pimagedine has been researched along with Hypotension in 14 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compares the effects of aminoguanidine, a relatively selective inhibitor of inducible nitric oxide (NO) synthase, and N omega-nitro-L-arginine methyl ester (L-NAME), a selective inhibitor of endothelial NO synthase, on hypotension and multiple organ dysfunction caused by endotoxaemia in the anaesthetised rat." | 3.69 | Comparison of the effects of aminoguanidine and N omega-nitro-L-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat. ( Ruetten, H; Thiemermann, C; Wu, CC, 1996) |
| "Septic shock is characterized by arteriolar vasodilation and hypotension." | 1.31 | Inducible nitric oxide synthase pathway in the central nervous system and vasopressin release during experimental septic shock. ( Antunes-Rodrigues, J; Carnio, EC; De Castro, M; Giusti-Paiva, A, 2002) |
| "Furthermore, acidosis caused lung inflammation, as suggested by the increase in lung myeloperoxidase activity (282." | 1.30 | Acidosis stimulates nitric oxide production and lung damage in rats. ( Camporesi, EM; Caruso, JE; Hakim, TS; Hoffmann, SP; McGraw, DJ; Nandi, J; Oler, A; Pedoto, A; Tassiopoulos, AK, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Doursout, MF | 1 |
| Oguchi, T | 1 |
| Fischer, UM | 1 |
| Liang, Y | 1 |
| Chelly, B | 1 |
| Hartley, CJ | 1 |
| Chelly, JE | 1 |
| Lin, HC | 2 |
| Wan, FJ | 2 |
| Calvert, TJ | 1 |
| Chicoine, LG | 1 |
| Liu, Y | 1 |
| Nelin, LD | 1 |
| Zhang, W | 1 |
| Shibamoto, T | 1 |
| Cui, S | 1 |
| Takano, H | 1 |
| Kurata, Y | 1 |
| Lomis, TJ | 1 |
| Siffring, CW | 1 |
| Chalasani, S | 1 |
| Ziegler, DW | 1 |
| Lentz, KE | 1 |
| Stauffer, KE | 1 |
| McMillan, A | 1 |
| Agarwal, N | 1 |
| Lowenstein, CJ | 1 |
| Rhoads, JE | 1 |
| Klabunde, RE | 1 |
| Coston, AF | 1 |
| Wu, CC | 4 |
| Chen, SJ | 1 |
| Szabó, C | 1 |
| Thiemermann, C | 2 |
| Vane, JR | 1 |
| Ruetten, H | 1 |
| Yen, MH | 1 |
| Pedoto, A | 1 |
| Caruso, JE | 1 |
| Nandi, J | 1 |
| Oler, A | 1 |
| Hoffmann, SP | 1 |
| Tassiopoulos, AK | 1 |
| McGraw, DJ | 1 |
| Camporesi, EM | 1 |
| Hakim, TS | 1 |
| Kang, BH | 1 |
| Tseng, CJ | 1 |
| Chan, JY | 1 |
| Wang, SH | 1 |
| Chan, SH | 1 |
| Metcalf, K | 1 |
| Jungersten, L | 1 |
| Lisander, B | 1 |
| Giusti-Paiva, A | 1 |
| De Castro, M | 1 |
| Antunes-Rodrigues, J | 1 |
| Carnio, EC | 1 |
14 other studies available for pimagedine and Hypotension
| Article | Year |
|---|---|
Distribution of NOS isoforms in a porcine endotoxin shock model.
Topics: Animals; Cardiomyopathies; Coronary Circulation; Disease Models, Animal; Enzyme Activation; Enzyme I | 2008 |
Hyperbaric oxygenation reduces overexpression of c-Fos and oxidative stress in the brain stem of experimental endotoxemic rats.
Topics: Analysis of Variance; Animals; Brain Stem; Guanidines; Hydralazine; Hyperbaric Oxygenation; Hypotens | 2008 |
Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin.
Topics: Animals; Blood Pressure; Breath Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Dua | 2008 |
7-nitroindazole, but not L-NAME or aminoguanidine, attenuates anaphylactic hypotension in conscious rats.
Topics: Anaphylaxis; Animals; Antigens; Enzyme Inhibitors; Guanidines; Hypotension; Indazoles; Male; NG-Nitr | 2009 |
First place winner of the Conrad Jobst Award in the gold medal paper competition. Nitric oxide synthase inhibitors N-monomethylarginine and aminoguanidine prevent the progressive and severe hypotension associated with a rat model of pancreatitis.
Topics: Amylases; Animals; Arginine; Blood Pressure; Calcium; Clinical Protocols; Disease Models, Animal; Dr | 1995 |
Nitric oxide synthase inhibition does not prevent cardiac depression in endotoxic shock.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cardiac Output, Low; Dexamethasone; Guanidines; Heart | 1995 |
Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Disease Models, Animal; Dose-Response | 1995 |
Comparison of the effects of aminoguanidine and N omega-nitro-L-arginine methyl ester on the multiple organ dysfunction caused by endotoxaemia in the rat.
Topics: Animals; Arginine; Blood Pressure; Dose-Response Relationship, Drug; Endotoxins; Enzyme Inhibitors; | 1996 |
Combined effects of dexamethasone and aminoguanidine on rats with endotoxemia.
Topics: Animals; Blood Pressure; Dexamethasone; Drug Interactions; Endotoxemia; Enzyme Inhibitors; Guanidine | 1998 |
Acidosis stimulates nitric oxide production and lung damage in rats.
Topics: Acidosis; Animals; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Dose-Response Relatio | 1999 |
Systemic administration of lipopolysaccharide induces release of nitric oxide and glutamate and c-fos expression in the nucleus tractus solitarii of rats.
Topics: Animals; Cardiovascular Physiological Phenomena; Chromatography, High Pressure Liquid; Data Interpre | 1999 |
Differential roles of iNOS and nNOS at rostral ventrolateral medulla during experimental endotoxemia in the rat.
Topics: Animals; Blood Pressure; Endotoxemia; Enzyme Inhibitors; Escherichia coli; Guanidines; Hypotension; | 2001 |
Effective inhibition of nitric oxide production by aminoguanidine does not reverse hypotension in endotoxaemic rats.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Endotoxemia; Guanidines; Hypotension; Mal | 2002 |
Inducible nitric oxide synthase pathway in the central nervous system and vasopressin release during experimental septic shock.
Topics: Animals; Central Nervous System; Enzyme Inhibitors; Guanidines; Hemodynamics; Hypotension; Lipopolys | 2002 |