pimagedine has been researched along with Seizures in 17 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was designed to investigate whether acute or subchronic treatment with coenzyme Q10 altered the seizures induced by pentylenetetrazole or electroshock in mice." | 7.80 | The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide. ( Moezi, L; Mousavi, Z; Sattarinezhad, E; Shafaroodi, H; Sheikhnouri, K, 2014) |
| "The present study demonstrates the anticonvulsant effect of acute pioglitazone on PTZ-induced seizures in mice." | 7.78 | Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in mice. ( Adabi Mohazab, R; Dehpour, AR; Delfan, B; Javadi-Paydar, M, 2012) |
| "Aripiprazole is a novel atypical antipsychotic." | 5.42 | The Effects of Sub-Chronic Treatment with Aripiprazole on Pentylenetetrazole- and Electroshock-Induced Seizures in Mice: The Role of Nitric Oxide. ( Hosseini, M; Moezi, L; Niknahad, H; Oveisi, S; Shafaroodi, H, 2015) |
| "Aripiprazole is an antipsychotic drug which acts through dopamine and serotonin receptors." | 5.42 | The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide. ( Hosseini, M; Moezi, L; Niknahad, H; Oveisi, S; Shafaroodi, H, 2015) |
| " This study investigates the effect of Arginine-Vasopressin (AVP) in pentylenetetrazol (PTZ)-induced seizures threshold and the probable role of nitric oxide (NO)." | 3.83 | The modulatory effect of nitric oxide in pro- and anti-convulsive effects of vasopressin in PTZ-induced seizures threshold in mice. ( Dehpour, AR; Doustimotlagh, AH; Javadi-Paydar, M; Javadian, N; Rahimi, N, 2016) |
| " This study was designed to investigate whether acute or subchronic treatment with coenzyme Q10 altered the seizures induced by pentylenetetrazole or electroshock in mice." | 3.80 | The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide. ( Moezi, L; Mousavi, Z; Sattarinezhad, E; Shafaroodi, H; Sheikhnouri, K, 2014) |
| "The present study was designed to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice." | 3.79 | Involvement of the nitric oxide/cyclic guanylate monophosphate pathway in the pilocarpine-induced seizure model in mice. ( Cavalcante Melo, FH; de Carvalho Lima, CN; de França Fonteles, MM; Freire Vasconcelos, L; Leite Dias, M; Moura Rocha, NF; Rodrigues Carvalho, AM; Soares Lopes, K; Vasconcelos Rios, ER, 2013) |
| "The present study demonstrates the anticonvulsant effect of acute pioglitazone on PTZ-induced seizures in mice." | 3.78 | Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in mice. ( Adabi Mohazab, R; Dehpour, AR; Delfan, B; Javadi-Paydar, M, 2012) |
| " In the present study, the involvement of NO pathway in the anticonvulsant effect of melatonin in pentylenetetrazole (PTZ)-induced clonic seizures was investigated in mice." | 3.73 | Involvement of nitric oxide pathway in the acute anticonvulsant effect of melatonin in mice. ( Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N, 2006) |
| "Determination of seizure threshold revealed significant enhancement after preconditioning with low dose of PTZ." | 1.51 | The Possible Role of Nitric Oxide Pathway in Pentylenetetrazole Preconditioning Against Seizure in Mice. ( Bahramnejad, E; Dehpour, AR; Faghir-Ghanesefat, H; Kazemi Roodsari, S; Keshavarz-Bahaghighat, H; Mokhtari, T; Rajai, N, 2019) |
| "Methadone is a synthetic opioid used to treat opiate withdrawal and addiction." | 1.51 | Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling. ( Aghaei, I; Bahramnejad, E; Dehpour, AR; Kazemi Roodsari, S; Rahimi, N, 2019) |
