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pimagedine and Cataract

pimagedine has been researched along with Cataract in 19 studies

pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.

Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to investigate whether curcumin and aminoguanidine (AG) prevent selenium-induced cataractogenesis in vitro."7.75Anti-cataractogenic effect of curcumin and aminoguanidine against selenium-induced oxidative stress in the eye lens of Wistar rat pups: An in vitro study using isolated lens. ( Arumugam, M; Beulaja, S; Chindhu, S; Manikandan, R; Mariammal, K; Sudhandiran, G; Thiagarajan, R, 2009)
"To investigate the effect of carnosine (CA), aminoguanidine (AG), and aspirin (ASA) drops, all inhibitors of glycation, on the development of diabetic cataract in rat."7.74Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats. ( Ding, Z; Guo, Y; Ha, W; Harding, JJ; Yan, H; Zhang, J, 2008)
"We examined the ability of a pyridoxal-aminoguanidine adduct with both antiglycation and antioxidant activities in vitro to protect against neuropathy and cataract in streptozotocin-diabetic rats and compared the result with that of aminoguanidine."7.72Pyridoxal-aminoguanidine adduct is more effective than aminoguanidine in preventing neuropathy and cataract in diabetic rats. ( Chen, AS; Kamei, A; Miwa, I; Sugiura, M; Taguchi, T; Wakasugi, Y; Wang, MW, 2004)
"It is well known that m-calpain, a ubiquitous calpain, is involved in cataract formation in rodent lens."7.71Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR). ( Hayashi, M; Inomata, M; Ito, Y; Kawashima, S; Matsubara, Y; Shumiya, S; Takehana, M, 2002)
"The aim of this study was to investigate whether curcumin and aminoguanidine (AG) prevent selenium-induced cataractogenesis in vitro."3.75Anti-cataractogenic effect of curcumin and aminoguanidine against selenium-induced oxidative stress in the eye lens of Wistar rat pups: An in vitro study using isolated lens. ( Arumugam, M; Beulaja, S; Chindhu, S; Manikandan, R; Mariammal, K; Sudhandiran, G; Thiagarajan, R, 2009)
"To investigate the effect of carnosine (CA), aminoguanidine (AG), and aspirin (ASA) drops, all inhibitors of glycation, on the development of diabetic cataract in rat."3.74Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats. ( Ding, Z; Guo, Y; Ha, W; Harding, JJ; Yan, H; Zhang, J, 2008)
"We examined the ability of a pyridoxal-aminoguanidine adduct with both antiglycation and antioxidant activities in vitro to protect against neuropathy and cataract in streptozotocin-diabetic rats and compared the result with that of aminoguanidine."3.72Pyridoxal-aminoguanidine adduct is more effective than aminoguanidine in preventing neuropathy and cataract in diabetic rats. ( Chen, AS; Kamei, A; Miwa, I; Sugiura, M; Taguchi, T; Wakasugi, Y; Wang, MW, 2004)
"It is well known that m-calpain, a ubiquitous calpain, is involved in cataract formation in rodent lens."3.71Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR). ( Hayashi, M; Inomata, M; Ito, Y; Kawashima, S; Matsubara, Y; Shumiya, S; Takehana, M, 2002)
"Subcutaneous injection of sodium selenite was used to induce cataracts in rats, with or without pretreatment with NOS inhibitors."3.71Nitric oxide participates in cataract development in selenite-treated rats. ( Hori, R; Ito, Y; Nabekura, T; Nakao, M; Takeda, M; Terao, M; Tomohiro, M, 2001)
"Cataract formation occurred after 13 weeks in diabetic animals compared with 17 weeks for those treated with aminoguanidine, and 16 weeks for those treated with probucol (p < 0."3.70Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats. ( Agardh, C; Agardh, E; Hultberg, B, 2000)
"To study the effects of an aldose reductase inhibitor (ARI-509, Wyeth-Ayerst, Princeton, NJ) and aminoguanidine (AMG), agents that have been reported to prevent or delay diabetic retinopathy, on retinal vascular abnormalities and the immunocytochemical expression in the retina of vascular endothelial growth factor (VEGF) in rats maintained for up to 2 years on a 50% galactose diet."3.69An aldose reductase inhibitor and aminoguanidine prevent vascular endothelial growth factor expression in rats with long-term galactosemia. ( Amin, R; Frank, RN; Hohman, TC; Kennedy, A, 1997)
"Cataract was observed in all six of the surviving rats in Groups 2 and 4, and in one of 6 surviving rats in group 3."1.31Effects of aminoguanidine and tolrestat on the development of ocular and renal structural changes in experimental diabetic rats. ( Azal, O; Baydar, A; Cakir, B; Corakçi, A; Güler, S; Kutlu, M; Yönem, A, 2002)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (21.05)18.2507
2000's15 (78.95)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yan, H1
Guo, Y1
Zhang, J1
Ding, Z1
Ha, W1
Harding, JJ1
Manikandan, R1
Thiagarajan, R1
Beulaja, S1
Chindhu, S1
Mariammal, K1
Sudhandiran, G1
Arumugam, M1
Kawakami, M1
Kuroki, M1
Nabekura, T3
Koizumi, Y1
Nakao, M2
Tomohiro, M3
Inomata, M4
Ito, Y8
Hayashi, M3
Matsubara, Y1
Takehana, M1
Kawashima, S3
Shumiya, S3
Kitagawa, S1
Chen, AS1
Taguchi, T1
Sugiura, M1
Wakasugi, Y1
Kamei, A1
Wang, MW1
Miwa, I1
Nagai, N2
Fukuhata, T1
Joon, TL1
Foo, K1
Panagiotopoulos, S1
Jerums, G1
Taylor, HR1
Stevens, A1
Swamy-Mruthinti, S1
Green, K1
Abraham, EC1
Frank, RN1
Amin, R1
Kennedy, A1
Hohman, TC1
Agardh, E1
Hultberg, B1
Agardh, C1
Stitt, AW1
Takeda, M1
Terao, M1
Hori, R1
Azal, O1
Yönem, A1
Güler, S1
Cakir, B1
Baydar, A1
Corakçi, A1
Kutlu, M1

