, D; Stratford, IJ; Williams, KJ | 1 |
| Davidson, SE; Harris, AL; Hunter, RD; Hutchison, GJ; Loncaster, JA; Price, PM; Roberts, SA; Stratford, IJ; Valentine, HR; West, CM | 1 |
| Amin, K; Arcasoy, MO; Chou, SC; Haroon, ZA; Raleigh, JA; Varia, M | 1 |
| Doege, K; Heine, S; Jelkmann, W; Jensen, I; Metzen, E | 1 |
| Asosingh, K; De Raeve, H; de Ridder, M; Storme, GA; Van Camp, B; Van Riet, I; Vanderkerken, K; Willems, A | 1 |
| Céspedes, C; Villanueva, S; Vio, CP | 1 |
| Bernhardt, W; Eckardt, KU; Frei, U; Heyman, SN; Rosen, S; Rosenberger, C; Shina, A; Wiesener, MS | 1 |
| Aly, S; Bange, FC; Brandau, S; Ehlers, S; Keller, C; Malm, S; Malzan, A; Wagner, K | 1 |
| Curtis, TM; de Gooyer, TE; Gardiner, TA; Humphries, P; Simpson, DA; Stevenson, KA; Stitt, AW | 1 |
| Donadieu, E; Lavieille, JP; Magnan, J; Riva, C | 1 |
| Deveze, A; Donadieu, E; Hamdi, W; Lavieille, JP; Lucciano, M; Magnan, J; Riva, C | 1 |
| Down, JD; Mauch, P; Parmar, K; Sackstein, R; Vergilio, JA | 1 |
| Aly, S; Andries, K; Basaraba, RJ; Cantarero, L; Ehlers, S; Hoff, D; Lenaerts, AJ; Orme, IM | 1 |
| Echevarría, M; López-Barneo, J; Muñoz-Cabello, AM; Sánchez-Silva, R; Toledo-Aral, JJ | 1 |
| Ohno, N; Ohno, S; Saitoh, S; Terada, N | 1 |
| Cheluvappa, R; Cogger, VC; Hilmer, SN; Kwun, SY; LE Couteur, DG | 1 |
| Abassi, Z; Eckardt, KU; Goldfarb, M; Heyman, SN; Khamaisi, M; Rosen, S; Rosenberger, C; Shilo, V; Shina, A; Weksler-Zangen, S; Zibertrest, F | 1 |
| Chastagner, P; Fouyssac, F; Karcher, G; Pinel, S; Plenat, F; Poussier, S; Scigliano, S | 1 |
| Allen, SS; Barry, CE; Carrillo, J; Cho, SN; Eum, SY; Flynn, JL; Gonzales, J; Klein, E; Lee, EG; Lin, PL; Manjunatha, U; McMurray, DN; Park, SK; Raleigh, JA; Ray, SM; Taylor, K; Via, LE | 1 |
| Bijnens, AP; Cleutjens, JP; Corvol, P; Daemen, MJ; Gasc, JM; Groeneweg, M; Kisters, N; Sluimer, JC; Sollewijn Gelpke, MD; van den Akker, LH; van Wanroij, JL; Wouters, BG | 1 |
| Mayr, M; Sidibe, A; Zampetaki, A | 1 |
| Azuma, C; Raleigh, JA; Thrall, DE | 1 |
| Arteel, GE; Raleigh, JA; Thurman, RG | 1 |
| Arteel, GE; Connor, HD; Frankenberg, MV; Mason, RP; Raleigh, JA; Stachlewitz, RF; Thurman, RG; Yin, M; Zhong, Z | 1 |
| Bunzendahl, H; Raleigh, JA; Schemmer, P; Thurman, RG | 1 |
| Arteel, GE; Bunzendahl, H; Connor, HD; Mason, RP; Raleigh, JA; Schemmer, P; Thurman, RG | 1 |
| Bakker, JH; Bernsen, HJ; Boerman, RH; Peters, JP; Rijken, PF; van der Kogel, AJ; Wesseling, P | 1 |
| Bussink, J; de Wilde, PC; Kaanders, JH; Marres, HA; Raleigh, JA; Rijken, PF; van den Hoogen, FJ; van der Kogel, AJ; Wijffels, KI | 1 |
| Bernsen, HJ; Jeuken, JW; Peters, H; Raleigh, JA; Rijken, PF; van der Kogel, AJ; Wesseling, P | 1 |
| Beasley, NJ; Harris, AL; Maxwell, PH; Pastorek, J; Pugh, CW; Ratcliffe, PJ; Sibtain, A; Talks, KL; Turley, H; Turner, KJ; Watson, PH; Wilson, GD; Wykoff, CC | 1 |
| Bae, SK; Chung, HY; Jeong, CH; Kim, KW; Koo, SY; Lee, YM; Raleigh, JA; Son, MJ; Song, HS; Yoo, MA | 1 |
| Aquino-Parsons, C; Banáth, JP; Olive, PL | 1 |
| Balm, A; Begg, AC; Blommestijn, G; Delaere, P; Hofland, I; Janssen, H; Raleigh, JA; Sciot, R; Sprong, D; Van Velthuyzen, L; Varia, M | 1 |
| Braun, RD; Dewhirst, MW; Greer, PK; Gwinn, WM; Hale, LP | 1 |
| Peters, JP; Rijken, PF; Van der Kogel, AJ | 1 |
| Dische, S | 1 |
| Adams, GE; Stratford, IJ | 1 |
1 review(s) available for pimonidazole and Hypoxia
| Article | Year |
|---|---|
Hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer. An overview.
