pimagedine has been researched along with Multiple Organ Failure in 9 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Multiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compares the effects of aminoguanidine, a relatively selective inhibitor of inducible nitric oxide (NO) synthase, and N omega-nitro-L-arginine methyl ester (L-NAME), a selective inhibitor of endothelial NO synthase, on hypotension and multiple organ dysfunction caused by endotoxaemia in the anaesthetised rat." | 3.69 | Comparison of the effects of aminoguanidine and N omega-nitro-L-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat. ( Ruetten, H; Thiemermann, C; Wu, CC, 1996) |
| "Although septic shock is a highly complex pathophysiological state, the course of septic shock has different phases with different characteristics which need different (special) treatment strategy." | 2.42 | Effects of endothelin and nitric oxide on organ injury, mesenteric ischemia, and survival in experimental models of septic shock. ( Guc, O; Iskit, AB, 2003) |
| "Circulatory failure in multiple organ dysfunction syndromes (MODS) is characterized with systemic vasodilation, diminished blood flow to various vascular beds." | 1.33 | The effects of selective nitric oxide synthase blocker on survival, mesenteric blood flow and multiple organ failure induced by zymosan. ( Guc, MO; Guler, G; Iskit, AB; Korkmaz, A; Rasa, K; Tanriverdi, P; Yuksel, BC, 2005) |
| " Anaesthetized rats challenged with a high dosage of endotoxin (Escherichia coli lipopolysaccharide; LPS; 50 mg kg(-1), i." | 1.31 | Evodia rutaecarpa protects against circulation failure and organ dysfunction in endotoxaemic rats through modulating nitric oxide release. ( Chen, CF; Chiou, WF; Chou, CJ; Ko, HC, 2002) |
| "Sepsis was induced by the intravenous administration of E." | 1.31 | Hemodynamic, biochemical and morphological changes induced by aminoguanidine in normal and septic sheep. ( Delgado, MA; Esteban, A; Fernández-Segoviano, P; Jara, N; Lorente, JA; Moscoso, A; Rodríguez-Corcos, A; Tejedor, C; Tobalina, R, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Volman, TJ | 1 |
| Goris, RJ | 1 |
| van der Jagt, M | 1 |
| van de Loo, FA | 1 |
| Hendriks, T | 1 |
| Chiou, WF | 1 |
| Ko, HC | 1 |
| Chen, CF | 1 |
| Chou, CJ | 1 |
| Iskit, AB | 3 |
| Guc, O | 1 |
| Tanriverdi, P | 1 |
| Yuksel, BC | 1 |
| Rasa, K | 1 |
| Guler, G | 1 |
| Guc, MO | 2 |
| Korkmaz, A | 1 |
| Lomis, TJ | 1 |
| Siffring, CW | 1 |
| Chalasani, S | 1 |
| Ziegler, DW | 1 |
| Lentz, KE | 1 |
| Stauffer, KE | 1 |
| McMillan, A | 1 |
| Agarwal, N | 1 |
| Lowenstein, CJ | 1 |
| Rhoads, JE | 1 |
| Wu, CC | 1 |
| Ruetten, H | 1 |
| Thiemermann, C | 1 |
| Baykal, A | 1 |
| Kavuklu, B | 1 |
| Hascelik, G | 1 |
| Sayek, I | 1 |
| Lorente, JA | 1 |
| Tejedor, C | 1 |
| Delgado, MA | 1 |
| Fernández-Segoviano, P | 1 |
| Jara, N | 1 |
| Tobalina, R | 1 |
| Rodríguez-Corcos, A | 1 |
| Moscoso, A | 1 |
| Esteban, A | 1 |
| Cuzzocrea, S | 1 |
| Mazzon, E | 1 |
| Dugo, L | 1 |
| Barbera, A | 1 |
| Centorrino, T | 1 |
| Ciccolo, A | 1 |
| Fonti, MT | 1 |
| Caputi, AP | 1 |
1 review available for pimagedine and Multiple Organ Failure
| Article | Year |
|---|---|
Effects of endothelin and nitric oxide on organ injury, mesenteric ischemia, and survival in experimental models of septic shock.
Topics: Animals; Bacterial Translocation; Bosentan; Endothelin Receptor Antagonists; Endothelins; Guanidines | 2003 |
8 other studies available for pimagedine and Multiple Organ Failure
| Article | Year |
|---|---|
Organ damage in zymosan-induced multiple organ dysfunction syndrome in mice is not mediated by inducible nitric oxide synthase.
Topics: Animals; Guanidines; Mice; Mice, Inbred C57BL; Multiple Organ Failure; Nitric Oxide Synthase; Random | 2002 |
Evodia rutaecarpa protects against circulation failure and organ dysfunction in endotoxaemic rats through modulating nitric oxide release.
Topics: Animals; Aspartate Aminotransferases; Endothelium, Vascular; Endotoxemia; Endotoxins; Evodia; Fruit; | 2002 |
The effects of selective nitric oxide synthase blocker on survival, mesenteric blood flow and multiple organ failure induced by zymosan.
Topics: Animals; beta-Glucans; Enzyme Inhibitors; Guanidines; Kidney; Liver; Lung; Mice; Multiple Organ Fail | 2005 |
First place winner of the Conrad Jobst Award in the gold medal paper competition. Nitric oxide synthase inhibitors N-monomethylarginine and aminoguanidine prevent the progressive and severe hypotension associated with a rat model of pancreatitis.
Topics: Amylases; Animals; Arginine; Blood Pressure; Calcium; Clinical Protocols; Disease Models, Animal; Dr | 1995 |
Comparison of the effects of aminoguanidine and N omega-nitro-L-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat.
Topics: Animals; Arginine; Blood Pressure; Dose-Response Relationship, Drug; Endotoxins; Enzyme Inhibitors; | 1996 |
Experimental study of the effect of nitric oxide inhibition on mesenteric blood flow and interleukin-10 levels with a lipopolysaccharide challenge.
Topics: Animals; Female; Guanidines; Interleukin-10; Lipopolysaccharides; Mesentery; Mice; Mice, Inbred Stra | 2000 |
Hemodynamic, biochemical and morphological changes induced by aminoguanidine in normal and septic sheep.
Topics: Acidosis; Analysis of Variance; Animals; Blood Pressure; Case-Control Studies; Enzyme Inhibitors; Gu | 2000 |
Inducible nitric oxide synthase knockout mice exhibit resistance to the multiple organ failure induced by zymosan.
Topics: Animals; Enzyme Inhibitors; Exudates and Transudates; Guanidines; Lipid Peroxidation; Liver; Lung; M | 2001 |