pimagedine has been researched along with Diabetes Mellitus, Type 2 in 30 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Type 2 diabetes mellitus is a complex metabolic disorder requiring polypharmacology approaches for effective treatment." | 1.51 | Towards multi-target antidiabetic agents: Discovery of biphenyl-benzimidazole conjugates as AMPK activators. ( Babkov, DA; Babkova, VA; Borisov, AV; Borodkin, GS; Brigadirova, AA; Kolodina, AA; Litvinov, RA; Morkovnik, AS; Sochnev, VS; Sokolova, EV; Spasov, AA; Zhukowskaya, ON, 2019) |
| "After induction of type 2 diabetes, rats received daily injections of AG (50 mg kg(-1), i." | 1.35 | Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes. ( Chang, KC; Liang, JT; Lin, YD; Tseng, YZ; Wu, ET; Wu, MS, 2008) |
| "Humans with type 2 diabetes and nephropathy displayed similar alterations in MMP-7 to their rodent counterparts." | 1.34 | Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy? ( Dy, V; Gilbert, RE; Kelly, DJ; Langham, RG; McLennan, SV; Schache, M; Waltham, M; Yue, DK, 2007) |
| " In this study, we show that the development of diabetes, measured by increased water intake and concomitant midday blood glucose levels in type II genetically diabetic mice, is reduced by treatment with aminoguanidine at a dosage of 500 mg/kg/d for 12 weeks in the diet." | 1.30 | Potential benefit of inhibitors of advanced glycation end products in the progression of type II diabetes: a study with aminoguanidine in C57/BLKsJ diabetic mice. ( Piercy, V; Toseland, CD; Turner, NC, 1998) |
| "Chronic exposure of pancreatic islets to supraphysiologic concentrations of glucose causes adverse alterations in beta cell function, a phenomenon termed glucose toxicity and one that may play a secondary pathogenic role in type 2 diabetes." | 1.30 | Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. ( Gleason, CE; Harmon, JS; Robertson, RP; Tanaka, Y; Tran, PO, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (40.00) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 9 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Babkov, DA | 1 |
| Zhukowskaya, ON | 1 |
| Borisov, AV | 1 |
| Babkova, VA | 1 |
| Sokolova, EV | 1 |
| Brigadirova, AA | 1 |
| Litvinov, RA | 1 |
| Kolodina, AA | 1 |
| Morkovnik, AS | 1 |
| Sochnev, VS | 1 |
| Borodkin, GS | 1 |
| Spasov, AA | 1 |
| Zheng, N | 1 |
| Lin, X | 1 |
| Wen, Q | 1 |
| Zhang, S | 1 |
| Huang, J | 1 |
| Xu, X | 1 |
| Huang, R | 1 |
| Bano, B | 1 |
| Abbasi, S | 1 |
| Khan, JA | 1 |
| Hussain, S | 1 |
| Rasheed, S | 1 |
| Perveen, S | 1 |
| Khan, KM | 1 |
| Choudhary, MI | 1 |
| Xie, B | 1 |
| Lin, F | 1 |
| Peng, L | 1 |
| Ullah, K | 1 |
| Wu, H | 1 |
| Qing, H | 1 |
| Deng, Y | 1 |
| Jung, E | 1 |
| Kim, J | 1 |
| Kim, SH | 1 |
| Kim, S | 1 |
| Cho, MH | 1 |
| Wei, Y | 1 |
| Han, C | 1 |
| Wang, Y | 1 |
| Wu, B | 1 |
| Su, T | 1 |
| Liu, Y | 1 |
| He, R | 1 |
| Bhat, S | 1 |
| Jagadeeshaprasad, MG | 1 |
| Patil, YR | 1 |
| Shaikh, ML | 1 |
| Regin, BS | 1 |
| Mohan, V | 1 |
| Giri, AP | 1 |
| Balasubramanyam, M | 1 |
| Boppana, R | 1 |
| Kulkarni, MJ | 1 |
| Nemoto, S | 1 |
| Taguchi, K | 1 |
| Matsumoto, T | 1 |
| Kamata, K | 1 |
| Kobayashi, T | 1 |
| Engelen, L | 1 |
| Stehouwer, CD | 1 |
| Schalkwijk, CG | 1 |
| Yu, PH | 1 |
| Wang, M | 1 |
| Deng, YL | 1 |
| Fan, H | 1 |
| Shira-Bock, L | 1 |
| Lertsiri, S | 1 |
| Oak, JH | 1 |
| Nakagawa, K | 1 |
| Miyazawa, T | 1 |
| Jerums, G | 1 |
