pimagedine has been researched along with Muscle Contraction in 41 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Caffeine and ryanodine contractions were augmented during endotoxemia without NOS contribution." | 3.72 | The role of nitric oxide on contractile impairment during endotoxemia in rat diaphragm muscle. ( Ertunc, M; Onur, R; Sara, Y, 2004) |
| "Peritonitis was induced by cecal ligation and puncture in 8 rats." | 1.35 | Alterations in spontaneous contractions of rat ileum and jejunum after peritonitis. ( Altun, A; Bagcivan, I; Durmus, N; Guney, C; Karadas, B; Kaya, T; Koyluoglu, G, 2008) |
| "Sepsis was induced by cecal ligation and perforation in rats." | 1.32 | Septic diaphragmatic dysfunction is prevented by Mn(III)porphyrin therapy and inducible nitric oxide synthase inhibition. ( Alfonso, E; Batthyány, C; Boggia, J; Botti, H; Cassina, A; Hurtado, FJ; Nin, N; Peluffo, G; Radi, R; Rubbo, H; Trostchansky, A, 2004) |
| " Histamine dose-dependently induced the contraction of sections of the guinea-pig small intestine, and the pretreatment of the tissue section with aminoguanidine (100 microM), a diamine oxidase inhibitor, but not with S-[4-(N,N-dimethylamino)butyl]isothiourea (100 microM), an inhibitor of histamine N-methyltransferase, shifted the dose-response curve of histamine-induced contraction to lower concentrations." | 1.31 | Expression of diamine oxidase (histaminase) in guinea-pig tissues. ( Kitanaka, J; Kitanaka, N; Takemura, M; Terada, N; Tsujimura, T, 2002) |
| "Future clinical trials in treating septic shock should therefore consider the preferential inhibition of iNOS while maintaining the integrity of endothelial NOS." | 1.29 | Expression and preferential inhibition of inducible nitric oxide synthase in aortas of endotoxemic rats. ( Higa, EM; McMurtry, IF; Niederberger, M; Raynolds, M; Schrier, RW; Weigert, AL, 1995) |
| "Acute inflammation was associated with enlarged colonic perimeter." | 1.29 | Toxic dilatation of colon in a rat model of colitis is linked to an inducible form of nitric oxide synthase. ( Guarner, F; Malagelada, JR; Mourelle, M; Salas, A; Vilaseca, J, 1996) |
| " Conversely, following potentiation of the response to histamine with DTT, exposure of the tissue to desensitizing concentrations of histamine resulted in a dextral shift of the dose-response curve (dose ratio = 39." | 1.27 | Selective enhancement of histamine H1-receptor responses in guinea-pig ileal smooth muscle by 1,4-dithiothreitol. ( Donaldson, J; Hill, SJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.44) | 18.7374 |
| 1990's | 20 (48.78) | 18.2507 |
| 2000's | 19 (46.34) | 29.6817 |
| 2010's | 1 (2.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Towiwat, P | 1 |
| Phattanarudee, S | 2 |
| Maher, TJ | 2 |
| Ally, A | 2 |
| Xu, J | 1 |
| Li, N | 1 |
| Dai, DZ | 1 |
| Yu, F | 1 |
| Dai, Y | 1 |
| Strapkova, A | 1 |
| Antosova, M | 1 |
| Nosalova, G | 1 |
| Geyik, S | 1 |
| Kumcu, EK | 1 |
| Büyüknacar, HS | 1 |
| Aridoğan, A | 1 |
| Göçmen, C | 1 |
| Onder, S | 1 |
| Soylu, S | 1 |
| Aydin, C | 1 |
| Bagcivan, I | 2 |
| Yildirim, S | 1 |
| Koyuncu, A | 1 |
| Topcu, O | 1 |
| Arici, S | 1 |
| Wan, BY | 1 |
| Alic, A | 1 |
| Peh, KH | 1 |
