pimagedine has been researched along with Brain Injuries in 18 studies
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure
aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Daily treatment of AG at the dosage of 100 mg/kg or normal saline was given intraperitoneally into rats starting 2 h before or 30 min after brain injury." | 1.32 | Neuroprotection by aminoguanidine after lateral fluid-percussive brain injury in rats: a combined magnetic resonance imaging, histopathologic and functional study. ( Ling, EA; Lu, J; Moochhala, S; Moore, XL; Ng, KC; Shirhan, M; Tan, MH; Teo, AL; Wong, MC, 2003) |
| "After sham treatment, the necrosis expanded to 8." | 1.32 | Secondary growth of a cortical necrosis: effect of NOS inhibition by aminoguanidine post insult. ( Baethmann, A; Plesnila, N; Rinecker, M; Stoffel, M, 2003) |
| " bolus 10 min prior to trauma (300 mg/kg body weight; n = 10) and a second bolus of the same dosage intraperitoneally 1 h after trauma." | 1.31 | Role of nitric oxide in the secondary expansion of a cortical brain lesion from cold injury. ( Baethmann, A; Eriskat, J; Plesnila, N; Rinecker, M; Stoffel, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 14 (77.78) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Di, F | 1 |
| Yan-Ting, G | 1 |
| Hui, L | 1 |
| Tao, T | 1 |
| Zai-Hua, X | 1 |
| Xue-Ying, S | 1 |
| Hong-Li, X | 1 |
| Yun-Jie, W | 1 |
| Hao, W | 1 |
| Wu, XQ | 1 |
| Xu, RT | 1 |
| Fan, D | 1 |
| Gu, YT | 1 |
| Lv, H | 1 |
| Tang, T | 1 |
| Xu, ZH | 1 |
| Song, ZQ | 1 |
| Tong, XJ | 1 |
| Lu, J | 4 |
| Moochhala, S | 3 |
| Shirhan, M | 2 |
| Ng, KC | 3 |
| Tan, MH | 2 |
| Teo, AL | 3 |
| Ling, EA | 2 |
| Moore, XL | 1 |
| Wong, MC | 1 |
| Rinecker, M | 3 |
| Plesnila, N | 3 |
| Baethmann, A | 3 |
| Stoffel, M | 3 |
| Atan, MS | 1 |
| Moochhala, SM | 1 |
| Low, K | 1 |
| Zhao, P | 1 |
| Zuo, Z | 1 |
| Louin, G | 1 |
| Marchand-Verrecchia, C | 1 |
| Palmier, B | 1 |
| Plotkine, M | 2 |
| Jafarian-Tehrani, M | 1 |
| Wang, YB | 1 |
| Ou, SW | 1 |
| Li, GY | 1 |
| Liu, YH | 1 |
| Kawano, T | 1 |
| Kunz, A | 1 |
| Abe, T | 1 |
| Girouard, H | 1 |
| Anrather, J | 1 |
| Zhou, P | 1 |
| Iadecola, C | 1 |
| Lecanu, L | 1 |
| Verrecchia, C | 1 |
| Margaill, I | 1 |
| Boulu, RG | 1 |
| Wada, K | 1 |
| Chatzipanteli, K | 1 |
| Kraydieh, S | 1 |
| Busto, R | 1 |
| Dietrich, WD | 1 |
| Sinz, EH | 1 |
| Kochanek, PM | 1 |
| Dixon, CE | 1 |
| Clark, RS | 1 |
| Carcillo, JA | 1 |
| Schiding, JK | 1 |
| Chen, M | 1 |
| Wisniewski, SR | 1 |
| Carlos, TM | 1 |
| Williams, D | 1 |
| DeKosky, ST | 1 |
| Watkins, SC | 1 |
| Marion, DW | 1 |
| Billiar, TR | 1 |
| Görlach, C | 1 |
| Hortobágyi, T | 1 |
| Benyó, Z | 1 |
| Wahl, M | 1 |
| Eriskat, J | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Inhalatorial Sedation in Patient With SAH Versus Conventional Intravenous Sedation (GAS-SAH)[NCT00830843] | Phase 4 | 13 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 other studies available for pimagedine and Brain Injuries
| Article | Year |
|---|---|
Role of aminoguanidine in brain protection in surgical brain injury in rat.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Brain; Brain Chemistry; Brain Edema; Brain Injuries | 2008 |
The molecular mechanism of aminoguanidine-mediated reduction on the brain edema after surgical brain injury in rats.
