pimagedine has been researched along with Hypertension in 29 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The involvement of nitric oxide (NO), prostaglandins, and calcium-dependent potassium channel (K(Ca)) activators on the negative modulation of phenylephrine-induced contractions was evaluated on the isolated aorta and caudal (CAU) artery obtained from rats treated with ouabain for 5 wk to induce hypertension." | 7.71 | Ouabain-induced hypertension is accompanied by increases in endothelial vasodilator factors. ( Alonso, MJ; Barker, LA; Briones, AM; Miguel, M; Rossoni, LV; Salaices, M; Vassallo, DV, 2002) |
| " Obesity was induced by the administration of 4 mg/g body weight of monosodium glutamate (MSG) or equimolar saline (CTR) in newborn rats." | 3.85 | iNOS inhibition improves autonomic dysfunction and oxidative status in hypertensive obese rats. ( Cecchini, R; da Cunha, NV; Lopes, FN; Martins-Pinge, MC; Panis, C; Pinge-Filho, P, 2017) |
| "The expression of HO-1 and iNOS in aorta increased with the SBP elevation during the development of SHR and was attenuated when the hypertension was lowered with the vasodilator hydralazine." | 3.72 | The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats. ( Chen, JJ; Cheng, PY; Yen, MH, 2004) |
| "The involvement of nitric oxide (NO), prostaglandins, and calcium-dependent potassium channel (K(Ca)) activators on the negative modulation of phenylephrine-induced contractions was evaluated on the isolated aorta and caudal (CAU) artery obtained from rats treated with ouabain for 5 wk to induce hypertension." | 3.71 | Ouabain-induced hypertension is accompanied by increases in endothelial vasodilator factors. ( Alonso, MJ; Barker, LA; Briones, AM; Miguel, M; Rossoni, LV; Salaices, M; Vassallo, DV, 2002) |
| "Reduced vascular histamine content is postulated to contribute to increased peripheral vascular resistance in experimental hypertension in rats." | 3.67 | Studies on uptake and catabolism of vascular histamine in spontaneously hypertensive rats. ( Holcslaw, TL; Nichols, G; Wilson, C, 1985) |
| " Chronic administration of AG did not modify significantly any parameter in cirrhotic and control animals." | 1.31 | [Renal effects of the chronic inhibition of nitric oxide synthesis in cirrhotic rats with ascites]. ( Atucha, NM; Eleno, N; Fortepiani, LA; García-Estañ, J; López-Novoa, JM; Martínez-Salgado, C; Ortiz, MC, 2001) |
| "Arterial hypertension has been identified as a major secondary risk factor for diabetic retinopathy." | 1.29 | Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat. ( Brownlee, M; Edelstein, D; Federlin, K; Hammes, HP; Martin, S; Saleck, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 6 (20.69) | 18.2507 |
| 2000's | 16 (55.17) | 29.6817 |
| 2010's | 5 (17.24) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Zicha, J | 2 |
| Řezáčová, L | 1 |
| Vaněčková, I | 1 |
| da Cunha, NV | 1 |
| Lopes, FN | 1 |
| Panis, C | 1 |
| Cecchini, R | 1 |
| Pinge-Filho, P | 1 |
| Martins-Pinge, MC | 1 |
| Kimura, Y | 1 |
| Hirooka, Y | 1 |
| Kishi, T | 1 |
| Ito, K | 1 |
| Sagara, Y | 1 |
| Sunagawa, K | 1 |
| Carnevale, D | 1 |
| Mascio, G | 1 |
| D'Andrea, I | 1 |
| Fardella, V | 1 |
| Bell, RD | 1 |
| Branchi, I | 1 |
| Pallante, F | 1 |
| Zlokovic, B | 1 |
| Yan, SS | 1 |
| Lembo, G | 1 |
| Mukohda, M | 1 |
| Okada, M | 1 |
| Hara, Y | 1 |
