Compounds > pimonidazole
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pimonidazole and Carcinoma, Squamous Cell

pimonidazole has been researched along with Carcinoma, Squamous Cell in 53 studies

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.89)18.7374
1990's5 (9.43)18.2507
2000's30 (56.60)29.6817
2010's17 (32.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baker, LCJ; Bhide, SA; Box, C; d'Arcy, JA; Dunlop, A; Eccles, SA; Harrington, KJ; Hopkinson, G; Koh, DM; Leach, MO; Mcquaid, D; Newbold, KL; Nutting, CM; Panek, R; Richardson, C; Riddell, AM; Robinson, SP; Schmidt, MA; Welsh, L; Wong, KH1
Dadgar, S; Rajaram, N; Troncoso, JR1
Busk, M; Horsman, MR; Iversen, AB; Jakobsen, S; Ji, X; Lee, DY; Mortensen, LS; Nordsmark, M; Overgaard, J; Raleigh, JR1
Baumann, M; Brüchner, K; Gurtner, K; Helbig, L; Hess-Stumpp, H; Koi, L; Pruschy, M; Unterschemmann, K; Yaromina, A; Zips, D1
Galoforo, S; Grills, IS; Kane, JL; Krueger, SA; Marples, B; Wilson, GD; Wobb, J1
Bollineni, VR; Bruine de Bruin, L; de Bock, GH; Halmos, GB; Langendijk, JA; Pruim, J; Schuuring, E; Slagter-Menkema, L; Steenbakkers, RJ; van der Laan, BF; van der Wal, JE; van Hemel, BM; Wachters, JE1
Baumann, M; Mönnich, D; Thorwarth, D; Wack, LJ; Yaromina, A; Zips, D1
Busk, M; Horsman, MR; Overgaard, J1
Baumann, M; Eckardt, A; Eicheler, W; Schuetze, C; Thames, H; Yaromina, A; Zips, D1
Hoogsteen, IJ; Kaanders, JH; Lok, J; Marres, HA; Rijken, PF; Takes, RP; van der Kogel, AJ1
Busk, M; Bussink, J; Hansen, KV; Horsman, MR; Jakobsen, S; Overgaard, J; van der Kogel, A1
Baumann, M; Meyer, S; Mueller-Klieser, W; Quennet, V; Shakirin, G; Walenta, S; Yaromina, A; Zips, D1
Baumann, M; Flentje, M; Jakob, PM; Melkus, G; Mörchel, P; Yaromina, A; Zips, D1
Baumann, M; Dörfler, A; Eicheler, W; Hering, S; Leichtner, T; Thames, H; Yaromina, A; Zhou, X; Zips, D1
Baumann, M; Beuthien-Baumann, B; Bussink, J; Eicheler, W; Krause, M; Rijken, P; Santiago, A; van der Kogel, AJ; Yaromina, A1
Baumann, M; Boeke, S; Kroeber, T; Meinzer, A; Thames, H; Yaromina, A; Zips, D1
Betts, G; Bonington, SC; Buckley, DL; Donaldson, SB; Homer, JJ; Kershaw, LE; Slevin, NJ; Valentine, H; West, CM1
Busk, M; Horsman, MR; Jakobsen, S; Mueller-Klieser, W; Overgaard, J; Steiniche, T; Walenta, S1
Bussink, J; Hoogsteen, IJ; Kaanders, JH; Lok, J; Marres, HA; Rijken, PF; van den Hoogen, FJ1
Bartlett, R; Carlin, S; Humm, JL; McCall, KC; Reese, M1
Bussink, J; Grénman, R; Iida, M; Kaanders, JH; Span, PN; Stegeman, H; van der Kogel, AJ; Verheijen, MM; Waaijer, SJ; Wheeler, DL1
