pimagedine has been researched along with Endotoxemia in 34 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effect of ornithine which is known to inhibit L-arginine uptake via cationic amino acid transport system has been tested, and compared to aminoguanidine, an iNOS inhibitor in lypopolysaccharide (LPS)-induced endotoxemia in rats." | 7.72 | Effect of ornithine on the ileal histology, nitric oxide production and lipid peroxidation in LPS-induced endotoxemia. ( Aydin, S; Büyükafşar, K; Caglikülekçi, M; Cinel, I; Cinel, L; Dirlik, M; Oral, U; Tamer, L, 2003) |
| "Effect of ornithine which is known to inhibit L-arginine uptake via cationic amino acid transport system has been tested, and compared to aminoguanidine, an iNOS inhibitor in lypopolysaccharide (LPS)-induced endotoxemia in rats." | 3.72 | Effect of ornithine on the ileal histology, nitric oxide production and lipid peroxidation in LPS-induced endotoxemia. ( Aydin, S; Büyükafşar, K; Caglikülekçi, M; Cinel, I; Cinel, L; Dirlik, M; Oral, U; Tamer, L, 2003) |
| " Caffeine and ryanodine contractions were augmented during endotoxemia without NOS contribution." | 3.72 | The role of nitric oxide on contractile impairment during endotoxemia in rat diaphragm muscle. ( Ertunc, M; Onur, R; Sara, Y, 2004) |
| "Pretreatment with gadolinium inhibited the activation of macrophages and the induction of iNOS in intestinal resident macrophages, and restored the number of KIT-positive cells and intestinal contractions." | 1.40 | Nitric oxide-mediated injury of interstitial cells of Cajal and intestinal dysmotility under endotoxemia of mice. ( Koike, M; Matsuda, H; Nishida, T; Sawa, Y; Uchiyama, Y; Ueshima, S, 2014) |
| " Anaesthetized rats challenged with a high dosage of endotoxin (Escherichia coli lipopolysaccharide; LPS; 50 mg kg(-1), i." | 1.31 | Evodia rutaecarpa protects against circulation failure and organ dysfunction in endotoxaemic rats through modulating nitric oxide release. ( Chen, CF; Chiou, WF; Chou, CJ; Ko, HC, 2002) |
| "Endotoxemia is associated with diminished intestinal mucosal oxygen utilization due to an intrinsic acquired derangement in cellular respiration that is caused, at least in part, by an aminoguanidine-inhibitable mechanism." | 1.30 | Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine. ( Delude, RL; Fink, MP; King, CJ; Tytgat, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (29.41) | 18.2507 |
| 2000's | 22 (64.71) | 29.6817 |
| 2010's | 2 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ueshima, S | 1 |
| Nishida, T | 2 |
| Koike, M | 1 |
| Matsuda, H | 2 |
| Sawa, Y | 1 |
| Uchiyama, Y | 1 |
| Motawi, TK | 1 |
| Darwish, HA | 1 |
| Abd El Tawab, AM | 1 |
| Chiou, WF | 1 |
| Ko, HC | 1 |
| Chen, CF | 1 |
| Chou, CJ | 1 |
| Dirlik, M | 2 |
| Büyükafşar, K | 1 |
| Cinel, I | 1 |
| Cinel, L | 1 |
| Caglikülekçi, M | 2 |
| Tamer, L | 2 |
| Aydin, S | 2 |
| Oral, U | 1 |
| Sara, Y | 1 |
| Ertunc, M | 1 |
| Onur, R | 1 |
| Rose, R | 1 |
| Banerjee, A | 1 |
| Ramaiah, SK | 1 |
| Heemskerk, S | 2 |
| van Koppen, A | 1 |
| van den Broek, L | 1 |
| Poelen, GJ | 1 |
| Wouterse, AC | 2 |
| Dijkman, HB | 1 |
| Russel, FG | 2 |
| Masereeuw, R | 2 |
| Shen, KP | 1 |
| Liou, SF | 1 |
| Hsieh, SL | 1 |
| Chen, IJ | 1 |
| Wu, BN | 1 |
| Kemna, EH | 1 |
| Pickkers, P | 1 |
| Tjalsma, H | 1 |
| Swinkels, DW | 1 |
| Zhang, HY | 1 |
| Han, DW | 1 |
| Su, AR | 1 |
| Zhang, LT | 1 |
| Zhao, ZF | 1 |
| Ji, JQ | 1 |
| Li, BH | 1 |
| Ji, C | 1 |
| Yaylak, F | 1 |
| Canbaz, H | 1 |
| Ogetman, Z | 1 |
| Polat, Y | 1 |
| Kanik, A | 1 |
| Gardiner, SM | 1 |
| Kemp, PA | 1 |
| March, JE | 1 |
| Bennett, T | 1 |
| Arkovitz, MS | 1 |
| Wispé, JR | 1 |
| Garcia, VF | 1 |
| Szabó, C | 1 |
