pimagedine has been researched along with Diabetes Mellitus, Type 1 in 19 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Morphine is one of the strongest analgesics and is commonly used for the treatment of chronic pain." | 3.77 | Decreased expression of intestinal P-glycoprotein increases the analgesic effects of oral morphine in a streptozotocin-induced diabetic mouse model. ( Fujita-Hamabe, W; Kishioka, S; Nawa, A; Tokuyama, S, 2011) |
| " A 24-hr pharmacokinetic analysis showed that AG was readily absorbed after i." | 1.29 | Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice. ( Atkinson, MA; Bowman, MA; Cornelius, J; Look, Z; Luchetta, R; Maclaren, NK; Peck, AB; Simell, OG, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (57.89) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Arif, B | 1 |
| Arif, Z | 1 |
| Ahmad, J | 1 |
| Perveen, K | 1 |
| Bukhari, NA | 1 |
| Ashraf, JM | 1 |
| Alam, K | 1 |
| Ingaramo, PI | 1 |
| Ronco, MT | 1 |
| Francés, DE | 1 |
| Monti, JA | 1 |
| Pisani, GB | 1 |
| Ceballos, MP | 1 |
| Galleano, M | 1 |
| Carrillo, MC | 1 |
| Carnovale, CE | 1 |
| Nawa, A | 1 |
| Fujita-Hamabe, W | 1 |
| Kishioka, S | 1 |
| Tokuyama, S | 1 |
| Engelen, L | 1 |
| Stehouwer, CD | 1 |
| Schalkwijk, CG | 1 |
| Beder, I | 1 |
| Kittova, M | 1 |
| Mataseje, A | 1 |
| Carsky, J | 2 |
| Orszaghova, Z | 1 |
| Babinska, K | 1 |
| Stoppa, GR | 1 |
| Cesquini, M | 1 |
| Roman, EA | 1 |
| Ogo, SH | 1 |
| Torsoni, MA | 1 |
| Brooks, BA | 1 |
| Heffernan, S | 1 |
| Thomson, S | 1 |
| McLennan, SV | 1 |
| Twigg, SM | 1 |
| Yue, DK | 2 |
| Wu, G | 1 |
| Corbett, JA | 1 |
| Mikhael, A | 1 |
| Shimizu, J | 1 |
| Frederick, K | 1 |
| Misko, TP | 1 |
| McDaniel, ML | 1 |
| Kanagawa, O | 1 |
| Unanue, ER | 1 |
| Pieper, GM | 1 |
| Moore-Hilton, G | 1 |
| Roza, AM | 1 |
| Bowman, MA | 1 |
| Simell, OG | 1 |
| Peck, AB | 1 |
| Cornelius, J | 1 |
| Luchetta, R | 1 |
| Look, Z | 1 |
| Maclaren, NK | 1 |
| Atkinson, MA | 1 |
| Hirasawa, K | 1 |
| Jun, HS | 1 |
| Maeda, K | 1 |
| Kawaguchi, Y | 1 |
| Itagaki, S | 1 |
| Mikami, T | 1 |
| Baek, HS | 1 |
| Doi, K | 1 |
| Yoon, JW | 1 |
| Holstad, M | 1 |
| Jansson, L | 2 |
| Sandler, S | 2 |
| Takamura, T | 1 |
| Kato, I | 1 |
| Kimura, N | 1 |
| Nakazawa, T | 1 |
| Yonekura, H | 1 |
| Takasawa, S | 1 |
| Okamoto, H | 1 |
| Carlsson, PO | 1 |
| Hao, W | 1 |
| Myhre, AP | 1 |
| Palmer, JP | 1 |
| Jakus, V | 1 |
| Hrnciarová, M | 1 |
| Krahulec, B | 1 |
| Rietbrock, N | 1 |
| Birrell, AM | 1 |
| Heffernan, SJ | 1 |
| Ansselin, AD | 1 |
| McLennan, S | 1 |
| Church, DK | 1 |
| Gillin, AG | 1 |
| Makita, Z | 1 |
| Vlassara, H | 1 |
| Rayfield, E | 1 |
| Cartwright, K | 1 |
| Friedman, E | 1 |
| Rodby, R | 1 |
| Cerami, A | 1 |
| Bucala, R | 1 |
2 reviews available for pimagedine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Current therapeutic interventions in the glycation pathway: evidence from clinical studies.
Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathie | 2013 |
Inhibition of nitric oxide formation by aminoguanidine: an attempt to prevent insulin-dependent diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Guanidines; Humans; Islets of Langerhans; Nit | 1997 |
2 trials available for pimagedine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
The effect of selected membrane active substances on erythrocyte deformability.
Topics: Adult; Antioxidants; Diabetes Mellitus, Type 1; Erythrocyte Deformability; Erythrocyte Membrane; Gua | 2003 |
Inhibition of nonenzymatic protein glycation and lipid peroxidation by drugs with antioxidant activity.
Topics: Aged; Antioxidants; Captopril; Depression, Chemical; Diabetes Mellitus, Type 1; Erythrocytes; Glycos | 1999 |
15 other studies available for pimagedine and Diabetes Mellitus, Type 1
| Article | Year |
|---|---|
Attenuation of hyperglycemia and amadori products by aminoguanidine in alloxan-diabetic rabbits occurs via enhancement in antioxidant defenses and control of stress.
Topics: Alloxan; Animals; Antioxidants; Case-Control Studies; Catalase; Diabetes Mellitus, Experimental; Dia | 2022 |
Tumor necrosis factor alpha pathways develops liver apoptosis in type 1 diabetes mellitus.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspase Inhibitors; Diabetes Mellitus, | 2011 |
Decreased expression of intestinal P-glycoprotein increases the analgesic effects of oral morphine in a streptozotocin-induced diabetic mouse model.
Topics: Administration, Oral; Analgesics; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; | 2011 |
Aminoguanidine prevented impairment of blood antioxidant system in insulin-dependent diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Enzyme Inhibitors | 2006 |
The effects of diabetes and aminoguanidine treatment on endothelial function in a primate model of type 1 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Endothe | 2008 |
Nitric oxide synthesis and the effect of aminoguanidine and NG-monomethyl-L-arginine on the onset of diabetes in the spontaneously diabetic BB rat.
Topics: Aging; Amino Acid Oxidoreductases; Animals; Arginine; Diabetes Mellitus, Type 1; Guanidines; Male; N | 1995 |
Nitric oxide production in islets from nonobese diabetic mice: aminoguanidine-sensitive and -resistant stages in the immunological diabetic process.
Topics: Amino Acid Oxidoreductases; Animals; Diabetes Mellitus, Type 1; Female; Guanidines; Immunotherapy, A | 1993 |
Evaluation of the mechanism of endothelial dysfunction in the genetically-diabetic BB rat.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Diabetes Mellitus, Type 1; Endothelium, Vascular; | 1996 |
Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice.
Topics: Animals; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Female; Guanidines; Islets of Langerhans; Mic | 1996 |
Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice.
Topics: Animals; Cardiovirus Infections; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Encepha | 1997 |
Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; DNA Damage; Guanidines; Insulin | 1998 |
Pancreatic islet blood perfusion in the nonobese diabetic mouse: diabetes-prone female mice exhibit a higher blood flow compared with male mice in the prediabetic phase.
Topics: Aging; Animals; Blood Flow Velocity; Blood Glucose; Blood Pressure; Colon; Diabetes Mellitus, Type 1 | 1998 |
Nitric oxide mediates IL-1beta stimulation of heat shock protein but not IL-1beta inhibition of glutamic acid decarboxylase.
Topics: Animals; Diabetes Mellitus, Type 1; Glutamate Decarboxylase; Guanidines; HSP70 Heat-Shock Proteins; | 1999 |
Functional and structural abnormalities in the nerves of type I diabetic baboons: aminoguanidine treatment does not improve nerve function.
Topics: Aging; Animals; Axons; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Di | 2000 |
Hemoglobin-AGE: a circulating marker of advanced glycosylation.
Topics: Adult; Aging; Biomarkers; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Enzyme-Linked Immuno | 1992 |