Baumann, M; Böke, S; Helbig, L; Koi, L; Sriramareddy, SN; Thames, HD; Yaromina, A; Zips, D1
Balm, AJ; Begg, AC; Blijweert, E; Blommestijn, G; Delaere, P; Haustermans, KM; Hoebers, FJ; Hofland, I; Janssen, HL; Raleigh, JA; Sciot, R; Semenza, GL; Sprong, D; van Velthuysen, ML; Varia, MA1
Bennewith, KL; Durand, RE; Raleigh, JA1
Bussink, J; de Wilde, PC; Kaanders, JH; Ljungkvist, AS; Marres, HA; Pop, LA; Raleigh, JA; van den Hoogen, FJ; van der Kogel, AJ; Wijffels, KI1
Airley, RE; Davidson, SE; Harris, AL; Hunter, RD; Loncaster, J; Raleigh, JA; Stratford, IJ; West, CM1
Bussink, J; Kaanders, JH; van der Kogel, AJ2
Azuma, Y; Chou, SC; Lininger, RA; Murphy, BJ; Raleigh, JA; Varia, MA1
Balm, AJ; Begg, AC; Goethals, L; Haustermans, KM; Hoebers, FJ; Janssen, HL; Sprong, D; Stratford, IJ; Williams, KJ1
Bennewith, KL; Durand, RE1
Baumann, M; Eicheler, W; Hessel, F; Hölscher, T; Krause, M; Petersen, C; Rosner, A; Thames, HD; Yaromina, A; Zips, D1
Hoogsteen, IJ; Kaanders, JH; Marres, HA; Peeters, WJ; Rijken, PF; van den Hoogen, FJ; van der Kogel, AJ1
Boerman, OC; Bussink, J; Kaanders, JH; Laverman, P; Lok, J; Oyen, WJ; Philippens, M; Troost, EG; van der Kogel, AJ1
Balm, A; Barbé, B; Begg, AC; De Schutter, H; Gregoire, V; Haustermans, K; Mahy, P; Nuyts, S; Spaepen, M; Vander Poorten, V1
Aquino-Parsons, C; Durand, RE1
Baumann, M; Eicheler, W; Haase, M; Krause, M; Mueller-Klieser, W; Petersen, C; Quennet, V; Raleigh, JA; Rosner, A; Thames, HD; Walenta, S; Yaromina, A; Zips, D1
Kaanders, JH; Marres, HA; Peters, JP; Rijken, PF; van der Kogel, AJ; Wijffels, KI1
Le, QT1
Busk, M; Bussink, J; Horsman, MR; Jakobsen, S; Keiding, S; Overgaard, J; van der Kogel, AJ1
Calkins, DP; Kennedy, AS; Novotny, DB; Perez, GM; Raleigh, JA; Thrall, DE; Varia, MA1
Ballenger, CA; Calkins-Adams, DP; Fowler, WC; Novotny, DB; Raleigh, JA; Rinker, LH; Varia, MA; Weissler, MC1
Ballenger, CA; Calkins-Adams, DP; Chou, SC; Novotny, DB; Raleigh, JA; Varia, MA1
Begg, AC; Geboes, K; Haustermans, K; Hofland, I; Raleigh, J; Van de Pavert, L; Varia, M1
Bussink, J; de Wilde, PC; Kaanders, JH; Marres, HA; Raleigh, JA; Rijken, PF; van den Hoogen, FJ; van der Kogel, AJ; Wijffels, KI1
Aquino-Parsons, C; Durand, RE; Luo, C; Olive, PL; Raleigh, JA1
Bussink, J; Denekamp, J; Ljungkvist, AS; Raleigh, JA; Rijken, PF; Van Der Kogel, AJ1
Bono, EL; Chou, SC; Raleigh, JA; Thrall, DE; Varia, MA1
Banáth, JP; Luo, CM; Olive, PL1
Bleehen, NM; Newman, HF; Smithen, CE; Ward, R; Workman, P1
Wagner, W1
Bennett, MH; Des Rochers, C; Dische, S; Dunphy, EP; Minchinton, AI; Saunders, MI; Stratford, MR; Wardman, P1

