pimagedine has been researched along with Sepsis in 21 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sepsis is an arginine-deficient state and is associated with overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS)." | 7.74 | The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model. ( Akaishi, S; Endo, T; Hojo, N; Kobayashi, M; Kudo, D; Nomura, R; Sasaki, J; Shinozawa, Y; Takuma, K; Xie, XQ; Yamanouchi, S, 2008) |
| "Sepsis is an arginine-deficient state and is associated with overproduction of nitric oxide (NO) by inducible nitric oxide synthase (iNOS)." | 3.74 | The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model. ( Akaishi, S; Endo, T; Hojo, N; Kobayashi, M; Kudo, D; Nomura, R; Sasaki, J; Shinozawa, Y; Takuma, K; Xie, XQ; Yamanouchi, S, 2008) |
| "Sepsis was induced by cecal ligation and perforation in rats." | 1.32 | Septic diaphragmatic dysfunction is prevented by Mn(III)porphyrin therapy and inducible nitric oxide synthase inhibition. ( Alfonso, E; Batthyány, C; Boggia, J; Botti, H; Cassina, A; Hurtado, FJ; Nin, N; Peluffo, G; Radi, R; Rubbo, H; Trostchansky, A, 2004) |
| "Sepsis was induced by the intravenous administration of E." | 1.31 | Hemodynamic, biochemical and morphological changes induced by aminoguanidine in normal and septic sheep. ( Delgado, MA; Esteban, A; Fernández-Segoviano, P; Jara, N; Lorente, JA; Moscoso, A; Rodríguez-Corcos, A; Tejedor, C; Tobalina, R, 2000) |
| "Although sepsis is known to affect vascular function, little is known about changes at the capillary level." | 1.30 | Capillary and arteriolar responses to local vasodilators are impaired in a rat model of sepsis. ( McCormack, DG; Tyml, K; Yu, J, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shafaroodi, H | 1 |
| Hassanipour, M | 1 |
| Mousavi, Z | 1 |
| Rahimi, N | 1 |
| Dehpour, AR | 1 |
| Bruhn, FH | 1 |
| Corrêa, PB | 2 |
| Oliveira-Pelegrin, GR | 2 |
| Rocha, MJ | 3 |
| Branco, LG | 1 |
| Ishikawa, K | 1 |
| Calzavacca, P | 1 |
| Bellomo, R | 1 |
| Bailey, M | 1 |
| May, CN | 1 |
| Seija, M | 1 |
| Baccino, C | 1 |
| Nin, N | 2 |
| Sánchez-Rodríguez, C | 1 |
| Granados, R | 1 |
| Ferruelo, A | 1 |
| Martínez-Caro, L | 1 |
| Ruíz-Cabello, J | 1 |
| de Paula, M | 1 |
| Noboa, O | 1 |
| Esteban, A | 2 |
| Lorente, JA | 2 |
| Anderson, RJ | 1 |
| Raykova, VD | 1 |
| Glibetic, M | 1 |
| Ofenstein, JP | 1 |
| Aranda, JV | 1 |
| HOFFMAN, DB | 1 |
| POLLACK, E | 1 |
| Puliti, M | 1 |
| von Hunolstein, C | 1 |
| Bistoni, F | 1 |
| Orefici, G | 1 |
| Tissi, L | 1 |
| Cassina, A | 1 |
| Boggia, J | 1 |
| Alfonso, E | 1 |
| Botti, H | 1 |
| Peluffo, G | 1 |
| Trostchansky, A | 1 |
| Batthyány, C | 1 |
| Radi, R | 1 |
| Rubbo, H | 1 |
| Hurtado, FJ | 1 |
| Pancoto, JA | 1 |
| de Oliveira-Pelegrin, GR | 1 |
| Cárnio, EC | 1 |
| Astolfi, RS | 1 |
| Khouri, DG | 1 |
| Brandizzi, LI | 1 |
| Avila-Campos, MJ | 1 |
| Andrade, HF | 1 |
| Xie, XQ | 1 |
| Shinozawa, Y | 1 |
| Sasaki, J | 1 |
| Takuma, K | 1 |
| Akaishi, S | 1 |
| Yamanouchi, S | 1 |
| Endo, T | 1 |
| Nomura, R | 1 |
| Kobayashi, M | 1 |
| Kudo, D | 1 |
| Hojo, N | 1 |
| Fretland, DJ | 1 |
| Anglin, C | 1 |
| Widomski, D | 1 |
| Connor, J | 1 |
| Wyatt, P | 1 |
| Manning, P | 1 |
| Currie, M | 1 |
| Tyml, K | 1 |
| Yu, J | 1 |
| McCormack, DG | 2 |
| Alden, KJ | 1 |
| Motew, SJ | 1 |
| Sharma, AC | 1 |
| Ferguson, JL | 1 |
| Tunçtan, B | 1 |
| Uludag, O | 1 |
| Altug, S | 1 |
| Abacioglu, N | 1 |
| Scott, JA | 1 |
| Wang, Y | 1 |
| Steinsland, OS | 1 |
| Nelson, SH | 1 |
| Benjamim, CF | 1 |
| Ferreira, SH | 1 |
| Cunha, FQ | 1 |
| Tejedor, C | 1 |
| Delgado, MA | 1 |
| Fernández-Segoviano, P | 1 |
| Jara, N | 1 |
| Tobalina, R | 1 |
| Rodríguez-Corcos, A | 1 |
| Moscoso, A | 1 |
21 other studies available for pimagedine and Sepsis
| Article | Year |
|---|---|
The Effects of Sub-Chronic Treatment with Pioglitazone on the Septic Mice Mortality in the Model of Cecal Ligation and Puncture: Involvement of Nitric Oxide Pathway.
