pimagedine has been researched along with Reperfusion Injury in 46 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
Excerpt | Relevance | Reference |
---|---|---|
"This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia-reperfusion in the rat intestine." | 7.70 | Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion. ( Fujimoto, K; Fukuyama, K; Iwakiri, R; Kojima, M; Noda, T; Okamoto, K; Yoshida, T, 2000) |
"Recent studies have demonstrated a connection between xanthine oxidase-generated reactive oxygen intermediates and histamine release during ischemia-reperfusion." | 7.68 | Studies on the relationship between xanthine oxidase and histamine release during intestinal ischemia-reperfusion. ( Bakó, L; Boros, M; Kaszaki, J; Nagy, S, 1992) |
"Ozone treatment may have important clinical implications, particularly in view of the minimizing renal damage before transplantation." | 5.35 | Ozone oxidative preconditioning protects the rat kidney from reperfusion injury: the role of nitric oxide. ( Chen, H; Chen, Z; Liu, X; Xing, B; Zhan, B; Zhou, J; Zhu, H, 2008) |
"This study aimed to examine the relationship between a harmful effect of histamine and apoptosis following ischemia-reperfusion in the rat intestine." | 3.70 | Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion. ( Fujimoto, K; Fukuyama, K; Iwakiri, R; Kojima, M; Noda, T; Okamoto, K; Yoshida, T, 2000) |
"Recent studies have demonstrated a connection between xanthine oxidase-generated reactive oxygen intermediates and histamine release during ischemia-reperfusion." | 3.68 | Studies on the relationship between xanthine oxidase and histamine release during intestinal ischemia-reperfusion. ( Bakó, L; Boros, M; Kaszaki, J; Nagy, S, 1992) |
"Acute kidney injury is usually associated with distant organ dysfunction." | 1.43 | Distant effects of unilateral renal ischemia/reperfusion on contralateral kidney but not lung in rats: the roles of ROS and iNOS. ( Fatemikia, H; Karimi, Z; Ketabchi, F; Moosavi, SM, 2016) |
"Ozone treatment may have important clinical implications, particularly in view of the minimizing renal damage before transplantation." | 1.35 | Ozone oxidative preconditioning protects the rat kidney from reperfusion injury: the role of nitric oxide. ( Chen, H; Chen, Z; Liu, X; Xing, B; Zhan, B; Zhou, J; Zhu, H, 2008) |
"Liver ischemia-reperfusion injury is a serious problem during liver resection and transplantation." | 1.32 | The role of nitric oxide after a short period of liver ischemia-reperfusion. ( Kawachi, S; Kitajima, M; Matsumoto, K; Morisue, A; Mukai, M; Shimazu, M; Tanabe, M; Wakabayashi, G; Yamamoto, S; Yoshida, M, 2003) |
"3." | 1.30 | Pacing-induced delayed protection against arrhythmias is attenuated by aminoguanidine, an inhibitor of nitric oxide synthase. ( Kis, A; Papp, J; Parratt, J; Végh, A, 1999) |
"During a cerebral infarction, a complex cascade of cytotoxic events ultimately determines the volume of brain cell loss." | 1.29 | Cerebroprotective effects of aminoguanidine in a rodent model of stroke. ( Bloom, O; Cerami, A; Cockroft, KM; Meistrell, M; Risucci, D; Tracey, KJ; Zimmerman, GA, 1996) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 10 (21.74) | 18.2507 |