| Tárnoky, K | 1 |
| Kaszaki, J | 1 |
| Szalay, L | 1 |
| Boros, M | 1 |
| Nagy, S | 1 |
| Hock, CE | 1 |
| Yin, K | 1 |
| Yue, G | 1 |
| Wong, PY | 1 |
| Huang, TP | 1 |
| Kamike, W | 1 |
| Kosaka, H | 1 |
| Seiyama, A | 1 |
| Morimoto, Y | 1 |
| Tanaka, S | 1 |
| Obunai, S | 1 |
| Takei, Y | 1 |
| Shiga, T | 1 |
| Shiomi, M | 1 |
| Wakabayashi, Y | 1 |
| Sano, T | 1 |
| Shinoda, Y | 1 |
| Nimura, Y | 1 |
| Ishimura, Y | 1 |
| Suematsu, M | 1 |
| Wu, CC | 1 |
| Yen, MH | 1 |
| Kavuklu, B | 1 |
| Agalar, C | 1 |
| Guc, MO | 1 |
| Sayek, I | 2 |
| Castañeda, AA | 1 |
| Denning, JW | 1 |
| Chang, L | 1 |
| Mercer, DW | 1 |
| King, CJ | 1 |
| Tytgat, S | 1 |
| Delude, RL | 1 |
| Fink, MP | 1 |
| Evgenov, OV | 1 |
| Hevroy, O | 1 |
| Bremnes, KE | 1 |
| Bjertnaes, LJ | 1 |
| Erol, A | 1 |
| Koşay, S | 1 |
| Yorganci, K | 2 |
| Ismailoglu, UB | 2 |
| Sahin-Erdemli, I | 2 |
| Anderson, JL | 1 |
| Williams, G | 1 |
| Head, SI | 1 |
| Metcalf, K | 2 |
| Lisander, B | 2 |
| Hall, DM | 1 |
| Buettner, GR | 1 |
| Oberley, LW | 1 |
| Xu, L | 1 |
| Matthes, RD | 1 |
| Gisolfi, CV | 1 |
| Chan, JY | 1 |
| Wang, SH | 1 |
| Chan, SH | 1 |
| Pekiner, C | 1 |
| Jungersten, L | 1 |
| Mohn, C | 1 |
| Lomniczi, A | 1 |
| Faletti, A | 1 |
| Scorticati, C | 1 |
| Elverdin, JC | 1 |
| McCann, SM | 1 |
| Rettori, V | 1 |
| Vona-Davis, L | 1 |
| Wearden, P | 1 |
| Hill, J | 1 |
| Hill, R | 1 |
| Ahmad, N | 1 |
| Chen, LC | 1 |
| Gordon, MA | 1 |
| Laskin, JD | 1 |
| Laskin, DL | 1 |
1 trial available for pimagedine and Endotoxemia
| Article | Year |
|---|---|
Nitric oxide does not contribute to inflammation-induced hypoferremia in humans.
Topics: Adolescent; Adult; Anemia, Iron-Deficiency; Antimicrobial Cationic Peptides; Cytokines; Endotoxemia; | 2007 |
33 other studies available for pimagedine and Endotoxemia
| Article | Year |
|---|---|
Nitric oxide-mediated injury of interstitial cells of Cajal and intestinal dysmotility under endotoxemia of mice.
Topics: Animals; Disease Models, Animal; Endotoxemia; Gadolinium; Guanidines; Indazoles; Interstitial Cells | 2014 |
The relative efficacy of aminoguanidine and pentoxifylline in modulating endotoxin-induced cardiac stress.
Topics: Animals; Endotoxemia; Endotoxins; Guanidines; Heart; Humans; Lipopolysaccharides; Male; Myocardium; | 2011 |
Evodia rutaecarpa protects against circulation failure and organ dysfunction in endotoxaemic rats through modulating nitric oxide release.
Topics: Animals; Aspartate Aminotransferases; Endothelium, Vascular; Endotoxemia; Endotoxins; Evodia; Fruit; | 2002 |
Effect of ornithine on the ileal histology, nitric oxide production and lipid peroxidation in LPS-induced endotoxemia.
Topics: Animals; Dose-Response Relationship, Drug; Endotoxemia; Enzyme Inhibitors; Female; Guanidines; Ileum | 2003 |
The role of nitric oxide on contractile impairment during endotoxemia in rat diaphragm muscle.
Topics: Animals; Caffeine; Diaphragm; Endotoxemia; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Indaz | 2004 |
Calpain inhibition attenuates iNOS production and midzonal hepatic necrosis in a repeat dose model of endotoxemia in rats.
Topics: Animals; Anticoagulants; Blood Coagulation; Blotting, Western; Calpain; Carrier Proteins; Chemical a | 2006 |
Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, | 2007 |
Eugenosedin-A amelioration of lipopolysaccharide-induced up-regulation of p38 MAPK, inducible nitric oxide synthase and cyclooxygenase-2.
Topics: Adrenergic alpha-Antagonists; Animals; Antioxidants; Aorta, Thoracic; Ascorbic Acid; Blotting, Weste | 2007 |
Intestinal endotoxemia plays a central role in development of hepatopulmonary syndrome in a cirrhotic rat model induced by multiple pathogenic factors.
