pimagedine has been researched along with Cerebral Infarction in 9 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| "During a cerebral infarction, a complex cascade of cytotoxic events ultimately determines the volume of brain cell loss." | 1.29 | Cerebroprotective effects of aminoguanidine in a rodent model of stroke. ( Bloom, O; Cerami, A; Cockroft, KM; Meistrell, M; Risucci, D; Tracey, KJ; Zimmerman, GA, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, M | 1 |
| Zhao, Y | 1 |
| Gu, Y | 1 |
| Xu, C | 1 |
| Zhu, DY | 1 |
| Deng, Q | 1 |
| Yao, HH | 1 |
| Wang, DC | 1 |
| Deng, Y | 1 |
| Liu, GQ | 1 |
| Park, EM | 1 |
| Cho, S | 1 |
| Frys, KA | 1 |
| Glickstein, SB | 1 |
| Zhou, P | 1 |
| Anrather, J | 1 |
| Ross, ME | 3 |
| Iadecola, C | 5 |
| Zhang, F | 4 |
| Xu, X | 1 |
| Zimmerman, GA | 2 |
| Meistrell, M | 2 |
| Bloom, O | 2 |
| Cockroft, KM | 2 |
| Bianchi, M | 1 |
| Risucci, D | 2 |
| Broome, J | 1 |
| Farmer, P | 1 |
| Cerami, A | 2 |
| Vlassara, H | 1 |
| Casey, RM | 1 |
| Casey, R | 1 |
| Clark, HB | 1 |
| Tracey, KJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study of the Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage[NCT01095731] | Phase 2 | 60 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for pimagedine and Cerebral Infarction
| Article | Year |
|---|---|
Neuroprotective actions of aminoguanidine involve reduced the activation of calpain and caspase-3 in a rat model of stroke.
Topics: Animals; Apoptosis; Biotransformation; Blotting, Western; Brain; Brain Edema; Calcium-Binding Protei | 2010 |
Inducible nitric oxide synthase expression in the ischemic core and penumbra after transient focal cerebral ischemia in mice.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Enzyme Inhibitors; Guanidines; | 2002 |
Inducible nitric oxide synthase contributes to gender differences in ischemic brain injury.
Topics: Animals; Cerebral Infarction; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression Reg | 2006 |
Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Arginine; Blood Glucose; Blood Pressure; | 1995 |
Neurotoxicity of advanced glycation endproducts during focal stroke and neuroprotective effects of aminoguanidine.
Topics: Animals; Cerebral Infarction; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Glycati | 1995 |
Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion.
Topics: Animals; Arginine; Arterial Occlusive Diseases; Base Sequence; Body Water; Brain; Brain Damage, Chro | 1996 |
Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia.
Topics: Animals; Base Sequence; Cerebral Infarction; Cerebrovascular Circulation; Endothelium, Vascular; Enz | 1996 |
Cerebroprotective effects of aminoguanidine in a rodent model of stroke.
Topics: Animals; Cerebral Infarction; Cerebrovascular Circulation; Cerebrovascular Disorders; Disease Models | 1996 |
Temporal characteristics of the protective effect of aminoguanidine on cerebral ischemic damage.
Topics: Animals; Blood Glucose; Blood Pressure; Body Temperature; Brain Ischemia; Cerebral Infarction; Gases | 1998 |