Reviews

1 review(s) available for pimonidazole and Carcinoma, Squamous Cell

ArticleYear
Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2003, Volume: 67, Issue:1

    Topics: Antigens, Neoplasm; Biomarkers, Tumor; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; DNA-Binding Proteins; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Neoplasm Proteins; Nitroimidazoles; Nuclear Proteins; Oxygen; Radiation-Sensitizing Agents; Transcription Factors; Treatment Outcome; Vascular Endothelial Growth Factor A

2003

Trials

4 trial(s) available for pimonidazole and Carcinoma, Squamous Cell

ArticleYear
Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.
    Cancer research, 2002, Dec-01, Volume: 62, Issue:23

    Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Carbon Dioxide; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Proteins; Niacinamide; Nitroimidazoles; Oxygen; Predictive Value of Tests; Treatment Outcome

2002
The fate of hypoxic (pimonidazole-labelled) cells in human cervix tumours undergoing chemo-radiotherapy.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2006, Volume: 80, Issue:2

    Topics: Adult; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Combined Modality Therapy; Female; Humans; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Spheroids, Cellular; Uterine Cervical Neoplasms

2006
A trial of Ro 03-8799 (pimonidazole) in carcinoma of the uterine cervix: an interim report from the Medical Research Council Working Party on advanced carcinoma of the cervix.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1993, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Aged; Blood Transfusion; Brachytherapy; Carcinoma, Squamous Cell; Diarrhea; Female; Follow-Up Studies; Humans; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage; Remission Induction; Survival Rate; Uterine Cervical Neoplasms; Vomiting

1993
A clinical study of hypoxia and metallothionein protein expression in squamous cell carcinomas.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:3

    Topics: Biomarkers; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Metallothionein; Neoplasm Staging; Nitroimidazoles; Proliferating Cell Nuclear Antigen; Protein Precursors; Uterine Cervical Neoplasms

2000

Other Studies

48 other study(ies) available for pimonidazole and Carcinoma, Squamous Cell

ArticleYear
Noninvasive Imaging of Cycling Hypoxia in Head and Neck Cancer Using Intrinsic Susceptibility MRI.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2017, Aug-01, Volume: 23, Issue:15

    Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Contrast Media; Female; Head and Neck Neoplasms; Humans; Lymph Nodes; Magnetic Resonance Imaging; Male; Mice; Neovascularization, Pathologic; Nitroimidazoles; Radiation Tolerance; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome; Xenograft Model Antitumor Assays

2017
Optical spectroscopic sensing of tumor hypoxia.
    Journal of biomedical optics, 2018, Volume: 23, Issue:6

    Topics: Animals; Biosensing Techniques; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Hemoglobins; Humans; Mice; Mice, Nude; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Spectrum Analysis; Tumor Cells, Cultured; Tumor Hypoxia

2018
PET imaging of tumor hypoxia using 18F-labeled pimonidazole.
    Acta oncologica (Stockholm, Sweden), 2013, Volume: 52, Issue:7

    Topics: Animals; Carcinoma, Squamous Cell; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Hypoxia; Mammary Neoplasms, Animal; Mice; Mice, Inbred C3H; Mice, Nude; Nitroimidazoles; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tumor Cells, Cultured

2013
Hypoxia-inducible factor pathway inhibition resolves tumor hypoxia and improves local tumor control after single-dose irradiation.
    International journal of radiation oncology, biology, physics, 2014, Jan-01, Volume: 88, Issue:1

    Topics: Amines; Animals; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Nucleus; Dose Fractionation, Radiation; Electron Transport Complex I; Female; Heterografts; Humans; Hypoxia-Inducible Factor 1; Ki-67 Antigen; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Random Allocation; Tumor Microenvironment

2014
The Effects of Pulsed Radiation Therapy on Tumor Oxygenation in 2 Murine Models of Head and Neck Squamous Cell Carcinoma.
    International journal of radiation oncology, biology, physics, 2015, Jul-15, Volume: 92, Issue:4

    Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Coloring Agents; Disease Models, Animal; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Heterografts; Mice; Mice, Nude; Misonidazole; Neoplasm Recurrence, Local; Nitroimidazoles; Oxygen Consumption; Positron-Emission Tomography; Radiopharmaceuticals; Squamous Cell Carcinoma of Head and Neck; Tumor Burden

2015
Assessment of hypoxic subvolumes in laryngeal cancer with (18)F-fluoroazomycinarabinoside ((18)F-FAZA)-PET/CT scanning and immunohistochemistry.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2015, Volume: 117, Issue:1

    Topics: Aged; Aged, 80 and over; Biomarkers; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Hypoxia; Laryngeal Neoplasms; Laryngectomy; Male; Middle Aged; Multimodal Imaging; Neoplasm Recurrence, Local; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Squamous Cell Carcinoma of Head and Neck; Tomography, X-Ray Computed

2015
Correlation of FMISO simulations with pimonidazole-stained tumor xenografts: A question of O2 consumption?
    Medical physics, 2016, Volume: 43, Issue:7

    Topics: Animals; Benzimidazoles; Carcinoma, Squamous Cell; Cell Line, Tumor; Computer Simulation; Feasibility Studies; Fluorescent Antibody Technique; Head and Neck Neoplasms; Humans; Hypoxia; Mice, Nude; Misonidazole; Models, Biological; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Platelet Endothelial Cell Adhesion Molecule-1; Tumor Microenvironment