| Assem, ES | 1 |
| Pearce, FL | 1 |
| Nin, N | 1 |
| Cassina, A | 1 |
| Boggia, J | 1 |
| Alfonso, E | 1 |
| Botti, H | 1 |
| Peluffo, G | 1 |
| Trostchansky, A | 1 |
| Batthyány, C | 1 |
| Radi, R | 2 |
| Rubbo, H | 1 |
| Hurtado, FJ | 1 |
| Sara, Y | 1 |
| Ertunc, M | 1 |
| Onur, R | 1 |
| Anctil, M | 1 |
| Poulain, I | 1 |
| Pelletier, C | 1 |
| Kabadi, S | 1 |
| Patel, M | 1 |
| Ebrahimi, F | 1 |
| Tavakoli, S | 1 |
| Hajrasouliha, AR | 1 |
| Sadeghipour, H | 1 |
| Dehghani, M | 1 |
| Ahmadi, SH | 1 |
| Dehpour, AR | 1 |
| Shen, KP | 1 |
| Liou, SF | 1 |
| Hsieh, SL | 1 |
| Chen, IJ | 1 |
| Wu, BN | 1 |
| Koyluoglu, G | 1 |
| Karadas, B | 1 |
| Guney, C | 1 |
| Durmus, N | 1 |
| Altun, A | 1 |
| Kaya, T | 1 |
| Griffiths, MJ | 3 |
| Messent, M | 3 |
| MacAllister, RJ | 1 |
| Evans, TW | 3 |
| Liu, S | 1 |
| Curzen, NP | 2 |
| Weigert, AL | 1 |
| Higa, EM | 1 |
| Niederberger, M | 1 |
| McMurtry, IF | 1 |
| Raynolds, M | 1 |
| Schrier, RW | 1 |
| Way, KJ | 1 |
| Reid, JJ | 1 |
| Mourelle, M | 1 |
| Vilaseca, J | 1 |
| Guarner, F | 1 |
| Salas, A | 1 |
| Malagelada, JR | 1 |
| Hall, S | 1 |
| Turcato, S | 1 |
| Clapp, L | 1 |
| Archibald, V | 1 |
| Cotter, MA | 1 |
| Keegan, A | 1 |
| Cameron, NE | 1 |
| Scott, JA | 1 |
| Machoun, M | 1 |
| McCormack, DG | 1 |
| Wu, CC | 2 |
| Hong, HJ | 1 |
| Chou, TC | 1 |
| Ding, YA | 1 |
| Yen, MH | 2 |
| Szabó, C | 1 |
| Ferrer-Sueta, G | 1 |
| Zingarelli, B | 1 |
| Southan, GJ | 1 |
| Salzman, AL | 1 |
| Michielsen, PP | 1 |
| Boeckxstaens, GE | 1 |
| Sys, SU | 1 |
| Herman, AG | 1 |
| Pelckmans, PA | 1 |
| Gunnett, CA | 2 |
| Chu, Y | 1 |
| Heistad, DD | 2 |
| Loihl, A | 2 |
| Faraci, FM | 2 |
| Chen, SJ | 1 |
| Perez Martinez, S | 1 |
| Franchi, AM | 1 |
| Viggiano, JM | 1 |
| Herrero, MB | 1 |
| Gimeno, M | 1 |
| Gadano, AC | 1 |
| Sogni, P | 1 |
| Heller, J | 1 |
| Moreau, R | 1 |
| Bories, PN | 1 |
| Lebrec, D | 1 |
| Torihashi, S | 1 |
| Ozaki, H | 1 |
| Hori, M | 1 |
| Kita, M | 1 |
| Ohota, S | 1 |
| Karaki, H | 1 |
| Pulido, EJ | 1 |
| Shames, BD | 1 |
| Fullerton, DA | 1 |
| Sheridan, BC | 1 |
| Selzman, CH | 1 |
| Gamboni-Robertson, F | 1 |
| Bensard, DD | 1 |
| McIntyre, RC | 1 |
| Russell, RJ | 1 |
| Anderson, JL | 1 |
| Williams, G | 1 |
| Head, SI | 1 |
| Reid, MB | 1 |
| Kobzik, L | 1 |
| Bredt, DS | 1 |
| Stamler, JS | 1 |
| Bossone, C | 1 |
| Hosseini, JM | 1 |
| Piñeiro-Carrero, V | 1 |
| Shea-Donohue, T | 1 |
| Ziolo, MT | 1 |
| Harshbarger, CH | 1 |
| Roycroft, KE | 1 |
| Smith, JM | 1 |
| Romano, FD | 1 |
| Sondgeroth, KL | 1 |
| Wahler, GM | 1 |
| Kitanaka, J | 1 |
| Kitanaka, N | 1 |
| Tsujimura, T | 1 |
| Terada, N | 1 |
| Takemura, M | 2 |
| Ohrui, T | 1 |
| Yamauchi, K | 1 |
| Sekizawa, K | 1 |
| Ohkawara, Y | 1 |
| Maeyama, K | 1 |
| Sasaki, M | 1 |
| Wada, H | 1 |
| Watanabe, T | 1 |
| Sasaki, H | 1 |
| Lindström, EG | 1 |
| Andersson, RG | 1 |
| Granérus, G | 1 |
| Grundström, N | 1 |
| Donaldson, J | 1 |
| Hill, SJ | 1 |
41 other studies available for pimagedine and Muscle Contraction
| Article | Year |
|---|---|
Modulation of inducible nitric oxide synthase (iNOS) expression and cardiovascular responses during static exercise following iNOS antagonism within the ventrolateral medulla.