Topics: Alkylating Agents; Animals; Cell Survival; Drug Synergism; Etanidazole; Hypoxia; Misonidazole; Neoplasms, Experimental; Nitrofurans; Nitrofurazone; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1986 |
3 trial(s) available for pimonidazole and Hypoxia
| Article | Year |
|---|---|
Correlation and colocalization of HIF-1α and pimonidazole staining for hypoxia in laryngeal squamous cell carcinomas: A digital, single-cell-based analysis.
Topics: Biomarkers; Biomarkers, Tumor; Cell Hypoxia; Head and Neck Neoplasms; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Laryngeal Neoplasms; Nitroimidazoles; Prognosis; Squamous Cell Carcinoma of Head and Neck; Staining and Labeling | 2022 |
Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia.
Topics: Adult; Aged; Anemia; Antigens, Neoplasm; Antineoplastic Agents, Alkylating; Biomarkers; Bone Marrow; Carbonic Anhydrase IX; Carbonic Anhydrases; Enterocolitis; Female; Gene Expression; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Myeloid, Acute; Male; Middle Aged; Neutropenia; Nitrogen Mustard Compounds; Nitroimidazoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prodrugs; Recurrence; Remission Induction; Thrombocytopenia | 2015 |
Hypoxia and perfusion measurements in human tumors--initial experience with pimonidazole and IUdR.
Topics: Antibodies; Biopsy; Diffusion; Esophageal Neoplasms; Female; Head and Neck Neoplasms; Humans; Hypoxia; Idoxuridine; Kinetics; Male; Nitroimidazoles; Nucleic Acid Synthesis Inhibitors; Radiation-Sensitizing Agents; Rectal Neoplasms; Regional Blood Flow; Specimen Handling; Uterine Cervical Neoplasms | 2001 |
93 other study(ies) available for pimonidazole and Hypoxia
| Article | Year |
|---|---|
Assessment of hypoxia by pimonidazole staining following radiotherapy.
Topics: Biomarkers; Cell Hypoxia; Humans; Hypoxia; Neoplasms; Nitroimidazoles; Oxygen; Staining and Labeling; Tumor Microenvironment | 2022 |
Pancreatic stellate cells promote pancreatic β-cell death through exosomal microRNA transfer in hypoxia.
Topics: Animals; Cell Death; Diabetes Mellitus, Type 2; Glucose; Hypoxia; Insulin; Islets of Langerhans; Mice; MicroRNAs; Pancreatic Stellate Cells | 2023 |
In Vivo Imaging of Tumor Hypoxia by Maintaining Green Fluorescence of 9-Aminoanthracene Under Hypoxic Conditions.
Topics: Animals; Anthracenes; Cell Hypoxia; Diagnostic Imaging; Fluorescence; Hypoxia; Mice; Neoplasms; Tumor Hypoxia | 2023 |
Persistence and expansion of hypoxia detected by pimonidazole adduct immunostaining during progression of diabetic nephropathy in diabetic mice.
Topics: Animals; Child, Preschool; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Nitroimidazoles | 2023 |
Chronic exposure to hypoxia attenuates renal injury and innate immunity activation in the remnant kidney model.
Topics: Animals; Gene Expression Regulation; Hypoxia; Immunity, Innate; Kidney; Male; Nephrectomy; Nitroimidazoles; Organ Size; Oxygen; Radiation-Sensitizing Agents; Rats; Renal Insufficiency, Chronic | 2019 |
Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with evidence for chronic hypoxia.
Topics: Animals; Cohort Studies; Erythropoietin; Female; Fetal Development; Fetal Growth Retardation; Guinea Pigs; Hypoxia; Immunohistochemistry; Male; Maternal Nutritional Physiological Phenomena; Maternal-Fetal Exchange; Nitroimidazoles; Placenta; Pregnancy; Signal Transduction; Vascular Endothelial Growth Factor A | 2017 |
Altered glucose metabolism and hypoxic response in alloxan-induced diabetic atherosclerosis in rabbits.
Topics: Alloxan; Animals; Apoptosis; Atherosclerosis; Autoradiography; Body Weight; Cluster Analysis; Diabetes Mellitus, Experimental; Diet, High-Fat; Electrophoresis, Capillary; Femoral Artery; Fluorodeoxyglucose F18; Glucose; Glycolysis; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Macrophages; Mass Spectrometry; Metabolomics; Microscopy, Fluorescence; Nitroimidazoles; Principal Component Analysis; Rabbits | 2017 |
Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts.