2016
Resolution in PET hypoxia imaging: voxel size matters.
    Acta oncologica (Stockholm, Sweden), 2008, Volume: 47, Issue:7

    Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Mice; Mice, Nude; Microscopy, Fluorescence; Necrosis; Neoplasms, Experimental; Nitroimidazoles; Positron-Emission Tomography

2008
Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studies.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2009, Volume: 92, Issue:3

    Topics: Animals; Biopsy, Needle; Carcinoma, Squamous Cell; Confidence Intervals; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Environment; Female; Humans; Hypoxia; Immunohistochemistry; Longitudinal Studies; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Probability; Radiobiology; Random Allocation; Reference Values

2009
Hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of CA-IX and vascularity as surrogate markers of hypoxia.
    European journal of cancer (Oxford, England : 1990), 2009, Volume: 45, Issue:16

    Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Humans; Immunohistochemistry; Laryngeal Neoplasms; Male; Middle Aged; Nitroimidazoles; Radiation-Sensitizing Agents

2009
Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2009, Volume: 92, Issue:3

    Topics: Animals; Carcinoma, Squamous Cell; Cell Count; Cell Hypoxia; Disease Models, Animal; Female; Hypoxia; Mice; Mice, Inbred C3H; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Random Allocation; Sensitivity and Specificity; Tissue Distribution

2009
Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.
    International journal of radiation biology, 2009, Volume: 85, Issue:11

    Topics: Animals; Benzimidazoles; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Female; Fluorescent Dyes; Glucose; Humans; Hypoxia; Lactic Acid; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Transplantation, Heterologous

2009
Correlating quantitative MR measurements of standardized tumor lines with histological parameters and tumor control dose.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2010, Volume: 96, Issue:1

    Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Humans; Immunohistochemistry; Lactic Acid; Magnetic Resonance Imaging; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Radiation Dosage; Radiation-Sensitizing Agents; Sensitivity and Specificity; Transplantation, Heterologous

2010
Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2010, Volume: 96, Issue:1

    Topics: Animals; Carcinoma, Squamous Cell; Cell Division; Cell Hypoxia; Confidence Intervals; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Radiobiology; Transplantation, Heterologous; Tumor Microenvironment

2010
Effect of cetuximab and fractionated irradiation on tumour micro-environment.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2010, Volume: 97, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Combined Modality Therapy; Dose Fractionation, Radiation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Male; Mice; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Signal Transduction; Transplantation, Heterologous; Xenograft Model Antitumor Assays

2010
Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts.
    International journal of radiation oncology, biology, physics, 2011, Jul-15, Volume: 80, Issue:4

    Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Dose Fractionation, Radiation; Humans; Mice; Mice, Nude; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Tumor Microenvironment; Xenograft Model Antitumor Assays

2011
Perfusion estimated with rapid dynamic contrast-enhanced magnetic resonance imaging correlates inversely with vascular endothelial growth factor expression and pimonidazole staining in head-and-neck cancer: a pilot study.
    International journal of radiation oncology, biology, physics, 2011, Nov-15, Volume: 81, Issue:4

    Topics: Aged; Algorithms; Carcinoma, Squamous Cell; Cell Hypoxia; Coloring Agents; Contrast Media; Female; Head and Neck Neoplasms; Humans; Kinetics; Magnetic Resonance Imaging; Male; Middle Aged; Models, Biological; Neoplasm Proteins; Neovascularization, Pathologic; Nitroimidazoles; Pilot Projects; Real-Time Polymerase Chain Reaction; Tumor Burden; Vascular Endothelial Growth Factor A

2011
Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2011, Volume: 99, Issue:3

    Topics: Animals; Autoradiography; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cinnamates; Female; Fluorodeoxyglucose F18; Glucose; Glycolysis; Head and Neck Neoplasms; Immunoenzyme Techniques; Lactates; Linear Models; Luminescent Measurements; Mice; Mice, Nude; Monocarboxylic Acid Transporters; Nitroimidazoles; Oxidation-Reduction; Symporters; Tumor Microenvironment; Uterine Cervical Neoplasms

2011
Expression of EGFR under tumor hypoxia: identification of a subpopulation of tumor cells responsible for aggressiveness and treatment resistance.
    International journal of radiation oncology, biology, physics, 2012, Nov-01, Volume: 84, Issue:3

