pimagedine has been researched along with Intraocular Pressure in 6 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Intraocular Pressure: The pressure of the fluids in the eye.
| Excerpt | Relevance | Reference |
|---|---|---|
| "4 mg) caused no significant toxic ocular effects in rabbit eyes." | 1.46 | TOWARDS A TREATMENT FOR DIABETIC RETINOPATHY: Intravitreal Toxicity and Preclinical Safety Evaluation of Inducible Nitric Oxide Synthase Inhibitors. ( Bennett, LD; Birch, DG; Carr, BC; Emigh, CE; Nguyen, C; Pansick, AD, 2017) |
| "Elevated intraocular pressure was induced unilaterally by translimbal laser photocoagulation of the trabecular meshwork in Sprague-Dawley rats." | 1.37 | Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats. ( Dai, Y; Ellisman, MH; Ju, WK; Kim, KY; Lindsey, JD; Nguyen, D; Park, S; Sun, X; Weinreb, RN, 2011) |
| "Glaucoma is an optic neuropathy with cupping of the optic disk, degeneration of retinal ganglion cells, and characteristic visual field loss." | 1.30 | Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. ( Becker, B; Neufeld, AH; Sawada, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carr, BC | 1 |
| Emigh, CE | 1 |
| Bennett, LD | 1 |
| Pansick, AD | 1 |
| Birch, DG | 1 |
| Nguyen, C | 1 |
| Dai, Y | 1 |
| Weinreb, RN | 1 |
| Kim, KY | 1 |
| Nguyen, D | 1 |
| Park, S | 1 |
| Sun, X | 1 |
| Lindsey, JD | 1 |
| Ellisman, MH | 1 |
| Ju, WK | 1 |
| Pang, IH | 1 |
| Johnson, EC | 1 |
| Jia, L | 1 |
| Cepurna, WO | 1 |
| Shepard, AR | 1 |
| Hellberg, MR | 1 |
| Clark, AF | 1 |
| Morrison, JC | 1 |
| Geyer, O | 1 |
| Almog, J | 1 |
| Lupu-Meiri, M | 1 |
| Lazar, M | 1 |
| Oron, Y | 1 |
| Taniguchi, T | 1 |
| Kawakami, H | 1 |
| Sawada, A | 2 |
| Iwaki, M | 1 |
| Tsuji, A | 1 |
| Sugiyama, K | 1 |
| Kitazawa, Y | 1 |
| Neufeld, AH | 1 |
| Becker, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Trial Of The Effect Of Tropical Fruits On Intraocular Pressure And Retinal Nerve Fibre Layer Thickness In Patients With Primary Glaucoma[NCT06071494] | 102 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for pimagedine and Intraocular Pressure
| Article | Year |
|---|---|
TOWARDS A TREATMENT FOR DIABETIC RETINOPATHY: Intravitreal Toxicity and Preclinical Safety Evaluation of Inducible Nitric Oxide Synthase Inhibitors.
Topics: Amidines; Animals; Aqueous Humor; Benzylamines; Diabetic Retinopathy; Disease Models, Animal; Electr | 2017 |
Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats.
Topics: Animals; Blotting, Western; Cell Survival; Disease Models, Animal; Enzyme Inhibitors; Gene Expressio | 2011 |
Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage.
Topics: Aged; Animals; Caenorhabditis elegans Proteins; Disease Models, Animal; Enzyme Inhibitors; Gene Expr | 2005 |
Nitric oxide synthase inhibitors protect rat retina against ischemic injury.
Topics: Animals; Arginine; Cell Count; Enzyme Inhibitors; Guanidines; Intraocular Pressure; Ischemia; Male; | 1995 |
Effects of nitric oxide synthase inhibitor on intraocular pressure and ocular inflammation following laser irradiation in rabbits.
Topics: Animals; Aqueous Humor; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eye Prote | 1998 |
Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma.
Topics: Animals; Chronic Disease; Enzyme Inhibitors; Glaucoma; Guanidines; Humans; Intraocular Pressure; Mal | 1999 |