Topics: Animals; Aquaporin 4; Brain Edema; Brain Injuries; Disease Models, Animal; Dose-Response Relationshi | 2009 |
The protective mechanism for the blood-brain barrier induced by aminoguanidine in surgical brain injury in rats.
Topics: Animals; Blood-Brain Barrier; Brain Injuries; Glutathione; Guanidines; Humans; Male; Malondialdehyde | 2011 |
Nitric oxide induces macrophage apoptosis following traumatic brain injury in rats.
Topics: Animals; Apoptosis; Brain Injuries; Fluorescent Antibody Technique; Guanidines; Macrophages; Male; N | 2003 |
Neuroprotection by aminoguanidine after lateral fluid-percussive brain injury in rats: a combined magnetic resonance imaging, histopathologic and functional study.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Protein | 2003 |
Secondary growth of a cortical necrosis: effect of NOS inhibition by aminoguanidine post insult.
Topics: Animals; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Drug Administration Schedule; Guan | 2003 |
Application of combined magnetic resonance imaging and histopathologic and functional studies for evaluation of aminoguanidine following traumatic brain injury in rats.
Topics: Animals; Apoptosis; Brain; Brain Chemistry; Brain Injuries; Caspase 3; Caspases; Enzyme Inhibitors; | 2004 |
Effects of aminoguanidine and L-arginine methyl ester resuscitation following induction of fluid-percussion injury and severe controlled hemorrhagic shock in the rat brain.
Topics: Animals; Blood Pressure; Brain; Brain Injuries; Cerebrovascular Circulation; Disease Models, Animal; | 2004 |
Isoflurane preconditioning induces neuroprotection that is inducible nitric oxide synthase-dependent in neonatal rats.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Blood Gas Analysis; Blotting, Western; Body Weig | 2004 |
Selective inhibition of inducible nitric oxide synthase reduces neurological deficit but not cerebral edema following traumatic brain injury.
Topics: Amidines; Animals; Benzylamines; Blood-Brain Barrier; Body Water; Brain Edema; Brain Injuries; Enzym | 2006 |
Concentrations of nitric oxide in rat brain tissues after diffuse brain injury and neuroprotection by the selective inducible nitric oxide synthase inhibitor aminoguanidine.
Topics: Animals; Brain; Brain Injuries; Enzyme Inhibitors; Guanidines; Neuroprotective Agents; Nitric Oxide; | 2005 |
iNOS-derived NO and nox2-derived superoxide confer tolerance to excitotoxic brain injury through peroxynitrite.
Topics: Animals; Body Temperature; Brain; Brain Injuries; Carotid Arteries; Guanidines; Ischemic Preconditio | 2007 |
iNOS contribution to the NMDA-induced excitotoxic lesion in the rat striatum.
Topics: Animals; Brain Injuries; Corpus Striatum; Dexamethasone; Dizocilpine Maleate; Guanidines; Male; N-Me | 1998 |
Inducible nitric oxide synthase expression after traumatic brain injury and neuroprotection with aminoguanidine treatment in rats.
Topics: Animals; Astrocytes; Brain Injuries; Enzyme Induction; Enzyme Inhibitors; Guanidines; Macrophages; M | 1998 |
Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice.
Topics: Animals; Brain Damage, Chronic; Brain Injuries; Cognition Disorders; Enzyme Induction; Enzyme Inhibi | 1999 |
Aminoguanidine reduces brain lesion volume after cold injury in the rat.
Topics: Animals; Blood Pressure; Brain; Brain Injuries; Cold Temperature; Enzyme Inhibitors; Guanidines; Mal | 2000 |
Role of nitric oxide in the secondary expansion of a cortical brain lesion from cold injury.
Topics: Animals; Arginine; Brain; Brain Injuries; Cold Temperature; Enzyme Inhibitors; Guanidines; Male; Nec | 2001 |
Attenuation of secondary lesion growth in the brain after trauma by selective inhibition of the inducible NO-synthase.
Topics: Animals; Brain Damage, Chronic; Brain Edema; Brain Injuries; Cerebral Cortex; Enzyme Inhibitors; Gua | 2000 |