    Topics: Carcinoma, Squamous Cell; Cell Hypoxia; Cell Survival; Disease-Free Survival; ErbB Receptors; Head and Neck Neoplasms; Humans; Nitroimidazoles; Prognosis; Radiation Tolerance; Radiation-Sensitizing Agents

2012
Copper-64-diacetyl-bis(N(4)-methylthiosemicarbazone) pharmacokinetics in FaDu xenograft tumors and correlation with microscopic markers of hypoxia.
    International journal of radiation oncology, biology, physics, 2012, Nov-01, Volume: 84, Issue:3

    Topics: Animals; Autoradiography; Biomarkers; Carcinoma, Squamous Cell; Cell Hypoxia; Coordination Complexes; Head and Neck Neoplasms; Humans; Immunohistochemistry; Muscles; Nitroimidazoles; Organometallic Compounds; Partial Pressure; Radionuclide Imaging; Rats; Rats, Nude; Thiosemicarbazones; Tissue Distribution; Transplantation, Heterologous; Tumor Microenvironment; Xenograft Model Antitumor Assays

2012
Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck.
    BMC cancer, 2012, Oct-10, Volume: 12

    Topics: Animals; Blotting, Western; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; ErbB Receptors; Fluorescent Antibody Technique; Head and Neck Neoplasms; Heterocyclic Compounds, 3-Ring; Humans; Hypoxia; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Radiation-Sensitizing Agents; Radiotherapy; Receptor, ErbB-2; Signal Transduction; Tumor Microenvironment; Xenograft Model Antitumor Assays

2012
Prognostic value of HIF-1α expression during fractionated irradiation.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2012, Volume: 188, Issue:11

    Topics: Animals; Biomarkers, Tumor; Blotting, Western; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Dose Fractionation, Radiation; Female; Gene Expression; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Otorhinolaryngologic Neoplasms; Prognosis; Radiation-Sensitizing Agents; Statistics as Topic; Transplantation, Heterologous

2012
HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors.
    International journal of radiation oncology, biology, physics, 2002, Dec-01, Volume: 54, Issue:5

    Topics: Carcinoma, Squamous Cell; Dimerization; Dose-Response Relationship, Drug; Head and Neck Neoplasms; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Idoxuridine; Immunohistochemistry; Ki-67 Antigen; Neovascularization, Pathologic; Nitroimidazoles; Nucleic Acid Synthesis Inhibitors; Perfusion; Transcription Factors; Treatment Outcome

2002
Orally administered pimonidazole to label hypoxic tumor cells.
    Cancer research, 2002, Dec-01, Volume: 62, Issue:23

    Topics: Administration, Oral; Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Flow Cytometry; Humans; Male; Mice; Mice, SCID; Neoplasm Transplantation; Nitroimidazoles; Transplantation, Heterologous; Tumor Cells, Cultured; Uterine Cervical Neoplasms

2002
GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: relationship to pimonidazole binding.
    International journal of cancer, 2003, Mar-10, Volume: 104, Issue:1

    Topics: Adult; Antigens, Neoplasm; Biomarkers; Biopsy; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; DNA-Binding Proteins; Energy Metabolism; Female; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Microelectrodes; Middle Aged; Monosaccharide Transport Proteins; Neoplasm Proteins; Nitroimidazoles; Nuclear Proteins; Observer Variation; Oxygen; Partial Pressure; Radiation-Sensitizing Agents; Reproducibility of Results; Transcription Factors; Uterine Cervical Neoplasms

2003
Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: pimonidazole and involucrin.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Oct-15, Volume: 9, Issue:13

    Topics: Biopsy; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line, Tumor; Female; Humans; Hypoxia; Immunohistochemistry; In Situ Hybridization; Metallothionein; Nitroimidazoles; Oxygen; Prognosis; Protein Precursors; Radiation-Sensitizing Agents; RNA, Messenger; Transcription, Genetic; Uterine Cervical Neoplasms

2003
Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2004, Volume: 70, Issue:1

    Topics: Antibodies, Anti-Idiotypic; Biomarkers; Carcinoma, Squamous Cell; Flow Cytometry; Frozen Sections; Head and Neck Neoplasms; Humans; Hypoxia; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Staining and Labeling

2004
Quantifying transient hypoxia in human tumor xenografts by flow cytometry.
    Cancer research, 2004, Sep-01, Volume: 64, Issue:17

    Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; Female; Flow Cytometry; Humans; Mice; Mice, SCID; Nitroimidazoles; Oxygen; Partial Pressure; Transplantation, Heterologous; Uterine Cervical Neoplasms

2004
Does heterogeneity of pimonidazole labelling correspond to the heterogeneity of radiation-response of FaDu human squamous cell carcinoma?
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2005, Volume: 76, Issue:2

    Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Dose-Response Relationship, Radiation; Female; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Radiation Tolerance

2005
Erythropoietin receptor is not a surrogate marker for tumor hypoxia and does not correlate with survival in head and neck squamous cell carcinomas.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2005, Volume: 76, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Male; Middle Aged; Nitroimidazoles; Receptors, Erythropoietin; Survival Rate

2005
Imaging hypoxia after oxygenation-modification: comparing [18F]FMISO autoradiography with pimonidazole immunohistochemistry in human xenograft tumors.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2006, Volume: 80, Issue:2

    Topics: Animals; Autoradiography; Carcinoma, Squamous Cell; Cell Hypoxia; Fluorine Radioisotopes; Glioblastoma; Head and Neck Neoplasms; Humans; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Radionuclide Imaging

2006
Microsatellite alterations in head and neck squamous cell carcinoma and relation to expression of pimonidazole, CA IX and GLUT-1.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2006, Volume: 80, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Base Sequence; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; Excitatory Amino Acid Transporter 2; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Loss of Heterozygosity; Male; Microsatellite Instability; Middle Aged; Molecular Sequence Data; Nitroimidazoles

2006
Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: the need for a multivariate approach in biomarker studies.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2006, Volume: 81, Issue:2

    Topics: Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Dose Fractionation, Radiation; Female; Humans; Imaging, Three-Dimensional; Male; Mice; Mice, Nude; Nitroimidazoles; Prognosis; Treatment Outcome; Xenograft Model Antitumor Assays

2006
Tumour cell proliferation under hypoxic conditions in human head and neck squamous cell carcinomas.
    Oral oncology, 2008, Volume: 44, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Biopsy; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Proliferation; Female; Head and Neck Neoplasms; Humans; Idoxuridine; Image Processing, Computer-Assisted; Male; Middle Aged; Neoplasm Staging; Neovascularization, Pathologic; Nitroimidazoles; Nucleic Acid Synthesis Inhibitors; Radiation-Sensitizing Agents; Treatment Outcome

2008
Identifying and targeting hypoxia in head and neck cancer: a brief overview of current approaches.
    International journal of radiation oncology, biology, physics, 2007, Volume: 69, Issue:2 Suppl

    Topics: Antigens, Neoplasm; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; Electrodes; Etanidazole; Head and Neck Neoplasms; Humans; Hydrocarbons, Fluorinated; Intracellular Signaling Peptides and Proteins; Mitochondrial Proteins; Neoplasm Proteins; Nitroimidazoles; Osteopontin; Oxygen; Partial Pressure; Radiation-Sensitizing Agents; Tirapazamine; Triazines

2007
Imaging hypoxia in xenografted and murine tumors with 18F-fluoroazomycin arabinoside: a comparative study involving microPET, autoradiography, PO2-polarography, and fluorescence microscopy.
    International journal of radiation oncology, biology, physics, 2008, Mar-15, Volume: 70, Issue:4

    Topics: Animals; Autoradiography; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Fibrosarcoma; Fluorine Radioisotopes; Immunocompromised Host; Immunohistochemistry; Mice; Mice, Inbred C3H; Mice, Nude; Microscopy, Fluorescence; Nitroimidazoles; Oxygen; Polarography; Positron-Emission Tomography; Radiation-Sensitizing Agents; Transplantation, Heterologous

2008
Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome: in regard to Evans et al. (Int J Radiat Oncol Biol Phys 2007;69:1024-1031).
    International journal of radiation oncology, biology, physics, 2008, Apr-01, Volume: 70, Issue:5

    Topics: Carbon Dioxide; Carcinoma, Squamous Cell; Cell Hypoxia; Head and Neck Neoplasms; Humans; Nitroimidazoles; Oxygen; Prognosis; Radiation-Sensitizing Agents; Time Factors

2008
Proliferation and hypoxia in human squamous cell carcinoma of the cervix: first report of combined immunohistochemical assays.
    International journal of radiation oncology, biology, physics, 1997, Mar-01, Volume: 37, Issue:4

