pimagedine has been researched along with Cardiac Hypertrophy in 7 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We conclude that long-term administration of AG to the STZ-treated rats imparts significant protection against the diabetes-derived deterioration in vascular dynamics, at least partly through inhibition of the AGEs accumulation on collagen in the arterial wall." | 1.33 | Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin-induced diabetes in rats. ( Chang, KC; Cho, YL; Hsu, KL; Lin, YD; Tseng, CD; Tseng, YZ, 2006) |
| "We investigated the hypothesis that cardiac hypertrophy due to volume overload produces changes in myocardial diastolic mechanics and stiffness that are in part due to alterations in advanced glycation end-product (AGE) collagen cross-linking." | 1.32 | Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy. ( Herrmann, KL; McCulloch, AD; Omens, JH, 2003) |
| "Aging is associated with cardiac hypertrophy and arterial stiffening possibly associated with accumulation of advanced glycation end products (AGEs)." | 1.30 | Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy. ( Bruneval, P; Corman, B; Duriez, M; Heudes, D; Levy, BI; Poitevin, P; Tedgui, A, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Parthasarathy, A | 1 |
| Gopi, V | 1 |
| Devi K M, S | 1 |
| Balaji, N | 1 |
| Vellaichamy, E | 1 |
| Maulik, SK | 1 |
| Prabhakar, P | 1 |
| Dinda, AK | 1 |
| Seth, S | 1 |
| Herrmann, KL | 1 |
| McCulloch, AD | 1 |
| Omens, JH | 1 |
| Stadler, K | 1 |
| Jenei, V | 1 |
| Somogyi, A | 1 |
| Jakus, J | 1 |
| Chang, KC | 1 |
| Hsu, KL | 1 |
| Tseng, CD | 1 |
| Lin, YD | 1 |
| Cho, YL | 1 |
| Tseng, YZ | 1 |
| Li, YM | 1 |
| Steffes, M | 1 |
| Donnelly, T | 1 |
| Liu, C | 1 |
| Fuh, H | 1 |
| Basgen, J | 1 |
| Bucala, R | 1 |
| Vlassara, H | 1 |
| Corman, B | 1 |
| Duriez, M | 1 |
| Poitevin, P | 1 |
| Heudes, D | 1 |
| Bruneval, P | 1 |
| Tedgui, A | 1 |
| Levy, BI | 1 |
7 other studies available for pimagedine and Cardiac Hypertrophy
| Article | Year |
|---|---|
Aminoguanidine inhibits ventricular fibrosis and remodeling process in isoproterenol-induced hypertrophied rat hearts by suppressing ROS and MMPs.
Topics: Animals; Antioxidants; Cardiomegaly; Fibrosis; Guanidines; Heart Ventricles; Isoproterenol; Male; Ma | 2014 |
Genistein prevents isoproterenol-induced cardiac hypertrophy in rats.
Topics: Animals; Cardiomegaly; Cardiotonic Agents; Catalase; Disease Models, Animal; Enzyme Inhibitors; Fibr | 2012 |
Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy.
Topics: Animals; Arteriovenous Fistula; Biomechanical Phenomena; Body Weight; Cardiac Volume; Cardiomegaly; | 2003 |
[Aminoguanidine prevents peroxynitrite production and cardiac hypertrophy in streptozotocin-induced diabetic rats].
Topics: Animals; Cardiomegaly; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glycation End Products, A | 2004 |
Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin-induced diabetes in rats.
Topics: Animals; Aorta; Blood Pressure; Cardiomegaly; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gu | 2006 |
Prevention of cardiovascular and renal pathology of aging by the advanced glycation inhibitor aminoguanidine.
Topics: Acetylcholine; Aging; Animals; Aorta; Blood Pressure; Body Weight; Cardiomegaly; Creatinine; Enzyme | 1996 |
Aminoguanidine prevents age-related arterial stiffening and cardiac hypertrophy.
Topics: Aging; Animals; Aorta; Blood Pressure; Cardiac Output; Cardiomegaly; Carotid Arteries; Elasticity; E | 1998 |