pimagedine has been researched along with Cardiomegaly in 7 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We conclude that long-term administration of AG to the STZ-treated rats imparts significant protection against the diabetes-derived deterioration in vascular dynamics, at least partly through inhibition of the AGEs accumulation on collagen in the arterial wall." | 1.33 | Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin-induced diabetes in rats. ( Chang, KC; Cho, YL; Hsu, KL; Lin, YD; Tseng, CD; Tseng, YZ, 2006) |
| "We investigated the hypothesis that cardiac hypertrophy due to volume overload produces changes in myocardial diastolic mechanics and stiffness that are in part due to alterations in advanced glycation end-product (AGE) collagen cross-linking." | 1.32 | Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy. ( Herrmann, KL; McCulloch, AD; Omens, JH, 2003) |
| "Aging is associated with cardiac hypertrophy and arterial stiffening possibly associated with accumulation of advanced glycation end products (AGEs)." | 1.30 | Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy. ( Bruneval, P; Corman, B; Duriez, M; Heudes, D; Levy, BI; Poitevin, P; Tedgui, A, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Parthasarathy, A | 1 |
| Gopi, V | 1 |
| Devi K M, S | 1 |
| Balaji, N | 1 |
| Vellaichamy, E | 1 |
| Maulik, SK | 1 |
| Prabhakar, P | 1 |
| Dinda, AK | 1 |
| Seth, S | 1 |
| Herrmann, KL | 1 |
| McCulloch, AD | 1 |
| Omens, JH | 1 |
| Stadler, K | 1 |
| Jenei, V | 1 |
| Somogyi, A | 1 |
| Jakus, J | 1 |
| Chang, KC | 1 |
| Hsu, KL | 1 |
| Tseng, CD | 1 |
| Lin, YD | 1 |
| Cho, YL | 1 |
| Tseng, YZ | 1 |
| Li, YM | 1 |
| Steffes, M | 1 |
| Donnelly, T | 1 |
| Liu, C | 1 |
| Fuh, H | 1 |
| Basgen, J | 1 |
| Bucala, R | 1 |
| Vlassara, H | 1 |
| Corman, B | 1 |
| Duriez, M | 1 |
| Poitevin, P | 1 |
| Heudes, D | 1 |
| Bruneval, P | 1 |
| Tedgui, A | 1 |
| Levy, BI | 1 |
7 other studies available for pimagedine and Cardiomegaly
| Article | Year |
|---|---|
Aminoguanidine inhibits ventricular fibrosis and remodeling process in isoproterenol-induced hypertrophied rat hearts by suppressing ROS and MMPs.
Topics: Animals; Antioxidants; Cardiomegaly; Fibrosis; Guanidines; Heart Ventricles; Isoproterenol; Male; Ma | 2014 |
Genistein prevents isoproterenol-induced cardiac hypertrophy in rats.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Catalase; Disease Models, Animal; Enzyme Inhibitors; Fibr | 2012 |
Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy.
Topics: Animals; Arteriovenous Fistula; Biomechanical Phenomena; Body Weight; Cardiac Volume; Cardiomegaly; | 2003 |
[Aminoguanidine prevents peroxynitrite production and cardiac hypertrophy in streptozotocin-induced diabetic rats].
Topics: Animals; Cardiomegaly; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glycation End Products, A | 2004 |
Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin-induced diabetes in rats.
Topics: Animals; Aorta; Blood Pressure; Cardiomegaly; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gu | 2006 |
Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine.
Topics: Acetylcholine; Aging; Animals; Aorta; Blood Pressure; Body Weight; Cardiomegaly; Creatinine; Enzyme | 1996 |
Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy.
Topics: Aging; Animals; Aorta; Blood Pressure; Cardiac Output; Cardiomegaly; Carotid Arteries; Elasticity; E | 1998 |