Topics: Animals; Carcinoma, Pancreatic Ductal; Contrast Media; Extracellular Fluid; Female; Heterocyclic Compounds; Heterografts; Humans; Hypoxia; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Nude; Microvessels; Neoplasm Transplantation; Nitroimidazoles; Organometallic Compounds; Pancreatic Neoplasms; Platelet Endothelial Cell Adhesion Molecule-1; Pressure; Tumor Microenvironment | 2017 |
In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO).
Topics: Animals; Disease Models, Animal; Fluorescein Angiography; Fluoresceins; Fluorescent Dyes; Hypoxia; Image Processing, Computer-Assisted; Macular Edema; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Radiation-Sensitizing Agents; Retinal Neovascularization; Retinal Vein; Retinal Vein Occlusion; Tomography, Optical Coherence | 2017 |
Evaluation of Vascularity, Blood Perfusion, and Oxygen Tension in Tumor Xenografts with Fluorescent Microscopy.
Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; Heterografts; Humans; Hypoxia; Mice; Microscopy, Fluorescence; Neoplasm Staging; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; Oxygen | 2018 |
Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice.
Topics: Adipose Tissue; Alleles; Animals; Bone Marrow Cells; Cell Polarity; Flow Cytometry; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Nitroimidazoles; Phenotype | 2013 |
The teratogenic effect of dofetilide during rat limb development and association with drug-induced bradycardia and hypoxia in the embryo.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Heart; Hypoxia; Limb Deformities, Congenital; Nitroimidazoles; Phenethylamines; Rats; Rats, Sprague-Dawley; Sulfonamides; Teratogens | 2013 |
PET imaging of tumor hypoxia using 18F-labeled pimonidazole.
Topics: Animals; Carcinoma, Squamous Cell; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Hypoxia; Mammary Neoplasms, Animal; Mice; Mice, Inbred C3H; Mice, Nude; Nitroimidazoles; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tumor Cells, Cultured | 2013 |
Molecular probes for imaging of hypoxia in the retina.
Topics: Animals; Cell Line; Cell Survival; Fluorescein-5-isothiocyanate; Humans; Hypoxia; Mice; Molecular Imaging; Molecular Probes; Nitroimidazoles; Retina; Retinal Neurons | 2014 |
The reverse Warburg effect and 18F-FDG uptake in non-small cell lung cancer A549 in mice: a pilot study.
Topics: Animals; Blood Glucose; Body Weight; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diet; Female; Fluorodeoxyglucose F18; Glucose; Humans; Hypoxia; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Radiopharmaceuticals; Tumor Microenvironment | 2015 |
64Cu-ATSM Hypoxia Positron Emission Tomography for Detection of Conduit Ischemia in an Experimental Rat Esophagectomy Model.
Topics: Anastomotic Leak; Animals; Autoradiography; Coordination Complexes; Copper Radioisotopes; Esophagectomy; Esophagogastric Junction; Gastric Fundus; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Ischemia; Male; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Thiosemicarbazones | 2015 |
Assessment of hypoxic subvolumes in laryngeal cancer with (18)F-fluoroazomycinarabinoside ((18)F-FAZA)-PET/CT scanning and immunohistochemistry.
Topics: Aged; Aged, 80 and over; Biomarkers; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Hypoxia; Laryngeal Neoplasms; Laryngectomy; Male; Middle Aged; Multimodal Imaging; Neoplasm Recurrence, Local; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Squamous Cell Carcinoma of Head and Neck; Tomography, X-Ray Computed | 2015 |
Histological Image Processing Features Induce a Quantitative Characterization of Chronic Tumor Hypoxia.
Topics: Algorithms; Animals; Cell Line, Tumor; Colonic Neoplasms; Humans; Hypoxia; Image Processing, Computer-Assisted; Mice; Mice, Nude; Nitroimidazoles | 2016 |
Cerebral and extracerebral vulnerability to hypoxic insults after diffuse traumatic brain injury in rats.
Topics: Animals; Arterial Pressure; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Hypotension; Hypoxia; Hypoxia, Brain; Kidney; Liver; Male; Myocardium; Nitroimidazoles; Rats; Rats, Sprague-Dawley | 2016 |
Correlation of FMISO simulations with pimonidazole-stained tumor xenografts: A question of O2 consumption?
Topics: Animals; Benzimidazoles; Carcinoma, Squamous Cell; Cell Line, Tumor; Computer Simulation; Feasibility Studies; Fluorescent Antibody Technique; Head and Neck Neoplasms; Humans; Hypoxia; Mice, Nude; Misonidazole; Models, Biological; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Platelet Endothelial Cell Adhesion Molecule-1; Tumor Microenvironment | 2016 |
Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy.
Topics: Animals; Animals, Newborn; Blotting, Western; Disease Models, Animal; Galectin 1; Gene Silencing; Hypoxia; Intravitreal Injections; Ischemia; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Real-Time Polymerase Chain Reaction; Retinal Neovascularization; RNA; RNA, Messenger | 2017 |
Assessment of intratumor hypoxia by integrated 18F-FDG PET / perfusion CT in a liver tumor model.