| Yamawaki, H | 1 |
| Huang, CF | 1 |
| Hsu, CN | 1 |
| Chien, SJ | 1 |
| Lin, YJ | 1 |
| Huang, LT | 1 |
| Tain, YL | 1 |
| Sharma, B | 1 |
| Singh, N | 1 |
| Rossoni, LV | 1 |
| Salaices, M | 1 |
| Miguel, M | 1 |
| Briones, AM | 1 |
| Barker, LA | 1 |
| Vassallo, DV | 1 |
| Alonso, MJ | 1 |
| Tian, N | 1 |
| Gannon, AW | 1 |
| Khalil, RA | 1 |
| Manning, RD | 2 |
| Kobayashi, N | 1 |
| Horinaka, S | 1 |
| Mita, S | 1 |
| Yoshida, K | 1 |
| Honda, T | 1 |
| Kobayashi, T | 1 |
| Hara, K | 1 |
| Nishikimi, T | 1 |
| Matsuoka, H | 1 |
| Pechánová, O | 1 |
| Dobesová, Z | 1 |
| Cejka, J | 1 |
| Kunes, J | 1 |
| Cheng, PY | 1 |
| Chen, JJ | 1 |
| Yen, MH | 3 |
| Sun, Y | 1 |
| Iemitsu, M | 1 |
| Shimojo, N | 2 |
| Miyauchi, T | 1 |
| Amamiya, M | 1 |
| Sumi, D | 1 |
| Hayashi, T | 1 |
| Sun, G | 1 |
| Kumagai, Y | 1 |
| Neves, SR | 1 |
| Machado, CR | 1 |
| Pinto, AM | 1 |
| Borges, AH | 1 |
| Cunha, FQ | 1 |
| Camargos, ER | 1 |
| McEniery, CM | 1 |
| Chan, V | 1 |
| Hoey, A | 1 |
| Brown, L | 1 |
| Wang, X | 1 |
| Chang, T | 1 |
| Jiang, B | 1 |
| Desai, K | 1 |
| Wu, L | 1 |
| Castellino, P | 1 |
| Tuttle, KR | 1 |
| DeFronzo, RA | 1 |
| Hammes, HP | 1 |
| Brownlee, M | 2 |
| Edelstein, D | 2 |
| Saleck, M | 1 |
| Martin, S | 1 |
| Federlin, K | 1 |
| Wolffenbuttel, BH | 1 |
| van Haeften, TW | 1 |
| Tsukahara, H | 1 |
| Imura, T | 1 |
| Tsuchida, S | 1 |
| Nunose, M | 1 |
| Hori, C | 1 |
| Hiraoka, M | 1 |
| Gejyo, F | 1 |
| Sudo, M | 1 |
| Liu, YC | 1 |
| Hong, HJ | 2 |
| Sheu, JR | 1 |
| Wu, CC | 1 |
| Arai, T | 1 |
| Morimoto, K | 1 |
| Oka, M | 1 |
| Hikita, T | 1 |
| Arai, K | 1 |
| Umezawa, K | 1 |
| Nagase, M | 1 |
| Yamamoto, T | 1 |
| Loh, SH | 1 |
| Tan, DY | 1 |
| Meng, S | 1 |
| Cason, GW | 1 |
| Zhu, Y | 1 |
| Bian, Z | 1 |
| Lu, P | 1 |
| Karas, RH | 1 |
| Bao, L | 1 |
| Cox, D | 1 |
| Hodgin, J | 1 |
| Shaul, PW | 1 |
| Thoren, P | 1 |
| Smithies, O | 1 |
| Gustafsson, JA | 1 |
| Mendelsohn, ME | 1 |
| Ortiz, MC | 1 |
| Fortepiani, LA | 1 |
| Martínez-Salgado, C | 1 |
| Eleno, N | 1 |
| Atucha, NM | 1 |
| López-Novoa, JM | 1 |
| García-Estañ, J | 1 |
| Holcslaw, TL | 1 |
| Nichols, G | 1 |
| Wilson, C | 1 |
1 review available for pimagedine and Hypertension
| Article | Year |
|---|---|
Prevention of complications in non-insulin-dependent diabetes mellitus (NIDDM).
Topics: Acarbose; Aldehyde Reductase; Biguanides; Diabetes Mellitus, Type 2; Glucose; Guanidines; Humans; Hy | 1995 |
28 other studies available for pimagedine and Hypertension
| Article | Year |
|---|---|
Nitric oxide and salt resistance in Dahl rats: no role of inducible NO synthase.
Topics: Animals; Blood Pressure; Hypertension; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Ty | 2023 |
iNOS inhibition improves autonomic dysfunction and oxidative status in hypertensive obese rats.
Topics: Animals; Arterial Pressure; Autonomic Nervous System; Dinoprostone; Enzyme Inhibitors; Guanidines; H | 2017 |
Role of inducible nitric oxide synthase in rostral ventrolateral medulla in blood pressure regulation in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Guanidines; Heart | 2009 |
Hypertension induces brain β-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Alzheimer Disease; Amyloid beta-Peptides; An | 2012 |
Methylglyoxal accumulation in arterial walls causes vascular contractile dysfunction in spontaneously hypertensive rats.
