pimagedine has been researched along with Hyperglycemia in 23 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Hyperglycemia: Abnormally high BLOOD GLUCOSE level.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperglycemia is considered a key causal factor in the development of diabetic vascular complications and can mediate its adverse effects through multiple pathways." | 2.41 | Glycation as the glucose link to diabetic complications. ( Gugliucci, A, 2000) |
| "In rats with untreated diabetes, hyperglycaemia, increased activity of inducible nitric oxide (NO) synthase, increased NO, mild vascular spasm, reduced NO bioavailability and diminished vasorelaxation were found." | 1.36 | NaHS ameliorates diabetic vascular injury by correcting depressed connexin 43 and 40 in the vasculature in streptozotocin-injected rats. ( Dai, DZ; Dai, Y; Zheng, YF, 2010) |
| " In this study, we show that the development of diabetes, measured by increased water intake and concomitant midday blood glucose levels in type II genetically diabetic mice, is reduced by treatment with aminoguanidine at a dosage of 500 mg/kg/d for 12 weeks in the diet." | 1.30 | Potential benefit of inhibitors of advanced glycation end products in the progression of type II diabetes: a study with aminoguanidine in C57/BLKsJ diabetic mice. ( Piercy, V; Toseland, CD; Turner, NC, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (43.48) | 18.2507 |
| 2000's | 7 (30.43) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Arif, B | 1 |
| Arif, Z | 1 |
| Ahmad, J | 1 |
| Perveen, K | 1 |
| Bukhari, NA | 1 |
| Ashraf, JM | 1 |
| Alam, K | 1 |
| Song, Y | 1 |
| Zhang, F | 1 |
| Ying, C | 1 |
| Kumar, KA | 1 |
| Zhou, X | 1 |
| Joseph, D | 1 |
| Kimar, C | 1 |
| Symington, B | 1 |
| Milne, R | 1 |
| Essop, MF | 1 |
| Zheng, YF | 1 |
| Dai, DZ | 1 |
| Dai, Y | 1 |
| Labieniec-Watala, M | 1 |
| Siewiera, K | 1 |
| Jozwiak, Z | 1 |
| Engelen, L | 1 |
| Stehouwer, CD | 1 |
| Schalkwijk, CG | 1 |
| Jakus, V | 1 |
| Rietbrock, N | 1 |
| Pennathur, S | 1 |
| Ido, Y | 1 |
| Heller, JI | 1 |
| Byun, J | 1 |
| Danda, R | 1 |
| Pergola, P | 1 |
| Williamson, JR | 1 |
| Heinecke, JW | 1 |
| Holstad, M | 1 |
| Sandler, S | 1 |
| Wolffenbuttel, BH | 1 |
| van Haeften, TW | 1 |
| Friedman, EA | 2 |
| Bucala, R | 1 |
| Piercy, V | 1 |
| Toseland, CD | 1 |
| Turner, NC | 1 |
| Teixeira, AS | 1 |
| Andrade, SP | 1 |
| Iqbal, M | 1 |
| Probert, LL | 1 |
| Alhumadi, NH | 1 |
| Klandorf, H | 1 |
| Kajimoto, Y | 1 |
| Matsuoka, T | 1 |
| Kaneto, H | 1 |
| Watada, H | 1 |
| Fujitani, Y | 1 |
| Kishimoto, M | 1 |
| Sakamoto, K | 1 |
| Matsuhisa, M | 1 |
| Kawamori, R | 1 |
| Yamasaki, Y | 1 |
| Hori, M | 1 |
| Gugliucci, A | 1 |
| El-Khatib, AS | 1 |
| Moustafa, AM | 1 |
| Abdel-Aziz, AA | 1 |
| Al-Shabanah, OA | 1 |
| El-Kashef, HA | 1 |
| Sugita, H | 1 |
| Kaneki, M | 1 |
| Tokunaga, E | 1 |
| Sugita, M | 1 |
| Koike, C | 1 |
| Yasuhara, S | 1 |
| Tompkins, RG | 1 |
| Martyn, JA | 1 |
| Du, Y | 1 |
| Smith, MA | 1 |
| Miller, CM | 1 |
| Kern, TS | 1 |
| Portero-Otín, M | 1 |
| Pamplona, R | 1 |
| Bellmunt, MJ | 1 |
| Ruiz, MC | 1 |
| Prat, J | 1 |
| Salvayre, R | 1 |
| Nègre-Salvayre, A | 1 |
| Brownlee, M | 1 |
8 reviews available for pimagedine and Hyperglycemia
| Article | Year |
|---|---|
Current therapeutic interventions in the glycation pathway: evidence from clinical studies.
Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathie | 2013 |
Advanced glycation end-products and the progress of diabetic vascular complications.
Topics: Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; Glyco | 2004 |
Prevention of complications in non-insulin-dependent diabetes mellitus (NIDDM).
