pimagedine has been researched along with Disease Models, Animal in 193 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was designed to investigate whether acute or subchronic treatment with coenzyme Q10 altered the seizures induced by pentylenetetrazole or electroshock in mice." | 7.80 | The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide. ( Moezi, L; Mousavi, Z; Sattarinezhad, E; Shafaroodi, H; Sheikhnouri, K, 2014) |
| "Piperine produced significant antianxiety-like activity in unstressed and stressed mice." | 7.80 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| "It is demonstrated that administration of arginine together with the selective iNOS inhibitor in the early phase of sepsis restores plasma arginine, reduces oxidative stress by probably maintaining NO derived from constitutive NOS, and attenuates neuroendocrine stress responses." | 7.74 | The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model. ( Akaishi, S; Endo, T; Hojo, N; Kobayashi, M; Kudo, D; Nomura, R; Sasaki, J; Shinozawa, Y; Takuma, K; Xie, XQ; Yamanouchi, S, 2008) |
| "While m-calpain-mediated proteolysis was detected predominantly in cataractous lenses, Lp82-mediated proteolysis was detected not only in cataractous but in normal lenses." | 7.71 | Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR). ( Hayashi, M; Inomata, M; Ito, Y; Kawashima, S; Matsubara, Y; Shumiya, S; Takehana, M, 2002) |
| "It was first reported in China that injection of a low dose of D-galactose into mice could induce changes which resembled accelerated aging." | 7.70 | Advanced glycation in D-galactose induced mouse aging model. ( Bao, M; Li, D; Li, YM; Song, X, 1999) |
| "Recent studies have demonstrated a connection between xanthine oxidase-generated reactive oxygen intermediates and histamine release during ischemia-reperfusion." | 7.68 | Studies on the relationship between xanthine oxidase and histamine release during intestinal ischemia-reperfusion. ( Bakó, L; Boros, M; Kaszaki, J; Nagy, S, 1992) |
| "Histamine release could be shown in 50% of the dogs suffering from acute haemorrhagic pancreatitis in Pfeffer's preparation." | 7.66 | Histamine and pancreatitis: increase of plasma histamine levels in dogs with Pfeffer preparation and influence of aminoguanidine on the survival time. ( Kresse, U; Lange, E; Lorenz, W; Maroske, D; Neuhaus, H; Reimann, HJ; Schult, H; Schwarz, B, 1978) |
| " On day 21 after BDL, chronic L-NAME produced only a nonsignificant decrease in the beneficial effect of naltrexone, whereas on day 28, chronic administration of both L-NAME and aminoguanidine significantly reversed this effect of naltrexone." | 6.78 | Nitric oxide mediates the beneficial effect of chronic naltrexone on cholestasis-induced memory impairment in male rats. ( Dehpour, AR; Ebadian, S; Ghiassy, B; Javadi-Paydar, M; Norouzi, A; Rahimi, N, 2013) |
| "However, meningitis-induced CSF leukocytosis at 4 h and increased CSF lactate and tumor necrosis factor alpha levels were not significantly attenuated." | 5.31 | 7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet. ( Chang, YS; Lee, M; Park, WS, 2001) |
| " This study investigates the effect of Arginine-Vasopressin (AVP) in pentylenetetrazol (PTZ)-induced seizures threshold and the probable role of nitric oxide (NO)." | 3.83 | The modulatory effect of nitric oxide in pro- and anti-convulsive effects of vasopressin in PTZ-induced seizures threshold in mice. ( Dehpour, AR; Doustimotlagh, AH; Javadi-Paydar, M; Javadian, N; Rahimi, N, 2016) |
| " This study was designed to investigate whether acute or subchronic treatment with coenzyme Q10 altered the seizures induced by pentylenetetrazole or electroshock in mice." | 3.80 | The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide. ( Moezi, L; Mousavi, Z; Sattarinezhad, E; Shafaroodi, H; Sheikhnouri, K, 2014) |
| "Piperine produced significant antianxiety-like activity in unstressed and stressed mice." | 3.80 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| " Optical densities of nitrotyrosine bands increased significantly in radiculopathy groups, but they were lowered by administration of aminoguanidine." | 3.79 | Inhibition of nitric oxide mediated protein nitration: therapeutic implications in experimental radiculopathy. ( Kim, TU; Lee, SJ; Park, JS; Ra, JY, 2013) |
| "The present study was designed to investigate the involvement of the nitric oxide (NO)/cyclic guanylate monophosphate pathway in pilocarpine-induced seizures in mice." | 3.79 | Involvement of the nitric oxide/cyclic guanylate monophosphate pathway in the pilocarpine-induced seizure model in mice. ( Cavalcante Melo, FH; de Carvalho Lima, CN; de França Fonteles, MM; Freire Vasconcelos, L; Leite Dias, M; Moura Rocha, NF; Rodrigues Carvalho, AM; Soares Lopes, K; Vasconcelos Rios, ER, 2013) |
| " Our study was designed to investigate the involvement of MMPs and of tissue inhibitors of metalloproteinases (TIMPs) in rat retinal ischemic injury, the effect of nitric oxide synthase (NOS) inhibitors on MMPs' activity in this model and whether minocycline (an MMP inhibitor) is protective in retinal ischemia." | 3.74 | The involvement of matrix metalloproteinases 2 and 9 in rat retinal ischemia. ( Bahar-Shany, K; Geyer, O; Lahat, N; Mathalone, N; Oron, Y; Rahat, MA, 2007) |
| "It is demonstrated that administration of arginine together with the selective iNOS inhibitor in the early phase of sepsis restores plasma arginine, reduces oxidative stress by probably maintaining NO derived from constitutive NOS, and attenuates neuroendocrine stress responses." | 3.74 | The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model. ( Akaishi, S; Endo, T; Hojo, N; Kobayashi, M; Kudo, D; Nomura, R; Sasaki, J; Shinozawa, Y; Takuma, K; Xie, XQ; Yamanouchi, S, 2008) |
| " Progression of the chronic synovitis in zymosan-induced arthritis (ZYA) was associated with increased nitrite and nitrotyrosine (3-NT) levels in the joint exudates that paralleled a progressive loss of the GAG content." | 3.72 | Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis. ( Bezerra, MM; Brain, SD; da Rocha, FA; de Melo, LB; Greenacre, S; Jerônimo, SM; Keeble, J, 2004) |
| " Both aminoguanidine and perindopril retarded the increase in albuminuria, which was completely abrogated by combination therapy." | 3.72 | Superior renoprotective effects of combination therapy with ACE and AGE inhibition in the diabetic spontaneously hypertensive rat. ( Allen, TJ; Burns, WC; Cooper, ME; Davis, BJ; Forbes, JM; Jerums, G; Kawachi, H; Thomas, MC, 2004) |
| "The expression of HO-1 and iNOS in aorta increased with the SBP elevation during the development of SHR and was attenuated when the hypertension was lowered with the vasodilator hydralazine." | 3.72 | The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats. ( Chen, JJ; Cheng, PY; Yen, MH, 2004) |
| "While m-calpain-mediated proteolysis was detected predominantly in cataractous lenses, Lp82-mediated proteolysis was detected not only in cataractous but in normal lenses." | 3.71 | Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR). ( Hayashi, M; Inomata, M; Ito, Y; Kawashima, S; Matsubara, Y; Shumiya, S; Takehana, M, 2002) |
| "It was first reported in China that injection of a low dose of D-galactose into mice could induce changes which resembled accelerated aging." | 3.70 | Advanced glycation in D-galactose induced mouse aging model. ( Bao, M; Li, D; Li, YM; Song, X, 1999) |
