pimagedine has been researched along with Pregnancy in 37 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes." | 7.69 | Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997) |
| "To investigate the effect of cervical application of nonselective and selective inhibitors of nitric oxide synthases--N-nitro-L-arginine methyl ester, L-N-iminoethyl-lysine, and aminoguanidine--as well as inhibitors of cyclooxygenases--indomethacin, and nimesulide--on timing of delivery and fetal death and disease in pregnant rats." | 3.71 | The effects of cervical application of inhibitors of inducible nitric oxide synthase, cyclooxygenase-1, and cyclooxygenase-2 on delivery in rats. ( Bukowski, R; Garfield, RE; McKay, L; Saade, GR; Shi, SQ, 2001) |
| "In order to localize the site of production of nitrogen monoxide (NO) in first trimester human pregnancy, the cytosol and microsome fractions prepared from homogenized primordial placentas were tested for NO-synthase (NOS) activities by measuring the NADPH-dependent conversion of [3H]arginine to [3H]citrulline." | 3.69 | Ca(2+)-dependent and Ca(2+)-independent NO-synthesizing activities of human primordial placenta. ( Kukor, Z; Tóth, M, 1994) |
| "Administration of the nitric oxide synthase (NOS) inhibitor, NG-nitro-L-arginine methyl ester (L-NAME) during pregnancy has been shown to compromise fetal growth." | 3.69 | Perinatal nitric oxide synthase inhibition retards neonatal growth by inducing hypertrophic pyloric stenosis in rats. ( Clark, DA; Eloby-Childress, S; Miller, MJ; Pierce, MR; Voelker, CA; Zhang, XJ, 1995) |
| "N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes." | 3.69 | Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997) |
| "The effects of inhibiting histamine catabolism, via oxidative deamination, on the course of pregnancy on rats and on their offspring were studied." | 3.67 | Effects of diamine oxidase inhibition during pregnancy in the rat. ( Fraile, A; Nava, MP, 1988) |
| "Renal functional decline in diabetic nephropathy is slowed by establishment of euglycaemia and normalization of hypertensive blood pressure." | 2.40 | Advanced glycation end-products in diabetic nephropathy. ( Friedman, EA, 1999) |
| "Successful pregnancy is strictly dependent on the trophoblast-decidual interaction and on an adequate blood supply to the implantation sites." | 1.30 | Synergistic role of nitric oxide and progesterone during the establishment of pregnancy in the rat. ( Chwalisz, K; Garfield, RE; Thienel, T; Winterhager, E, 1999) |
| "In early embryo loss, the fetus may be considered to be an allograft and, therefore, may be rejected by maternal immunocytes." | 1.29 | Early embryo loss is associated with local production of nitric oxide by decidual mononuclear cells. ( Baines, MG; Duclos, AJ; Haddad, EK, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (18.92) | 18.7374 |
| 1990's | 11 (29.73) | 18.2507 |
| 2000's | 16 (43.24) | 29.6817 |
| 2010's | 2 (5.41) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Yaremchuk, O | 1 |
| Soroka, Y | 1 |
| Kulitska, M | 1 |
| Kuzmak, I | 1 |
| Chernyashova, V | 1 |
| Namoradze, M | 1 |
