Page last updated: 2024-10-22

pimagedine and Edema

pimagedine has been researched along with Edema in 13 studies

pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
" Diclofenac significantly reduced the carrageenan-induced edema in rat paw at all the time points studied."7.72Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan-induced acute inflammation in rats: the role of nitric oxide. ( Al-Majed, AA; Al-Shabanah, OA; Khattab, M; Mostafa, AM; Raza, M, 2003)
" Diclofenac significantly reduced the carrageenan-induced edema in rat paw at all the time points studied."3.72Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan-induced acute inflammation in rats: the role of nitric oxide. ( Al-Majed, AA; Al-Shabanah, OA; Khattab, M; Mostafa, AM; Raza, M, 2003)
" The optimal dosage of AG was screened by dry-wet weight method with the percentage of water content at 0, 12, 24, and 48 hours after injury."1.38[Effect of aminoguanidine on spinal cord edema of acute spinal cord injury in rats]. ( Cao, Y; Fan, Z; Lü, G; Mei, X; Wang, Y; Yu, D; Zhang, M; Zhang, Z, 2012)
" Compared to SCI group without treatment, AG at the dosage of 150mg/kg induced a reduction in the permeability of blood-spinal cord barrier (BSCB) after injury 48h (from 59."1.36The effect of aminoguanidine on compression spinal cord injury in rats. ( Cao, Y; Fan, ZK; Lu, W; Lv, G; Wang, YF; Zhang, MC; Zhang, YQ; Zhang, Z, 2010)
"Myocardial edema has previously been implicated in diastolic dysfunction during allograft rejection."1.31Improvement of rejection-induced diastolic abnormalities in rat cardiac allografts with inducible nitric oxide synthase inhibition. ( Carter, YM; Fisher, PE; Hart, JP; Hsu, DT; Jia, CX; Pinsky, DJ; Rabkin, DG; Sardo, MJ; Soto, PF; Spotnitz, HM, 2000)
"The role of nitric oxide in allergic conjunctivitis was studied in a guinea pig model."1.29Nitric oxide plays a role as a mediator of conjunctival edema in experimental allergic conjunctivitis. ( Garrelds, IM; Kijlstra, A; Meijer, F; Van Delft, JL; Van Haeringen, NJ, 1996)
"3 Paw oedema was maximal by 6 h and remained elevated for 10 h following carrageenan administration."1.29Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. ( Bourdon, DM; Currie, MG; Manning, PT; Marino, MH; Salvemini, D; Wang, ZQ; Wyatt, PS, 1996)
"Paw edema was inhibited 8 h following the administration of carrageenan by N-iminoethyl-L-lysine (3-30 mg/kg, n = 6) or aminoguanidine (30-300 mg/kg, n = 6), two selective inhibitors of inducible nitric oxide synthase and by recombinant human Cu/Zn superoxide dismutase coupled to polyethyleneglycol (12 x 10(3) U/kg, n = 6, P < 0."1.29Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema. ( Bourdon, DM; Currie, MG; Manning, PT; Salvemini, D; Stern, MK; Wang, ZQ, 1996)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (30.77)18.2507
2000's6 (46.15)29.6817
2010's3 (23.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Brito, TV1
Prudêncio, Rda S1
Sales, AB1
Vieira, Fd1
Candeira, SJ1
Franco, ÁX1
Aragão, KS1
Ribeiro, Rde A1
Ponte de Souza, MH1
Chaves, Lde S1
Freitas, AL1
Medeiros, JV1
dos Reis Barbosa, AL1
Fan, ZK1
Wang, YF1
Cao, Y2
Zhang, MC1
Zhang, Z2
Lv, G1
Lu, W1
Zhang, YQ1
Fan, Z1
Wang, Y1
Yu, D1
Zhang, M1
Mei, X1
Lü, G1
Al-Majed, AA1
Khattab, M1
Raza, M1
Al-Shabanah, OA1
Mostafa, AM1
Chaves, F1
Teixeira, CF1
Gutiérrez, JM1
Meijer, F1
Van Delft, JL1
Garrelds, IM1
Van Haeringen, NJ1
Kijlstra, A1
Salvemini, D2
Wang, ZQ2
Wyatt, PS1
Bourdon, DM2
Marino, MH1
Manning, PT2
Currie, MG2
Stern, MK1
Nishino, T1
Watanabe, S1
Oyama, H1
Fukuya, Y1
Hayashi, N1
Kobayashi, M1
Soto, PF1
Jia, CX1
Rabkin, DG1
Hart, JP1
Carter, YM1
Sardo, MJ1
Hsu, DT1
Fisher, PE1
Pinsky, DJ1
Spotnitz, HM1
Brisby, H1
Byröd, G1
Olmarker, K1
Miller, VM1
Aoki, Y1
Rydevik, B1
Omote, K1
Hazama, K1
Kawamata, T1
Kawamata, M1
Nakayaka, Y1
Toriyabe, M1
Namiki, A1
da S Rocha, JC1
Peixoto, ME1
Jancar, S1
de Q Cunha, F1
de A Ribeiro, R1
da Rocha, FA1

