pimagedine has been researched along with Kidney Failure, Chronic in 13 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " During the interdialytic period, the maximum aminoguanidine concentration (Cmax) and time to reach Cmax was 4." | 2.68 | The pharmacokinetics of aminoguanidine in end-stage renal disease patients on hemodialysis. ( Foote, EF; Giles, P; Halstenson, CE; Keane, WF; Look, ZM, 1995) |
| "Renal functional decline in diabetic nephropathy is slowed by establishment of euglycaemia and normalization of hypertensive blood pressure." | 2.40 | Advanced glycation end-products in diabetic nephropathy. ( Friedman, EA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (61.54) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, S | 1 |
| Li, B | 1 |
| Li, C | 1 |
| Cui, W | 1 |
| Miao, L | 1 |
| Tomino, Y | 1 |
| Inagi, R | 1 |
| Miyata, T | 1 |
| Ueda, Y | 1 |
| Yoshino, A | 1 |
| Nangaku, M | 1 |
| van Ypersele de Strihou, C | 1 |
| Kurokawa, K | 1 |
| Foote, EF | 1 |
| Look, ZM | 1 |
| Giles, P | 1 |
| Keane, WF | 1 |
| Halstenson, CE | 1 |
| Bucala, R | 1 |
| Makita, Z | 1 |
| Vega, G | 1 |
| Grundy, S | 1 |
| Koschinsky, T | 1 |
| Cerami, A | 1 |
| Vlassara, H | 1 |
| Friedman, EA | 3 |
| Distant, DA | 1 |
| Fleishhacker, JF | 1 |
| Boyd, TA | 1 |
| Cartwright, K | 2 |
| Brooks, DP | 1 |
| Contino, LC | 1 |
| Weiss, MF | 2 |
| Saxena, AK | 1 |
| Monnier, VM | 2 |
| Freedman, BI | 1 |
| Wuerth, JP | 1 |
| Bain, RP | 1 |
| Dippe, S | 1 |
| Hershon, K | 1 |
| Mooradian, AD | 1 |
| Spinowitz, BS | 1 |
| Erhard, P | 1 |
| Kader-Attia, FA | 1 |
| Wu, YC | 1 |
| Deoreo, PB | 1 |
| Araki, A | 1 |
| Glomb, MA | 1 |
| Nohara, Y | 1 |
| Usui, T | 1 |
| Kinoshita, T | 1 |
| Watanabe, M | 1 |
4 reviews available for pimagedine and Kidney Failure, Chronic
| Article | Year |
|---|---|
Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy.
Topics: Animals; Anthocyanins; Antibodies, Monoclonal; Connective Tissue Growth Factor; Diabetes Mellitus; D | 2015 |
Mechanisms and interventions in peritoneal fibrosis.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Epithelial Cell | 2012 |
Will pimagidine improve survival of diabetics on dialysis?
Topics: Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; Guani | 1996 |
Advanced glycation end-products in diabetic nephropathy.
Topics: Animals; Diabetic Nephropathies; Enzyme Inhibitors; Female; Glucose; Glycation End Products, Advance | 1999 |
3 trials available for pimagedine and Kidney Failure, Chronic
| Article | Year |
|---|---|
The pharmacokinetics of aminoguanidine in end-stage renal disease patients on hemodialysis.
Topics: Diabetic Nephropathies; Female; Guanidines; Half-Life; Humans; Kidney; Kidney Failure, Chronic; Male | 1995 |
Modification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency.
Topics: Animals; Cholesterol; Diabetes Mellitus; Diabetic Nephropathies; Enzyme-Linked Immunosorbent Assay; | 1994 |
Design and baseline characteristics for the aminoguanidine Clinical Trial in Overt Type 2 Diabetic Nephropathy (ACTION II).
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Drug Administra | 1999 |
6 other studies available for pimagedine and Kidney Failure, Chronic
| Article | Year |
|---|---|
Efficient in vitro lowering of carbonyl stress by the glyoxalase system in conventional glucose peritoneal dialysis fluid.
Topics: Animals; CHO Cells; Cricetinae; Deoxyglucose; Dialysis Solutions; Gene Expression Regulation, Enzymo | 2002 |
Aminoguanidine prolongs survival in azotemic-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Glycation End P | 1997 |
Involvement of nitric oxide synthase in proteinuria associated with chronic renal disease in rats.
Topics: Animals; Blood Pressure; Blood Urea Nitrogen; Creatinine; Enzyme Inhibitors; Guanidines; Kidney Fail | 1998 |
Pharmacological modulation of AGEs: a unique role for redox-active metal ions.
Topics: Animals; Antioxidants; Chelating Agents; Diabetes Mellitus; Glycation End Products, Advanced; Guanid | 1999 |
Mechanisms for the formation of glycoxidation products in end-stage renal disease.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Enzyme Inhibitors; Female; Glucose; Glycation End Products | 2000 |
Generation of superoxide anions during the reaction of guanidino compounds with methylglyoxal.
Topics: Guanidine; Guanidines; Humans; Kidney Failure, Chronic; Oxidative Stress; Pyruvaldehyde; Superoxides | 2002 |