2000's | 28 (60.87) | 29.6817 |
2010's | 8 (17.39) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Solanki, S | 1 |
Srinivas, M | 1 |
Sinha, A | 1 |
Mittal, D | 1 |
Mallick, S | 1 |
Agarwala, S | 1 |
Bhatnagar, V | 1 |
Alipour, M | 2 |
Mohsen, A | 1 |
Gadiri-Soufi, F | 1 |
Farhad, GS | 1 |
Jafari, MR | 1 |
Mohammad-Reza, J | 1 |
Fatemikia, H | 1 |
Ketabchi, F | 1 |
Karimi, Z | 1 |
Moosavi, SM | 1 |
Shin, JK | 1 |
Kang, JW | 1 |
Lee, SM | 1 |
Franco, PJ | 1 |
Fernandez, DC | 1 |
Sande, PH | 1 |
Keller Sarmiento, MI | 1 |
Chianelli, M | 1 |
Sáenz, DA | 1 |
Rosenstein, RE | 1 |
Breithaupt-Faloppa, AC | 1 |
Vitoretti, LB | 1 |
Coelho, FR | 2 |
dos Santos Franco, AL | 1 |
Domingos, HV | 2 |
Sudo-Hayashi, LS | 2 |
Oliveira-Filho, RM | 3 |
Tavares de Lima, W | 2 |
Onem, Y | 1 |
Ipcioglu, OM | 1 |
Haholu, A | 1 |
Sen, H | 1 |
Aydinoz, S | 1 |
Suleymanoglu, S | 1 |
Bilgi, O | 1 |
Akyol, I | 1 |
Hüser, N | 1 |
Doll, D | 1 |
Altomonte, J | 1 |
Werner, M | 1 |
Kriner, M | 1 |
Preissel, A | 1 |
Thorban, S | 1 |
Matevossian, E | 1 |
Zheng, L | 2 |
Liu, S | 1 |
Sun, MZ | 1 |
Chang, J | 1 |
Chance, MR | 1 |
Kern, TS | 2 |
Zhang, R | 1 |
Dong, J | 1 |
Xu, YG | 1 |
Hua, WY | 1 |
Wen, N | 1 |
You, QD | 1 |
Shi, ZL | 1 |
Ling, YL | 1 |
Yao, YX | 1 |
Zhou, JL | 1 |
Jackman, KA | 1 |
Brait, VH | 1 |
Wang, Y | 1 |
Maghzal, GJ | 1 |
Ball, HJ | 1 |
McKenzie, G | 1 |
De Silva, TM | 1 |
Stocker, R | 1 |
Sobey, CG | 1 |
Belaidi, E | 1 |
Beguin, PC | 1 |
Levy, P | 1 |
Ribuot, C | 1 |
Godin-Ribuot, D | 1 |
Gholami, MR | 1 |
Jafari Anarkooli, I | 1 |
Sohrabi, D | 1 |
Tajki, J | 1 |
Pourheidar, M | 1 |
Takizawa, Y | 1 |
Kitazato, T | 1 |
Ishizaka, H | 1 |
Kamiya, N | 1 |
Tomita, M | 1 |
Hayashi, M | 1 |
Zhu, DY | 1 |
Deng, Q | 1 |
Yao, HH | 1 |
Wang, DC | 1 |
Deng, Y | 1 |
Liu, GQ | 1 |
Badhwar, A | 1 |
Dungey, AA | 1 |
Harris, KA | 1 |
Scott, JA | 1 |
McCarter, SD | 1 |
Scott, JR | 1 |
Forbes, TL | 1 |
Potter, RF | 1 |
Morisue, A | 1 |
Wakabayashi, G | 1 |
Shimazu, M | 1 |
Tanabe, M | 1 |
Mukai, M | 1 |
Matsumoto, K | 1 |
Kawachi, S | 1 |
Yoshida, M | 1 |
Yamamoto, S | 1 |
Kitajima, M | 1 |
Cavriani, G | 2 |
Trezena, AG | 1 |
da Silva, ZL | 1 |
de Arruda, MJ | 1 |
Jancar, S | 1 |
Zimiani, K | 1 |
Guarnier, FA | 1 |
Miranda, HC | 1 |
Watanabe, MA | 1 |
Cecchini, R | 1 |
Barocelli, E | 1 |
Ballabeni, V | 1 |
Ghizzardi, P | 1 |
Cattaruzza, F | 1 |
Bertoni, S | 1 |
Lagrasta, CA | 1 |
Impicciatore, M | 1 |
Cao, DQ | 1 |
Chen, YP | 1 |
Chang, YT | 1 |
Li, YG | 1 |
Gong, B | 1 |
Hatala, DA | 1 |
Wu, D | 1 |
Bassuk, J | 1 |
Arias, J | 1 |
Kurlansky, P | 1 |
Lozano, H | 1 |
Lamas, G | 1 |
Adams, JA | 1 |
Soares, AL | 1 |
Teixeira, SA | 1 |
Almeida, PC | 1 |
Muscará, MN | 1 |
Vargaftig, BB | 1 |
Tavares-de-Lima, W | 1 |
Vakili, A | 2 |
Hosseinzadeh, F | 1 |
Sadogh, T | 1 |
Joviliano, EE | 1 |
Piccinato, CE | 1 |
Cherri, J | 1 |
Viaro, F | 1 |
Moryia, T | 1 |
Celotto, AC | 1 |
Bonaventura, D | 1 |
Evora, PR | 1 |
Uchida, K | 1 |
Mishima, S | 1 |
Ohta, S | 1 |
Yukioka, T | 1 |