Topics: Animals; Disease Models, Animal; Fluorodeoxyglucose F18; Glucose; Humans; Hypoxia; Liver Neoplasms; Male; Neovascularization, Pathologic; Nitroimidazoles; Oxygen Consumption; Perfusion; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Rabbits | 2017 |
Imaging hypoxia in orthotopic rat liver tumors with iodine 124-labeled iodoazomycin galactopyranoside PET.
Topics: Animals; Carcinoma, Hepatocellular; Hypoxia; Image Processing, Computer-Assisted; Iodine Radioisotopes; Liver Neoplasms; Monosaccharides; Nitroimidazoles; Positron-Emission Tomography; Rats; Rats, Nude | 2008 |
Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Fibrosis; Hypoxia; Immunohistochemistry; Inflammation; Kidney Tubules; Macrophages; Nitroimidazoles; Osteopontin; Perindopril; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Renin-Angiotensin System; Time Factors | 2008 |
Effect of artificial oxygen carrier with chemotherapy on tumor hypoxia and neovascularization.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Cricetinae; HeLa Cells; Hemoglobins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mesocricetus; Microvessels; Neoplasms, Experimental; Neovascularization, Pathologic; Nitroimidazoles; Oxygen; Oxygen Inhalation Therapy; Polyethylene Glycols; Tumor Burden | 2008 |
Influence of PEG-conjugated hemoglobin on tumor oxygenation and response to chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Substitutes; Cisplatin; Drug Synergism; Female; Hemoglobins; Hypoxia; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oxygen Consumption; Polyethylene Glycols; Treatment Outcome; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2008 |
Pimonidazole adduct immunohistochemistry in the rat kidney: detection of tissue hypoxia.
Topics: Animals; Hypoxia; Immunohistochemistry; Kidney; Molecular Structure; Nitroimidazoles; Rats; Tissue Fixation | 2009 |
Radio-copper-labeled Cu-ATSM: an indicator of quiescent but clonogenic cells under mild hypoxia in a Lewis lung carcinoma model.
Topics: Animals; Autoradiography; Bromodeoxyuridine; Carcinoma, Lewis Lung; Cell Proliferation; Colony-Forming Units Assay; Coordination Complexes; Copper Radioisotopes; Disease Models, Animal; Fluorodeoxyglucose F18; Hypoxia; Image Processing, Computer-Assisted; Immunohistochemistry; Ki-67 Antigen; Male; Mice; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Staining and Labeling; Thiosemicarbazones | 2009 |
Increased hypoxia following vessel targeting in a murine model of retinoblastoma.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carboplatin; Disease Models, Animal; Hypoxia; Mice; Mice, Transgenic; Microscopy, Confocal; Neovascularization, Pathologic; Nitroimidazoles; Pregnadienediols; Retinal Neoplasms; Retinoblastoma | 2009 |
Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studies.
Topics: Animals; Biopsy, Needle; Carcinoma, Squamous Cell; Confidence Intervals; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Environment; Female; Humans; Hypoxia; Immunohistochemistry; Longitudinal Studies; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Probability; Radiobiology; Random Allocation; Reference Values | 2009 |
Atrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model.
Topics: Adenocarcinoma; Animals; Atrasentan; Colonic Neoplasms; Combined Modality Therapy; Etanidazole; Gadolinium DTPA; HT29 Cells; Humans; Hydrocarbons, Fluorinated; Hypoxia; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Nitroimidazoles; Perfusion; Pyrrolidines; Radiation-Sensitizing Agents; Radiotherapy; Treatment Outcome; Xenograft Model Antitumor Assays | 2009 |
Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?
Topics: Animals; Carcinoma, Squamous Cell; Cell Count; Cell Hypoxia; Disease Models, Animal; Female; Hypoxia; Mice; Mice, Inbred C3H; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Random Allocation; Sensitivity and Specificity; Tissue Distribution | 2009 |
Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.
Topics: Animals; Benzimidazoles; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Female; Fluorescent Dyes; Glucose; Humans; Hypoxia; Lactic Acid; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Transplantation, Heterologous | 2009 |
Immunohistochemical detection of tumour hypoxia.
Topics: Animals; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mice; Neoplasms; Nitroimidazoles | 2010 |
Intrinsic susceptibility MR imaging of chemically induced rat mammary tumors: relationship to histologic assessment of hypoxia and fibrosis.
Topics: Animals; Biomarkers, Tumor; Carbon Dioxide; Female; Fibrosis; Hypoxia; Keratin-14; Linear Models; Magnetic Resonance Imaging; Mammary Neoplasms, Experimental; Methylnitrosourea; Necrosis; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Rats; Rats, Wistar | 2010 |
Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs.
Topics: Abnormalities, Drug-Induced; Animals; Astemizole; Cetirizine; Drug Evaluation, Preclinical; Embryo Culture Techniques; Embryo, Mammalian; Embryonic Development; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart Rate; Histamine H1 Antagonists, Non-Sedating; Hypoxia; Image Processing, Computer-Assisted; Maternal Exposure; Nitroimidazoles; Potassium Channels, Inwardly Rectifying; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens | 2010 |
High 18F-FDG uptake in microscopic peritoneal tumors requires physiologic hypoxia.