Topics: Acetylcholine; Angiotensin II; Animals; Endothelium, Vascular; Glycation End Products, Advanced; Gua | 2012 |
Aminoguanidine attenuates hypertension, whereas 7-nitroindazole exacerbates kidney damage in spontaneously hypertensive rats: the role of nitric oxide.
Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Citrulline; Guanidines; Hypertension; Indazoles; | 2013 |
Pharmacological inhibition of inducible nitric oxide synthase (iNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, convalesce behavior and biochemistry of hypertension induced vascular dementia in rats.
Topics: Acetophenones; Animals; Brain Chemistry; Convalescence; Dementia, Vascular; Guanidines; Hypertension | 2013 |
Ouabain-induced hypertension is accompanied by increases in endothelial vasodilator factors.
Topics: Animals; Biological Factors; Blood Pressure; Cardiotonic Agents; Cyclooxygenase Inhibitors; Endothel | 2002 |
Mechanisms of salt-sensitive hypertension: role of renal medullary inducible nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Enzyme Induction; Glomerular Filtration Rate; Guanidines; Heart Rate | 2003 |
Aminoguanidine inhibits mitogen-activated protein kinase and improves cardiac performance and cardiovascular remodeling in failing hearts of salt-sensitive hypertensive rats.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Gene Expression; Guanidines; Heart; Heart Failure; Hyper | 2002 |
Vasoactive systems in L-NAME hypertension: the role of inducible nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inh | 2004 |
The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Biomarkers; Blood Pressure; Blotting, Western; Disease Mode | 2004 |
2,4,6-Trinitrotoluene inhibits endothelial nitric oxide synthase activity and elevates blood pressure in rats.
Topics: Animals; Blood Pressure; Cell Membrane; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Guani | 2005 |
Macrophage populations and cardiac sympathetic denervation during L-NAME-induced hypertension in rats.
Topics: Animals; Drug Therapy, Combination; Enzyme Inhibitors; Guanidines; Heart; Hemodynamics; Hypertension | 2006 |
Novel therapeutic strategies for reducing arterial stiffness.
Topics: Arteries; Cardiovascular Agents; Cardiovascular Diseases; Glycation End Products, Advanced; Guanidin | 2006 |
Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats.
Topics: Action Potentials; Animals; Aorta, Thoracic; Cardiovascular Diseases; Collagen; Cross-Linking Reagen | 2006 |
Attenuation of hypertension development by aminoguanidine in spontaneously hypertensive rats: role of methylglyoxal.
Topics: Animals; Aorta; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Free Radicals; Glutathione | 2007 |
Diabetic nephropathy.
Topics: Adrenergic beta-Antagonists; Aldehyde Reductase; Angiotensin-Converting Enzyme Inhibitors; Animals; | 1994 |
Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat.
Topics: Aneurysm; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Angiopat | 1994 |
Renal functional measurements in young rats with chronic inhibition of nitric oxide synthase.
Topics: Animals; Cholesterol; Creatinine; Enzyme Inhibitors; Guanidines; Hypertension; Kidney; Male; NG-Nitr | 1996 |
Role of nitric oxide in lipopolysaccharide-induced mortality from spontaneously hypertensive rats.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherich | 1997 |
Aminoguanidine induces haematuria of non-glomerular origin in spontaneously hypertensive rats.
Topics: Albuminuria; Animals; Arterioles; Blood Pressure; Creatinine; Glomerulonephritis; Guanidines; Hematu | 2000 |
Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hypertension; | 2000 |
Mechanisms of salt-sensitive hypertension: role of inducible nitric oxide synthase.
Topics: Animals; Blood Pressure; Diuresis; Glomerular Filtration Rate; Guanidines; Hemodynamics; Hypertensio | 2000 |
Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Blood Pressure; Cells, Cultured; Estradiol; Estrogen Anta | 2002 |
[Renal effects of the chronic inhibition of nitric oxide synthesis in cirrhotic rats with ascites].
Topics: Animals; Ascites; Blood Pressure; Carbon Tetrachloride; Diuresis; Glomerular Filtration Rate; Guanid | 2001 |
Aminoguanidine ameliorates albuminuria in diabetic hypertensive rats.
Topics: Albuminuria; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; | 1992 |
Studies on uptake and catabolism of vascular histamine in spontaneously hypertensive rats.
Topics: Animals; Blood Vessels; Guanidines; Histamine; Hypertension; Imidazoles; In Vitro Techniques; Male; | 1985 |