| "Administration of the nitric oxide synthase (NOS) inhibitor, NG-nitro-L-arginine methyl ester (L-NAME) during pregnancy has been shown to compromise fetal growth." | 3.69 | Perinatal nitric oxide synthase inhibition retards neonatal growth by inducing hypertrophic pyloric stenosis in rats. ( Clark, DA; Eloby-Childress, S; Miller, MJ; Pierce, MR; Voelker, CA; Zhang, XJ, 1995) |
| "Recent studies have demonstrated a connection between xanthine oxidase-generated reactive oxygen intermediates and histamine release during ischemia-reperfusion." | 3.68 | Studies on the relationship between xanthine oxidase and histamine release during intestinal ischemia-reperfusion. ( Bakó, L; Boros, M; Kaszaki, J; Nagy, S, 1992) |
| "Histamine release could be shown in 50% of the dogs suffering from acute haemorrhagic pancreatitis in Pfeffer's preparation." | 3.66 | Histamine and pancreatitis: increase of plasma histamine levels in dogs with Pfeffer preparation and influence of aminoguanidine on the survival time. ( Kresse, U; Lange, E; Lorenz, W; Maroske, D; Neuhaus, H; Reimann, HJ; Schult, H; Schwarz, B, 1978) |
| " On day 21 after BDL, chronic L-NAME produced only a nonsignificant decrease in the beneficial effect of naltrexone, whereas on day 28, chronic administration of both L-NAME and aminoguanidine significantly reversed this effect of naltrexone." | 2.78 | Nitric oxide mediates the beneficial effect of chronic naltrexone on cholestasis-induced memory impairment in male rats. ( Dehpour, AR; Ebadian, S; Ghiassy, B; Javadi-Paydar, M; Norouzi, A; Rahimi, N, 2013) |
| "Background Although diabetes attenuates abdominal aortic aneurysms (AAAs), the mechanisms by which diabetes suppresses AAAs remain incompletely understood." | 1.91 | Treatment With Small Molecule Inhibitors of Advanced Glycation End-Products Formation and Advanced Glycation End-Products-Mediated Collagen Cross-Linking Promotes Experimental Aortic Aneurysm Progression in Diabetic Mice. ( Chen, X; Dalman, RL; Ge, Y; Guo, J; Ikezoe, T; Li, G; Li, Y; Miyata, M; Samura, M; Shoji, T; Xu, B; Zhao, S; Zheng, X, 2023) |
| "Changes in vascular reactivity during endotoxic shock are organ-specific." | 1.48 | Organ-specific changes in vascular reactivity and roles of inducible nitric oxide synthase and endothelin-1 in a rabbit endotoxic shock model. ( Chen, W; Li, T; Liu, LM; Zhang, ZS, 2018) |
| "4 mg) caused no significant toxic ocular effects in rabbit eyes." | 1.46 | TOWARDS A TREATMENT FOR DIABETIC RETINOPATHY: Intravitreal Toxicity and Preclinical Safety Evaluation of Inducible Nitric Oxide Synthase Inhibitors. ( Bennett, LD; Birch, DG; Carr, BC; Emigh, CE; Nguyen, C; Pansick, AD, 2017) |
| "Colitis was induced by intrarectal (i." | 1.43 | Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway. ( Abbasi, A; Dehpour, AR; Fakhfouri, G; Fakhraei, N; Ghia, JE; Heydarpour, P; Khoshkish, S; Rahimian, R; Salehi-Sadaghiani, M; Wang, H, 2016) |
| "Acute kidney injury is usually associated with distant organ dysfunction." | 1.43 | Distant effects of unilateral renal ischemia/reperfusion on contralateral kidney but not lung in rats: the roles of ROS and iNOS. ( Fatemikia, H; Karimi, Z; Ketabchi, F; Moosavi, SM, 2016) |
| "Chloroquine has long been used for the treatment of malaria and rheumatological disorders." | 1.43 | Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice. ( Abkhoo, A; Amiri, S; Boojar, MM; Dehpour, AR; Delazar, S; Hassanipour, M; Ostadhadi, S; Rahimi, N; Shirzadian, A, 2016) |
| "Intradermal serotonin caused scratching in mice with a bell-shaped dose-response correlation, and the peak effective dose was 141 nmol per site." | 1.42 | Involvement of nitric oxide in serotonin-induced scratching in mice. ( Azimi, E; Dehpour, AR; Haj-Mirzaian, A; Mansouri, P; Ostadhadi, S, 2015) |
| "Sepsis is a systemic inflammatory response syndrome caused by an infection and remains as a major challenge in health care." | 1.42 | The Effects of Sub-Chronic Treatment with Pioglitazone on the Septic Mice Mortality in the Model of Cecal Ligation and Puncture: Involvement of Nitric Oxide Pathway. ( Dehpour, AR; Hassanipour, M; Mousavi, Z; Rahimi, N; Shafaroodi, H, 2015) |
| "Pretreatment with gadolinium inhibited the activation of macrophages and the induction of iNOS in intestinal resident macrophages, and restored the number of KIT-positive cells and intestinal contractions." | 1.40 | Nitric oxide-mediated injury of interstitial cells of Cajal and intestinal dysmotility under endotoxemia of mice. ( Koike, M; Matsuda, H; Nishida, T; Sawa, Y; Uchiyama, Y; Ueshima, S, 2014) |
| "AG reduced periodontal bone loss during the induction of experimental periodontitis, and the effects appeared to be insignificant in the progression and recovery phases." | 1.40 | Aminoguanidine inhibits the AGE-RAGE axis to modulate the induction of periodontitis but has limited effects on the progression and recovery of experimental periodontitis: a preliminary study. ( Chang, PC; Chong, LY; Lim, LP; Tsai, SC, 2014) |
| "Ulcerative colitis is an inflammatory bowel disease characterized by acute inflammation, ulceration, and bleeding of the colonic mucosa." | 1.40 | Involvement of nitric oxide with activation of Toll-like receptor 4 signaling in mice with dextran sodium sulfate-induced colitis. ( Tun, X; Yamada, K; Yasukawa, K, 2014) |
| "All rats underwent middle cerebral artery occlusion (MCAO) by subtemporal craniectomy, and permanent ischemia was created." | 1.38 | An evaluation of the effectiveness of pre-ischemic hyperbaric oxygen and post-ischemic aminoguanidine in experimental cerebral ischemia. ( Duz, B; Gonul, E; Harman, F; Hasturk, AE; Korkmaz, A, 2012) |
| " The optimal dosage of AG was screened by dry-wet weight method with the percentage of water content at 0, 12, 24, and 48 hours after injury." | 1.38 | [Effect of aminoguanidine on spinal cord edema of acute spinal cord injury in rats]. ( Cao, Y; Fan, Z; Lü, G; Mei, X; Wang, Y; Yu, D; Zhang, M; Zhang, Z, 2012) |
| "Elevated intraocular pressure was induced unilaterally by translimbal laser photocoagulation of the trabecular meshwork in Sprague-Dawley rats." | 1.37 | Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats. ( Dai, Y; Ellisman, MH; Ju, WK; Kim, KY; Lindsey, JD; Nguyen, D; Park, S; Sun, X; Weinreb, RN, 2011) |
| "Periodontitis was produced by a ligature placed around the cervix of the two lower first molar." | 1.36 | Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis. ( Borda, E; Busch, L; Miozza, V; S-Borda, L, 2010) |
| "CTA data revealed that cerebral vasospasm of SAH rabbits was significantly prevented via AG treatment." | 1.36 | Aminoguanidine inhibition of iNOS activity ameliorates cerebral vasospasm after subarachnoid hemorrhage in rabbits via restoration of dysfunctional endothelial cells. ( Chen, X; Shi, C; Wang, L; Zhao, S; Zheng, B; Zheng, T, 2010) |
| "After induction of type 2 diabetes, rats received daily injections of AG (50 mg kg(-1), i." | 1.35 | Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes. ( Chang, KC; Liang, JT; Lin, YD; Tseng, YZ; Wu, ET; Wu, MS, 2008) |
| "Diabetic nephropathy is currently the most common cause of end-stage renal disease (ESRD) in the western world." | 1.34 | Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors. ( Grahovac, G; Kalluri, R; Sugimoto, H; Zeisberg, M, 2007) |
| "Our aim was to evaluate NO role in renal failure induced during decompensated cirrhosis, using the following inhibitors: aminoguanidine (AG), a specific inducible nitric oxide synthase (iNOS) inhibitor and NG-nitro-l-arginine methyl ester (L-NAME), a nonselective blocker of NOS isoforms." | 1.33 | Nitric oxide synthases inhibition results in renal failure improvement in cirrhotic rats. ( Alvarez-Rodríguez, A; Armendáriz-Borunda, J; Covarrubias, A; Grijalva, G; Islas-Carbajal, MC; Rincón-Sánchez, AR, 2005) |