| Delibashvili, D | 1 |
| Posokhova, K | 1 |
| Giannone, PJ | 1 |
| Nankervis, CA | 1 |
| Richter, JM | 1 |
| Schanbacher, BL | 1 |
| Reber, KM | 1 |
| Cella, M | 4 |
| Farina, MG | 1 |
| Dominguez Rubio, AP | 1 |
| Di Girolamo, G | 1 |
| Ribeiro, ML | 3 |
| Franchi, AM | 4 |
| Burdet, J | 1 |
| Sacerdoti, F | 1 |
| Ibarra, C | 1 |
| Ogando, DG | 1 |
| Paz, D | 1 |
| Asagiri, K | 1 |
| Nakatsuka, M | 2 |
| Konishi, H | 2 |
| Noguchi, S | 2 |
| Takata, M | 1 |
| Habara, T | 1 |
| Kudo, T | 1 |
| ROBERTS, M | 1 |
| HOFFMAN, DB | 2 |
| POLLACK, E | 2 |
| BANIK, UK | 1 |
| KOBAYASHI, Y | 1 |
| KETCHEL, MM | 1 |
| Wainwright, MS | 1 |
| Brennan, LA | 1 |
| Dizon, ML | 1 |
| Black, SM | 1 |
| Ribeiro, M | 1 |
| Farina, M | 3 |
| Franchi, A | 2 |
| Chekir, C | 1 |
| Kamada, Y | 1 |
| Sasaki, A | 1 |
| Hiramatsu, Y | 1 |
| Zhang, H | 1 |
| Yao, ZW | 1 |
| Wu, WX | 1 |
| Sengupta, J | 1 |
| Dhawan, L | 1 |
| Lalitkumar, PG | 1 |
| Ghosh, D | 1 |
| Dingman, A | 1 |
| Lee, SY | 1 |
| Derugin, N | 1 |
| Wendland, MF | 1 |
| Vexler, ZS | 1 |
| Nijboer, CH | 1 |
| Groenendaal, F | 1 |
| Kavelaars, A | 1 |
| Hagberg, HH | 1 |
| van Bel, F | 1 |
| Heijnen, CJ | 1 |
| Datti, F | 1 |
| Datti, M | 1 |
| Antunes, E | 1 |
| Takeuchi, K | 1 |
| Okabe, S | 1 |
| Imamura, I | 1 |
| Maeyama, K | 1 |
| Wada, H | 1 |
| Watanabe, T | 1 |
| Kukor, Z | 1 |
| Tóth, M | 1 |
| Haddad, EK | 1 |
| Duclos, AJ | 1 |
| Baines, MG | 1 |
| Cremades, A | 1 |
| Sánchez-Capelo, A | 1 |
| Tovar, A | 1 |
| Peñafiel, R | 1 |
| Voelker, CA | 1 |
| Miller, MJ | 1 |
| Zhang, XJ | 1 |
| Eloby-Childress, S | 1 |
| Clark, DA | 1 |
| Pierce, MR | 1 |
| Schleicher, ED | 1 |
| Wagner, E | 1 |
| Nerlich, AG | 1 |
| Lubarsky, SL | 1 |
| Ahokas, RA | 1 |
| Friedman, SA | 1 |
| Sibai, BM | 1 |
| Greenberg, SS | 1 |
| Lancaster, JR | 1 |
| Xie, J | 1 |
| Sarphie, TG | 1 |
| Zhao, X | 1 |
| Hua, L | 1 |
| Freeman, T | 1 |
| Kapusta, DR | 1 |
| Giles, TD | 1 |
| Powers, DR | 1 |
| Wang, JY | 3 |
| Shum, AY | 1 |
| Hwang, CP | 1 |
| Chwalisz, K | 2 |
| Winterhager, E | 2 |
| Thienel, T | 2 |
| Garfield, RE | 2 |
| Friedman, EA | 1 |
| Athanassakis, I | 1 |
| Aifantis, I | 1 |
| Ranella, A | 1 |
| Giouremou, K | 1 |
| Vassiliadis, S | 1 |
| Ogando, D | 1 |
| Gimeno, M | 1 |
| Rairigh, RL | 1 |
| Parker, TA | 1 |
| Ivy, DD | 1 |
| Kinsella, JP | 1 |
| Fan, ID | 1 |
| Abman, SH | 1 |
| Bukowski, R | 1 |
| McKay, L | 1 |
| Shi, SQ | 1 |
| Saade, GR | 1 |
| Nava, MP | 1 |
| Fraile, A | 1 |
1 review available for pimagedine and Pregnancy
| Article | Year |
|---|---|
Advanced glycation end-products in diabetic nephropathy.
Topics: Animals; Diabetic Nephropathies; Enzyme Inhibitors; Female; Glucose; Glycation End Products, Advance | 1999 |
36 other studies available for pimagedine and Pregnancy
| Article | Year |
|---|---|
[NEUROPROTECTIVE EFFECT OF AMINOGUANIDINE IN EXPERIMENTAL OBSTETRIC ANTIPHOSPHOLIPID SYNDROME].
Topics: Animals; Antiphospholipid Syndrome; Female; Guanidines; Mice; Mice, Inbred BALB C; Neuroprotective A | 2020 |
Prenatal lipopolysaccharide increases postnatal intestinal injury in a rat model of necrotizing enterocolitis.