Topics: Alanine Transaminase; Animals; Bronchoalveolar Lavage Fluid; Capillaries; Carboxyhemoglobin; Cytokin | 2007 |
Liver tissue inducible nitric oxide synthase (iNOS) expression and lipid peroxidation in experimental hepatic ischemia reperfusion injury stimulated with lipopolysaccharide: the role of aminoguanidine.
Topics: Animals; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Guanidines; Lipid Peroxidation; Lip | 2008 |
Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Catecholamine Plasma Membrane Tran | 2008 |
Influence of aminoguanidine and the endothelin antagonist, SB 209670, on the regional haemodynamic effects of endotoxaemia in conscious rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Biphenyl Compounds; Cardia | 1996 |
Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute endotoxemia.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Drug Evalua | 1996 |
Comparative study of the circulatory effects of aminoguanidine and N-nitro-L-arginine in hyperdynamic endotoxemia.
Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Endotoxemia; Endotoxins; Escherichia coli; Guanidines | 1996 |
Effects of inhibition of nitric oxide synthase by aminoguanidine in acute endotoxemia.
Topics: Acute Disease; Animals; Endotoxemia; Enzyme Inhibitors; Guanidines; Hemodynamics; Lipopolysaccharide | 1997 |
Role of nitric oxide in oxygen transport in rat liver sinusoids during endotoxemia.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Blood Pressure; Endotoxemia; Guanidines; Live | 1997 |
Nitric oxide suppression reversibly attenuates mitochondrial dysfunction and cholestasis in endotoxemic rat liver.
Topics: Animals; Bile; Cholestasis; Dimaprit; Endotoxemia; Endotoxins; Fluorescent Dyes; Fluorometry; Guanid | 1998 |
Combined effects of dexamethasone and aminoguanidine on rats with endotoxemia.
Topics: Animals; Blood Pressure; Dexamethasone; Drug Interactions; Endotoxemia; Enzyme Inhibitors; Guanidine | 1998 |
Evidence that aminoguanidine inhibits endotoxin-induced bacterial translocation.
Topics: Animals; Bacterial Translocation; Endotoxemia; Endotoxins; Enzyme Inhibitors; Escherichia coli; Guan | 1998 |
Does upregulation of inducible nitric oxide synthase (iNOS) render the stomach more susceptible to damage?
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Endotoxemia; Enzyme Inhibitors; Ethanol; | 1999 |
Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine.
Topics: Animals; Cell Respiration; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Escherichia coli; | 1999 |
Effect of aminoguanidine on lung fluid filtration after endotoxin in awake sheep.
Topics: Animals; Blood Pressure; Endotoxemia; Endotoxins; Enzyme Inhibitors; Extravascular Lung Water; Femal | 2000 |
Effects of aminoguanidine administration on vascular hyporeactivity in thoracic aorta from endotoxaemic rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Endothelium, Vascular; Endotoxemia; Guanidines; Lipopolysac | 2000 |
Detrimental effects of nitric oxide on mesenteric circulation during endotoxaemia and its reversal by aminoguanidine.
Topics: Acetylcholine; Algorithms; Analysis of Variance; Animals; Data Interpretation, Statistical; Endotoxe | 2000 |
The role of nitric oxide in diaphragmatic dysfunction in endotoxemic rats.
Topics: Adenosine Triphosphate; Animals; Benzamides; Diaphragm; Endotoxemia; Enzyme Inhibitors; Free Radical | 2001 |
Aminoguanidine does not influence tissue extravasation of albumin in endotoxaemic rats.
Topics: Albumins; Algorithms; Animals; Capillary Permeability; Endotoxemia; Enzyme Inhibitors; Guanidines; H | 2001 |
Mechanisms of circulatory and intestinal barrier dysfunction during whole body hyperthermia.
Topics: Allopurinol; Animals; Arginine; Blood Pressure; Electron Spin Resonance Spectroscopy; Endotoxemia; E | 2001 |
Differential roles of iNOS and nNOS at rostral ventrolateral medulla during experimental endotoxemia in the rat.
Topics: Animals; Blood Pressure; Endotoxemia; Enzyme Inhibitors; Escherichia coli; Guanidines; Hypotension; | 2001 |
Effects of aminoguanidine and N(omega)-nitro-L-arginine methyl ester on vascular hyporeactivity induced by endotoxaemia.
Topics: Acetylcholine; Animals; Aorta; Endotoxemia; Enzyme Inhibitors; Female; Guanidines; Hemodynamics; In | 2001 |
Effective inhibition of nitric oxide production by aminoguanidine does not reverse hypotension in endotoxaemic rats.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Endotoxemia; Guanidines; Hypotension; Mal | 2002 |
Effects of aminoguanidine and meloxicam on nitric oxide and prostaglandin E production induced by lipopolysaccharide in the hypothalamus and anterior pituitary of the rat.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; End | 2001 |
Cardiac response to nitric oxide synthase inhibition using aminoguanidine in a rat model of endotoxemia.
Topics: Animals; Disease Models, Animal; Endotoxemia; Endotoxins; Enzyme Inhibitors; Guanidines; Heart; In V | 2002 |
Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotoxemia.
Topics: Acute Disease; Animals; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygena | 2002 |