Topics: Air; Animals; Autoradiography; Biological Transport; Carbon Dioxide; Cell Proliferation; Female; Fluorescent Antibody Technique; Fluorodeoxyglucose F18; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; HT29 Cells; Humans; Hypoxia; Mice; Nitroimidazoles; Oxygen; Peritoneal Neoplasms; Respiration | 2010 |
PET of hypoxia with 89Zr-labeled cG250-F(ab')2 in head and neck tumors.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Carbonic Anhydrase Inhibitors; Head and Neck Neoplasms; Hypoxia; Image Processing, Computer-Assisted; Immunoglobulin Fab Fragments; Immunoglobulin G; Immunohistochemistry; Isotope Labeling; Mice; Mice, Inbred BALB C; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Quality Control; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tissue Distribution; Xenograft Model Antitumor Assays; Zirconium | 2010 |
Effect of cetuximab and fractionated irradiation on tumour micro-environment.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Combined Modality Therapy; Dose Fractionation, Radiation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Male; Mice; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Signal Transduction; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2010 |
Focal, periocular delivery of 2-deoxy-D-glucose as adjuvant to chemotherapy for treatment of advanced retinoblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Deoxyglucose; Disease Models, Animal; Drug Delivery Systems; Hypoxia; Mice; Mice, Transgenic; Microscopy, Fluorescence; Nitroimidazoles; Retinal Neoplasms; Retinoblastoma; Tumor Burden | 2010 |
Comparative study of tumor hypoxia by diffuse optical spectroscopy and immunohistochemistry in two tumor models.
Topics: Animals; Biomarkers, Tumor; Brain Neoplasms; Diffusion; Disease Models, Animal; Female; Hemoglobins; Hypoxia; Immunohistochemistry; Lymph Nodes; Male; Medical Oncology; Nitroimidazoles; Optical Devices; Oxygen; Radiation-Sensitizing Agents; Rats; Spectrum Analysis | 2010 |
Testing for hypoxia in forearm skin of patients with systemic sclerosis, assessed by pimonidazole.
Topics: Adult; Aged; Female; Forearm; Humans; Hypoxia; Male; Middle Aged; Nitroimidazoles; Radiation-Sensitizing Agents; Scleroderma, Systemic; Skin | 2010 |
Evaluation of renal hypoxia in diabetic mice by BOLD MRI.
Topics: Age Factors; Animals; Diabetic Nephropathies; Hypoxia; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Staining and Labeling | 2010 |
Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Dose-Response Relationship, Drug; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Nitroimidazoles; Oxidative Stress; Statistics, Nonparametric | 2011 |
Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.
Topics: Analysis of Variance; Animals; Aorta; Apolipoprotein B-100; Atherosclerosis; Autoradiography; Disease Models, Animal; Etanidazole; Female; Fluorine Radioisotopes; Genotype; Hydrocarbons, Fluorinated; Hypoxia; Immunohistochemistry; Insulin-Like Growth Factor II; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitroimidazoles; Phenotype; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, LDL; Tissue Distribution | 2011 |
Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat.
Topics: Animals; Disease Models, Animal; Female; Granuloma; Hypoxia; Immunohistochemistry; Lung; Mycobacterium tuberculosis; Nitroimidazoles; Rats; Tuberculosis, Pulmonary | 2011 |
CNS hypoxia is more pronounced in murine cerebral than noncerebral malaria and is reversed by erythropoietin.
Topics: Animals; Brain; Disease Models, Animal; Erythropoietin; Female; Fluorescent Dyes; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Malaria, Cerebral; Mice; Nitroimidazoles; Parasitemia; Plasmodium berghei; Poly(ADP-ribose) Polymerases; Survival Analysis; Treatment Outcome | 2011 |
Liposomal doxorubicin improves radiotherapy response in hypoxic prostate cancer xenografts.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Combined Modality Therapy; Contrast Media; Doxorubicin; Humans; Hypoxia; Immunohistochemistry; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Theoretical; Neoplasm Transplantation; Nitroimidazoles; Prostatic Neoplasms; Treatment Outcome | 2011 |
Conductive thermal ablation of 4T1 murine breast carcinoma reduces severe hypoxia in surviving tumour.
Topics: Animals; Combined Modality Therapy; Female; Hyperthermia, Induced; Hypoxia; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Nitroimidazoles; Radiation-Sensitizing Agents | 2012 |
Operable non-small cell lung cancer: correlation of volumetric helical dynamic contrast-enhanced CT parameters with immunohistochemical markers of tumor hypoxia.
Topics: Aged; Biomarkers, Tumor; Blood Volume; Carcinoma, Non-Small-Cell Lung; Contrast Media; Female; Humans; Hypoxia; Immunohistochemistry; Iohexol; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Nitroimidazoles; Prospective Studies; Radiation-Sensitizing Agents; Radiographic Image Interpretation, Computer-Assisted; Statistics, Nonparametric; Tomography, Spiral Computed | 2012 |
Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck.
Topics: Animals; Blotting, Western; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; ErbB Receptors; Fluorescent Antibody Technique; Head and Neck Neoplasms; Heterocyclic Compounds, 3-Ring; Humans; Hypoxia; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Radiation-Sensitizing Agents; Radiotherapy; Receptor, ErbB-2; Signal Transduction; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2012 |
Chronic activation of vasopressin V2 receptor signalling lowers renal medullary oxygen levels in rats.