Zahedi-Khorasani, M | 1 |
Yaylak, F | 1 |
Canbaz, H | 1 |
Caglikulekci, M | 1 |
Dirlik, M | 1 |
Tamer, L | 1 |
Ogetman, Z | 1 |
Polat, Y | 1 |
Kanik, A | 1 |
Aydin, S | 1 |
Chen, H | 1 |
Xing, B | 1 |
Liu, X | 1 |
Zhan, B | 1 |
Zhou, J | 1 |
Zhu, H | 1 |
Chen, Z | 1 |
Knox, LK | 1 |
Stewart, AG | 1 |
Hayward, PG | 1 |
Morrison, WA | 1 |
Kaszaki, J | 2 |
Boros, M | 2 |
Szabó, A | 1 |
Nagy, S | 2 |
Cockroft, KM | 1 |
Meistrell, M | 1 |
Zimmerman, GA | 1 |
Risucci, D | 1 |
Bloom, O | 1 |
Cerami, A | 1 |
Tracey, KJ | 1 |
Oshima, H | 1 |
Tassiopoulos, AK | 1 |
Carlin, RE | 1 |
Gao, Y | 1 |
Pedoto, A | 1 |
Finck, CM | 1 |
Landas, SK | 1 |
Tice, DG | 1 |
Marx, W | 1 |
Hakim, TS | 1 |
McGraw, DJ | 1 |
Lu, YT | 1 |
Liu, SF | 1 |
Mitchell, JA | 1 |
Malik, AB | 1 |
Hellewell, PG | 1 |
Evans, TW | 1 |
Takizawa, S | 1 |
Fukuyama, N | 1 |
Hirabayashi, H | 1 |
Nakazawa, H | 1 |
Shinohara, Y | 1 |
Kis, A | 1 |
Végh, A | 1 |
Papp, J | 1 |
Parratt, J | 1 |
Lo, CC | 1 |
Chen, JC | 2 |
Chen, HM | 2 |
Shyr, MH | 2 |
Lau, YT | 1 |
Lin, JN | 1 |
Chen, MF | 2 |
Fan, LL | 1 |
Chi, TY | 1 |
Chi, CP | 1 |
Yoshida, T | 1 |
Iwakiri, R | 1 |
Noda, T | 1 |
Okamoto, K | 1 |
Kojima, M | 1 |
Fukuyama, K | 1 |
Fujimoto, K | 1 |
Cash, D | 1 |
Beech, JS | 1 |
Rayne, RC | 1 |
Bath, PM | 1 |
Meldrum, BS | 1 |
Williams, SC | 1 |
Tabuchi, K | 1 |
Tsuji, S | 1 |
Asaka, Y | 1 |
Hara, A | 1 |
Kusakari, J | 1 |
Harada, N | 1 |
Okajima, K | 1 |
Uchiba, M | 1 |
Katsuragi, T | 1 |
Bakó, L | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Phase II Study of the Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage[NCT01095731] | Phase 2 | 60 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
46 other studies available for pimagedine and Reperfusion Injury
Article | Year |
---|---|
Histopathological changes at colonic anastomotic site after ischemia reperfusion injury: role of aminoguanidine in experimental model.
Topics: Anastomosis, Surgical; Animals; Collagen; Colon; Female; Guanidines; Humans; Intestinal Mucosa; Mode | 2015 |
Effect of aminoguanidine on sciatic functional index, oxidative stress, and rate of apoptosis in an experimental rat model of ischemia-reperfusion injury.
Topics: Animals; Antioxidants; Apoptosis; Guanidines; Male; Oxidative Stress; Rats, Sprague-Dawley; Reperfus | 2014 |
Distant effects of unilateral renal ischemia/reperfusion on contralateral kidney but not lung in rats: the roles of ROS and iNOS.
Topics: Acute Kidney Injury; alpha-Tocopherol; Animals; Antioxidants; Disease Models, Animal; Enzyme Inhibit | 2016 |
Enhanced nitric oxide-mediated autophagy contributes to the hepatoprotective effects of ischemic preconditioning during ischemia and reperfusion.
Topics: Animals; Autophagy; Chloroquine; Guanidines; Imidazoles; Ischemia; Ischemic Preconditioning; Liver; | 2016 |
Effect of bacterial lipopolysaccharide on ischemic damage in the rat retina.
Topics: Animals; Dose-Response Relationship, Drug; Electroretinography; Enzyme Inhibitors; Guanidines; Injec | 2008 |
Nitric oxide mediates lung vascular permeability and lymph-borne IL-6 after an intestinal ischemic insult.