| "We studied the effects of inhibitors of COX-2 (NS398) and iNOS (aminoguanidine) alone or in combination with olfactory ensheathing cell (OEC) grafts after spinal cord injury in the rat." | 1.33 | Effects of COX-2 and iNOS inhibitors alone or in combination with olfactory ensheathing cell grafts after spinal cord injury. ( Casas, C; Forés, J; García-Alías, G; Guzmán-Lenis, MS; López-Vales, R; Navarro, X; Verdú, E, 2006) |
| " Daily treatment of AG at the dosage of 100 mg/kg or normal saline was given intraperitoneally into rats starting 2 h before or 30 min after brain injury." | 1.32 | Neuroprotection by aminoguanidine after lateral fluid-percussive brain injury in rats: a combined magnetic resonance imaging, histopathologic and functional study. ( Ling, EA; Lu, J; Moochhala, S; Moore, XL; Ng, KC; Shirhan, M; Tan, MH; Teo, AL; Wong, MC, 2003) |
| "In groups 2 and 3, spinal cord trauma was produced at thoracic level by using weight the drop technique (at a severity of 50 gr-cm)." | 1.32 | Time-level relationship for nitric oxide and the protective effects of aminoguanidine in experimental spinal cord injury. ( Aslan, O; Barut, S; Belce, A; Colak, A; Iğdem, AA; Soy, O; Uzun, H, 2004) |
| "Cholesteatoma is a disease of inflammatory bone resorption in the middle ear leading to hearing loss and vestibular dysfunction." | 1.32 | A possible role for nitric oxide in osteoclastogenesis associated with cholesteatoma. ( Chole, RA; Faddis, BT; Jung, JY; Nishimoto, SY; Pashia, ME, 2004) |
| "After sham treatment, the necrosis expanded to 8." | 1.32 | Secondary growth of a cortical necrosis: effect of NOS inhibition by aminoguanidine post insult. ( Baethmann, A; Plesnila, N; Rinecker, M; Stoffel, M, 2003) |
| "In a porcine model of endotoxic shock, we evaluated the circulatory and respiratory effects of NO synthase (NOS) blockade." | 1.31 | Effect of NO synthase inhibition on cardiovascular and pulmonary dysfunction in a porcine short-term model of endotoxic shock. ( Albertini, M; Clement, MG; Hussain, SN; Lafortuna, CL; Mazzola, S; Radice, S, 2002) |
| "Clearly, in this model, early pulmonary edema and lethality are not directly related, and induced IFN-gamma has no role in causing early lung edema, but augments other events that result in death." | 1.31 | Role of interferon-gamma and nitric oxide in pulmonary edema and death induced by lipopolysaccharide. ( Billiau, A; Dillen, C; Groenen, M; Heremans, H; Matthys, P, 2000) |
| "Portal hypertension is often accompanied by a hyperdynamic circulation state." | 1.31 | Role of nitric oxide and endothelin-1 in a portal hypertensive rat model. ( Hashizume, M; Kawanaka, H; Kishihara, F; Migou, S; Sugimachi, K; Tanoue, K; Tomikawa, M; Tsugawa, K, 2000) |
| "Both abdominal aortic aneurysms (AAAs) and inducible nitric oxide synthase (iNOS) are associated with inflammatory states, yet the relationship between NO production by iNOS and AAA development is unknown." | 1.31 | Inhibition of inducible nitric oxide synthase limits nitric oxide production and experimental aneurysm expansion. ( Carey, DJ; Elmore, JR; Franklin, DP; Han, DC; Johanning, JM, 2001) |
| "However, meningitis-induced CSF leukocytosis at 4 h and increased CSF lactate and tumor necrosis factor alpha levels were not significantly attenuated." | 1.31 | 7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet. ( Chang, YS; Lee, M; Park, WS, 2001) |
| " In this study, we show that the development of diabetes, measured by increased water intake and concomitant midday blood glucose levels in type II genetically diabetic mice, is reduced by treatment with aminoguanidine at a dosage of 500 mg/kg/d for 12 weeks in the diet." | 1.30 | Potential benefit of inhibitors of advanced glycation end products in the progression of type II diabetes: a study with aminoguanidine in C57/BLKsJ diabetic mice. ( Piercy, V; Toseland, CD; Turner, NC, 1998) |
| "Furthermore, acidosis caused lung inflammation, as suggested by the increase in lung myeloperoxidase activity (282." | 1.30 | Acidosis stimulates nitric oxide production and lung damage in rats. ( Camporesi, EM; Caruso, JE; Hakim, TS; Hoffmann, SP; McGraw, DJ; Nandi, J; Oler, A; Pedoto, A; Tassiopoulos, AK, 1999) |
| "Myocardial infarction was induced by ligation of the left anterior descending coronary artery (LAD), and tissue was collected at selected times thereafter from both ligated and sham-operated rats." | 1.30 | Reduction of myocardial infarct size by inhibition of inducible nitric oxide synthase. ( Carretero, OA; LaPointe, MC; Liu, YH; Wang, D; Yang, XP, 1999) |
| "The incidence of ventricular tachycardia was reduced from 75% to 25% (P<0." | 1.30 | Delayed protection against ventricular arrhythmias by monophosphoryl lipid-A in a canine model of ischaemia and reperfusion. ( György, K; Papp, JG; Parratt, JR; Rastegar, MA; Végh, A, 1999) |
| "Endotoxemia is associated with diminished intestinal mucosal oxygen utilization due to an intrinsic acquired derangement in cellular respiration that is caused, at least in part, by an aminoguanidine-inhibitable mechanism." | 1.30 | Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine. ( Delude, RL; Fink, MP; King, CJ; Tytgat, S, 1999) |
| "Acute inflammation was associated with enlarged colonic perimeter." | 1.29 | Toxic dilatation of colon in a rat model of colitis is linked to an inducible form of nitric oxide synthase. ( Guarner, F; Malagelada, JR; Mourelle, M; Salas, A; Vilaseca, J, 1996) |
| "During a cerebral infarction, a complex cascade of cytotoxic events ultimately determines the volume of brain cell loss." | 1.29 | Cerebroprotective effects of aminoguanidine in a rodent model of stroke. ( Bloom, O; Cerami, A; Cockroft, KM; Meistrell, M; Risucci, D; Tracey, KJ; Zimmerman, GA, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.52) | 18.7374 |
| 1990's | 41 (21.24) | 18.2507 |
| 2000's | 101 (52.33) | 29.6817 |
| 2010's | 44 (22.80) | 24.3611 |
| 2020's | 6 (3.11) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Li, Y | 1 |
| Zheng, X | 1 |
| Guo, J | 1 |
| Samura, M | 1 |
| Ge, Y | 1 |
| Zhao, S | 2 |
| Li, G | 1 |
| Chen, X | 2 |
| Shoji, T | 1 |
| Ikezoe, T | 1 |
| Miyata, M | 1 |
| Xu, B | 1 |
| Dalman, RL | 1 |
| Gomes, JAS | 1 |
| Silva, JF | 1 |
| Marçal, AP | 1 |
| Silva, GC | 1 |
| Gomes, GF | 1 |
| de Oliveira, ACP | 1 |
| Soares, VL | 1 |
| Oliveira, MC | 1 |
| Ferreira, AVM | 1 |
| Aguiar, DC | 1 |
| Beheshti, F | 1 |
| Hosseini, M | 1 |
| Hashemzehi, M | 1 |
| Hadipanah, MR | 1 |
| Mahmoudabady, M | 1 |
| Abd El-Aleem, SA | 1 |
| Mohammed, HH | 1 |
| Saber, EA | 1 |
| Embaby, AS | 1 |
| Djouhri, L | 1 |
| Ahmad, S | 1 |
| Khan, MS | 1 |
| Alouffi, S | 1 |
| Khan, S | 1 |
| Khan, M | 1 |
| Akashah, R | 1 |
| Faisal, M | 1 |
| Shahab, U | 1 |
| Zhang, ZS | 1 |
| Chen, W | 1 |
| Li, T | 1 |
| Liu, LM | 1 |
| Wang, W | 1 |
| Shen, M | 1 |
| Sun, K | 1 |
| Wang, Y | 3 |
| Wang, X | 1 |
| Jin, X | 1 |
| Xu, J | 1 |
| Ding, L | 1 |
| Sun, X | 2 |
| Javadi-Paydar, M | 3 |
| Ghiassy, B | 1 |
| Ebadian, S | 1 |
| Rahimi, N | 4 |
| Norouzi, A | 2 |
| Dehpour, AR | 10 |
| Lee, SJ | 1 |
| Kim, TU | 1 |
| Park, JS | 1 |
| Ra, JY | 1 |
| Chang, PC | 2 |
| Chong, LY | 1 |
| Tsai, SC | 2 |
| Lim, LP | 1 |
| Jheng, YH | 1 |
| Wang, CY | 1 |
| Chen, YW | 1 |
| Lin, YF | 1 |
| Chen, CC | 1 |
| Tomaz, VS | 1 |
| Cordeiro, RC | 1 |
| Costa, AM | 1 |
| de Lucena, DF | 1 |
| Nobre Júnior, HV | 1 |
| de Sousa, FC | 1 |
| Vasconcelos, SM | 1 |
| Vale, ML | 1 |
| Quevedo, J | 1 |
| Macêdo, D | 1 |
| Sattarinezhad, E | 1 |