Topics: Animals; Animals, Newborn; Blood Pressure; Disease Models, Animal; Enterocolitis, Necrotizing; Enzym | 2009 |
Dual effect of nitric oxide on uterine prostaglandin synthesis in a murine model of preterm labour.
Topics: Animals; Blotting, Western; Cyclooxygenase 2 Inhibitors; Dinoprost; Dinoprostone; Disease Models, An | 2010 |
Role of TNF-α in the mechanisms responsible for preterm delivery induced by Stx2 in rats.
Topics: Animals; Cyclooxygenase 2; Decidua; Dinoprost; Dinoprostone; Drug Therapy, Combination; Etanercept; | 2013 |
The fundamental role of increased production of nitric oxide in lipopolysaccharide-induced embryonic resorption in mice.
Topics: Animals; Bacterial Infections; Blotting, Western; Decidua; Embryo Loss; Enzyme Activation; Enzyme In | 2003 |
Involvement of peroxynitrite in LPS-induced apoptosis of trophoblasts.
Topics: Apoptosis; Cells, Cultured; Chorioamnionitis; Female; Guanidines; Humans; Lipopolysaccharides; Nitri | 2003 |
The effect of a histaminase-inhibitor (aminoguanidine) on pregnancy in the rat.
Topics: Amidines; Amine Oxidase (Copper-Containing); Animals; Female; Guanidines; Pregnancy; Rats | 1954 |
Effect of a histaminase in hibitor (aminoguanidine sulfate) on pregnant and non-pregnant rats.
Topics: Amidines; Amine Oxidase (Copper-Containing); Animals; Female; Guanidines; Humans; Pre-Eclampsia; Pre | 1961 |
The protective effect of an antihistaminic on the toxemia-like changes caused by aminoguanidine sulfate in pregnant rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Cyproheptadine; Female; Guanidines; Pre-Eclampsia; Pregn | 1963 |
EFFECT OF AMINOGUANIDINE, HISTAMINE, HISTIDINE AND COMPOUND 48/80 ON PREGNANCY IN RATS AND MICE.
Topics: Contraceptive Devices; Guanidine; Guanidines; Histamine; Histamine Release; Histidine; Mice; p-Metho | 1963 |
p21ras activation following hypoxia-ischemia in the newborn rat brain is dependent on nitric oxide synthase activity but p21ras does not contribute to neurologic injury.
Topics: Animals; Animals, Newborn; Carotid Arteries; Drug Interactions; Enzyme Activation; Enzyme Inhibitors | 2003 |
Effects of aminoguanidine and cyclooxygenase inhibitors on nitric oxide and prostaglandin production, and nitric oxide synthase and cyclooxygenase expression induced by lipopolysaccharide in the estrogenized rat uterus.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dinopr | 2004 |
Advanced glycation end products induce secretion of chemokines and apoptosis in human first trimester trophoblasts.
Topics: Apoptosis; Benzamidines; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Chemokines | 2004 |
[Effects of nitric oxide synthase inhibitors on cerebral mitochondrial structure and function in fetal rats with intrauterine distress].
Topics: Animals; Brain; Female; Fetal Distress; Guanidines; Mitochondria; Nerve Tissue Proteins; Nitric Oxid | 2004 |
Nitric oxide in blastocyst implantation in the rhesus monkey.
Topics: Animals; Blastocyst; Decidua; Dihydrolipoamide Dehydrogenase; Embryo Implantation; Epithelium; Femal | 2005 |
Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient cerebral ischemia.
Topics: Animals; Animals, Newborn; Blotting, Western; Calpain; Caspase 3; Caspases; Cell Count; Cell Death; | 2006 |
Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway.
Topics: Animals; Animals, Newborn; Biotin; Blotting, Western; Caspases; Enzyme Inhibitors; Female; Guanidine | 2007 |
Prenatal exposure to endotoxin in rats attenuates the allergic airways eosinophil infiltration in the adult offspring: role of inducible nitric oxide synthase activation.
Topics: Animals; Bone Marrow Cells; Bronchoalveolar Lavage Fluid; Enzyme Activation; Eosinophils; Female; Gu | 2008 |
Factors related to gastric hypersecretion during pregnancy and lactation in rats.