Topics: Animals; Cecum; Cytokines; Disease Models, Animal; Guanidines; Ligation; Male; Mice; Nitric Oxide; N | 2015 |
Blocking systemic nitric oxide production alters neuronal activation in brain structures involved in cardiovascular regulation during polymicrobial sepsis.
Topics: Animals; Area Postrema; Cardiovascular Physiological Phenomena; Guanidines; Locus Coeruleus; Male; M | 2009 |
Central NO-cGMP pathway in thermoregulation and survival rate during polymicrobial sepsis.
Topics: Animals; Body Temperature; Body Temperature Regulation; Cecum; Cyclic GMP; Guanidines; Injections, I | 2010 |
Effect of selective inhibition of renal inducible nitric oxide synthase on renal blood flow and function in experimental hyperdynamic sepsis.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Female; Guanidines; Hemodynamics; Infusions, I | 2012 |
Role of peroxynitrite in sepsis-induced acute kidney injury in an experimental model of sepsis in rats.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Aorta; Blood Flow Velocity; Blood Pressure; Dise | 2012 |
Acute kidney injury with sepsis: is nitric oxide a friend, foe, both, or neither?
Topics: Animals; Female; Guanidines; Nitric Oxide Synthase Type II; Renal Circulation; Sepsis | 2012 |
Nitric oxide-dependent regulation of pro-inflammatory cytokines in group B streptococcal inflammation of rat lung.
Topics: Animals; Arginine; Chemokine CXCL2; Chemokines, CXC; Gene Expression; Guanidines; Intercellular Sign | 2003 |
The protective effect of an antihistaminic on the toxemia-like changes caused by aminoguanidine sulfate in pregnant rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Cyproheptadine; Female; Guanidines; Pre-Eclampsia; Pregn | 1963 |
Inhibition of nitric oxide synthase exacerbates group B streptococcus sepsis and arthritis in mice.
Topics: Animals; Animals, Outbred Strains; Arthritis, Infectious; Enzyme Inhibitors; Female; Guanidines; Hum | 2004 |
Septic diaphragmatic dysfunction is prevented by Mn(III)porphyrin therapy and inducible nitric oxide synthase inhibition.
Topics: Animals; Blood Pressure; Diaphragm; Enzyme Inhibitors; Guanidines; Heart Rate; Male; Metalloporphyri | 2004 |
Participation of iNOS-derived NO in hypothalamic activation and vasopressin release during polymicrobial sepsis.
Topics: Animals; Bacterial Infections; Blood Pressure; Drinking; Enzyme Inhibitors; Gene Expression Regulati | 2007 |
Antagonic effect of the inhibition of inducible nitric oxide on the mortality of mice acutely infected with Escherichia coli and Bacteroides fragilis.
Topics: Acute Disease; Animals; Bacteroides fragilis; Bacteroides Infections; Disease Models, Animal; Escher | 2007 |
The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model.
Topics: Animals; Arginine; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Guanidines; | 2008 |
Temporal relationships of cytokine production in mouse non-lethal sepsis: effect of nitric oxide synthase inhibitors.
Topics: Animals; Cytokines; Enzyme Inhibitors; Guanidines; Interleukin-1; Interleukin-10; Kinetics; Lipopoly | 1997 |
Capillary and arteriolar responses to local vasodilators are impaired in a rat model of sepsis.
Topics: Acetylcholine; Animals; Arterioles; Body Weight; Capillaries; Enzyme Inhibitors; Guanidines; Iontoph | 1998 |
Effect of aminoguanidine on plasma nitric oxide by-products and blood flow during chronic peritoneal sepsis.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Enzyme Inhibitors; Guanidines; Heart Rate; Hemodynamic | 1998 |
Effects of nitric oxide synthase inhibition in lipopolysaccharide-induced sepsis in mice.
Topics: Animals; Econazole; Enzyme Inhibitors; Female; Guanidines; Lipopolysaccharides; Male; Mice; Nitric O | 1998 |
Selective in vivo inhibition of inducible nitric oxide synthase in a rat model of sepsis.
Topics: Animals; Aorta, Thoracic; Blood Gas Analysis; Blood Pressure; Blood Vessels; Cecum; Enzyme Inhibitor | 1999 |
A role for nitric oxide in endotoxin-induced depletion of the peripheral catecholamine stores.
Topics: Adrenal Glands; Animals; Aorta; Arteries; Enzyme Inhibitors; Epinephrine; Female; Guanidines; Lipopo | 2000 |
Role of nitric oxide in the failure of neutrophil migration in sepsis.
Topics: Animals; Ascitic Fluid; Bacteremia; Cell Movement; Colony Count, Microbial; Cytokines; Disease Model | 2000 |
Hemodynamic, biochemical and morphological changes induced by aminoguanidine in normal and septic sheep.
Topics: Acidosis; Analysis of Variance; Animals; Blood Pressure; Case-Control Studies; Enzyme Inhibitors; Gu | 2000 |