| Shafaroodi, H | 4 |
| Sheikhnouri, K | 1 |
| Mousavi, Z | 2 |
| Moezi, L | 4 |
| Tun, X | 1 |
| Yasukawa, K | 1 |
| Yamada, K | 1 |
| Gilhotra, N | 2 |
| Dhingra, D | 2 |
| Ueshima, S | 1 |
| Nishida, T | 1 |
| Koike, M | 1 |
| Matsuda, H | 1 |
| Sawa, Y | 1 |
| Uchiyama, Y | 1 |
| Ostadhadi, S | 2 |
| Haj-Mirzaian, A | 1 |
| Azimi, E | 1 |
| Mansouri, P | 1 |
| Moura, JF | 1 |
| Mota, JM | 1 |
| Leite, CA | 1 |
| Wong, DV | 1 |
| Bezerra, NP | 1 |
| Brito, GA | 1 |
| Lima, V | 1 |
| Cunha, FQ | 2 |
| Ribeiro, RA | 1 |
| Yanilmaz, M | 1 |
| Akduman, D | 1 |
| Sagun, ÖF | 1 |
| Haksever, M | 1 |
| Yazicilar, O | 1 |
| Orhan, I | 1 |
| Akpolat, N | 1 |
| Gök, U | 1 |
| Heydarpour, P | 1 |
| Rahimian, R | 1 |
| Fakhfouri, G | 1 |
| Khoshkish, S | 1 |
| Fakhraei, N | 2 |
| Salehi-Sadaghiani, M | 1 |
| Wang, H | 1 |
| Abbasi, A | 1 |
| Ghia, JE | 1 |
| Hassanipour, M | 4 |
| Shirzadian, A | 1 |
| Boojar, MM | 1 |
| Abkhoo, A | 2 |
| Delazar, S | 1 |
| Amiri, S | 1 |
| Fatemikia, H | 1 |
| Ketabchi, F | 1 |
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| Thielemans, L | 1 |
| Akçay, MN | 1 |
| Ozcan, O | 1 |
| Gündoğdu, C | 1 |
| Akçay, G | 1 |
| Balik, A | 1 |
| Köse, K | 1 |
| Oren, D | 1 |
| Hong, HJ | 1 |
| Loh, SH | 1 |
| Stefek, M | 1 |
| Gajdosik, A | 1 |
| Gajdosikova, A | 1 |
| Krizanova, L | 1 |
| Tsugawa, K | 1 |
| Hashizume, M | 1 |
| Migou, S | 1 |
| Kishihara, F | 1 |
| Kawanaka, H | 1 |
| Tomikawa, M | 1 |
| Tanoue, K | 1 |
| Sugimachi, K | 1 |
| Carmo, A | 1 |
| Cunha-Vaz, JG | 1 |
| Carvalho, AP | 1 |
| Lopes, MC | 1 |
| Iskit, AB | 1 |
| Guc, MO | 1 |
| Johanning, JM | 1 |
| Franklin, DP | 1 |
| Han, DC | 1 |
| Carey, DJ | 1 |
| Elmore, JR | 1 |
| Bossone, C | 1 |
| Hosseini, JM | 1 |
| Piñeiro-Carrero, V | 1 |
| Shea-Donohue, T | 1 |
| Demougeot, C | 1 |
| Garnier, P | 1 |
| Mossiat, C | 1 |
| Bertrand, N | 1 |
| Giroud, M | 1 |
| Beley, A | 1 |
| Marie, C | 1 |
| Cash, D | 1 |
| Beech, JS | 1 |
| Rayne, RC | 1 |
| Bath, PM | 1 |
| Meldrum, BS | 1 |
| Williams, SC | 1 |
| Park, WS | 1 |
| Chang, YS | 1 |
| Lee, M | 1 |
| Vona-Davis, L | 1 |
| Wearden, P | 1 |
| Hill, J | 1 |
| Hill, R | 1 |
| Lange, E | 1 |
| Schult, H | 1 |
| Lorenz, W | 1 |
| Reimann, HJ | 1 |
| Maroske, D | 1 |
| Neuhaus, H | 1 |
| Schwarz, B | 1 |
| Kresse, U | 1 |
| Boros, M | 1 |
| Kaszaki, J | 1 |
| Bakó, L | 1 |
| Nagy, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study of the Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage[NCT01095731] | Phase 2 | 60 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for pimagedine and Disease Models, Animal
| Article | Year |
|---|---|
[Nitric oxide synthase-mediated alteration of intestinal P-glycoprotein under hyperglycemic stress].
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Diabetes Mellitus, Experimental; D | 2011 |
[Aminoguanidine and other AGE inhibitors].
Topics: Amides; Animals; Arteriosclerosis; Cardiovascular Diseases; Cataract; Clinical Trials as Topic; Diab | 2002 |
[OPB-9195].
Topics: Animals; Diabetic Angiopathies; Disease Models, Animal; Drug Design; Glycation End Products, Advance | 2002 |
Can advanced glycation end product inhibitors modulate more than one pathway to enhance renoprotection in diabetes?
Topics: Animals; Diabetic Nephropathies; Disease Models, Animal; Glycation End Products, Advanced; Guanidine | 2005 |
Selective inhibition of the activity of inducible nitric oxide synthase in septic shock.
Topics: Animals; Arginine; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Guanidines; Humans; | 1995 |
Advanced glycosylated end products and hyperglycemia in the pathogenesis of diabetic complications.
Topics: Aldehyde Reductase; Animals; Clinical Trials as Topic; Diabetes Mellitus; Disease Models, Animal; En | 1999 |
1 trial available for pimagedine and Disease Models, Animal
| Article | Year |
|---|---|
Nitric oxide mediates the beneficial effect of chronic naltrexone on cholestasis-induced memory impairment in male rats.
Topics: Animals; Cholestasis; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Guani | 2013 |
186 other studies available for pimagedine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Treatment With Small Molecule Inhibitors of Advanced Glycation End-Products Formation and Advanced Glycation End-Products-Mediated Collagen Cross-Linking Promotes Experimental Aortic Aneurysm Progression in Diabetic Mice.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Collagen; Diabetes Mellitus, Experimental; Di | 2023 |
High-refined carbohydrate diet consumption induces neuroinflammation and anxiety-like behavior in mice.
Topics: Adipose Tissue; Animals; Anxiety; Behavior, Animal; Dietary Carbohydrates; Disease Models, Animal; G | 2020 |
The Cardioprotective Effects of Aminoguanidine on Lipopolysaccharide Induced Inflammation in Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cardiotoxicity; Cardiovascular Diseases; Cardiovasc | 2020 |
Mutual inter-regulation between iNOS and TGF-β1: Possible molecular and cellular mechanisms of iNOS in wound healing.
Topics: Animals; Arginase; Collagen; Disease Models, Animal; Fibroblasts; Guanidines; Humans; Male; Nitric O | 2020 |
Gold Nanoparticle-Bioconjugated Aminoguanidine Inhibits Glycation Reaction: An
Topics: Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Ani | 2021 |
Organ-specific changes in vascular reactivity and roles of inducible nitric oxide synthase and endothelin-1 in a rabbit endotoxic shock model.
Topics: Acetylcholine; Animals; Celiac Artery; Disease Models, Animal; Endothelin A Receptor Antagonists; En | 2018 |
Aminoguanidine reverses cognitive deficits and activation of cAMP/CREB/BDNF pathway in mouse hippocampus after traumatic brain injury (TBI).
Topics: Animals; Brain Injuries, Traumatic; Brain-Derived Neurotrophic Factor; Cognition Disorders; CREB-Bin | 2018 |
Inhibition of nitric oxide mediated protein nitration: therapeutic implications in experimental radiculopathy.
Topics: Animals; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hindlimb; Hyperal | 2013 |
Aminoguanidine inhibits the AGE-RAGE axis to modulate the induction of periodontitis but has limited effects on the progression and recovery of experimental periodontitis: a preliminary study.
Topics: Alveolar Bone Loss; Alveolar Process; Angiogenesis Inducing Agents; Animals; Biomarkers; Cell Adhesi | 2014 |
Osseous wound repair under inhibition of the axis of advanced glycation end-products and the advanced glycation end-products receptor.
Topics: Animals; Collagen Type I; Disease Models, Animal; Fibronectins; Glycation End Products, Advanced; Gu | 2015 |
Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice.
Topics: Animals; Antidepressive Agents; Arginine; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor | 2014 |
The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide.
Topics: Animals; Arginine; Brain; Disease Models, Animal; Electroshock; Epilepsy, Tonic-Clonic; Guanidines; | 2014 |
Involvement of nitric oxide with activation of Toll-like receptor 4 signaling in mice with dextran sodium sulfate-induced colitis.
Topics: Animals; Benzoates; Cells, Cultured; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, An | 2014 |
Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Anxiety; Benzodioxoles; Diazepam; Disease Models, Animal; D | 2014 |
Nitric oxide-mediated injury of interstitial cells of Cajal and intestinal dysmotility under endotoxemia of mice.
Topics: Animals; Disease Models, Animal; Endotoxemia; Gadolinium; Guanidines; Indazoles; Interstitial Cells | 2014 |
Involvement of nitric oxide in serotonin-induced scratching in mice.