Reviews

2 reviews available for pimagedine and Cataract

ArticleYear
[Aminoguanidine and other AGE inhibitors].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 9

    Topics: Amides; Animals; Arteriosclerosis; Cardiovascular Diseases; Cataract; Clinical Trials as Topic; Diab

2002
Advanced glycation: an important pathological event in diabetic and age related ocular disease.
    The British journal of ophthalmology, 2001, Volume: 85, Issue:6

    Topics: Aging; Animals; Cataract; Diabetic Retinopathy; Enzyme Inhibitors; Glaucoma; Glycation End Products,

2001

Other Studies

17 other studies available for pimagedine and Cataract

ArticleYear
Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats.
    Molecular vision, 2008, Volume: 14

    Topics: Animals; Aspirin; Blood Glucose; Body Weight; Carnosine; Cataract; Cornea; Diabetes Mellitus, Experi

2008
Anti-cataractogenic effect of curcumin and aminoguanidine against selenium-induced oxidative stress in the eye lens of Wistar rat pups: An in vitro study using isolated lens.
    Chemico-biological interactions, 2009, Oct-07, Volume: 181, Issue:2

    Topics: Animals; Base Sequence; Catalase; Cataract; Curcumin; DNA Primers; Glutathione; Glutathione Peroxida

2009
Delay of cataract development in hereditary cataract UPL rats by disulfiram and aminoguanidine.
    Experimental eye research, 2003, Volume: 76, Issue:2

    Topics: Aging; Animals; Antioxidants; Calcium; Cataract; Crystallins; Disulfiram; Enzyme Inhibitors; Eye Dis

2003
Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR).
    Current eye research, 2002, Volume: 25, Issue:4