    Topics: Adult; Antigens, Nuclear; Biomarkers; Carcinoma, Squamous Cell; Cell Division; Cell Hypoxia; Female; Humans; Immunohistochemistry; Ki-67 Antigen; Nitroimidazoles; Nuclear Proteins; Proliferating Cell Nuclear Antigen; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms

1997
Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker.
    Cancer research, 1998, Sep-01, Volume: 58, Issue:17

    Topics: Biomarkers; Carcinoma, Squamous Cell; Cell Hypoxia; Endothelial Growth Factors; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Lymphokines; Nitroimidazoles; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

1998
Diffusion limited hypoxia estimated by vascular image analysis: comparison with pimonidazole staining in human tumors.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2000, Volume: 55, Issue:3

    Topics: Adenocarcinoma; Blood Vessels; Carcinoma, Squamous Cell; Cell Hypoxia; Diffusion; Esophageal Neoplasms; Female; Humans; Image Processing, Computer-Assisted; Nitroimidazoles; Observer Variation; Radiation-Sensitizing Agents; Rectal Neoplasms; Reproducibility of Results; Uterine Cervical Neoplasms

2000
Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas.
    British journal of cancer, 2000, Volume: 83, Issue:5

    Topics: Aged; Biomarkers; Biopsy; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Hypopharyngeal Neoplasms; Hypoxia; Image Processing, Computer-Assisted; Immunohistochemistry; Laryngeal Neoplasms; Male; Microscopy, Fluorescence; Middle Aged; Nitroimidazoles; Oropharyngeal Neoplasms; Prognosis

2000
Comparison between the comet assay and pimonidazole binding for measuring tumour hypoxia.
    British journal of cancer, 2000, Volume: 83, Issue:11

    Topics: Animals; Antibodies, Monoclonal; Carcinoma, Squamous Cell; Cell Hypoxia; Comet Assay; Cricetinae; Cricetulus; DNA, Neoplasm; Female; Flow Cytometry; Fluorescein-5-isothiocyanate; Humans; Immunoconjugates; Male; Mice; Mice, Inbred C3H; Mice, Inbred NOD; Mice, SCID; Nitroimidazoles; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

2000
Changes in tumor hypoxia measured with a double hypoxic marker technique.
    International journal of radiation oncology, biology, physics, 2000, Dec-01, Volume: 48, Issue:5

    Topics: Animals; Benzimidazoles; Biomarkers; Carbon Dioxide; Carcinoma, Squamous Cell; Cell Hypoxia; Endothelium, Vascular; Fluorescent Dyes; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Tumor Cells, Cultured

2000
Semiquantitative immunohistochemical analysis for hypoxia in human tumors.
    International journal of radiation oncology, biology, physics, 2001, Feb-01, Volume: 49, Issue:2

    Topics: Calibration; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Nitroimidazoles; Observer Variation; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms

2001
Local hypoxia is produced at sites of intratumour injection.
    British journal of cancer, 2002, Feb-01, Volume: 86, Issue:3

    Topics: Animals; Benzimidazoles; Carcinoma, Squamous Cell; Cell Hypoxia; Comet Assay; DNA Damage; Humans; Injections; Mice; Nitroimidazoles; Radiation-Sensitizing Agents

2002
Lack of stereoselectivity in the pharmacokinetics and metabolism of the radiosensitizer Ro 03-8799 in man.
    Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:2

    Topics: Adenocarcinoma; Aged; Carcinoma, Squamous Cell; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Radiation-Sensitizing Agents; Stereoisomerism

1991
[New results with delayed progression in the cell cycle of solid squamous cell carcinomas of the head-neck area after single and fractionated irradiation with cobalt-60 and neutrons].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1990, Volume: 166, Issue:11

    Topics: Animals; Carcinoma, Squamous Cell; Cell Cycle; Cobalt Radioisotopes; Head and Neck Neoplasms; Neoplasm Transplantation; Neutrons; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors; Transplantation, Heterologous

1990
A comparison of the tumour concentrations obtainable with misonidazole and Ro 03-8799.
    The British journal of radiology, 1986, Volume: 59, Issue:705

    Topics: Adult; Aged; Animals; Carcinoma, Squamous Cell; Cricetinae; Cricetulus; Female; Humans; Male; Melanoma; Mice; Middle Aged; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms

1986