Topics: Analysis of Variance; Animals; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 2015 |
A novel model of megavoltage radiation-induced oral mucositis in hamsters: Role of inflammatory cytokines and nitric oxide.
Topics: Animals; Cobalt Radioisotopes; Cricetinae; Cytokines; Disease Models, Animal; Guanidines; Head and N | 2015 |
The effects of aminoguanidine, methylprednisolone, and melatonin on nerve recovery in peripheral facial nerve neurorrhaphy.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Facial Nerve Diseases; Female; Guanidines; Melat | 2015 |
Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway.
Topics: Animals; Antidepressive Agents; Colitis; Colon; Crohn Disease; Depression; Disease Models, Animal; E | 2016 |
The Effects of Sub-Chronic Treatment with Pioglitazone on the Septic Mice Mortality in the Model of Cecal Ligation and Puncture: Involvement of Nitric Oxide Pathway.
Topics: Animals; Cecum; Cytokines; Disease Models, Animal; Guanidines; Ligation; Male; Mice; Nitric Oxide; N | 2015 |
Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Arginine; Chloroquine; Disease M | 2016 |
Distant effects of unilateral renal ischemia/reperfusion on contralateral kidney but not lung in rats: the roles of ROS and iNOS.
Topics: Acute Kidney Injury; alpha-Tocopherol; Animals; Antioxidants; Disease Models, Animal; Enzyme Inhibit | 2016 |
The Effect of Inducible Nitric Oxide Synthase on Multiterritory Perforator Flap Survival in Rats.
Topics: Animals; Blood Flow Velocity; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Graft Su | 2016 |
TOWARDS A TREATMENT FOR DIABETIC RETINOPATHY: Intravitreal Toxicity and Preclinical Safety Evaluation of Inducible Nitric Oxide Synthase Inhibitors.
Topics: Amidines; Animals; Aqueous Humor; Benzylamines; Diabetic Retinopathy; Disease Models, Animal; Electr | 2017 |
The modulatory effect of nitric oxide in pro- and anti-convulsive effects of vasopressin in PTZ-induced seizures threshold in mice.
Topics: Animals; Anticonvulsants; Antidiuretic Hormone Receptor Antagonists; Arginine; Arginine Vasopressin; | 2016 |
[SIMULATION OF CHRONIC TUBERCULOSIS INFECTION IN MICE BY INTRAPERITONEAL INOCULATION AND THE TESTING OF AMINOGUANIDINE-INDUCED ACTIVATION OF RPF GENE/DELETION MUTANTS OF THE H37Rv STRAIN].
Topics: Animals; Bacterial Proteins; Bacterial Typing Techniques; Cytokines; Disease Models, Animal; Enzyme | 2010 |
Flavonoids from Litsea japonica Inhibit AGEs Formation and Rat Lense Aldose Reductase In Vitro and Vessel Dilation in Zebrafish.
Topics: Aldehyde Reductase; Animals; Diabetic Angiopathies; Disease Models, Animal; Flavonoids; Glycation En | 2017 |
Aminoguanidine alleviated MMA-induced impairment of cognitive ability in rats by downregulating oxidative stress and inflammatory reaction.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Animals, Newborn; Antioxidants; Apoptosis; Cognitive | 2017 |
Aminoguanidine ameliorates radiation-induced oxidative lung damage in rats.
Topics: Animals; Catalase; Disease Models, Animal; Enzyme Inhibitors; Glutathione Peroxidase; Guanidines; Lu | 2008 |
Nicotine attenuates iNOS expression and contributes to neuroprotection in a compressive model of spinal cord injury.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Injections, Intraperitoneal; Male; M | 2009 |
The effect of iNOS inhibitors and hyperbaric oxygen treatment in a rat model of experimental colitis.
Topics: Acetic Acid; Animals; Colitis; Combined Modality Therapy; Disease Models, Animal; Female; Guanidines | 2009 |
Antinociceptive effect of chronic lithium on visceral hypersensitivity in a rat model of diarrhea-predominant irritable bowel syndrome: The role of nitric oxide pathway.
Topics: Administration, Oral; Analgesics; Animals; Colon; Defecation; Diarrhea; Disease Models, Animal; Drug | 2009 |
Aminoguanidine, selective nitric oxide synthase inhibitor, ameliorates cyclophosphamide-induced hemorrhagic cystitis by inhibiting protein nitration and PARS activation.
Topics: Animals; Cyclophosphamide; Cystitis; Disease Models, Animal; Guanidines; Hemorrhage; Male; Nitric Ox | 2009 |
Prenatal lipopolysaccharide increases postnatal intestinal injury in a rat model of necrotizing enterocolitis.
Topics: Animals; Animals, Newborn; Blood Pressure; Disease Models, Animal; Enterocolitis, Necrotizing; Enzym | 2009 |
Role of inducible nitric oxide synthase in rostral ventrolateral medulla in blood pressure regulation in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Guanidines; Heart | 2009 |
The molecular mechanism of aminoguanidine-mediated reduction on the brain edema after surgical brain injury in rats.
Topics: Animals; Aquaporin 4; Brain Edema; Brain Injuries; Disease Models, Animal; Dose-Response Relationshi | 2009 |
Hippocampal alterations in rats submitted to streptozotocin-induced dementia model are prevented by aminoguanidine.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dementia; Disease Models, Animal; Enzyme Inhibitors | 2009 |
Involvement of NO-cGMP pathway in anti-anxiety effect of aminoguanidine in stressed mice.
Topics: Adaptation, Ocular; Analysis of Variance; Animals; Anti-Asthmatic Agents; Cyclic GMP; Disease Models | 2009 |
[Nitric oxide synthase (NOS) expression and nitric oxide (NO) content in the skeletal muscles in transverse process syndrome of the 3rd lumbar vertebra of model rats treated with acupotomology therapy].
Topics: Animals; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Guanidines; Lumbar Vertebr | 2009 |
Inhibition of inducible nitric oxide controls pathogen load and brain damage by enhancing phagocytosis of Escherichia coli K1 in neonatal meningitis.
Topics: Administration, Intranasal; Animals; Animals, Newborn; Brain; Cell Survival; Cytokines; Disease Mode | 2010 |
Upregulation of AT1R and iNOS in the rostral ventrolateral medulla (RVLM) is essential for the sympathetic hyperactivity and hypertension in the 2K-1C Wistar rat model.
Topics: Animals; Brain Stem; Disease Models, Animal; Enzyme Inhibitors; Gene Expression; Guanidines; Hyperte | 2010 |
Aminoguanidine inhibition of iNOS activity ameliorates cerebral vasospasm after subarachnoid hemorrhage in rabbits via restoration of dysfunctional endothelial cells.
Topics: Analysis of Variance; Animals; Basilar Artery; Cerebral Angiography; Disease Models, Animal; Endothe | 2010 |
Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis.
Topics: Adenine; Amylases; Animals; Calcium; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cycloox | 2010 |
Diabetes depresses synaptic transmission in sympathetic ganglia by inactivating nAChRs through a conserved intracellular cysteine residue.
Topics: Acetylcholine; Adenoviridae; Age Factors; Aldehydes; Animals; Animals, Newborn; Body Temperature; Ce | 2010 |
Dual effect of nitric oxide on uterine prostaglandin synthesis in a murine model of preterm labour.
Topics: Animals; Blotting, Western; Cyclooxygenase 2 Inhibitors; Dinoprost; Dinoprostone; Disease Models, An | 2010 |
Inducible nitric oxide synthase-mediated alteration of mitochondrial OPA1 expression in ocular hypertensive rats.
Topics: Animals; Blotting, Western; Cell Survival; Disease Models, Animal; Enzyme Inhibitors; Gene Expressio | 2011 |
Atorvastatin improved scopolamine-induced impairment in memory acquisition in mice: involvement of nitric oxide.
Topics: Animals; Arginine; Atorvastatin; Cholinergic Antagonists; Disease Models, Animal; Enzyme Inhibitors; | 2011 |
Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice.
Topics: Animals; Arterioles; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Immunoh | 2011 |
Chronic administration of atorvastatin induced anti-convulsant effects in mice: the role of nitric oxide.
Topics: Analysis of Variance; Animals; Anticonvulsants; Atorvastatin; Convulsants; Disease Models, Animal; D | 2012 |
An evaluation of the effectiveness of pre-ischemic hyperbaric oxygen and post-ischemic aminoguanidine in experimental cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; Enzyme Inhibitors | 2012 |
In vivo participation of nitric oxide in hyperproliferative epidermal phenomena in mice.