Topics: Acarbose; Aldehyde Reductase; Biguanides; Diabetes Mellitus, Type 2; Glucose; Guanidines; Humans; Hy | 1995 |
Will pimagidine improve survival of diabetics on dialysis?
Topics: Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Glycation End Products, Advanced; Guani | 1996 |
What is the effect of hyperglycemia on atherogenesis and can it be reversed by aminoguanidine?
Topics: Animals; Arteriosclerosis; Glycation End Products, Advanced; Glycosylation; Guanidines; Humans; Hype | 1996 |
Advanced glycosylated end products and hyperglycemia in the pathogenesis of diabetic complications.
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetes Mellitus; Disease Models, Animal; En | 1999 |
Glycation as the glucose link to diabetic complications.
Topics: Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Glycated Hemoglo | 2000 |
Glycation products and the pathogenesis of diabetic complications.
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Retino | 1992 |
15 other studies available for pimagedine and Hyperglycemia
| Article | Year |
|---|---|
Attenuation of hyperglycemia and amadori products by aminoguanidine in alloxan-diabetic rabbits occurs via enhancement in antioxidant defenses and control of stress.
Topics: Alloxan; Animals; Antioxidants; Case-Control Studies; Catalase; Diabetes Mellitus, Experimental; Dia | 2022 |
Inhibition of NF-κB activity by aminoguanidine alleviates neuroinflammation induced by hyperglycemia.
Topics: Animals; Brain; Calcium-Binding Proteins; Cytoplasm; Diabetes Mellitus, Experimental; Diabetic Nephr | 2017 |
The detrimental effects of acute hyperglycemia on myocardial glucose uptake.
Topics: Analysis of Variance; Animals; Benzophenanthridines; Benzothiazoles; Cell Line; Coumaric Acids; Diaz | 2014 |
NaHS ameliorates diabetic vascular injury by correcting depressed connexin 43 and 40 in the vasculature in streptozotocin-injected rats.
Topics: Animals; Aorta, Thoracic; Connexin 43; Connexins; Diabetes Mellitus, Experimental; Diabetic Angiopat | 2010 |
Resorcylidene aminoguanidine (RAG) improves cardiac mitochondrial bioenergetics impaired by hyperglycaemia in a model of experimental diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Electron Transport; Energy Metabolism; Enzy | 2011 |
Reactive carbonyls and polyunsaturated fatty acids produce a hydroxyl radical-like species: a potential pathway for oxidative damage of retinal proteins in diabetes.
Topics: Amino Acids; Animals; Antioxidants; Carbon; Cerebral Cortex; Chromatography, High Pressure Liquid; D | 2005 |
Aminoguanidine, an inhibitor of nitric oxide formation, fails to protect against insulitis and hyperglycemia induced by multiple low dose streptozotocin injections in mice.
Topics: Animals; Glucose; Guanidines; Hyperglycemia; In Vitro Techniques; Islets of Langerhans; Male; Mice; | 1993 |
Potential benefit of inhibitors of advanced glycation end products in the progression of type II diabetes: a study with aminoguanidine in C57/BLKsJ diabetic mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Drinking; Fe | 1998 |
Glucose-induced inhibition of angiogenesis in the rat sponge granuloma is prevented by aminoguanidine.
Topics: Animals; Disease Models, Animal; Glucose; Granulation Tissue; Granuloma, Foreign-Body; Guanidines; H | 1999 |
Protein glycosylation and advanced glycosylated endproducts (AGEs) accumulation: an avian solution?
Topics: Aging; Animals; Arginine; Blood Glucose; Body Weight; Chickens; Cross-Linking Reagents; Diet; Enzyme | 1999 |
Induction of glycation suppresses glucokinase gene expression in HIT-T15 cells.
Topics: Acetylcysteine; Cell Line; DNA; DNA-Binding Proteins; Gene Expression; Glucokinase; Glycosylation; G | 1999 |
Effects of aminoguanidine and desferrioxamine on some vascular and biochemical changes associated with streptozotocin-induced hyperglycaemia in rats.
Topics: Analysis of Variance; Animals; Blood Glucose; Body Weight; Chelating Agents; Deferoxamine; Drug Inte | 2001 |
Inducible nitric oxide synthase plays a role in LPS-induced hyperglycemia and insulin resistance.
Topics: Animals; Enzyme Induction; Enzyme Inhibitors; Glucose; Glycogen Phosphorylase; Guanidines; Hyperglyc | 2002 |
Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine.
Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Diabetes Complications; Diabetes Mellitus; Diabetic Re | 2002 |
Advanced glycation end product precursors impair epidermal growth factor receptor signaling.
Topics: Cell Line, Transformed; Enzyme Inhibitors; ErbB Receptors; Fibroblasts; Glycation End Products, Adva | 2002 |