pimagedine has been researched along with Brain Ischemia in 20 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "All rats underwent middle cerebral artery occlusion (MCAO) by subtemporal craniectomy, and permanent ischemia was created." | 1.38 | An evaluation of the effectiveness of pre-ischemic hyperbaric oxygen and post-ischemic aminoguanidine in experimental cerebral ischemia. ( Duz, B; Gonul, E; Harman, F; Hasturk, AE; Korkmaz, A, 2012) |
| "Neuroprotection against cerebral ischemia can be realized if the brain is preconditioned by previous exposure to a brief period of sublethal ischemia." | 1.30 | Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning. ( Gidday, JM; Holtzman, DM; Maceren, RG; Park, TS; Pelligrino, DA; Shah, AR; Wang, Q, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 12 (60.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harman, F | 1 |
| Hasturk, AE | 1 |
| Duz, B | 1 |
| Gonul, E | 1 |
| Korkmaz, A | 1 |
| Zhu, DY | 1 |
| Deng, Q | 1 |
| Yao, HH | 1 |
| Wang, DC | 1 |
| Deng, Y | 1 |
| Liu, GQ | 1 |
| Sugimoto, K | 1 |
| Iadecola, C | 6 |
| Chang, CP | 1 |
| Lee, CC | 1 |
| Chen, SH | 1 |
| Lin, MT | 1 |
| Danielisová, V | 1 |
| Némethová, M | 1 |
| Burda, J | 1 |
| Park, EM | 2 |
| Cho, S | 2 |
| Frys, K | 2 |
| Racchumi, G | 1 |
| Zhou, P | 2 |
| Anrather, J | 1 |
| Ross, ME | 1 |
| Yao, Y | 1 |
| Zhou, JY | 1 |
| Zhu, XJ | 1 |
| Millerot-Serrurot, E | 1 |
| Chausset, A | 1 |
| Mossiat, C | 2 |
| Prigent-Tessier, A | 1 |
| Bertrand, N | 2 |
| Garnier, P | 2 |
| Beley, A | 2 |
| Marie, C | 2 |
| Zhang, F | 3 |
| Xu, X | 1 |
| Leib, SL | 1 |
| Kim, YS | 1 |
| Black, SM | 1 |
| Tureen, JH | 1 |
| Täuber, MG | 1 |
| Higuchi, Y | 2 |
| Hattori, H | 2 |
| Kume, T | 2 |
| Tsuji, M | 2 |
| Akaike, A | 2 |
| Furusho, K | 1 |
| Nagayama, M | 1 |
| Gidday, JM | 1 |
| Shah, AR | 1 |
| Maceren, RG | 1 |
| Wang, Q | 1 |
| Pelligrino, DA | 1 |
| Holtzman, DM | 1 |
| Park, TS | 1 |
| Takizawa, S | 1 |
| Fukuyama, N | 1 |
| Hirabayashi, H | 1 |
| Nakazawa, H | 1 |
| Shinohara, Y | 1 |
| Shiraishi, K | 1 |
| Fassbender, K | 1 |
| Fatar, M | 1 |
| Ragoschke, A | 1 |
| Picard, M | 1 |
| Bertsch, T | 1 |
| Kuehl, S | 1 |
| Hennerici, M | 1 |
| Demougeot, C | 1 |
| Giroud, M | 1 |
| Cash, D | 1 |
| Beech, JS | 1 |
| Rayne, RC | 1 |
| Bath, PM | 1 |
| Meldrum, BS | 1 |
| Williams, SC | 1 |
20 other studies available for pimagedine and Brain Ischemia
| Article | Year |
|---|---|
An evaluation of the effectiveness of pre-ischemic hyperbaric oxygen and post-ischemic aminoguanidine in experimental cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Combined Modality Therapy; Disease Models, Animal; Enzyme Inhibitors | 2012 |
Inducible nitric oxide synthase expression in the ischemic core and penumbra after transient focal cerebral ischemia in mice.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Enzyme Inhibitors; Guanidines; | 2002 |
Effects of aminoguanidine on cerebral ischemia in mice: comparison between mice with and without inducible nitric oxide synthase gene.
