pimagedine has been researched along with Diabetic Angiopathies in 27 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Diabetic Angiopathies: VASCULAR DISEASES that are associated with DIABETES MELLITUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim was to investigate whether argirein, which releases rhein and L-arginine after medication, could improve erectile dysfunction (ED) in diabetic rats through normalising the abnormalities of nitric oxide synthase (NOS), p66Shc and immunoglobulin heavy-chain binding protein (Bip), in the corpus cavernosum (CC)." | 3.79 | Argirein alleviates corpus cavernosum dysfunction by suppressing pro-inflammatory factors p66Shc and ER stress chaperone Bip in diabetic rats. ( Cheng, YS; Cong, XD; Dai, DZ; Dai, Y; Zhang, Y, 2013) |
| "Hyperglycemia is considered a key causal factor in the development of diabetic vascular complications and can mediate its adverse effects through multiple pathways." | 2.41 | Glycation as the glucose link to diabetic complications. ( Gugliucci, A, 2000) |
| "In rats with untreated diabetes, hyperglycaemia, increased activity of inducible nitric oxide (NO) synthase, increased NO, mild vascular spasm, reduced NO bioavailability and diminished vasorelaxation were found." | 1.36 | NaHS ameliorates diabetic vascular injury by correcting depressed connexin 43 and 40 in the vasculature in streptozotocin-injected rats. ( Dai, DZ; Dai, Y; Zheng, YF, 2010) |
| "Methylguanidine was only approximately 7% as effective as aminoguanidine as an inhibitor of AGE formation from L-lysine and G6P; both compounds were poor inhibitors of AR." | 1.29 | Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. ( Chang, K; Corbett, JA; Currie, MG; Hasan, KS; McDaniel, ML; Misko, TP; Moore, WM; Petrash, JM; Smith, SR; Tilton, RG, 1993) |
| "Arterial hypertension has been identified as a major secondary risk factor for diabetic retinopathy." | 1.29 | Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat. ( Brownlee, M; Edelstein, D; Federlin, K; Hammes, HP; Martin, S; Saleck, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (37.04) | 18.2507 |
| 2000's | 12 (44.44) | 29.6817 |
| 2010's | 5 (18.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zou, XQ | 1 |
| Peng, SM | 1 |
| Hu, CP | 1 |
| Tan, LF | 1 |
| Yuan, Q | 1 |
| Deng, HW | 1 |
| Li, YJ | 1 |
| Lee, IS | 1 |
| Kim, YJ | 1 |
| Jung, SH | 1 |
| Kim, JH | 1 |
| Kim, JS | 1 |
| Zheng, YF | 1 |
| Dai, DZ | 2 |
| Dai, Y | 2 |
| Cheng, YS | 1 |
| Cong, XD | 1 |
| Zhang, Y | 1 |
| Engelen, L | 1 |
| Stehouwer, CD | 1 |
| Schalkwijk, CG | 1 |
| Yu, PH | 2 |
| Wang, M | 1 |
| Deng, YL | 1 |
| Fan, H | 1 |
| Shira-Bock, L | 1 |
| Takeuchi, M | 1 |
| Yamagishi, S | 2 |
| Makita, Z | 1 |
| Usta, MF | 2 |
| Bivalacqua, TJ | 2 |
| Yang, DY | 1 |
| Ramanitharan, A | 1 |
| Sell, DR | 1 |
| Viswanathan, A | 1 |
| Monnier, VM | 1 |
| Hellstrom, WJ | 2 |
| Jerums, G | 1 |
| Panagiotopoulos, S | 1 |
| Forbes, J | 1 |
| Osicka, T | 1 |
| Cooper, M | 1 |
| Forbes, JM | 1 |
| Yee, LT | 1 |
| Thallas, V | 2 |
| Lassila, M | 1 |
| Candido, R | 1 |
| Jandeleit-Dahm, KA | 1 |
| Thomas, MC | 2 |
| Burns, WC | 1 |
| Deemer, EK | 1 |
| Thorpe, SR | 2 |
| Thorpe, SM | 1 |
| Cooper, ME | 4 |
| Allen, TJ | 1 |
| Imaizumi, T | 1 |
| Baynes, JW | 1 |
| Cameron, NE | 2 |
| Gibson, TM | 1 |
| Nangle, MR | 1 |
| Cotter, MA | 2 |
| Kendirci, M | 1 |
| Gur, S | 1 |
| Foxwell, NA | 1 |
| Cellek, S | 1 |
| Kazachkov, M | 1 |
| Chen, K | 1 |
| Babiy, S | 1 |
| Tilton, RG | 2 |
| Chang, K | 2 |
| Hasan, KS | 2 |
| Smith, SR | 1 |
| Petrash, JM | 1 |
| Misko, TP | 1 |
| Moore, WM | 1 |
| Currie, MG | 1 |
| Corbett, JA | 2 |
| McDaniel, ML | 2 |
| Hammes, HP | 1 |
| Brownlee, M | 3 |
| Edelstein, D | 1 |
| Saleck, M | 1 |
| Martin, S | 1 |
| Federlin, K | 1 |
| Gries, FA | 1 |
| Che, W | 1 |
| Asahi, M | 1 |
| Takahashi, M | 1 |
| Kaneto, H | 1 |
| Okado, A | 1 |
| Higashiyama, S | 1 |
| Taniguchi, N | 1 |
| Soulis, T | 1 |
| Youssef, S | 1 |
| Gilbert, RE | 2 |
| McWilliam, BG | 1 |
| Murray-McIntosh, RP | 1 |
| Kawano, M | 1 |
| Kawakami, M | 1 |
| Jandeleit-Dahm, K | 1 |
| Rumble, J | 1 |
| Cox, AJ | 1 |
| Kelly, DJ | 1 |
| Dziadek, M | 1 |
| Gugliucci, A | 1 |
| Ido, Y | 1 |
| Wang, JL | 1 |
| Sweetland, MA | 1 |
| Lancaster, JR | 1 |
| Williamson, JR | 1 |
10 reviews available for pimagedine and Diabetic Angiopathies
| Article | Year |
|---|---|
Current therapeutic interventions in the glycation pathway: evidence from clinical studies.
Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathie | 2013 |
[OPB-9195].
Topics: Animals; Diabetic Angiopathies; Disease Models, Animal; Drug Design; Glycation End Products, Advance | 2002 |
Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Type 2; Diabetic | 2003 |
[Progress on the drug therapy for diabetic microangiopathies: AGE inhibitors].
Topics: Animals; Clinical Trials as Topic; Depression, Chemical; Diabetic Angiopathies; Glycation End Produc | 2005 |
The role of AGEs and AGE inhibitors in diabetic cardiovascular disease.
Topics: Animals; Diabetic Angiopathies; Glycation End Products, Advanced; Guanidines; Humans; Ligands; Oxida | 2005 |
Inhibitors of advanced glycation end product formation and neurovascular dysfunction in experimental diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Neuropathies; Glycation En | 2005 |
Alternative therapeutic principles in the prevention of microvascular and neuropathic complications.
Topics: Aldehyde Reductase; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Neuropa | 1995 |
[Aminoguanidine].
Topics: Animals; Depression, Chemical; Diabetic Angiopathies; Enzyme Inhibitors; Glycation End Products, Adv | 1997 |
Glycation as the glucose link to diabetic complications.
Topics: Arteriosclerosis; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Glycated Hemoglo | 2000 |
Nonenzymatic glycosylation of macromolecules. Prospects of pharmacologic modulation.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glycosylation; G | 1992 |
17 other studies available for pimagedine and Diabetic Angiopathies
| Article | Year |
|---|---|
Synthesis, characterization and vasculoprotective effects of nitric oxide-donating derivatives of chrysin.
Topics: Diabetic Angiopathies; Flavonoids; Hep G2 Cells; Humans; Molecular Structure; Nitric Oxide; Protecti | 2010 |
Flavonoids from Litsea japonica Inhibit AGEs Formation and Rat Lense Aldose Reductase In Vitro and Vessel Dilation in Zebrafish.
Topics: Aldehyde Reductase; Animals; Diabetic Angiopathies; Disease Models, Animal; Flavonoids; Glycation En | 2017 |
NaHS ameliorates diabetic vascular injury by correcting depressed connexin 43 and 40 in the vasculature in streptozotocin-injected rats.
Topics: Animals; Aorta, Thoracic; Connexin 43; Connexins; Diabetes Mellitus, Experimental; Diabetic Angiopat | 2010 |
Argirein alleviates corpus cavernosum dysfunction by suppressing pro-inflammatory factors p66Shc and ER stress chaperone Bip in diabetic rats.
Topics: Animals; Anthraquinones; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Biomarkers; Diabetic Ang | 2013 |
Involvement of semicarbazide-sensitive amine oxidase-mediated deamination in atherogenesis in KKAy diabetic mice fed with high cholesterol diet.
Topics: Albuminuria; Allyl Compounds; Amine Oxidase (Copper-Containing); Amines; Animals; Arteriosclerosis; | 2002 |
The protective effect of aminoguanidine on erectile function in streptozotocin diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Enzyme Inhibitors; Guanidines; Immu | 2003 |
Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis.
Topics: Actins; Animals; Aorta; Arteriosclerosis; Collagen; Cytokines; Diabetes Mellitus, Experimental; Diab | 2004 |
The breakdown of preformed advanced glycation end products reverses erectile dysfunction in streptozotocin-induced diabetic rats: preventive versus curative treatment.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dose-Response Relationship, Drug; G | 2006 |
Evidence for in vivo scavenging by aminoguanidine of formaldehyde produced via semicarbazide-sensitive amine oxidase-mediated deamination.
Topics: Aldehydes; Amination; Amine Oxidase (Copper-Containing); Animals; Diabetic Angiopathies; Formaldehyd | 2007 |
Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation.
Topics: Aldehyde Reductase; Amino Acid Oxidoreductases; Animals; Arginine; Benzothiazoles; Blood Pressure; B | 1993 |
Aminoguanidine inhibits the development of accelerated diabetic retinopathy in the spontaneous hypertensive rat.
Topics: Aneurysm; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Angiopat | 1994 |
Rapid reversal by aminoguanidine of the neurovascular effects of diabetes in rats: modulation by nitric oxide synthase inhibition.
Topics: Animals; Arginine; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Angiopat | 1996 |
Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogenesis in
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Arteriosclerosis; Cell Nucleus; Cells, Cultured; Cyclohexi | 1997 |
Advanced glycation end products and their receptors co-localise in rat organs susceptible to diabetic microvascular injury.
Topics: Animals; Aorta; Blood Glucose; Body Weight; Cattle; Diabetes Mellitus, Experimental; Diabetic Angiop | 1997 |
SPARC gene expression is increased in diabetes-related mesenteric vascular hypertrophy.
Topics: Animals; Antibody Specificity; Blotting, Northern; Diabetes Mellitus, Experimental; Diabetic Angiopa | 2000 |
Glycosylation of proteins and microangiopathy.
Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diglycerides; Dogs; Gl | 1992 |
Aminoguanidine, a novel inhibitor of nitric oxide formation, prevents diabetic vascular dysfunction.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Blood Vessels; Cells, Cultured; Diabe | 1992 |