Topics: Animals; DNA; Female; Gastric Acid; Gastric Juice; Gastric Mucosa; Gastrins; Guanidines; Histamine; | 1984 |
Determination of imidazole acetic acid and its conjugate(s) levels in urine, serum and tissues of rats: studies on changes in their levels under various conditions.
Topics: Animals; Cimetidine; Creatinine; Female; Fetus; Guanidines; Imidazoles; Male; Metabolic Clearance Ra | 1984 |
Ca(2+)-dependent and Ca(2+)-independent NO-synthesizing activities of human primordial placenta.
Topics: Amino Acid Oxidoreductases; Arginine; Calcium; Citrulline; Cytosol; Egtazic Acid; Female; Guanidines | 1994 |
Early embryo loss is associated with local production of nitric oxide by decidual mononuclear cells.
Topics: Abortion, Veterinary; Animals; Crosses, Genetic; Decidua; Embryo Implantation; Embryo Loss; Female; | 1995 |
Involvement of polyamines in the contragestational effect of hyperthermia.
Topics: Amine Oxidase (Copper-Containing); Analysis of Variance; Animals; Embryonic and Fetal Development; F | 1995 |
Perinatal nitric oxide synthase inhibition retards neonatal growth by inducing hypertrophic pyloric stenosis in rats.
Topics: Animals; Animals, Newborn; Arginine; Body Weight; Disease Models, Animal; Embryonic and Fetal Develo | 1995 |
Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.
Topics: Adult; Aged; Aging; Antibodies; Arteries; Arteriosclerosis; Biomarkers; Blood Proteins; Catalase; Ch | 1997 |
The effect of chronic nitric oxide synthesis inhibition on blood pressure and angiotensin II responsiveness in the pregnant rat.
Topics: Angiotensin II; Animals; Blood Pressure; Enzyme Inhibitors; Female; Guanidines; Heart Rate; Hematocr | 1997 |
Effects of NO synthase inhibitors, arginine-deficient diet, and amiloride in pregnant rats.
Topics: Abnormalities, Drug-Induced; Amiloride; Analysis of Variance; Animals; Arginine; Female; Fetal Death | 1997 |
Ethanol modulates induction of nitric oxide synthase in glial cells by endotoxin.
Topics: Animals; Animals, Newborn; Cell Survival; Cells, Cultured; DNA Primers; Dose-Response Relationship, | 1998 |
Synergistic role of nitric oxide and progesterone during the establishment of pregnancy in the rat.
Topics: Animals; Contraceptive Agents; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; | 1999 |
Inhibition of nitric oxide production rescues LPS-induced fetal abortion in mice.
Topics: Abortion, Induced; Abortion, Spontaneous; Animals; Cell Line; Cells, Cultured; Enzyme Inhibitors; Es | 1999 |
IL1alpha augments prostaglandin synthesis in pregnant rat uteri by a nitric oxide mediated mechanism.
Topics: Animals; Arachidonic Acid; Carbon Radioisotopes; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Femal | 2000 |
Nitric oxide synthases in pregnant rat uterus.
Topics: Animals; Arginine; Blotting, Western; Carbon Radioisotopes; Citrulline; Diestrus; Female; Gestationa | 2001 |
Role of inducible nitric oxide synthase in the pulmonary vascular response to birth-related stimuli in the ovine fetus.
Topics: Acetylcholine; Administration, Inhalation; Amidines; Animals; Benzylamines; Enzyme Inhibitors; Femal | 2001 |
The effects of cervical application of inhibitors of inducible nitric oxide synthase, cyclooxygenase-1, and cyclooxygenase-2 on delivery in rats.
Topics: Administration, Topical; Animals; Cervical Ripening; Cervix Uteri; Cyclooxygenase Inhibitors; Delive | 2001 |
Expression of MAPkinases (Erk1/2) during decidualization in the rat: regulation by progesterone and nitric oxide.
Topics: Animals; Decidua; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Female; Go | 2002 |
Effects of diamine oxidase inhibition during pregnancy in the rat.
Topics: Abnormalities, Drug-Induced; Amine Oxidase (Copper-Containing); Animals; Female; Fetus; Guanidines; | 1988 |