    Topics: Aging; alpha-Crystallin A Chain; Animals; Antibodies; Blotting, Western; Calpain; Case-Control Studi

2002
Changes in plasma membrane Ca2+ -ATPase expression and ATP content in lenses of hereditary cataract UPL rats.
    Toxicology, 2004, Apr-15, Volume: 197, Issue:2

    Topics: Adenosine Triphosphate; Animals; Calcium-Transporting ATPases; Cataract; Cell Membrane; Disease Mode

2004
Pyridoxal-aminoguanidine adduct is more effective than aminoguanidine in preventing neuropathy and cataract in diabetic rats.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2004, Volume: 36, Issue:3

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cataract; Deoxyguanosine; Diabetes Mellitus, Experimental; Dia

2004
Effect of magnesium deficiency on intracellular ATP levels in human lens epithelial cells.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:1

    Topics: Adenosine Triphosphate; Calcium-Transporting ATPases; Cataract; Cell Line; Chelating Agents; Disease

2007
Adverse effects of excessive nitric oxide on cytochrome c oxidase in lenses of hereditary cataract UPL rats.
    Toxicology, 2007, Dec-05, Volume: 242, Issue:1-3

    Topics: Adenosine Triphosphate; Administration, Oral; Animals; Cataract; Disease Models, Animal; Disulfiram;

2007
In vivo assessment of an animal model of diabetic cataract: medical intervention studies.
    Developments in ophthalmology, 1994, Volume: 26

    Topics: Aldehyde Reductase; Animals; Antioxidants; Cataract; Diabetes Mellitus, Experimental; Disease Models

1994
The effectiveness of putative anti-cataract agents in the prevention of protein glycation.
    Journal of the American Optometric Association, 1995, Volume: 66, Issue:12

    Topics: Animals; Aspirin; Cataract; Cattle; Eye Proteins; Glycation End Products, Advanced; Glycosylation; G

1995
Inhibition of cataracts in moderately diabetic rats by aminoguanidine.
    Experimental eye research, 1996, Volume: 62, Issue:5

    Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Disease Progression; Glycation End Products, Adv

1996
An aldose reductase inhibitor and aminoguanidine prevent vascular endothelial growth factor expression in rats with long-term galactosemia.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1997, Volume: 115, Issue:8

    Topics: Aldehyde Reductase; Animals; Cataract; Diabetic Retinopathy; Endothelial Growth Factors; Enzyme Inhi

1997
Effects of inhibition of glycation and oxidative stress on the development of cataract and retinal vessel abnormalities in diabetic rats.
    Current eye research, 2000, Volume: 21, Issue:1

    Topics: Animals; Blood Glucose; Body Weight; Cataract; Cysteine; Diabetes Mellitus, Experimental; Diabetic R

2000
Aminoguanidine-treatment results in the inhibition of lens opacification and calpain-mediated proteolysis in Shumiya cataract rats (SCR).
    Journal of biochemistry, 2000, Volume: 128, Issue:5

    Topics: Animals; Blotting, Western; Calcium; Calpain; Cataract; Crystallins; Disease Models, Animal; Guanidi

2000
Nitric oxide participates in cataract development in selenite-treated rats.
    Current eye research, 2001, Volume: 22, Issue:3

    Topics: Animals; Blotting, Western; Calcium; Cataract; Chromatography, High Pressure Liquid; Enzyme Inhibito

2001
Involvement of inducible nitric oxide synthase in cataract formation in Shumiya cataract rat (SCR).
    Current eye research, 2001, Volume: 23, Issue:4

    Topics: Animals; Blotting, Western; Calcium; Calpain; Cataract; Enzyme Inhibitors; Guanidines; Image Process

2001
Effects of aminoguanidine and tolrestat on the development of ocular and renal structural changes in experimental diabetic rats.
    Diabetes, obesity & metabolism, 2002, Volume: 4, Issue:1

    Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Mellitus, Experimental;

2002