pimagedine has been researched along with Pulmonary Disease, Chronic Obstructive in 2 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the role of increased NO in COPD, we administered a relatively selective iNOS inhibitor, aminoguanidine, by nebulization in a double-blind, placebo-controlled study in COPD patients, healthy smokers, and healthy nonsmoking subjects." | 2.74 | Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients. ( Barnes, PJ; Brindicci, C; Ito, K; Kharitonov, SA; Torre, O, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brindicci, C | 1 |
| Ito, K | 1 |
| Torre, O | 1 |
| Barnes, PJ | 1 |
| Kharitonov, SA | 1 |
| Lanzetti, M | 1 |
| da Costa, CA | 1 |
| Nesi, RT | 1 |
| Barroso, MV | 1 |
| Martins, V | 1 |
| Victoni, T | 1 |
| Lagente, V | 1 |
| Pires, KM | 1 |
| e Silva, PM | 1 |
| Resende, AC | 1 |
| Porto, LC | 1 |
| Benjamim, CF | 1 |
| Valença, SS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double Blind, Crossover Placebo-controlled Study to Evaluate the Effect of L-arginine and Aminoguanidine on Bronchial and Alveolar Nitric Oxide and Nitric Oxide Metabolites[NCT00180635] | 30 participants (Actual) | Interventional | 2003-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for pimagedine and Pulmonary Disease, Chronic Obstructive
| Article | Year |
|---|---|
Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients.
Topics: Administration, Inhalation; Aged; Biomarkers; Bronchial Provocation Tests; Cross-Over Studies; Doubl | 2009 |
1 other study available for pimagedine and Pulmonary Disease, Chronic Obstructive
| Article | Year |
|---|---|
Oxidative stress and nitrosative stress are involved in different stages of proteolytic pulmonary emphysema.
Topics: Animals; Glutathione Peroxidase; Guanidines; Leukocytes; Mice; Mice, Inbred C57BL; Nitric Oxide Synt | 2012 |