pimagedine has been researched along with Uremia in 6 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pentosidine levels were determined at intervals by HPLC assay." | 5.30 | Accumulation of carbonyls accelerates the formation of pentosidine, an advanced glycation end product: carbonyl stress in uremia. ( Izuhara, Y; Jadoul, M; Kurokawa, K; Miyata, T; Saito, A; Ueda, Y; van Ypersele de Strihou, C; Wada, T; Yamada, Y, 1998) |
| "Pentosidine levels were determined at intervals by HPLC assay." | 1.30 | Accumulation of carbonyls accelerates the formation of pentosidine, an advanced glycation end product: carbonyl stress in uremia. ( Izuhara, Y; Jadoul, M; Kurokawa, K; Miyata, T; Saito, A; Ueda, Y; van Ypersele de Strihou, C; Wada, T; Yamada, Y, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lamb, EJ | 1 |
| Cattell, WR | 1 |
| Dawnay, AB | 1 |
| Vlassara, H | 1 |
| Friedman, EA | 2 |
| Distant, DA | 1 |
| Fleishhacker, JF | 1 |
| Boyd, TA | 1 |
| Cartwright, K | 1 |
| Miyata, T | 1 |
| Ueda, Y | 1 |
| Yamada, Y | 1 |
| Izuhara, Y | 1 |
| Wada, T | 1 |
| Jadoul, M | 1 |
| Saito, A | 1 |
| Kurokawa, K | 1 |
| van Ypersele de Strihou, C | 1 |
| Weiss, MF | 1 |
| Saxena, AK | 1 |
| Monnier, VM | 1 |
| Brown, CD | 1 |
| Zhao, ZH | 1 |
| Thomas, LL | 1 |
| deGroof, R | 1 |
1 review available for pimagedine and Uremia
| Article | Year |
|---|---|
Serum advanced glycosylation end products: a new class of uremic toxins?
Topics: Animals; Blood Proteins; Combined Modality Therapy; Diabetes Mellitus, Experimental; Diabetic Nephro | 1994 |
1 trial available for pimagedine and Uremia
| Article | Year |
|---|---|
Effects of erythropoietin and aminoguanidine on red blood cell deformability in diabetic azotemic and uremic patients.
Topics: Area Under Curve; Diabetic Nephropathies; Drug Therapy, Combination; Erythrocyte Deformability; Eryt | 2001 |
4 other studies available for pimagedine and Uremia
| Article | Year |
|---|---|
In vitro formation of advanced glycation end products in peritoneal dialysis fluid.
Topics: Buffers; Dialysis Solutions; Fluorescence; Glycated Serum Albumin; Glycation End Products, Advanced; | 1995 |
Aminoguanidine prolongs survival in azotemic-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Glycation End P | 1997 |
Accumulation of carbonyls accelerates the formation of pentosidine, an advanced glycation end product: carbonyl stress in uremia.
Topics: Aged; Aldehydes; Arginine; Carboxylic Acids; Deoxyglucose; Depression, Chemical; Esters; Glycosylati | 1998 |
Pharmacological modulation of AGEs: a unique role for redox-active metal ions.
Topics: Animals; Antioxidants; Chelating Agents; Diabetes Mellitus; Glycation End Products, Advanced; Guanid | 1999 |