Topics: Animals; Brain Ischemia; Enzyme Inhibitors; Guanidines; Infarction, Middle Cerebral Artery; Male; Mi | 2002 |
Aminoguanidine protects against intracranial hypertension and cerebral ischemic injury in experimental heatstroke.
Topics: Animals; Brain Ischemia; Guanidines; Heat Stroke; Intracranial Hypertension; Male; Neuroprotective A | 2004 |
The protective effect of aminoguanidine on cerebral ischemic damage in the rat brain.
Topics: Animals; Apoptosis; Brain Ischemia; Dose-Response Relationship, Drug; Enzyme Activation; Guanidines; | 2004 |
Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Guanidines; Infarction, Middle Cerebral Artery; Int | 2004 |
Obligatory role of inducible nitric oxide synthase in ischemic preconditioning.
Topics: Animals; Brain Ischemia; Calcium; Carotid Stenosis; Guanidines; Immunohistochemistry; Infarction, Mi | 2005 |
The effect of inducible nitric oxide synthase inhibitor on microvascular permeability after cerebral ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Capillary Permeability; Enzyme Inhibitors; Guanidines; Male; Nitric Oxide S | 2005 |
Effect of early decrease in the lesion size on late brain tissue loss, synaptophysin expression and functionality after a focal brain lesion in rats.
Topics: 2,2'-Dipyridyl; Animals; Body Weight; Brain; Brain Ischemia; Cerebral Cortex; Guanidines; Immunohist | 2007 |
Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Arginine; Blood Glucose; Blood Pressure; | 1995 |
Inducible nitric oxide synthase and the effect of aminoguanidine in experimental neonatal meningitis.
Topics: Animals; Animals, Newborn; Brain Ischemia; Central Nervous System; Guanidines; Meningitis, Bacterial | 1998 |
Increase in nitric oxide in the hypoxic-ischemic neonatal rat brain and suppression by 7-nitroindazole and aminoguanidine.
Topics: Animals; Animals, Newborn; Brain Chemistry; Brain Ischemia; Enzyme Induction; Enzyme Inhibitors; Gua | 1998 |
Temporal characteristics of the protective effect of aminoguanidine on cerebral ischemic damage.
Topics: Animals; Blood Glucose; Blood Pressure; Body Temperature; Brain Ischemia; Cerebral Infarction; Gases | 1998 |
Delayed treatment with aminoguanidine decreases focal cerebral ischemic damage and enhances neurologic recovery in rats.
Topics: Animals; Arterial Occlusive Diseases; Brain Ischemia; Cerebral Arteries; Dose-Response Relationship, | 1998 |
Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning.
Topics: Animals; Animals, Newborn; Brain Ischemia; Calcium; Dizocilpine Maleate; Enzyme Inhibitors; Guanidin | 1999 |
Dynamics of nitrotyrosine formation and decay in rat brain during focal ischemia-reperfusion.
Topics: Animals; Brain Chemistry; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pressure | 1999 |
Protective effect of aminoguanidine on hypoxic-ischemic brain damage and temporal profile of brain nitric oxide in neonatal rat.
Topics: Animals; Animals, Newborn; Brain; Brain Ischemia; Guanidines; Hypoxia; Nitric Oxide; Rats | 2000 |
Subacute but not acute generation of nitric oxide in focal cerebral ischemia.
Topics: Animals; Brain Ischemia; Corpus Striatum; Enzyme Inhibitors; Guanidines; Microdialysis; Nerve Degene | 2000 |
N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury.
Topics: 2,2'-Dipyridyl; Acute Disease; Animals; Aspartic Acid; Biomarkers; Brain Chemistry; Brain Edema; Bra | 2001 |
Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain.
Topics: Animals; Brain; Brain Ischemia; Catalysis; Cell Survival; Disease Models, Animal; Drug Administratio | 2001 |