Topics: Animals; Deamino Arginine Vasopressin; Disease Models, Animal; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Medulla; Nitroimidazoles; Oxygen; Rats; Rats, Brattleboro; Rats, Sprague-Dawley; Receptors, Vasopressin; Signal Transduction; Vasopressins | 2013 |
Determination of organ-specific anemia tolerance.
Topics: Acute Disease; Anemia; Animals; Brain; Cell Hypoxia; Female; Hemodilution; Hemodynamics; Hypoxia; Hypoxia, Brain; Immune Tolerance; Intestine, Small; Kidney; Liver; Male; Muscle, Skeletal; Nitroimidazoles; Oxygen Consumption; Random Allocation; Swine; Vascular Endothelial Growth Factor A | 2013 |
Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage.
Topics: Acute Kidney Injury; Animals; Arginine; Chronic Disease; Disease Progression; Hypoxia; Ischemia; Kidney; Kidney Diseases; Kidney Failure, Chronic; Male; Nephrectomy; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Time Factors | 2003 |
HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors.
Topics: Carcinoma, Squamous Cell; Dimerization; Dose-Response Relationship, Drug; Head and Neck Neoplasms; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Idoxuridine; Immunohistochemistry; Ki-67 Antigen; Neovascularization, Pathologic; Nitroimidazoles; Nucleic Acid Synthesis Inhibitors; Perfusion; Transcription Factors; Treatment Outcome | 2002 |
Cellular responses to hypoxia after renal segmental infarction.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Division; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Infarction; Kidney; Male; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Trans-Activators; Transcription Factors; Vascular Endothelial Growth Factor A | 2003 |
Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: pimonidazole and involucrin.
Topics: Biopsy; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line, Tumor; Female; Humans; Hypoxia; Immunohistochemistry; In Situ Hybridization; Metallothionein; Nitroimidazoles; Oxygen; Prognosis; Protein Precursors; Radiation-Sensitizing Agents; RNA, Messenger; Transcription, Genetic; Uterine Cervical Neoplasms | 2003 |
TNP-470 promotes initial vascular sprouting in xenograft tumors.
Topics: Angiogenesis Inhibitors; Angiography; Animals; Antibiotics, Antineoplastic; Apoptosis; Capillaries; Cell Line, Tumor; Cyclohexanes; Fluorescein; Humans; Hypoxia; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Lectins; Mice; Mice, Nude; Microcirculation; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; O-(Chloroacetylcarbamoyl)fumagillol; Radiation-Sensitizing Agents; Sesquiterpenes; Vascular Endothelial Growth Factor A; Wilms Tumor | 2004 |
Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.
Topics: Antibodies, Anti-Idiotypic; Biomarkers; Carcinoma, Squamous Cell; Flow Cytometry; Frozen Sections; Head and Neck Neoplasms; Humans; Hypoxia; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Staining and Labeling | 2004 |
Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix.
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Carbonic Anhydrase IX; Carbonic Anhydrases; Disease-Free Survival; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ion-Selective Electrodes; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Oxygen; Prognosis; Radiation-Sensitizing Agents; Survival Rate; Transcription Factors; Treatment Outcome; Uterine Cervical Neoplasms | 2004 |
Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia.
Topics: Disease-Free Survival; Erythropoietin; Head and Neck Neoplasms; Humans; Hypoxia; Immunohistochemistry; Ligands; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Receptors, Erythropoietin; Recombinant Proteins; Time Factors | 2005 |
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact.
Topics: Active Transport, Cell Nucleus; Cell Line, Tumor; Cell Nucleus; DNA, Mitochondrial; Electron Transport; Fluorescent Dyes; Gene Expression Regulation; Humans; Hypoxia; Microscopy, Fluorescence; Mitochondria; Models, Theoretical; Nitroimidazoles; Osteosarcoma; Oxygen; Oxygen Consumption; Vascular Endothelial Growth Factor A | 2005 |
Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression.
Topics: Animals; Apoptosis; Bone Marrow Cells; Caspase 3; Caspases; Cell Hypoxia; Disease Progression; Flow Cytometry; Hematopoiesis; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leukocyte Common Antigens; Mice; Multiple Myeloma; Neovascularization, Pathologic; Nitroimidazoles | 2005 |
Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins.
Topics: Acute Kidney Injury; Animals; Biomarkers; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Carrier Proteins; Caspase 3; Caspases; Cell Death; Hypoxia; Immunohistochemistry; Kidney; Kidney Tubules; Male; Nitroimidazoles; Phosphorylation; Rats; Rats, Sprague-Dawley; Regeneration; Reperfusion Injury; Smad Proteins | 2006 |
Hypoxia-inducible factors and tubular cell survival in isolated perfused kidneys.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Survival; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Kidney Cortex; Kidney Medulla; Kidney Tubules, Collecting; Nitroimidazoles; Oxygen; Perfusion; Rats; Up-Regulation | 2006 |
Oxygen status of lung granulomas in Mycobacterium tuberculosis-infected mice.