Topics: Animals; Capillary Permeability; Cells, Cultured; Endothelial Cells; Guanidines; Humans; Immunohisto | 2009 |
Posttreatment with aminoguanidine attenuates renal ischemia/reperfusion injury in rats.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Drug Administration Schedule; Enzyme Inhibitors; | 2009 |
Graft preconditioning with low-dose tacrolimus (FK506) and nitric oxide inhibitor aminoguanidine (AGH) reduces ischemia/reperfusion injury after liver transplantation in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Guanidines; Liver; Liver Trans | 2009 |
Pharmacologic intervention targeting glycolytic-related pathways protects against retinal injury due to ischemia and reperfusion.
Topics: Analysis of Variance; Animals; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Gene Expres | 2009 |
Synthesis and bioactivity of substituted indan-1-ylideneaminoguanidine derivatives.
Topics: Animals; Blood Platelets; Cardiotonic Agents; Female; Guanidines; Indans; Male; Myocardial Infarctio | 2009 |
[Changes of iNOS genes expression in liver following ischemia and reperfusion of limbs and their significance in rats].
Topics: Animals; Guanidines; Hindlimb; Liver; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Typ | 2004 |
Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice.
Topics: Animals; Arterioles; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Immunoh | 2011 |
Delayed myocardial preconditioning induced by cobalt chloride in the rat: HIF-1α and iNOS involvement.
Topics: Animals; Cadmium; Cardiotonic Agents; Cobalt; Guanidines; Heart; Hypoxia; Hypoxia-Inducible Factor 1 | 2012 |
Intraperitoneal aminoguanidine improves sciatic nerve ischemia-reperfusion injury in male sprague-dawley rats.
Topics: Animals; Apoptosis; Behavior, Animal; Enzyme Inhibitors; Guanidines; Injections, Intraperitoneal; Ma | 2011 |
Effect of aminoguanidine on ischemia/reperfusion injury in rat small intestine.
Topics: Animals; Area Under Curve; Enzyme Inhibitors; Guanidines; Intestine, Small; Ischemia; Male; Nitric O | 2011 |
Inducible nitric oxide synthase expression in the ischemic core and penumbra after transient focal cerebral ischemia in mice.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Enzyme Inhibitors; Guanidines; | 2002 |
Limitations of ischemic tolerance in oxidative skeletal muscle: perfusion vs tissue protection.
Topics: Animals; Calcium; Enzyme Inhibitors; Guanidines; Ischemia; Ischemic Preconditioning; Male; Microcirc | 2003 |
The role of nitric oxide after a short period of liver ischemia-reperfusion.
Topics: Animals; Enzyme Inhibitors; Guanidines; Infusions, Parenteral; Liver; Male; Microcirculation; Models | 2003 |
Lung microvascular permeability and neutrophil recruitment are differently regulated by nitric oxide in a rat model of intestinal ischemia-reperfusion.
Topics: Animals; Anti-Inflammatory Agents; Capillary Permeability; Dexamethasone; Guanidines; Inflammation; | 2004 |
Nitric oxide mediated oxidative stress injury in rat skeletal muscle subjected to ischemia/reperfusion as evaluated by chemiluminescence.
Topics: Animals; Antioxidants; Guanidines; Luminescence; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Est | 2005 |
The selective inhibition of inducible nitric oxide synthase prevents intestinal ischemia-reperfusion injury in mice.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Female; Gastrointestinal Transit; Guanidines; Intestine, | 2006 |
[Effects of aminoguanidine on the lung injury induced by the total hepatic ischemia-reperfusion in rats].
Topics: Animals; Enzyme Inhibitors; Female; Guanidines; Liver; Male; Nitric Oxide Synthase Type II; Random A | 2006 |
Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes.
Topics: Animals; Apoptosis; Blotting, Western; Capillaries; Cyclooxygenase 2; Disease Models, Animal; Guanid | 2007 |
Different roles of nitric oxide synthase isoforms in cardiopulmonary resuscitation in pigs.
Topics: Acidosis; Animals; Blood Gas Analysis; Blood Pressure; Cardiopulmonary Resuscitation; Echocardiograp | 2007 |
Lymphatic-borne IL-1beta and the inducible isoform of nitric oxide synthase trigger the bronchial hyporesponsiveness after intestinal ischema/reperfusion in rats.