Topics: Anesthesia; Animals; Blood Pressure; Blotting, Western; Cardiovascular Physiological Phenomena; Enzy | 2015 |
The endothelin receptor antagonist CPU0213 is more effective than aminoguanidine to attenuate isoproterenol-induced vascular abnormality by suppressing overexpression of NADPH oxidase [correction of oxidas], ETA, ETB, and MMP9 in the vasculature.
Topics: Animals; Aorta, Thoracic; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Guan | 2008 |
Effect of NO-synthase and arginase inhibition in airway hyperreactivity.
Topics: Allergens; Animals; Arginase; Arginine; Bronchial Hyperreactivity; Enzyme Inhibitors; Guanidines; Gu | 2008 |
Effects of vitamin E and sodium selenate on impaired contractile activity by bacterial lipopolysaccharide in the rat vas deferens.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Electric Stimulation; Enzyme Inhibitors; Escherichia | 2009 |
Effects of NO/L-arginine pathway on gallbladder contractility in bile duct ligated guinea pigs.
Topics: Animals; Arginine; Carbachol; Cholecystitis; Common Bile Duct; Electric Stimulation; Gallbladder; Gu | 2009 |
Effect of protease-activated receptors on guinea-pig ileum contraction in vitro.
Topics: Animals; Calcimycin; Chymotrypsin; Cromolyn Sodium; Dose-Response Relationship, Drug; Enzyme Inhibit | 2003 |
Septic diaphragmatic dysfunction is prevented by Mn(III)porphyrin therapy and inducible nitric oxide synthase inhibition.
Topics: Animals; Blood Pressure; Diaphragm; Enzyme Inhibitors; Guanidines; Heart Rate; Male; Metalloporphyri | 2004 |
The role of nitric oxide on contractile impairment during endotoxemia in rat diaphragm muscle.
Topics: Animals; Caffeine; Diaphragm; Endotoxemia; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Indaz | 2004 |
Nitric oxide modulates peristaltic muscle activity associated with fluid circulation in the sea pansy Renilla koellikeri.
Topics: Animals; Anthozoa; Body Fluids; California; Guanidines; Immunohistochemistry; Indazoles; Muscle Cont | 2005 |
Cardiovascular responses and neurotransmitter changes during static muscle contraction following blockade of inducible nitric oxide synthase (iNOS) within the ventrolateral medulla.
Topics: Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Efferent Pathways; Enzyme Inhibitor | 2006 |
Involvement of endogenous opioid peptides and nitric oxide in the blunted chronotropic and inotropic responses to beta-adrenergic stimulation in cirrhotic rats.
Topics: Adrenergic beta-Agonists; Animals; Bile Ducts; Enzyme Inhibitors; Guanidines; Heart Atria; In Vitro | 2006 |
Eugenosedin-A amelioration of lipopolysaccharide-induced up-regulation of p38 MAPK, inducible nitric oxide synthase and cyclooxygenase-2.
Topics: Adrenergic alpha-Antagonists; Animals; Antioxidants; Aorta, Thoracic; Ascorbic Acid; Blotting, Weste | 2007 |
Alterations in spontaneous contractions of rat ileum and jejunum after peritonitis.
Topics: Animals; Celecoxib; Guanidines; Ileum; In Vitro Techniques; Indomethacin; Jejunum; Male; Muscle Cont | 2008 |
Aminoguanidine selectively inhibits inducible nitric oxide synthase.
Topics: Acetylcholine; Amino Acid Oxidoreductases; Animals; Arginine; Cimetidine; Endothelium, Vascular; End | 1993 |
In vivo treatment with endotoxin induces nitric oxide synthase in rat main pulmonary artery.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Base Sequence; Cyclic GMP; Dexamethasone; Endothelium | 1995 |
Expression and preferential inhibition of inducible nitric oxide synthase in aortas of endotoxemic rats.
Topics: Animals; Aorta, Thoracic; DNA, Complementary; Enzyme Induction; Guanidines; Lipopolysaccharides; Mal | 1995 |
Aminoguanidine selectively decreases cyclic GMP levels produced by inducible nitric oxide synthase.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Endot | 1995 |
Effect of aminoguanidine on the impaired nitric oxide-mediated neurotransmission in anococcygeus muscle from diabetic rats.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Expe | 1994 |
Toxic dilatation of colon in a rat model of colitis is linked to an inducible form of nitric oxide synthase.
Topics: Animals; Arginine; Colitis; Colon; Dexamethasone; Dilatation; Disease Models, Animal; Enzyme Inducti | 1996 |
Abnormal activation of K+ channels underlies relaxation to bacterial lipopolysaccharide in rat aorta.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta, Thoracic; Arginine; Enzyme Inhibitors; Guanidin | 1996 |
Contraction and relaxation of aortas from diabetic rats: effects of chronic anti-oxidant and aminoguanidine treatments.