Topics: Animals; Biomarkers; Disease Models, Animal; Electrodes; Female; Granuloma; Hypoxia; Immunohistochemistry; Lung; Mice; Mice, Inbred C57BL; Mutation; Mycobacterium tuberculosis; Necrosis; Nitrates; Nitroimidazoles; Oxygen; Time Factors; Tuberculosis, Pulmonary | 2006 |
Rod photoreceptor loss in Rho-/- mice reduces retinal hypoxia and hypoxia-regulated gene expression.
Topics: Animals; Apyrase; Cyclic Nucleotide Phosphodiesterases, Type 6; Dark Adaptation; Diltiazem; Enzyme-Linked Immunosorbent Assay; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Light; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitroimidazoles; Oxygen Consumption; Phosphoric Diester Hydrolases; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Rhodopsin; RNA, Messenger; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2006 |
Age-related hearing loss in CD/1 mice is associated to ROS formation and HIF target proteins up-regulation in the cochlea.
Topics: Action Potentials; Aging; Animals; Apoptosis; Caspase 3; Cochlea; Cochlear Nerve; Coloring Agents; Hearing Loss; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Injections, Intravenous; Insulin-Like Growth Factor I; Mice; Nitroimidazoles; Reactive Oxygen Species; Schwann Cells; Spiral Ganglion; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Up-Regulation | 2007 |
Improved cryosections and specific immunohistochemical methods for detecting hypoxia in mouse and rat cochleae.
Topics: Animals; Animals, Outbred Strains; Biomarkers; Cochlear Diseases; Fluorescent Antibody Technique, Indirect; Frozen Sections; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Tissue Embedding | 2007 |
Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia.
Topics: Animals; Benzimidazoles; Bone Marrow Cells; Cell Differentiation; Hematopoietic Stem Cells; Hematopoietic System; Hypoxia; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Perfusion; Stem Cells; Tirapazamine; Triazines | 2007 |
Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.
Topics: Animals; Antibiotics, Antitubercular; Antitubercular Agents; Colony Count, Microbial; Diarylquinolines; Female; Granuloma; Guinea Pigs; Hypoxia; Isoniazid; Lung; Mycobacterium tuberculosis; Nitroimidazoles; Pyrazinamide; Quinolines; Radiation-Sensitizing Agents; Rifampin; Spleen; Tuberculosis | 2007 |
Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression.
Topics: Animals; Aquaporin 1; Carbon Dioxide; Cell Membrane; Cytosol; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1; Lung; Microscopy, Confocal; Models, Biological; Nitroimidazoles; Oxygen; PC12 Cells; Permeability; Rats; Up-Regulation | 2007 |
Immunohistochemical detection of hypoxia in mouse liver tissues treated with pimonidazole using "in vivo cryotechnique".
Topics: Animals; Cryopreservation; Freeze Substitution; Hypoxia; Immunohistochemistry; Injections, Intraperitoneal; Liver; Mice; Mice, Inbred C57BL; Nitroimidazoles; Tissue Fixation | 2007 |
Effects of old age on hepatocyte oxygenation.
Topics: Aging; Animals; Biomarkers; Hepatocytes; Hypoxia; Male; Mitochondria; Nitroimidazoles; Oxygen; Oxygen Consumption; Rats; Rats, Inbred F344 | 2007 |
Adaptation to hypoxia in the diabetic rat kidney.
Topics: Adaptation, Physiological; Animals; Antioxidants; Basic Helix-Loop-Helix Transcription Factors; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomerular Filtration Rate; Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1; Insulin; Male; Nitroimidazoles; Rats; Rats, Inbred Strains; Spin Labels; Streptozocin | 2008 |
Measurement of hypoxia using invasive oxygen-sensitive electrode, pimonidazole binding and 18F-FDG uptake in anaemic or erythropoietin-treated mice bearing human glioma xenografts.
Topics: Anemia; Animals; Autoradiography; Electrodes; Erythropoietin; Fluorodeoxyglucose F18; Glioma; Hemoglobins; Humans; Hypoxia; Mice; Mice, Nude; Muscle, Skeletal; Neoplasm Transplantation; Nitroimidazoles; Recombinant Proteins; Transplantation, Heterologous | 2008 |
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Granuloma; Guinea Pigs; Humans; Hypoxia; Immunohistochemistry; Lung; Macaca fascicularis; Metronidazole; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mycobacterium tuberculosis; Nitroimidazoles; Oxygen; Rabbits; Radiation-Sensitizing Agents; Tuberculosis, Pulmonary | 2008 |
Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis.
Topics: Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; Carotid Stenosis; Cross-Sectional Studies; Disease Progression; Endarterectomy, Carotid; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Immunohistochemistry; Macrophages; Male; Middle Aged; Neovascularization, Pathologic; Nitroimidazoles; Oxidative Stress; RNA, Messenger; Vascular Endothelial Growth Factor A | 2008 |
The paradox of hypoxic and oxidative stress in atherosclerosis.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Atherosclerosis; Biomarkers; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Macrophages; Neovascularization, Pathologic; Nitroimidazoles; Oxidative Stress; Reactive Oxygen Species | 2008 |
Longevity of pimonidazole adducts in spontaneous canine tumors as an estimate of hypoxic cell lifetime.