Topics: Acetylglucosaminidase; Animals; Anti-Inflammatory Agents; Cell Proliferation; Croton Oil; Dermatitis | 2012 |
Effect of selective inhibition of renal inducible nitric oxide synthase on renal blood flow and function in experimental hyperdynamic sepsis.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Female; Guanidines; Hemodynamics; Infusions, I | 2012 |
Role of peroxynitrite in sepsis-induced acute kidney injury in an experimental model of sepsis in rats.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Animals; Aorta; Blood Flow Velocity; Blood Pressure; Dise | 2012 |
Genistein prevents isoproterenol-induced cardiac hypertrophy in rats.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Catalase; Disease Models, Animal; Enzyme Inhibitors; Fibr | 2012 |
The involvement of nitric oxide in the anti-seizure effect of acute atorvastatin treatment in mice.
Topics: Animals; Anticonvulsants; Atorvastatin; Brain; Convulsants; Disease Models, Animal; Dose-Response Re | 2012 |
[Effect of aminoguanidine on spinal cord edema of acute spinal cord injury in rats].
Topics: Acute Disease; Animals; Aquaporin 4; Blood-Brain Barrier; Blotting, Western; Disease Models, Animal; | 2012 |
Involvement of the nitric oxide/cyclic guanylate monophosphate pathway in the pilocarpine-induced seizure model in mice.
Topics: Amidines; Animals; Arginine; Benzylamines; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Gu | 2013 |
Inducible nitric oxide synthase expression in the ischemic core and penumbra after transient focal cerebral ischemia in mice.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Enzyme Inhibitors; Guanidines; | 2002 |
Abrogation of bleomycin-induced lung fibrosis by nitric oxide synthase inhibitor, aminoguanidine in mice.
Topics: Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Guanidines; Hy | 2002 |
Involvement of semicarbazide-sensitive amine oxidase-mediated deamination in atherogenesis in KKAy diabetic mice fed with high cholesterol diet.
Topics: Albuminuria; Allyl Compounds; Amine Oxidase (Copper-Containing); Amines; Animals; Arteriosclerosis; | 2002 |
Effects of aminoguanidine on glomerular basement membrane thickness and anionic charge in a diabetic rat model.
Topics: Administration, Oral; Animals; Basement Membrane; Diabetes Mellitus, Experimental; Disease Models, A | 2001 |
Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Diabetic Nephrop | 2002 |
Reactivation of latent tuberculosis by an inhibitor of inducible nitric oxide synthase in an aerosol murine model.
Topics: Animals; Antitubercular Agents; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; Guanidin | 2002 |
Effect of NO synthase inhibition on cardiovascular and pulmonary dysfunction in a porcine short-term model of endotoxic shock.
Topics: Animals; Blood Pressure; Cardiac Output; Cardiovascular System; Central Venous Pressure; Disease Mod | 2002 |
Neuroprotection by aminoguanidine after lateral fluid-percussive brain injury in rats: a combined magnetic resonance imaging, histopathologic and functional study.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Protein | 2003 |
Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR).
Topics: Aging; alpha-Crystallin A Chain; Animals; Antibodies; Blotting, Western; Calpain; Case-Control Studi | 2002 |
Intervention with nitric oxide synthase inhibitors for traumatic shock in rats.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Guanidines; Male; NG-Nitroarginine Methy | 2003 |
Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model.
Topics: Acute Disease; Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Guanidines; Indazoles; Lu | 2003 |
The role of inducible nitric oxide synthase inhibitor on the arteriolar hyporesponsiveness in hemorrhagic-shocked rats.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; | 2003 |
Secondary growth of a cortical necrosis: effect of NOS inhibition by aminoguanidine post insult.
Topics: Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Drug Administration Schedule; Guan | 2003 |
Superior renoprotective effects of combination therapy with ACE and AGE inhibition in the diabetic spontaneously hypertensive rat.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Dia | 2004 |
Comparison of iNOS inhibition by antisense and pharmacological inhibitors after spinal cord injury.
Topics: Amidines; Animals; Annexins; Astrocytes; Benzylamines; Blood-Brain Barrier; Cell Count; Cell Death; | 2003 |
Reactive nitrogen species scavenging, rather than nitric oxide inhibition, protects from articular cartilage damage in rat zymosan-induced arthritis.
Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Disease Models, Animal; Dose-Response Relati | 2004 |
Changes in plasma membrane Ca2+ -ATPase expression and ATP content in lenses of hereditary cataract UPL rats.
Topics: Adenosine Triphosphate; Animals; Calcium-Transporting ATPases; Cataract; Cell Membrane; Disease Mode | 2004 |
Effect of aminoguanidine in ligature-induced periodontitis in rats.
Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Enzyme Inhibitors; Gingiva; Guanidines; Ligatio | 2004 |
Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease.
Topics: Animals; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Guanidines; Huntingt | 2004 |
Vasoactive systems in L-NAME hypertension: the role of inducible nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inh | 2004 |
Early inhibition of nitric oxide production increases HSV-1 intranasal infection.
Topics: Animals; Brain; Disease Models, Animal; Gene Expression Regulation; Guanidines; Herpes Simplex; Herp | 2004 |
Effects of aminoguanidine and L-arginine methyl ester resuscitation following induction of fluid-percussion injury and severe controlled hemorrhagic shock in the rat brain.
Topics: Animals; Blood Pressure; Brain; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; | 2004 |
Protective effect of aminoguanidine against nephrotoxicity induced by amikacin in rats.
Topics: Amikacin; Analysis of Variance; Animals; Biopsy, Needle; Disease Models, Animal; Drug Interactions; | 2004 |
Time-level relationship for nitric oxide and the protective effects of aminoguanidine in experimental spinal cord injury.
Topics: Animals; Disease Models, Animal; Guanidines; Lipid Peroxidation; Male; Motor Activity; Neuroprotecti | 2004 |
A possible role for nitric oxide in osteoclastogenesis associated with cholesteatoma.
Topics: Animals; Bone Resorption; Cells, Cultured; Cholesteatoma; Cytokines; Disease Models, Animal; Enzyme | 2004 |
Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Guanidines; Infarction, Middle Cerebral Artery; Int | 2004 |
The expression of heme oxygenase-1 and inducible nitric oxide synthase in aorta during the development of hypertension in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Biomarkers; Blood Pressure; Blotting, Western; Disease Mode | 2004 |
Effects of nitric oxide synthase inhibition on intestinal damage in rats with experimental necrotizing enterocolitis.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Enterocolitis, Necrotizing; Guanidines; Ileum; Im | 2004 |
Nitric oxide synthases inhibition results in renal failure improvement in cirrhotic rats.
Topics: Animals; Aspartate Aminotransferases; Creatinine; Disease Models, Animal; Enzyme Inhibitors; Guanidi | 2005 |
In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamine.
Topics: Administration, Inhalation; Animals; Asthma; Bronchi; Bronchial Hyperreactivity; Bronchoalveolar Lav | 2005 |
Evaluation of inducible nitric oxide synthase in glaucomatous optic neuropathy and pressure-induced optic nerve damage.
Topics: Aged; Animals; Caenorhabditis elegans Proteins; Disease Models, Animal; Enzyme Inhibitors; Gene Expr | 2005 |
[Decrease of nitric oxide (NO)-cGMP-dependent vasodilatation in the vessels of lesser circulation in endothelial dysfunction].
Topics: Animals; Cyclic GMP; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Guanidines; H | 2005 |
[Aminoguanidin improves learning process in neonatal rats exposed to hypoxia-ischemia].
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Enzyme Inhibitors; Guanidines; | 2005 |
Chronic administration of aminoguanidine reduces vascular nitric oxide production and attenuates liver damage in bile duct-ligated rats.
Topics: Animals; Aorta; Bile Ducts; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation, E | 2005 |
Inducible nitric oxide synthase contributes to gender differences in ischemic brain injury.
Topics: Animals; Cerebral Infarction; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression Reg | 2006 |
Beneficial effects of aminoguanidine on peritoneal microcirculation and tissue remodelling in a rat model of PD.
Topics: Animals; Dialysis Solutions; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; Glycation End Prod | 2005 |
Transmission electron microscopy and autofluorescence findings in the cornea of diabetic rats treated with aminoguanidine.
Topics: Animals; Cornea; Corneal Diseases; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme I | 2006 |
Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient cerebral ischemia.
Topics: Animals; Animals, Newborn; Blotting, Western; Calpain; Caspase 3; Caspases; Cell Count; Cell Death; | 2006 |
IFN-gamma: regulation of nitric oxide in the P. aeruginosa-infected cornea.
Topics: Animals; Colony Count, Microbial; Cornea; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Enzy | 2006 |
Effects of COX-2 and iNOS inhibitors alone or in combination with olfactory ensheathing cell grafts after spinal cord injury.
Topics: Animals; Brain Tissue Transplantation; Cell Transplantation; Cyclooxygenase 2 Inhibitors; Disease Mo | 2006 |
Pathogenic role of endothelial nitric oxide synthase (eNOS/NOS-III) in cerulein-induced rat acute pancreatitis.