Topics: Acetylcholine; Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Aorta; Butylated Hydroxy | 1996 |
Inducible nitric oxide synthase and vascular reactivity in rat thoracic aorta: effect of aminoguanidine.
Topics: Animals; Aorta, Thoracic; Arginine; Enzyme Induction; Enzyme Inhibitors; Guanidines; In Vitro Techni | 1996 |
Evidence for inducible nitric oxide synthase in spontaneously hypertensive rats.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Aorta, Thoracic; Arginine; Blood Pressure; Cycl | 1996 |
Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage.
Topics: Animals; Cell Line; Enzyme Inhibitors; Guanidines; Kinetics; Models, Chemical; Muscle Contraction; M | 1997 |
Aminoguanidine reverses aortic hyporeactivity to noradrenaline in portal vein-ligated rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelium, Vascular; En | 1997 |
Vascular effects of LPS in mice deficient in expression of the gene for inducible nitric oxide synthase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Carotid Arteries; Citru | 1998 |
Nitric oxide-independent activation of soluble guanylyl cyclase contributes to endotoxin shock in rats.
Topics: Animals; Aorta; Blood Pressure; Charybdotoxin; Dexamethasone; Endothelium, Vascular; Enzyme Activati | 1998 |
Effect of prostaglandin F2 alpha (PGF2 alpha) on oviductal nitric oxide synthase (NOS) activity: possible role of endogenous NO on PGF2 alpha-induced contractions in rat oviduct.
Topics: Animals; Arginine; Calcium; Chelating Agents; Citrulline; Dinoprost; Egtazic Acid; Enzyme Inhibitors | 1998 |
Vascular nitric oxide production during the development of two experimental models of portal hypertension.
Topics: Animals; Aorta, Thoracic; Disease Models, Animal; Guanidines; Hypertension, Portal; In Vitro Techniq | 1999 |
Resident macrophages activated by lipopolysaccharide suppress muscle tension and initiate inflammatory response in the gastrointestinal muscle layer.
Topics: Animals; Carbachol; Cell Movement; Dextrans; Digestive System; Enzyme Inhibitors; Female; Fluorescei | 2000 |
Differential inducible nitric oxide synthase expression in systemic and pulmonary vessels after endotoxin.
Topics: Animals; Aorta; Enzyme Inhibitors; Fluorescent Antibody Technique; Guanidines; Immunoblotting; Lipop | 2000 |
Use of arginine analogs as inhibitors of nitric oxide synthase in rat-aortic rings.
Topics: Animals; Aorta, Thoracic; Arginine; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Kinetics; Ma | 1998 |
Tumor necrosis factor-alpha impairs contraction but not relaxation in carotid arteries from iNOS-deficient mice.
Topics: Acetylcholine; Animals; Carotid Arteries; Dinoprost; Enzyme Inhibitors; Guanidines; Mice; Mice, Inbr | 2000 |
The role of nitric oxide in diaphragmatic dysfunction in endotoxemic rats.
Topics: Adenosine Triphosphate; Animals; Benzamides; Diaphragm; Endotoxemia; Enzyme Inhibitors; Free Radical | 2001 |
Nitric oxide modulates excitation-contraction coupling in the diaphragm.
Topics: Animals; Diaphragm; Enzyme Inhibitors; Guanidines; Hindlimb; Indazoles; Male; Muscle Contraction; Mu | 1998 |
Alterations in spontaneous contractions in vitro after repeated inflammation of rat distal colon.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Motility; Guanidines; In Vitro Tec | 2001 |
Myocytes isolated from rejecting transplanted rat hearts exhibit a nitric oxide-mediated reduction in the calcium current.
Topics: Alkaloids; Animals; Arginine; Calcium; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Electrophys | 2001 |
Expression of diamine oxidase (histaminase) in guinea-pig tissues.
Topics: Amine Oxidase (Copper-Containing); Animals; Brain; Dimaprit; Dose-Response Relationship, Drug; Gastr | 2002 |
Histamine N-methyltransferase controls the contractile response of guinea pig trachea to histamine.
Topics: Animals; Dimaprit; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Histamine; Histamine N | 1992 |
Is the airway epithelium responsible for histamine metabolism in the trachea of guinea pigs?
Topics: Amine Oxidase (Copper-Containing); Animals; Antigens; Epithelium; Female; Guanidines; Guinea Pigs; H | 1991 |
Selective enhancement of histamine H1-receptor responses in guinea-pig ileal smooth muscle by 1,4-dithiothreitol.
Topics: Acetylcholine; Animals; Dimaprit; Dithionitrobenzoic Acid; Dithiothreitol; Dose-Response Relationshi | 1986 |