Topics: Animals; Cell Survival; DNA Adducts; DNA, Neoplasm; Dog Diseases; Dogs; Hypoxia; Neoplasms; Nitroimidazoles | 1997 |
Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Eating; Enzyme-Linked Immunosorbent Assay; Fasting; Glycolysis; Hypoxia; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Nitroimidazoles; Oxidation-Reduction; Oxygen Consumption; Potassium Cyanide; Radiation-Sensitizing Agents; Rats | 1998 |
Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine.
Topics: Animals; Creatinine; Cyclosporine; Food, Fortified; Free Radicals; Glomerular Filtration Rate; Glycine; Hypoxia; Kidney; Male; Models, Biological; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Time Factors; Vasoconstriction | 1998 |
Graft survival is improved by hepatic denervation before organ harvesting.
Topics: Animals; Antihypertensive Agents; Denervation; Female; Graft Survival; Hepatic Artery; Hexamethonium; Hypoxia; Liver; Liver Transplantation; Microcirculation; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Inbred Lew; Reperfusion Injury; Tissue and Organ Procurement | 1999 |
Reperfusion injury in livers due to gentle in situ organ manipulation during harvest involves hypoxia and free radicals.
Topics: Animals; Cryopreservation; Enzyme-Linked Immunosorbent Assay; Female; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Free Radicals; Hypoxia; Immunohistochemistry; In Vitro Techniques; Liver; Microcirculation; Nitroimidazoles; Organ Preservation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Specimen Handling; Trypan Blue | 1999 |
Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status.
Topics: Animals; Antineoplastic Agents; Blood Vessels; Brain Neoplasms; Glioma; Humans; Hypoxia; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Staining and Labeling; Suramin; Transplantation, Heterologous | 1999 |
Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas.
Topics: Aged; Biomarkers; Biopsy; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Hypopharyngeal Neoplasms; Hypoxia; Image Processing, Computer-Assisted; Immunohistochemistry; Laryngeal Neoplasms; Male; Microscopy, Fluorescence; Middle Aged; Nitroimidazoles; Oropharyngeal Neoplasms; Prognosis | 2000 |
Hypoxia in a human intracerebral glioma model.
Topics: Animals; Brain Neoplasms; Cell Division; Disease Models, Animal; Glioma; Hypoxia; Mice; Mice, Inbred BALB C; Microcirculation; Nitroimidazoles; Radiation-Sensitizing Agents | 2000 |
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
Topics: Blotting, Western; Carbonic Anhydrases; Carcinoma; Carcinoma, Renal Cell; DNA-Binding Proteins; Endothelial Growth Factors; Genes, Reporter; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunohistochemistry; In Situ Hybridization; Kidney Neoplasms; Lymphokines; Models, Genetic; Necrosis; Nitroimidazoles; Nuclear Proteins; Oxygen; Plasmids; Promoter Regions, Genetic; Radiation-Sensitizing Agents; RNA; RNA, Messenger; Skin Neoplasms; Transcription Factors; Tumor Cells, Cultured; Up-Regulation; Urinary Bladder Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development.
Topics: Animals; Antibodies, Monoclonal; Biomarkers; Blood Vessels; Brain; Bucladesine; Cell Differentiation; Cell Hypoxia; DNA-Binding Proteins; Embryonic and Fetal Development; Endothelial Growth Factors; Endothelium, Vascular; Gene Expression Regulation, Developmental; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Lymphokines; Mice; Mice, Inbred BALB C; Nitroimidazoles; Nuclear Proteins; Platelet Endothelial Cell Adhesion Molecule-1; Stem Cells; Teratoma; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Measuring hypoxia in solid tumours--is there a gold standard?
Topics: Biopsy, Needle; Comet Assay; Humans; Hypoxia; Microelectrodes; Neoplasms; Nitroimidazoles; Palliative Care; Predictive Value of Tests; Radiation-Sensitizing Agents; Radiotherapy; Reference Values | 2001 |
Hypoxia in the thymus: role of oxygen tension in thymocyte survival.
Topics: Animals; Cell Survival; Cyclooxygenase 2; DNA Primers; Exons; Gene Expression Regulation; Genetic Markers; Heme Oxygenase (Decyclizing); Hypoxia; In Vitro Techniques; Introns; Isoenzymes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Oxygen Consumption; Partial Pressure; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Radiation-Sensitizing Agents; RNA, Messenger; Thymus Gland; Transcription, Genetic | 2002 |
Quantitative analysis of varying profiles of hypoxia in relation to functional vessels in different human glioma xenograft lines.
Topics: Animals; Glioma; Humans; Hypoxia; Immunohistochemistry; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Perfusion; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
Radiotherapy using the hypoxic cell sensitizer Ro 03-8799 in malignant melanoma.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypoxia; Lymph Nodes; Male; Melanoma; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Palliative Care; Radiation Tolerance; Radiation-Sensitizing Agents; Skin Neoplasms | 1987 |