| Panagiotopoulos, S | 1 |
| Forbes, J | 1 |
| Osicka, T | 1 |
| Cooper, M | 1 |
| Reddy, VP | 1 |
| Beyaz, A | 1 |
| Chang, KC | 2 |
| Tseng, CD | 1 |
| Wu, MS | 2 |
| Liang, JT | 2 |
| Tsai, MS | 1 |
| Cho, YL | 1 |
| Tseng, YZ | 2 |
| McLennan, SV | 1 |
| Kelly, DJ | 1 |
| Schache, M | 1 |
| Waltham, M | 1 |
| Dy, V | 1 |
| Langham, RG | 1 |
| Yue, DK | 1 |
| Gilbert, RE | 1 |
| Lin, YD | 1 |
| Wu, ET | 1 |
| Castellino, P | 1 |
| Tuttle, KR | 1 |
| DeFronzo, RA | 1 |
| Wolffenbuttel, BH | 1 |
| van Haeften, TW | 1 |
| Gries, FA | 1 |
| Matsuoka, T | 1 |
| Kajimoto, Y | 1 |
| Watada, H | 1 |
| Kaneto, H | 1 |
| Kishimoto, M | 1 |
| Umayahara, Y | 1 |
| Fujitani, Y | 1 |
| Kamada, T | 1 |
| Kawamori, R | 1 |
| Yamasaki, Y | 1 |
| Yamauchi, A | 1 |
| Takei, I | 1 |
| Makita, Z | 2 |
| Nakamoto, S | 1 |
| Ohashi, N | 1 |
| Kiguchi, H | 1 |
| Ishii, T | 1 |
| Koike, T | 1 |
| Saruta, T | 1 |
| Shimabukuro, M | 2 |
| Ohneda, M | 1 |
| Lee, Y | 1 |
| Unger, RH | 2 |
| Zhou, YT | 1 |
| Levi, M | 1 |
| Agardh, CD | 1 |
| Agardh, E | 1 |
| Hultberg, B | 1 |
| Qian, Y | 1 |
| Ostenson, CG | 1 |
| Piercy, V | 1 |
| Toseland, CD | 1 |
| Turner, NC | 1 |
| Tanaka, Y | 1 |
| Gleason, CE | 1 |
| Tran, PO | 1 |
| Harmon, JS | 1 |
| Robertson, RP | 1 |
| Freedman, BI | 1 |
| Wuerth, JP | 1 |
| Cartwright, K | 2 |
| Bain, RP | 1 |
| Dippe, S | 1 |
| Hershon, K | 1 |
| Mooradian, AD | 1 |
| Spinowitz, BS | 1 |
| Kagota, S | 1 |
| Yamaguchi, Y | 1 |
| Nakamura, K | 1 |
| Kunitomo, M | 1 |
| Carmo, A | 1 |
| Cunha-Vaz, JG | 1 |
| Carvalho, AP | 1 |
| Lopes, MC | 1 |
| Vlassara, H | 1 |
| Rayfield, E | 1 |
| Friedman, E | 1 |
| Rodby, R | 1 |
| Cerami, A | 1 |
| Bucala, R | 1 |
5 reviews available for pimagedine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Current therapeutic interventions in the glycation pathway: evidence from clinical studies.
Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathie | 2013 |
Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Type 2; Diabetic | 2003 |
Inhibitors of the Maillard reaction and AGE breakers as therapeutics for multiple diseases.
Topics: Aging; Animals; Diabetes Mellitus, Type 2; Glycation End Products, Advanced; Guanidines; Humans; Hyp | 2006 |
Prevention of complications in non-insulin-dependent diabetes mellitus (NIDDM).
Topics: Acarbose; Aldehyde Reductase; Biguanides; Diabetes Mellitus, Type 2; Glucose; Guanidines; Humans; Hy | 1995 |
Alternative therapeutic principles in the prevention of microvascular and neuropathic complications.
Topics: Aldehyde Reductase; Antioxidants; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Neuropa | 1995 |
1 trial available for pimagedine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Design and baseline characteristics for the aminoguanidine Clinical Trial in Overt Type 2 Diabetic Nephropathy (ACTION II).
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Drug Administra | 1999 |
24 other studies available for pimagedine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Towards multi-target antidiabetic agents: Discovery of biphenyl-benzimidazole conjugates as AMPK activators.
Topics: AMP-Activated Protein Kinases; Animals; Benzimidazoles; Biphenyl Compounds; Cattle; Diabetes Mellitu | 2019 |
Effect of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L. (Oxalidaceae) roots, on advanced glycation end-product-mediated renal injury in type 2 diabetic KKAy mice.