Other Studies

13 other studies available for pimagedine and Edema

ArticleYear
Anti-inflammatory effect of a sulphated polysaccharide fraction extracted from the red algae Hypnea musciformis via the suppression of neutrophil migration by the nitric oxide signalling pathway.
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Arginine; Carrageenan; Dextrans; Edema; Enzyme Inhibitors; Guanid

2013
The effect of aminoguanidine on compression spinal cord injury in rats.
    Brain research, 2010, Jun-25, Volume: 1342

    Topics: Animals; Antioxidants; Edema; Guanidines; Male; Neuroprotective Agents; Oxidative Stress; Rats; Rats

2010
[Effect of aminoguanidine on spinal cord edema of acute spinal cord injury in rats].
    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2012, Volume: 26, Issue:8

    Topics: Acute Disease; Animals; Aquaporin 4; Blood-Brain Barrier; Blotting, Western; Disease Models, Animal;

2012
Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan-induced acute inflammation in rats: the role of nitric oxide.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2003, Volume: 52, Issue:9

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Drug Syner

2003
Role of nitric oxide in the local and systemic pathophysiological effects induced by Bothrops asper snake venom in mice.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2006, Volume: 55, Issue:6

    Topics: Animals; Bothrops; Crotalid Venoms; Edema; Enzyme Inhibitors; Guanidines; Hemorrhage; Mice; Muscle,

2006
Nitric oxide plays a role as a mediator of conjunctival edema in experimental allergic conjunctivitis.
    Experimental eye research, 1996, Volume: 62, Issue:4

    Topics: Animals; Arginine; Capillary Permeability; Conjunctival Diseases; Conjunctivitis, Allergic; Dose-Res

1996
Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation.
    British journal of pharmacology, 1996, Volume: 118, Issue:4

    Topics: Animals; Carrageenan; Dinoprostone; Edema; Enzyme Inhibitors; Excipients; Free Radical Scavengers; G

1996
Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema.
    European journal of pharmacology, 1996, May-15, Volume: 303, Issue:3

    Topics: Animals; Carrageenan; Edema; Guanidines; Male; Nitrates; Nitric Oxide Synthase; Rats; Rats, Sprague-

1996
An endothelial nitric oxide synthase inhibitor aggravates CDL-induced acute pancreatitis in rats.
    Pancreas, 1999, Volume: 19, Issue:4

    Topics: Acute Disease; Animals; Arginine; Ascitic Fluid; Duodenum; Edema; Enzyme Inhibitors; Guanidines; Lig

1999
Improvement of rejection-induced diastolic abnormalities in rat cardiac allografts with inducible nitric oxide synthase inhibition.
    The Journal of thoracic and cardiovascular surgery, 2000, Volume: 120, Issue:1

    Topics: Animals; Cardiomyopathies; Dexamethasone; Diastole; Edema; Graft Rejection; Guanidines; Heart Transp

2000
Nitric oxide as a mediator of nucleus pulposus-induced effects on spinal nerve roots.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2000, Volume: 18, Issue:5

    Topics: Animals; Capillary Permeability; Edema; Enzyme Inhibitors; Female; Guanidines; Intervertebral Disc;

2000
Peripheral nitric oxide in carrageenan-induced inflammation.
    Brain research, 2001, Sep-07, Volume: 912, Issue:2

    Topics: Animals; Carrageenan; Drug Interactions; Edema; Enzyme Inhibitors; Guanidines; Hyperalgesia; Inflamm

2001
Dual effect of nitric oxide in articular inflammatory pain in zymosan-induced arthritis in rats.
    British journal of pharmacology, 2002, Volume: 136, Issue:4

    Topics: Amidines; Animals; Arthritis, Experimental; Benzylamines; Cartilage, Articular; Dinoprost; Edema; En

2002