| "Chloroquine has long been used for the treatment of malaria and rheumatological disorders." | 1.43 | Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice. ( Abkhoo, A; Amiri, S; Boojar, MM; Dehpour, AR; Delazar, S; Hassanipour, M; Ostadhadi, S; Rahimi, N; Shirzadian, A, 2016) |
| "Aripiprazole is a novel atypical antipsychotic." | 1.42 | The Effects of Sub-Chronic Treatment with Aripiprazole on Pentylenetetrazole- and Electroshock-Induced Seizures in Mice: The Role of Nitric Oxide. ( Hosseini, M; Moezi, L; Niknahad, H; Oveisi, S; Shafaroodi, H, 2015) |
| "Aripiprazole is an antipsychotic drug which acts through dopamine and serotonin receptors." | 1.42 | The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide. ( Hosseini, M; Moezi, L; Niknahad, H; Oveisi, S; Shafaroodi, H, 2015) |
| "Atorvastatin has neuroprotective effects, and there is some evidence that nitric oxide is involved in atorvastatin effects." | 1.38 | Chronic administration of atorvastatin induced anti-convulsant effects in mice: the role of nitric oxide. ( Dehpour, AR; Fakhrzad, A; Hassanipour, M; Hassanpour, S; Moezi, L; Shafaroodi, H, 2012) |
| "Severity of kindled seizures was assessed in terms of a composite kindled seizure severity score (KSSS)." | 1.35 | Pharmacological inhibition of inducible nitric oxide synthase attenuates the development of seizures in mice. ( Kalra, R; Rehni, AK; Singh, N; Singh, TG, 2009) |
| "Furthermore, the increase in seizure threshold elicited by adenosine (100 mg/kg i." | 1.35 | Nitric oxide signaling pathway in the anti-convulsant effect of adenosine against pentylenetetrazol-induced seizure threshold in mice. ( Akula, KK; Dhir, A; Kulkarni, SK, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 12 (70.59) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Faghir-Ghanesefat, H | 1 |
| Keshavarz-Bahaghighat, H | 1 |
| Rajai, N | 1 |
| Mokhtari, T | 1 |
| Bahramnejad, E | 2 |
| Kazemi Roodsari, S | 2 |
| Dehpour, AR | 8 |
| Rahimi, N | 3 |
| Aghaei, I | 1 |
| Dastgheib, M | 1 |
| Moezi, L | 5 |
| Sattarinezhad, E | 1 |
| Shafaroodi, H | 4 |
| Sheikhnouri, K | 1 |
| Mousavi, Z | 1 |
| Hosseini, M | 2 |
| Oveisi, S | 2 |
| Niknahad, H | 2 |
| Hassanipour, M | 2 |
| Shirzadian, A | 1 |
| Boojar, MM | 1 |
| Abkhoo, A | 2 |
| Delazar, S | 1 |
| Amiri, S | 1 |
| Ostadhadi, S | 1 |
| Javadian, N | 1 |
| Javadi-Paydar, M | 2 |
| Doustimotlagh, AH | 1 |
| Rehni, AK | 1 |
| Singh, TG | 1 |
| Kalra, R | 1 |
| Singh, N | 1 |
| Krushinskii, AL | 1 |
| Kuzenkov, VS | 1 |
| D'yakonova, VE | 1 |
| Reutov, VP | 1 |
| Fakhrzad, A | 1 |
| Hassanpour, S | 1 |
| Adabi Mohazab, R | 1 |
| Delfan, B | 1 |
| Vasconcelos Rios, ER | 1 |
| Moura Rocha, NF | 1 |
| Rodrigues Carvalho, AM | 1 |
| Freire Vasconcelos, L | 1 |
| Leite Dias, M | 1 |
| de Carvalho Lima, CN | 1 |
| Soares Lopes, K | 1 |
| Cavalcante Melo, FH | 1 |
| de França Fonteles, MM | 1 |
| Yahyavi-Firouz-Abadi, N | 1 |
| Tahsili-Fahadan, P | 1 |
| Riazi, K | 1 |
| Ghahremani, MH | 1 |
| Akula, KK | 1 |
| Dhir, A | 1 |
| Kulkarni, SK | 1 |
| Okuda, Y | 1 |
| Sakoda, S | 1 |
| Fujimura, H | 1 |
| Yanagihara, T | 1 |
| Homayoun, H | 1 |
| Khavandgar, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 other studies available for pimagedine and Seizures
| Article | Year |
|---|---|
The Possible Role of Nitric Oxide Pathway in Pentylenetetrazole Preconditioning Against Seizure in Mice.
