pimagedine has been researched along with Glaucoma in 4 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Glaucoma: An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glaucoma is an optic neuropathy with cupping of the optic disk, degeneration of retinal ganglion cells, and characteristic visual field loss." | 1.30 | Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. ( Becker, B; Neufeld, AH; Sawada, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Husain, S | 1 |
| Abdul, Y | 1 |
| Singh, S | 1 |
| Ahmad, A | 1 |
| Husain, M | 1 |
| Kuprjanowicz, L | 1 |
| Karczewicz, D | 1 |
| Neufeld, AH | 1 |
| Sawada, A | 1 |
| Becker, B | 1 |
| Stitt, AW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Trial Of The Effect Of Tropical Fruits On Intraocular Pressure And Retinal Nerve Fibre Layer Thickness In Patients With Primary Glaucoma[NCT06071494] | 102 participants (Anticipated) | Interventional | 2023-10-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for pimagedine and Glaucoma
| Article | Year |
|---|---|
[Neuroprotection in glaucoma].
Topics: Betaxolol; Brimonidine Tartrate; Disease Progression; Glaucoma; Guanidines; Humans; Memantine; Neuro | 2007 |
Advanced glycation: an important pathological event in diabetic and age related ocular disease.
Topics: Aging; Animals; Cataract; Diabetic Retinopathy; Enzyme Inhibitors; Glaucoma; Glycation End Products, | 2001 |
2 other studies available for pimagedine and Glaucoma
| Article | Year |
|---|---|
Regulation of nitric oxide production by δ-opioid receptors during glaucomatous injury.
Topics: Analysis of Variance; Animals; Benzamides; Blotting, Western; Electroretinography; Female; Glaucoma; | 2014 |
Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma.
Topics: Animals; Chronic Disease; Enzyme Inhibitors; Glaucoma; Guanidines; Humans; Intraocular Pressure; Mal | 1999 |