Page last updated: 2024-10-22

pimagedine and Hypoxia

pimagedine has been researched along with Hypoxia in 14 studies

pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
" Vasoconstriction to hypoxia, angiotensin II (AII), and prostaglandin F2 alpha (PGF2 alpha) was enhanced or unchanged in LPS-treated rats despite NOS induction."3.69In vivo treatment with endotoxin increases rat pulmonary vascular contractility despite NOS induction. ( Curzen, NP; Evans, TW; Griffiths, MJ; Mitchell, JA, 1997)
"Neuroprotection against cerebral ischemia can be realized if the brain is preconditioned by previous exposure to a brief period of sublethal ischemia."1.30Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning. ( Gidday, JM; Holtzman, DM; Maceren, RG; Park, TS; Pelligrino, DA; Shah, AR; Wang, Q, 1999)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (28.57)18.2507
2000's8 (57.14)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Udayabanu, M1
Kumaran, D1
Nair, RU1
Srinivas, P1
Bhagat, N1
Aneja, R1
Katyal, A1
Belaidi, E2
Beguin, PC2
Levy, P2
Ribuot, C2
Godin-Ribuot, D2
Nordquist, L1
Liss, P1
Fasching, A1
Hansell, P1
Palm, F1
Coney, AM1
Bishay, M1
Marshall, JM2
Fike, CD1
Aschner, JL1
Zhang, Y1
Kaplowitz, MR1
Jiang, H1
Koubi, D1
Zhang, L1
Kuo, J1
Rodriguez, AI1
Hunter, TJ1
Gautam, SC1
Levine, RA1
Ding, HL1
Zhu, HF1
Dong, JW1
Zhu, WZ1
Yang, WW1
Yang, HT1
Zhou, ZN1
Walsh, MP1
Griffiths, MJ1
Curzen, NP1
Mitchell, JA1
Evans, TW1
Tyler, RC1
Muramatsu, M1
Abman, SH1
Stelzner, TJ1
Rodman, DM1
Bloch, KD1
McMurtry, IF1
Gidday, JM1
Shah, AR1
Maceren, RG1
Wang, Q1
Pelligrino, DA1
Holtzman, DM1
Park, TS1
Sinz, EH1
Kochanek, PM1
Dixon, CE1
Clark, RS1
Carcillo, JA1
Schiding, JK1
Chen, M1
Wisniewski, SR1
Carlos, TM1
Williams, D1
DeKosky, ST1
Watkins, SC1
Marion, DW1
Billiar, TR1
Tsuji, M1
Higuchi, Y1
Shiraishi, K1
Kume, T1
Akaike, A1
Hattori, H1

Other Studies

14 other studies available for pimagedine and Hypoxia

ArticleYear
Nitric oxide associated with iNOS expression inhibits acetylcholinesterase activity and induces memory impairment during acute hypobaric hypoxia.
    Brain research, 2008, Sep-16, Volume: 1230

    Topics: Acetylcholinesterase; Amnesia, Anterograde; Amnesia, Retrograde; Animals; Avoidance Learning; Blotti

2008
Delayed myocardial preconditioning induced by cobalt chloride in the rat: HIF-1α and iNOS involvement.
    Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:4

    Topics: Animals; Cadmium; Cardiotonic Agents; Cobalt; Guanidines; Heart; Hypoxia; Hypoxia-Inducible Factor 1

2012
Hypoxia in the diabetic kidney is independent of advanced glycation end-products.
    Advances in experimental medicine and biology, 2013, Volume: 765

    Topics: Animals; Diabetes Complications; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inh

2013
Influence of endogenous nitric oxide on sympathetic vasoconstriction in normoxia, acute and chronic systemic hypoxia in the rat.
    The Journal of physiology, 2004, Mar-16, Volume: 555, Issue:Pt 3

    Topics: Acute Disease; Animals; Chronic Disease; Electric Stimulation; Enzyme Inhibitors; Guanidines; Hindli

2004
Impaired NO signaling in small pulmonary arteries of chronically hypoxic newborn piglets.
    American journal of physiology. Lung cellular and molecular physiology, 2004, Volume: 286, Issue:6

    Topics: Animals; Animals, Newborn; Caveolin 1; Caveolins; Chronic Disease; Enzyme Inhibitors; Guanidines; HS

2004
Inhibitors of iNOS protects PC12 cells against the apoptosis induced by oxygen and glucose deprivation.
    Neuroscience letters, 2005, Feb-25, Volume: 375, Issue:1

    Topics: Amidines; Animals; Apoptosis; Benzylamines; Blotting, Western; Caspase 3; Caspases; Cytochromes c; D

2005
Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury.
    Acta pharmacologica Sinica, 2005, Volume: 26, Issue:3

    Topics: Animals; Guanidines; Hypoxia; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion

2005
The role of adenosine in the early respiratory and cardiovascular changes evoked by chronic hypoxia in the rat.
    The Journal of physiology, 2006, Aug-15, Volume: 575, Issue:Pt 1

    Topics: Adenosine; Animals; Blood Pressure; Cardiovascular System; Enzyme Inhibitors; Guanidines; Heart Rate

2006
Prevention of HIF-1 activation and iNOS gene targeting by low-dose cadmium results in loss of myocardial hypoxic preconditioning in the rat.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:2

    Topics: Animals; Biotransformation; Blotting, Western; Cadmium Chloride; Chromatin; Enzyme-Linked Immunosorb

2008
In vivo treatment with endotoxin increases rat pulmonary vascular contractility despite NOS induction.
    American journal of respiratory and critical care medicine, 1997, Volume: 156, Issue:2 Pt 1

    Topics: Angiotensin II; Animals; Dinoprost; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhib

1997
Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension.
    The American journal of physiology, 1999, Volume: 276, Issue:2

    Topics: Animals; Enzyme Inhibitors; Guanidines; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hyp

1999
Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1999, Volume: 19, Issue:3

    Topics: Animals; Animals, Newborn; Brain Ischemia; Calcium; Dizocilpine Maleate; Enzyme Inhibitors; Guanidin

1999
Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice.
    The Journal of clinical investigation, 1999, Volume: 104, Issue:5

    Topics: Animals; Brain Damage, Chronic; Brain Injuries; Cognition Disorders; Enzyme Induction; Enzyme Inhibi

1999
Protective effect of aminoguanidine on hypoxic-ischemic brain damage and temporal profile of brain nitric oxide in neonatal rat.
    Pediatric research, 2000, Volume: 47, Issue:1

    Topics: Animals; Animals, Newborn; Brain; Brain Ischemia; Guanidines; Hypoxia; Nitric Oxide; Rats

2000