Topics: Administration, Oral; Animals; Antioxidants; Blotting, Western; Cyclohexenes; Diabetes Mellitus, Exp | 2013 |
Antiglycation activity of quinoline derivatives- a new therapeutic class for the management of type 2 diabetes complications.
Topics: Animals; Antioxidants; Biphenyl Compounds; Cattle; Diabetes Mellitus, Type 2; Glycation End Products | 2014 |
Methylglyoxal increases dopamine level and leads to oxidative stress in SH-SY5Y cells.
Topics: Cell Line; Diabetes Mellitus, Type 2; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamin | 2014 |
Gemigliptin, a novel dipeptidyl peptidase-4 inhibitor, exhibits potent anti-glycation properties in vitro and in vivo.
Topics: Animals; Collagen; Diabetes Complications; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipept | 2014 |
Ribosylation triggering Alzheimer's disease-like Tau hyperphosphorylation via activation of CaMKII.
Topics: Alzheimer Disease; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Survival; Diabe | 2015 |
Proteomic Insight Reveals Elevated Levels of Albumin in Circulating Immune Complexes in Diabetic Plasma.
Topics: Animals; Blood Proteins; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gene | 2016 |
Aminoguanidine normalizes ET-1-induced aortic contraction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats by suppressing Jab1-mediated increase in ET(A)-receptor expression.
Topics: Acetylglucosamine; Animals; Aorta, Thoracic; Blood Glucose; Blood Pressure; COP9 Signalosome Complex | 2012 |
Involvement of semicarbazide-sensitive amine oxidase-mediated deamination in atherogenesis in KKAy diabetic mice fed with high cholesterol diet.
Topics: Albuminuria; Allyl Compounds; Amine Oxidase (Copper-Containing); Amines; Animals; Arteriosclerosis; | 2002 |
The occurrence of a novel hydrophilic hydroperoxide, 3-hydroxy-5-hydroperoxy-2-methyl-5,6-dihydropyran-4-one, as a reactive glycation product in human plasma.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Electrophoresis, Polyacrylamide Gel; Formaldehyde; Glycate | 2002 |
Aminoguanidine prevents arterial stiffening in a new rat model of type 2 diabetes.
Topics: Animals; Aorta; Blood Glucose; Body Weight; Cardiac Output; Diabetes Mellitus, Experimental; Diabete | 2006 |
Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy?
Topics: Adult; Animals; Antibodies; Cells, Cultured; Culture Media, Conditioned; Diabetes Mellitus, Experime | 2007 |
Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme | 2008 |
Diabetic nephropathy.
Topics: Adrenergic beta-Antagonists; Aldehyde Reductase; Angiotensin-Converting Enzyme Inhibitors; Animals; | 1994 |
Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells.
Topics: Acetylcysteine; B-Lymphocytes; Blotting, Northern; Cells, Cultured; Cloning, Molecular; Diabetes Mel | 1997 |
Effects of aminoguanidine on serum advanced glycation endproducts, urinary albilmin excretion, mesangial expansion, and glomerular basement membrane thickening in Otsuka Long-Evans Tokushima fatty rats.
Topics: Albuminuria; Animals; Basement Membrane; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Dise | 1997 |
Role of nitric oxide in obesity-induced beta cell disease.
Topics: Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fatty Acids, | 1997 |
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.
Topics: Animals; Apoptosis; Cells, Cultured; Ceramides; Chromans; Coenzyme A Ligases; Diabetes Mellitus; Dia | 1998 |
The glutathione levels are reduced in Goto-Kakizaki rat retina, but are not influenced by aminoguanidine treatment.
Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Diabetic Reti | 1998 |
Potential benefit of inhibitors of advanced glycation end products in the progression of type II diabetes: a study with aminoguanidine in C57/BLKsJ diabetic mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Drinking; Fe | 1998 |
Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants.
Topics: Acetylcysteine; Age Factors; Animals; Cell Line; Diabetes Mellitus, Type 2; Dose-Response Relationsh | 1999 |
Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus.
Topics: Acetylcholine; Animals; Aorta; Biological Factors; Blood Glucose; Body Weight; Cardiovascular Agents | 2000 |
Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: correlation with blood-retinal barrier permeability.
Topics: Animals; Arginine; Blood Glucose; Blood-Retinal Barrier; Blotting, Western; Densitometry; Diabetes M | 2000 |
Hemoglobin-AGE: a circulating marker of advanced glycosylation.
Topics: Adult; Aging; Biomarkers; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Enzyme-Linked Immuno | 1992 |