Topics: Animals; Biomarkers; Blotting, Western; Capillary Permeability; Ceruletide; Disease Models, Animal; | 2006 |
Comparison of FK 506, mycophenolate mofetil, and aminoguanidine effects on delay of corneal allograft rejection in an experimental model of low-risk and high-risk keratoplasty.
Topics: Animals; Corneal Diseases; Corneal Transplantation; Disease Models, Animal; Drug Combinations; Femal | 2006 |
Ameliorative effect of combined administration of inducible nitric oxide synthase inhibitor with cyclooxygenase-2 inhibitors in neuropathic pain in rats.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2007 |
Interplay of pneumococcal hydrogen peroxide and host-derived nitric oxide.
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Cells, Cultured; Disease Models, Animal; Gene Delet | 2006 |
Renal damage in rats induced by myocardial ischemia/reperfusion: Role of nitric oxide.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Kidney; Kidney Diseases; Male; Myoca | 2006 |
The involvement of matrix metalloproteinases 2 and 9 in rat retinal ischemia.
Topics: Animals; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Ischemia; Male; M | 2007 |
Role of endogenous nitric oxide (NO) and NO synthases in healing of indomethacin-induced intestinal ulcers in rats.
Topics: Animals; Disease Models, Animal; Duodenal Ulcer; Enzyme Inhibitors; Gene Expression Regulation, Enzy | 2007 |
Calpain inhibition attenuates iNOS production and midzonal hepatic necrosis in a repeat dose model of endotoxemia in rats.
Topics: Animals; Anticoagulants; Blood Coagulation; Blotting, Western; Calpain; Carrier Proteins; Chemical a | 2006 |
Retinal ischemia and reperfusion causes capillary degeneration: similarities to diabetes.
Topics: Animals; Apoptosis; Blotting, Western; Capillaries; Cyclooxygenase 2; Disease Models, Animal; Guanid | 2007 |
Antagonic effect of the inhibition of inducible nitric oxide on the mortality of mice acutely infected with Escherichia coli and Bacteroides fragilis.
Topics: Acute Disease; Animals; Bacteroides fragilis; Bacteroides Infections; Disease Models, Animal; Escher | 2007 |
Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors.
Topics: Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Diabetic Nephropathies; Disease | 2007 |
Nitric oxide and prostaglandin response to group B streptococcal infection in the lung.
Topics: Animals; Arginine; Cell Line; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Drug Therapy, | 2007 |
Distribution of NOS isoforms in a porcine endotoxin shock model.
Topics: Animals; Cardiomyopathies; Coronary Circulation; Disease Models, Animal; Enzyme Activation; Enzyme I | 2008 |
Intracerebroventricular injection of neuronal and inducible nitric oxide synthase inhibitors attenuates fever due to LPS in rats.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Fever; Guanidines; Injections, Intraventricular; | 2007 |
Adverse effects of excessive nitric oxide on cytochrome c oxidase in lenses of hereditary cataract UPL rats.
Topics: Adenosine Triphosphate; Administration, Oral; Animals; Cataract; Disease Models, Animal; Disulfiram; | 2007 |
The effects of arginine and selective inducible nitric oxide synthase inhibitor on pathophysiology of sepsis in a CLP model.
Topics: Animals; Arginine; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Guanidines; | 2008 |
The role of resuscitation promoting factors in pathogenesis and reactivation of Mycobacterium tuberculosis during intra-peritoneal infection in mice.
Topics: Animals; Antibodies, Monoclonal; Bacterial Proteins; Chronic Disease; Cytokines; Disease Models, Ani | 2007 |
Effect of aminoguanidine on post-ischemic damage in rodent model of stroke.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Admini | 2008 |
Effects of morphine during Mycobacterium tuberculosis H37Rv infection in mice.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guani | 2008 |
Intracerebroventricular injection of neuronal and inducible nitric oxide synthase inhibitors does not influence febrile response in rats during turpentine abscess.
Topics: Analysis of Variance; Animals; Body Temperature; Brain; Disease Models, Animal; Fever; Guanidines; I | 2007 |
Monocyte chemoattractant protein-1 and nitric oxide promote adipogenesis in a model that mimics obesity.
Topics: Adipogenesis; Adipose Tissue; Animals; Cell Movement; Chemokine CCL2; Disease Models, Animal; Enzyme | 2007 |
Liver tissue inducible nitric oxide synthase (iNOS) expression and lipid peroxidation in experimental hepatic ischemia reperfusion injury stimulated with lipopolysaccharide: the role of aminoguanidine.
Topics: Animals; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Guanidines; Lipid Peroxidation; Lip | 2008 |
Prevention of chronic stress-induced depression-like behavior by inducible nitric oxide inhibitor.
Topics: Animals; Appetite; Behavior, Animal; Body Weight; Chronic Disease; Depressive Disorder; Disease Mode | 2008 |
Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin.
Topics: Animals; Blood Pressure; Breath Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Dua | 2008 |
Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Catecholamine Plasma Membrane Tran | 2008 |
[Effect of aminoguanidine on hemodynamics and nitrogen monoxide in hemorrhagic shock in rabbit].
Topics: Animals; Disease Models, Animal; Female; Guanidines; Hemodynamics; Male; Nitric Oxide; Rabbits; Resu | 2008 |
Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme | 2008 |
Diabetic cardiomyopathy: how much does it depend on AGE?
Topics: Animals; Cardiomyopathies; Diabetes Complications; Disease Models, Animal; Drug Delivery Systems; En | 2008 |
The effects of diabetes and aminoguanidine treatment on endothelial function in a primate model of type 1 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Endothe | 2008 |
First place winner of the Conrad Jobst Award in the gold medal paper competition. Nitric oxide synthase inhibitors N-monomethylarginine and aminoguanidine prevent the progressive and severe hypotension associated with a rat model of pancreatitis.
Topics: Amylases; Animals; Arginine; Blood Pressure; Calcium; Clinical Protocols; Disease Models, Animal; Dr | 1995 |
Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Disease Models, Animal; Dose-Response | 1995 |
The role of inducible nitric oxide synthase in vascular hyporeactivity of endotoxin-treated and portal hypertensive rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Disease Models, Animal; Endotoxins; Enzyme Induction; | 1995 |
Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Disease Models, Animal; Enzyme Induction; Female; Gene | 1995 |
In vivo assessment of an animal model of diabetic cataract: medical intervention studies.
Topics: Aldehyde Reductase; Animals; Antioxidants; Cataract; Diabetes Mellitus, Experimental; Disease Models | 1994 |
Perinatal nitric oxide synthase inhibition retards neonatal growth by inducing hypertrophic pyloric stenosis in rats.
Topics: Animals; Animals, Newborn; Arginine; Body Weight; Disease Models, Animal; Embryonic and Fetal Develo | 1995 |
Toxic dilatation of colon in a rat model of colitis is linked to an inducible form of nitric oxide synthase.
Topics: Animals; Arginine; Colitis; Colon; Dexamethasone; Dilatation; Disease Models, Animal; Enzyme Inducti | 1996 |
Cerebroprotective effects of aminoguanidine in a rodent model of stroke.
Topics: Animals; Cerebral Infarction; Cerebrovascular Circulation; Cerebrovascular Disorders; Disease Models | 1996 |
Contraction and relaxation of aortas from diabetic rats: effects of chronic anti-oxidant and aminoguanidine treatments.
Topics: Acetylcholine; Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Aorta; Butylated Hydroxy | 1996 |
Protective role of nitric oxide in ocular toxoplasmosis.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Guanidines; Immunoenzyme Techniques; Mic | 1996 |
Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute endotoxemia.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Dexamethasone; Disease Models, Animal; Drug Evalua | 1996 |
Effects of aminoguanidine on serum advanced glycation endproducts, urinary albilmin excretion, mesangial expansion, and glomerular basement membrane thickening in Otsuka Long-Evans Tokushima fatty rats.
Topics: Albuminuria; Animals; Basement Membrane; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dise | 1997 |
Aminoguanidine corrects hyperdynamic circulation without ameliorating portal hypertension and portal hypertensive gastropathy in anesthetized portal hypertensive rats.
Topics: Animals; Body Weight; Disease Models, Animal; Enzyme Inhibitors; Gastric Mucosa; Guanidines; Hemodyn | 1997 |
Effects of aminoguanidine on systemic inflammatory response syndrome induced by platelet activating factor and by lipopolysaccharide in rats.
Topics: Animals; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Guanidines; Injections, Intrav | 1997 |
Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacy.
