pimagedine has been researched along with Meningitis in 3 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Meningitis: Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Rats were dosed with nimesulide (COX-2 inhibitor), aminoguanidine (iNOS inhibitor), or vehicle." | 1.32 | Neuroinflammatory role of prostaglandins during experimental meningitis: evidence suggestive of an in vivo relationship between nitric oxide and prostaglandins. ( Boje, KM; Jaworowicz, D; Raybon, JJ, 2003) |
| " Serum and regional brain tissues were obtained 0-30 min after tracer dosing and sucrose influx transfer coefficients (Kin(app)) were calculated from the brain tissue data." | 1.29 | Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis. ( Boje, KM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mittal, R | 1 |
| Gonzalez-Gomez, I | 1 |
| Goth, KA | 1 |
| Prasadarao, NV | 1 |
| Boje, KM | 2 |
| Jaworowicz, D | 1 |
| Raybon, JJ | 1 |
3 other studies available for pimagedine and Meningitis
| Article | Year |
|---|---|
Inhibition of inducible nitric oxide controls pathogen load and brain damage by enhancing phagocytosis of Escherichia coli K1 in neonatal meningitis.
Topics: Administration, Intranasal; Animals; Animals, Newborn; Brain; Cell Survival; Cytokines; Disease Mode | 2010 |
Neuroinflammatory role of prostaglandins during experimental meningitis: evidence suggestive of an in vivo relationship between nitric oxide and prostaglandins.
Topics: Animals; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Cyclooxygenase | 2003 |
Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis.
Topics: Animals; Behavior, Animal; Blood Volume; Blood-Brain Barrier; Chromatography, High Pressure Liquid; | 1996 |