Topics: Animals; Bronchial Hyperreactivity; Enzyme Inhibitors; Glyburide; Guanidines; Interleukin-10; Interl | 2007 |
Effect of aminoguanidine on post-ischemic brain edema in transient model of focal cerebral ischemia.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Infarction; Cerebral Arteries; Coloring Agents; Dos | 2007 |
In vitro pharmacological study of femoral artery vascular reactivity after inferior canine hindlimb ischemia/reperfusion: effects of in vivo nitric oxide blocker infusion.
Topics: Animals; Cyclooxygenase Inhibitors; Dogs; Endothelium-Dependent Relaxing Factors; Endothelium, Vascu | 2007 |
Inhibition of inducible nitric oxide synthase ameliorates lung injury in rats after gut ischemia-reperfusion.
Topics: Analysis of Variance; Animals; Bacterial Translocation; Chi-Square Distribution; Guanidines; Intesti | 2007 |
Effect of aminoguanidine on post-ischemic damage in rodent model of stroke.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Admini | 2008 |
Liver tissue inducible nitric oxide synthase (iNOS) expression and lipid peroxidation in experimental hepatic ischemia reperfusion injury stimulated with lipopolysaccharide: the role of aminoguanidine.
Topics: Animals; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Guanidines; Lipid Peroxidation; Lip | 2008 |
Ozone oxidative preconditioning protects the rat kidney from reperfusion injury: the role of nitric oxide.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Endothelin-1; Glutathione; Glutathion | 2008 |
Nitric oxide synthase inhibitors improve skin flap survival in the rat.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Guanidines; Male; NADPH Dehydrogenase; NG-Nitroargini | 1994 |
Role of histamine in the intestinal flow response following mesenteric ischemia.
Topics: Animals; Blood Flow Velocity; Cimetidine; Cromolyn Sodium; Dogs; Female; Guanidines; Histamine; Ileu | 1994 |
Cerebroprotective effects of aminoguanidine in a rodent model of stroke.
Topics: Animals; Cerebral Infarction; Cerebrovascular Circulation; Cerebrovascular Disorders; Disease Models | 1996 |
The influence of skin flap ischemia on serum nitric oxide concentrations.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Guanidines; Heparin; Ischemia; Male; NG-Nitroarginine Methyl | 1996 |
Role of nitric oxide and tumor necrosis factor on lung injury caused by ischemia/reperfusion of the lower extremities.
Topics: Animals; Aorta, Abdominal; Constriction; Dexamethasone; Enzyme Inhibitors; Guanidines; Hindlimb; Lun | 1997 |
The role of endogenous nitric oxide in modulating ischemia-reperfusion injury in the isolated, blood-perfused rat lung.
Topics: Animals; Disease Models, Animal; Guanidines; In Vitro Techniques; Male; NG-Nitroarginine Methyl Este | 1998 |
Dynamics of nitrotyrosine formation and decay in rat brain during focal ischemia-reperfusion.
Topics: Animals; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pressure | 1999 |
Pacing-induced delayed protection against arrhythmias is attenuated by aminoguanidine, an inhibitor of nitric oxide synthase.
Topics: Animals; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Blood Pressure; Cardiac Pacing, Artifici | 1999 |
Aminoguanidine attenuates hemodynamic and microcirculatory derangement in rat intestinal ischemia and reperfusion.
Topics: Animals; Blood Flow Velocity; Disease Models, Animal; Drug Evaluation, Preclinical; Granulocytes; Gu | 1999 |
Selective inhibition of inducible nitric oxide in ischemia-reperfusion of rat small intestine.
Topics: Animals; Arginine; Blood Pressure; CD11 Antigens; Enzyme Inhibitors; Guanidines; Intestine, Small; I | 2000 |
Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion.
Topics: Animals; Apoptosis; Chlorpheniramine; Cimetidine; Guanidines; Histamine; Histamine Antagonists; Inte | 2000 |
Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain.
Topics: Animals; Brain; Brain Ischemia; Catalysis; Cell Survival; Disease Models, Animal; Drug Administratio | 2001 |
Ischemia-reperfusion injury of the cochlea: effects of an iron chelator and nitric oxide synthase inhibitors.
Topics: Action Potentials; Animals; Auditory Threshold; Blood Flow Velocity; Blood Pressure; Cochlea; Defero | 2001 |
Ischemia/reperfusion-induced increase in the hepatic level of prostacyclin is mainly mediated by activation of capsaicin-sensitive sensory neurons in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase 1; | 2002 |
Studies on the relationship between xanthine oxidase and histamine release during intestinal ischemia-reperfusion.
Topics: Animals; Cromolyn Sodium; Disease Models, Animal; Dogs; Female; Guanidines; Histamine; Histamine Rel | 1992 |