pimagedine has been researched along with Melanoma in 2 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "As a result of bioassay-guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma-specific cytotoxic agent." | 7.69 | Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. ( Beecher, CW; Brown, DM; Chagwedera, TE; Chai, H; Cordell, GA; Farnsworth, NR; Fong, HH; Kinghorn, AD; Lee, IS; Pisha, E, 1995) |
| "As a result of bioassay-guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma-specific cytotoxic agent." | 3.69 | Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. ( Beecher, CW; Brown, DM; Chagwedera, TE; Chai, H; Cordell, GA; Farnsworth, NR; Fong, HH; Kinghorn, AD; Lee, IS; Pisha, E, 1995) |
| "Finally, comparison of control and AMG-treated melanoma cells by pathway-specific gene array analysis indicated that inhibition of NO synthesis led, before induction of apoptosis, to up-regulation of mRNA levels of genes involved in the apoptosis pathway such as Bax, caspase-1, caspase-3, caspase-6, gadd45beta, mdm2, and TRAIL." | 1.31 | Antiapoptotic role of endogenous nitric oxide in human melanoma cells. ( Anichini, A; Bersani, I; Carsana, M; Salvucci, O; Tragni, G, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pisha, E | 1 |
| Chai, H | 1 |
| Lee, IS | 1 |
| Chagwedera, TE | 1 |
| Farnsworth, NR | 1 |
| Cordell, GA | 1 |
| Beecher, CW | 1 |
| Fong, HH | 1 |
| Kinghorn, AD | 1 |
| Brown, DM | 1 |
| Salvucci, O | 1 |
| Carsana, M | 1 |
| Bersani, I | 1 |
| Tragni, G | 1 |
| Anichini, A | 1 |
2 other studies available for pimagedine and Melanoma
| Article | Year |
|---|---|
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; DNA Damage; Growth Inhibitors | 1995 |
Antiapoptotic role of endogenous nitric oxide in human melanoma cells.
Topics: Apoptosis; Caspase 1; Caspase 3; Caspases; Cell Cycle; Down-Regulation; Enzyme Inhibitors; Gene Expr | 2001 |