pimagedine has been researched along with Cholestasis in 4 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " On day 21 after BDL, chronic L-NAME produced only a nonsignificant decrease in the beneficial effect of naltrexone, whereas on day 28, chronic administration of both L-NAME and aminoguanidine significantly reversed this effect of naltrexone." | 6.78 | Nitric oxide mediates the beneficial effect of chronic naltrexone on cholestasis-induced memory impairment in male rats. ( Dehpour, AR; Ebadian, S; Ghiassy, B; Javadi-Paydar, M; Norouzi, A; Rahimi, N, 2013) |
| " On day 21 after BDL, chronic L-NAME produced only a nonsignificant decrease in the beneficial effect of naltrexone, whereas on day 28, chronic administration of both L-NAME and aminoguanidine significantly reversed this effect of naltrexone." | 2.78 | Nitric oxide mediates the beneficial effect of chronic naltrexone on cholestasis-induced memory impairment in male rats. ( Dehpour, AR; Ebadian, S; Ghiassy, B; Javadi-Paydar, M; Norouzi, A; Rahimi, N, 2013) |
| "Cholestasis is associated with vascular changes and in previous studies decreased response of visceral vessels of cholestatic animals to phenylephrine and acetylcholine has been shown." | 1.33 | alpha2-Adrenoceptor subsensitivity in mesenteric vascular bed of cholestatic rats: the role of nitric oxide and endogenous opioids. ( Borhani, AA; Dehpour, AR; Ebrahimi, F; Hajrasouliha, AR; Houshmand, G; Namiranian, K; Samini, M; Tavakoli, S, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Javadi-Paydar, M | 1 |
| Ghiassy, B | 1 |
| Ebadian, S | 1 |
| Rahimi, N | 1 |
| Norouzi, A | 1 |
| Dehpour, AR | 3 |
| Gaskari, SA | 1 |
| Mani, AR | 1 |
| Ejtemaei-Mehr, S | 1 |
| Namiranian, K | 2 |
| Homayoun, H | 1 |
| Ahmadi, H | 1 |
| Borhani, AA | 1 |
| Houshmand, G | 1 |
| Samini, M | 1 |
| Hajrasouliha, AR | 1 |
| Tavakoli, S | 1 |
| Ebrahimi, F | 1 |
| Shiomi, M | 1 |
| Wakabayashi, Y | 1 |
| Sano, T | 1 |
| Shinoda, Y | 1 |
| Nimura, Y | 1 |
| Ishimura, Y | 1 |
| Suematsu, M | 1 |
1 trial available for pimagedine and Cholestasis
| Article | Year |
|---|---|
Nitric oxide mediates the beneficial effect of chronic naltrexone on cholestasis-induced memory impairment in male rats.
Topics: Animals; Cholestasis; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Guani | 2013 |
3 other studies available for pimagedine and Cholestasis
| Article | Year |
|---|---|
Do endogenous opioids contribute to the bradycardia of rats with obstructive cholestasis?
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Arginine; Bradycardia; Cholestasis; Dose-Respon | 2002 |
alpha2-Adrenoceptor subsensitivity in mesenteric vascular bed of cholestatic rats: the role of nitric oxide and endogenous opioids.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2005 |
Nitric oxide suppression reversibly attenuates mitochondrial dysfunction and cholestasis in endotoxemic rat liver.
Topics: Animals; Bile; Cholestasis; Dimaprit; Endotoxemia; Endotoxins; Fluorescent Dyes; Fluorometry; Guanid | 1998 |