Topics: Animals; Brain; Enzyme Inhibitors; GABA Antagonists; Guanidines; Indazoles; Male; Mice; NG-Nitroargi | 2019 |
Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling.
Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Guanidines; Indazoles; Ketamine; Male; Methadone; Mic | 2019 |
Acute and chronic effects of agomelatine on intravenous penthylenetetrazol-induced seizure in mice and the probable role of nitric oxide.
Topics: Acetamides; Administration, Intravenous; Animals; Anticonvulsants; Convulsants; Guanidines; Indazole | 2014 |
The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide.
Topics: Animals; Arginine; Brain; Disease Models, Animal; Electroshock; Epilepsy, Tonic-Clonic; Guanidines; | 2014 |
The Effects of Sub-Chronic Treatment with Aripiprazole on Pentylenetetrazole- and Electroshock-Induced Seizures in Mice: The Role of Nitric Oxide.
Topics: Animals; Anticonvulsants; Arginine; Aripiprazole; Convulsants; Electroshock; Guanidines; Indazoles; | 2015 |
The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Arginine; Aripiprazole; Convulsants; Dose-Response R | 2015 |
Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Arginine; Chloroquine; Disease M | 2016 |
The modulatory effect of nitric oxide in pro- and anti-convulsive effects of vasopressin in PTZ-induced seizures threshold in mice.
Topics: Animals; Anticonvulsants; Antidiuretic Hormone Receptor Antagonists; Arginine; Arginine Vasopressin; | 2016 |
Pharmacological inhibition of inducible nitric oxide synthase attenuates the development of seizures in mice.
Topics: Analysis of Variance; Animals; Convulsants; Guanidines; Male; Mice; Nitric Oxide Synthase Type II; P | 2009 |
Effect of inhibitors of inducible and neuronal NO synthases on the development of audiogenic stress-induced damage in Krushinskii-Molodkina rats.
Topics: Animals; Enzyme Inhibitors; Guanidines; Indazoles; Male; Nitric Oxide Synthase Type I; Nitric Oxide | 2010 |
Chronic administration of atorvastatin induced anti-convulsant effects in mice: the role of nitric oxide.
Topics: Analysis of Variance; Animals; Anticonvulsants; Atorvastatin; Convulsants; Disease Models, Animal; D | 2012 |
Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in mice.
Topics: Anilides; Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Enzyme | 2012 |
Involvement of the nitric oxide/cyclic guanylate monophosphate pathway in the pilocarpine-induced seizure model in mice.
Topics: Amidines; Animals; Arginine; Benzylamines; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Gu | 2013 |
Involvement of nitric oxide pathway in the acute anticonvulsant effect of melatonin in mice.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Drug Therapy, Com | 2006 |
Nitric oxide signaling pathway in the anti-convulsant effect of adenosine against pentylenetetrazol-induced seizure threshold in mice.
Topics: Adenosine; Animals; Anticonvulsants; Arginine; Convulsants; Cyclic AMP; Cyclic Nucleotide Phosphodie | 2008 |
Aminoguanidine, a selective inhibitor of the inducible nitric oxide synthase, has different effects on experimental allergic encephalomyelitis in the induction and progression phase.
Topics: Acute Disease; Animals; Autoimmune Diseases; Disease Progression; Drug Administration Schedule; Ence | 1998 |
Anticonvulsant effects of cyclosporin A on pentylenetetrazole-induced seizure and kindling: modulation by nitricoxidergic system.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Cyclosporine; Dose-Response Relationship, Drug; Enz | 2002 |