Topics: Analysis of Variance; Animals; Blood Pressure; Citrulline; Disease Models, Animal; Dose-Response Rel | 1997 |
Inhibition of inducible nitric oxide synthase prolongs rat lung allograft survival.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Inhibitors; Graft Rejection; G | 1997 |
The role of endogenous nitric oxide in modulating ischemia-reperfusion injury in the isolated, blood-perfused rat lung.
Topics: Animals; Disease Models, Animal; Guanidines; In Vitro Techniques; Male; NG-Nitroarginine Methyl Este | 1998 |
Effects of aminoguanidine on latent murine tuberculosis.
Topics: Animals; Cytokines; Disease Models, Animal; Dose-Response Relationship, Immunologic; Enzyme Inductio | 1998 |
Role of nitric oxide and peroxynitrite in the cytokine-induced sustained myocardial dysfunction in dogs in vivo.
Topics: Animals; Creatine Kinase; Cytokines; Dexamethasone; Disease Models, Animal; Dogs; Guanidines; Heart; | 1998 |
Electron spin resonance analysis of heme-nitrosyl and reduced iron-sulfur centered complexes in allogeneic, heterotopic cardiac transplants: effects of treatment with pyrrolidine dithiocarbamate.
Topics: Animals; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Graft Rejection; Graft Surviv | 1998 |
Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbits.
Topics: Analysis of Variance; Animals; Consciousness; Disease Models, Animal; Enzyme Inhibitors; Guanidines; | 1998 |
Local nitric oxide synthase activity in a model of neuropathic pain.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Immunohistochemistry; Logistic Model | 1998 |
Dual action of iNOS-derived nitric oxide in allergen-induced airway hyperreactivity in conscious, unrestrained guinea pigs.
Topics: Acute Disease; Adjuvants, Immunologic; Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronch | 1998 |
Potential benefit of inhibitors of advanced glycation end products in the progression of type II diabetes: a study with aminoguanidine in C57/BLKsJ diabetic mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Drinking; Fe | 1998 |
Treatment of septic shock in rats with nitric oxide synthase inhibitors and inhaled nitric oxide.
Topics: Administration, Inhalation; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Ther | 1998 |
Influence of L-arginine, aminoguanidine, and NG-nitro-L-arginine methyl ester (L-name) on the survival rate in a rat model of hemorrhagic shock.
Topics: Animals; Arginine; Aspartate Aminotransferases; Blood Pressure; Creatinine; Dinoprostone; Disease Mo | 1999 |
Acidosis stimulates nitric oxide production and lung damage in rats.
Topics: Acidosis; Animals; Blood Gas Analysis; Blood Pressure; Disease Models, Animal; Dose-Response Relatio | 1999 |
Glucose-induced inhibition of angiogenesis in the rat sponge granuloma is prevented by aminoguanidine.
Topics: Animals; Disease Models, Animal; Glucose; Granulation Tissue; Granuloma, Foreign-Body; Guanidines; H | 1999 |
Involvement of nitric oxide in protecting mechanism during experimental cryptococcosis.
Topics: Animals; Cryptococcosis; Cryptococcus neoformans; Disease Models, Animal; Enzyme Inhibitors; Female; | 1999 |
Reduction of myocardial infarct size by inhibition of inducible nitric oxide synthase.
Topics: Animals; Animals, Newborn; Blotting, Northern; Blotting, Western; Cell Death; Cells, Cultured; Disea | 1999 |
Chronic aminoguanidine attenuates renal dysfunction and injury in aging rats.
Topics: Aging; Animals; Biomarkers; Blotting, Western; Dinoprost; Disease Models, Animal; Enzyme Inhibitors; | 1999 |
Vascular nitric oxide production during the development of two experimental models of portal hypertension.
Topics: Animals; Aorta, Thoracic; Disease Models, Animal; Guanidines; Hypertension, Portal; In Vitro Techniq | 1999 |
Advanced glycation in D-galactose induced mouse aging model.
Topics: Aging; Animals; Avoidance Learning; Cell Division; Disease Models, Animal; Enzyme Inhibitors; Erythr | 1999 |
Pulmonary artery contractility in pneumonia: role of cyclooxygenase products and nitric oxide.
Topics: Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Rela | 1999 |
Expression of NOS II and its role in experimental small bowel ulceration in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Disease Models, Animal; DNA Primers | 1999 |
Delayed protection against ventricular arrhythmias by monophosphoryl lipid-A in a canine model of ischaemia and reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Coronary Vessels | 1999 |
Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine.
Topics: Animals; Cell Respiration; Disease Models, Animal; Endotoxemia; Enzyme Inhibitors; Escherichia coli; | 1999 |
Roles of endogenous gamma interferon and macrophage microbicidal mechanisms in host response to chemotherapy in experimental visceral leishmaniasis.
Topics: Amphotericin B; Animals; Antimony; Antiprotozoal Agents; Disease Models, Animal; Enzyme Inhibitors; | 2000 |
Aminoguanidine attenuates hemodynamic and microcirculatory derangement in rat intestinal ischemia and reperfusion.
Topics: Animals; Blood Flow Velocity; Disease Models, Animal; Drug Evaluation, Preclinical; Granulocytes; Gu | 1999 |
Role of interferon-gamma and nitric oxide in pulmonary edema and death induced by lipopolysaccharide.
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Enzyme Inhibitors; Female; Guanidines | 2000 |
Differential effects of nitric oxide synthase inhibitors in an in vivo allergic rat model.
Topics: Animals; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Citrulline; Disease Models, Animal | 2000 |
Role of nitric oxide in the failure of neutrophil migration in sepsis.
Topics: Animals; Ascitic Fluid; Bacteremia; Cell Movement; Colony Count, Microbial; Cytokines; Disease Model | 2000 |
The effects of NO synthase inhibitors on murine collagen-induced arthritis do not support a role of NO in the protective effect of IFN-gamma.
Topics: Administration, Oral; Animals; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Collagen; | 2000 |
Effect of nitric oxide synthase inhibitor on experimentally induced burn wounds.
Topics: Animals; Burns; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Injections, Intraperitoneal; | 2000 |
Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hypertension; | 2000 |
Aminoguanidine-treatment results in the inhibition of lens opacification and calpain-mediated proteolysis in Shumiya cataract rats (SCR).
Topics: Animals; Blotting, Western; Calcium; Calpain; Cataract; Crystallins; Disease Models, Animal; Guanidi | 2000 |
p-Dimethylaminobenzaldehyde-reactive substances in tail tendon collagen of streptozotocin-diabetic rats: temporal relation to biomechanical properties and advanced glycation endproduct (AGE)-related fluorescence.
Topics: Animals; Benzaldehydes; Collagen; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme In | 2000 |
Role of nitric oxide and endothelin-1 in a portal hypertensive rat model.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelin-1; Enzyme Inhibitors; Guanidines; Hypert | 2000 |
Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: correlation with blood-retinal barrier permeability.
Topics: Animals; Arginine; Blood Glucose; Blood-Retinal Barrier; Blotting, Western; Densitometry; Diabetes M | 2000 |
The timing of endothelin and nitric oxide inhibition affects survival in a mice model of septic shock.
Topics: Animals; Antihypertensive Agents; Bosentan; Canavanine; Disease Models, Animal; Endothelin Receptor | 2001 |
Inhibition of inducible nitric oxide synthase limits nitric oxide production and experimental aneurysm expansion.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Disease Progression; | 2001 |
Alterations in spontaneous contractions in vitro after repeated inflammation of rat distal colon.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Motility; Guanidines; In Vitro Tec | 2001 |
N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury.
Topics: 2,2'-Dipyridyl; Acute Disease; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Brain Edema; Bra | 2001 |
Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain.
Topics: Animals; Brain; Brain Ischemia; Catalysis; Cell Survival; Disease Models, Animal; Drug Administratio | 2001 |
7-Nitroindazole, but not aminoguanidine, attenuates the acute inflammatory responses and brain injury during the early phase of Escherichia coli meningitis in the newborn piglet.
Topics: Animals; Animals, Newborn; Blood Glucose; Brain Diseases; Cerebral Cortex; Cerebrospinal Fluid; Dise | 2001 |
Cardiac response to nitric oxide synthase inhibition using aminoguanidine in a rat model of endotoxemia.
Topics: Animals; Disease Models, Animal; Endotoxemia; Endotoxins; Enzyme Inhibitors; Guanidines; Heart; In V | 2002 |
Histamine and pancreatitis: increase of plasma histamine levels in dogs with Pfeffer preparation and influence of aminoguanidine on the survival time.
Topics: Acute Disease; Amine Oxidase (Copper-Containing); Animals; Disease Models, Animal; Dogs; Duodenum; F | 1978 |
Studies on the relationship between xanthine oxidase and histamine release during intestinal ischemia-reperfusion.
Topics: Animals; Cromolyn Sodium; Disease Models, Animal; Dogs; Female; Guanidines; Histamine; Histamine Rel | 1992 |